The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9−/− mouse model of cystinuria

Authors: Mayayo-Vallverdú, Clara, López de Heredia, Miguel, Prat, Esther, González, Laura, Espino Guarch, Meritxell, Vilches, Clara, Muñoz, Lourdes, Asensi, Miguel A., Serra, Carmen, Llebaria, Amadeu, Casado, Mercedes, Artuch, Rafael, Garrabou, Gloria, Garcia-Roves, Pablo M., Pallardó, Federico V., Nunes, Virginia

Source: In Redox Biology August 2023 64

IL‐2 amplifies quantitative TCR signalling inputs to drive Th1 and Th2 differentiation.

Authors: Al‐Aghbar, Mohammad Ameen¹ (AUTHOR), Espino Guarch, Meritxell¹ (AUTHOR), van Panhuys, Nicholas^1,2,3 (AUTHOR) nvanpanhuys@sidra.org

Source: Immunology. Sep2024, Vol. 173 Issue 1, p196-208. 13p.

Subject Terms: *T cell receptors, *TH2 cells, *TH1 cells, *CELL differentiation, *CD4 antigen

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

Authors: Errasti-Murugarren, Ekaitz, Fort, Joana, Bartoccioni, Paola, Díaz, Lucía, Pardon, Els, Carpena, Xavier, Espino-Guarch, Meritxell, Zorzano, Antonio, Ziegler, Christine, Steyaert, Jan, Fernández-Recio, Juan, Fita, Ignacio, Palacín, Manuel

Source: Nature communications. 10(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132431729.0x000001&indx=1&recIds=ETOCvdc_100132431729.0x000001

Functional Characterization of the MYO6 Variant p.E60Q in Non-Syndromic Hearing Loss Patients.

Authors: Alkowari, Moza¹ (AUTHOR) mespinoguarch@sidra.org, Espino-Guarch, Meritxell¹ (AUTHOR) sdaas@sidra.org, Daas, Sahar^1,2 (AUTHOR) dabdelrahman@sidra.org, Abdelrahman, Doua¹ (AUTHOR) whasan@sidra.org, Hasan, Waseem¹ (AUTHOR) nkrishnamoorthy2@sidra.org, Krishnamoorthy, Navaneethakrishnan¹ (AUTHOR) asathappan@sidra.org, Sathappan, Abbirami¹ (AUTHOR) nvanpanhuys@sidra.org, Sheehan, Patrick³ (AUTHOR) psheehan@sidra.org, Van Panhuys, Nicholas¹ (AUTHOR) estivill@me.com, Estivill, Xavier^1,4 (AUTHOR)

Source: International Journal of Molecular Sciences. Mar2022, Vol. 23 Issue 6, p3369-3369. 14p.

Subject Terms: *HEARING disorders, *HAIR cells, *MISSENSE mutation, *HELA cells, *CELL membranes, *GENETIC disorders, *GENE frequency

Geographic Terms: QATAR

Applications of Genome-Editing Technologies for Type 1 Diabetes.

Authors: El Nahas, Rana, Al-Aghbar, Mohammad Ameen, Herrero, Laura, van Panhuys, Nicholas, Espino-Guarch, Meritxell

Source: International Journal of Molecular Sciences; Jan2024, Vol. 25 Issue 1, p344, 15p

Subject Terms: TYPE 1 diabetes, MESENCHYMAL stem cells, STEM cell transplantation, AUTOIMMUNE diseases, GENETIC regulation

Asthma and the Missing Heritability Problem: Necessity for Multiomics Approaches in Determining Accurate Risk Profiles.

Authors: Augustine, Tracy, Al-Aghbar, Mohammad Ameen, Al-Kowari, Moza, Espino-Guarch, Meritxell, van Panhuys, Nicholas

Source: Frontiers in Immunology; 5/25/2022, Vol. 13, p1-16, 16p

Subject Terms: HERITABILITY, GENOME-wide association studies, DISEASE incidence, ASTHMA, CYTOPLASMIC inheritance, WHEEZE

Gut microbial influences on the adaptive immune system and the development of cow milk allergy.

Authors: Augustine, Tracy, Badri, Fariada, Murugesan, Selvasankar, Espino Guarch, Meritxell, Ameen Al-Aghbar, Mohammad, El Nahas, Rana, Akobeng, Anthony, Elawad, Mamoun, Al Khodor, Souhaila, Adeli, Mehdi, van Panhuys, Nicholas

Source: Qatar Medical Journal; 2022, Vol. 2022 Issue 2, p1-2, 2p

Subject Terms: MILK allergy, GOAT milk, MONONUCLEAR leukocytes, REGULATORY T cells, SYSTEMS development, IMMUNE system, NUCLEOTIDE sequencing

Dendritic cell activation and screening for key molecular signatures required for the induction of allergic responses.

Authors: Ameen Al-Aghbar, Mohammad, Augustine, Tracy, Espino Guarch, Meritxell, El Nahas, Rana, Missous, Ghalia, van Panhuys, Nicholas

Source: Qatar Medical Journal; 2022, Vol. 2022 Issue 2, p1-2, 2p

Subject Terms: DENDRITIC cells, GENE expression profiling, PEPTIDES, TRANSCRIPTION factors, PAPAIN

Inducible Slc7a7 Knockout Mouse Model Recapitulates Lysinuric Protein Intolerance Disease.

Authors: Bodoy, Susanna, Sotillo, Fernando, Espino-Guarch, Meritxell, Sperandeo, Maria Pia, Ormazabal, Aida, Zorzano, Antonio, Sebastio, Gianfranco, Artuch, Rafael, Palacín, Manuel

Source: International Journal of Molecular Sciences; Nov2019, Vol. 20 Issue 21, p5294, 1p

Subject Terms: KNOCKOUT mice, HUMAN phenotype, PULMONARY alveolar proteinosis, AMINO acids, PROTEINS