Structural insight into recognition of Clostridioides difficile toxin A by novel neutralizing nanobodies targeting QTIN-like motifs within its receptor-binding domain

Authors: Sluchanko, Nikolai N., Sokolova, Irina V., Favorskaya, Irina A., Esmagambetov, Ilias B., Tukhvatulin, Amir I., Alekseeva, Irina A., Ungur, Anastasiya S., Varfolomeeva, Larisa A., Boyko, Konstantin M., Logunov, Denis Y., Gintsburg, Alexander L., Popov, Vladimir O., Shcheblyakov, Dmitry V., Belyi, Yury F.

Source: In International Journal of Biological Macromolecules December 2024 283 Part 4

Immunogenicity and protectivity of intranasally delivered vector-based heterologous prime-boost COVID-19 vaccine Sputnik V in mice and non-human primates

Authors: Tukhvatulin, Amir I., Gordeychuk, Ilya V., Dolzhikova, Inna V., Dzharullaeva, Alina S., Krasina, Marina E., Bayurova, Ekaterina O., Grousova, Daria M., Kovyrshina, Anna V., Kondrashova, Alla S., Avdoshina, Daria V., Gulyaev, Stanislav A., Gulyaeva, Tatiana V., Moroz, Andrey V., Illarionova, Viktoria V., Zorkov, Ilya D., Iliukhina, Anna A., Shelkov, Artem Y., Botikov, Andrei G., Erokhova, Alina S., Shcheblyakov, Dmitry V., Esmagambetov, Ilias B., Zubkova, Olga V., Tokarskaya, Elisaveta A., Savina, Daria M., Vereveyko, Yulia R., Ungur, Anastasiya S., Naroditsky, Boris S., Ishmukhametov, Aydar A., Logunov, Denis Y., Gintsburg, Alexander L.

Source: Emerging microbes & infections. 11(1):2229-2247

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194687024.0x000001&indx=1&recIds=ETOCvdc_100194687024.0x000001

An open, non-randomised, phase 1/2 trial on the safety, tolerability, and immunogenicity of single-dose vaccine “Sputnik Light” for prevention of coronavirus infection in healthy adults

Authors: Tukhvatulin, Amir I., Dolzhikova, Inna V., Shcheblyakov, Dmitry V., Zubkova, Olga V., Dzharullaeva, Alina S., Kovyrshina, Anna V., Lubenets, Nadezhda L., Grousova, Daria M., Erokhova, Alina S., Botikov, Andrei G., Izhaeva, Fatima M., Popova, Olga, Ozharovskaia, Tatiana A., Esmagambetov, Ilias B., Favorskaya, Irina A., Zrelkin, Denis I., Voronina, Daria V., Shcherbinin, Dmitry N., Semikhin, Alexander S., Simakova, Yana V., Tokarskaya, Elizaveta A., Shmarov, Maksim M., Nikitenko, Natalia A., Gushchin, Vladimir A., Smolyarchuk, Elena A., Zubkova, Tatiana G., Zakharov, Konstantin A., Vasilyuk, Vasiliy B., Borisevich, Sergei V., Naroditsky, Boris S., Logunov, Denis Y., Gintsburg, Alexander L.

Source: In The Lancet Regional Health - Europe December 2021 11

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

Authors: Logunov, Denis Y ^{*, *}, Dolzhikova, Inna V ^*, Shcheblyakov, Dmitry V, Tukhvatulin, Amir I, Zubkova, Olga V, Dzharullaeva, Alina S, Kovyrshina, Anna V, Lubenets, Nadezhda L, Grousova, Daria M, Erokhova, Alina S, Botikov, Andrei G, Izhaeva, Fatima M, Popova, Olga, Ozharovskaya, Tatiana A, Esmagambetov, Ilias B, Favorskaya, Irina A, Zrelkin, Denis I, Voronina, Daria V, Shcherbinin, Dmitry N, Semikhin, Alexander S, Simakova, Yana V, Tokarskaya, Elizaveta A, Egorova, Daria A, Shmarov, Maksim M, Nikitenko, Natalia A, Gushchin, Vladimir A, Smolyarchuk, Elena A, Zyryanov, Sergey K, Borisevich, Sergei V, Naroditsky, Boris S, Gintsburg, Alexander L

Source: In The Lancet 20-26 February 2021 397(10275):671-681

Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia

Authors: Logunov, Denis Y ^*, Dolzhikova, Inna V, Zubkova, Olga V, Tukhvatulin, Amir I, Shcheblyakov, Dmitry V, Dzharullaeva, Alina S, Grousova, Daria M, Erokhova, Alina S, Kovyrshina, Anna V, Botikov, Andrei G, Izhaeva, Fatima M, Popova, Olga, Ozharovskaya, Tatiana A, Esmagambetov, Ilias B, Favorskaya, Irina A, Zrelkin, Denis I, Voronina, Daria V, Shcherbinin, Dmitry N, Semikhin, Alexander S, Simakova, Yana V, Tokarskaya, Elizaveta A, Lubenets, Nadezhda L, Egorova, Daria A, Shmarov, Maksim M, Nikitenko, Natalia A, Morozova, Lola F, Smolyarchuk, Elena A, Kryukov, Evgeny V, Babira, Vladimir F, Borisevich, Sergei V, Naroditsky, Boris S, Gintsburg, Alexander L

Source: In The Lancet 26 September-2 October 2020 396(10255):887-897

Structural Basis for Evasion of New SARS-CoV-2 Variants from the Potent Virus-Neutralizing Nanobody Targeting the S-Protein Receptor-Binding Domain.

Authors: Sluchanko, Nikolai N., Shcheblyakov, Dmitry V., Varfolomeeva, Larisa A., Favorskaya, Irina A., Dolzhikova, Inna V., Korobkova, Anastasia I., Alekseeva, Irina A., Esmagambetov, Ilias B., Derkaev, Artem A., Prokofiev, Vladimir V., Zorkov, Ilya D., Logunov, Denis Y., Gintsburg, Alexander L., Popov, Vladimir O., Boyko, Konstantin M.

Source: Biochemistry (00062979); Jul2024, Vol. 89 Issue 7, p1260-1272, 13p

Subject Terms: SARS-CoV-2 Omicron variant, SARS-CoV-2 Delta variant, SARS-CoV-2, CORONAVIRUSES, BINDING site assay, MONOCLONAL antibodies

Safety and immunogenicity of rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine against SARS-CoV-2 in healthy adolescents: an open-label, non-randomized, multicenter, phase 1/2, dose-escalation study.

Authors: Tukhvatulin, Amir I., Dolzhikova, Inna V., Dzharullaeva, Alina S., Grousova, Daria M., Kovyrshina, Anna V., Zubkova, Olga V., Zorkov, Ilya D., Iliukhina, Anna A., Shelkov, Artem Y., Erokhova, Alina S., Popova, Olga, Ozharovskaia, Tatiana A., Zrelkin, Denis I., Izhaeva, Fatima M., Shcheblyakov, Dmitry V., Esmagambetov, Ilias B., Tokarskaya, Elisaveta A., Nikitenko, Natalia A., Lubenets, Nadezhda L., Khadorich, Elizaveta A.

Source: Frontiers in Immunology; 2023, p1-13, 13p

Subject Terms: COVID-19 vaccines, IMMUNE response, SARS-CoV-2 Omicron variant, SARS-CoV-2 Delta variant, NEUTRALIZATION tests, ANTIBODY titer

rAAV expressing recombinant antibody for emergency prevention and long-term prophylaxis of COVID-19.

Authors: Esmagambetov, Ilias B., Ryabova, Ekaterina I., Derkaev, Artem A., Shcheblyakov, Dmitry V., Dolzhikova, Inna V., Favorskaya, Irina A., Grousova, Daria M., Dovgiy, Mikhail A., Prokofiev, Vladimir V., Gosudarev, Andrey I., Byrikhina, Daria V., Zorkov, Ilia D., Iliukhina, Anna A., Kovyrshina, Anna V., Shelkov, Artem Y., Naroditsky, Boris S., Logunov, Denis Y., Gintsburg, Alexander L.

Source: Frontiers in Immunology; 3/30/2023, Vol. 14, p1-13, 13p

Subject Terms: RECOMBINANT antibodies, SARS-CoV-2 Omicron variant, GENETIC vectors, SARS-CoV-2, COVID-19

Single-domain antibody delivery using an mRNA platform protects against lethal doses of botulinum neurotoxin A.

Authors: Panova, Eugenia A., Kleymenov, Denis A., Shcheblyakov, Dmitry V., Bykonia, Evgeniia N., Mazunina, Elena P., Dzharullaeva, Alina S., Zolotar, Anastasia N., Derkaev, Artem A., Esmagambetov, Ilias B., Sorokin, Ivan I., Usachev, Evgeny V., Noskov, Anatoly N., Ivanov, Igor A., Zatsepin, Timofei S., Dmitriev, Sergey E., Gushchin, Vladimir A., Naroditsky, Boris S., Logunov, Denis Y., Gintsburg, Alexander L.

Source: Frontiers in Immunology; 2/14/2023, Vol. 14, p1-10, 10p

Subject Terms: BOTULINUM toxin, IMMUNOGLOBULINS, COVID-19 pandemic, MESSENGER RNA, GENE expression

Cross-Reactive Fc-Fused Single-Domain Antibodies to Hemagglutinin Stem Region Protect Mice from Group 1 Influenza a Virus Infection.

Authors: Voronina, Daria V., Shcheblyakov, Dmitry V., Favorskaya, Irina A., Esmagambetov, Ilias B., Dzharullaeva, Alina S., Tukhvatulin, Amir I., Zubkova, Olga V., Popova, Olga, Kan, Vladislav Y., Bandelyuk, Alina S., Shmarov, Maxim M., Logunov, Denis Y., Naroditskiy, Boris S., Gintsburg, Aleksandr L.

Source: Viruses (1999-4915); Nov2022, Vol. 14 Issue 11, p2485, 19p

Subject Terms: VIRUS diseases, INFLUENZA A virus, INFLUENZA viruses, INFLUENZA A virus, H1N1 subtype, HEMAGGLUTININ, PLANT viruses

rAAV expressing recombinant neutralizing antibody for the botulinum neurotoxin type A prophylaxis.

Authors: Derkaev, Artem A., Ryabova, Ekaterina I., Esmagambetov, Ilias B., Shcheblyakov, Dmitry V., Godakova, Svetlana A., Vinogradova, Irina D., Noskov, Anatoly N., Logunov, Denis Y., Naroditsky, Boris S., Gintsburg, Alexander L.

Source: Frontiers in Microbiology; 9/27/2022, Vol. 13, p01-15, 15p

Subject Terms: BOTULINUM toxin, BOTULINUM A toxins, RECOMBINANT antibodies, BLOOD coagulation factor VIII, BACTERIAL toxins, TOXINS, MONOCLONAL antibodies

Company/Entity: UNITED States. Food & Drug Administration

Single-Domain Antibodies Efficiently Neutralize SARS-CoV-2 Variants of Concern.

Authors: Favorskaya, Irina A., Shcheblyakov, Dmitry V., Esmagambetov, Ilias B., Dolzhikova, Inna V., Alekseeva, Irina A., Korobkova, Anastasia I., Voronina, Daria V., Ryabova, Ekaterina I., Derkaev, Artem A., Kovyrshina, Anna V., Iliukhina, Anna A., Botikov, Andrey G., Voronina, Olga L., Egorova, Daria A., Zubkova, Olga V., Ryzhova, Natalia N., Aksenova, Ekaterina I., Kunda, Marina S., Logunov, Denis Y., Naroditsky, Boris S.

Source: Frontiers in Immunology; 2/24/2022, Vol. 13, p1-9, 9p

Subject Terms: SARS-CoV-2, SARS-CoV-2 Omicron variant, SARS-CoV-2 Delta variant, IMMUNOGLOBULINS, COVID-19 treatment

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Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice.

Authors: Godakova, Svetlana A., Noskov, Anatoly N., Vinogradova, Irina D., Ugriumova, Galina A., Solovyev, Andrey I., Esmagambetov, Ilias B., Tukhvatulin, Amir I., Logunov, Denis Y., Naroditsky, Boris S., Shcheblyakov, Dmitry V., Gintsburg, Aleksandr L.

Source: Toxins; Aug2019, Vol. 11 Issue 8, p464-464, 1p

Subject Terms: BOTULINUM A toxins, CLOSTRIDIUM botulinum, BOTULINUM toxin, NERVOUS system, BOTULISM, IMMUNOGLOBULIN G, MICE