Metabotropic glutamate receptor orthosteric ligands and their binding sites

Authors: Acher, Francine C., Cabayé, Alexandre, Eshak, Floriane, Goupil-Lamy, Anne, Pin, Jean-Philippe

Source: In Neuropharmacology 15 February 2022 204

Epitope Identification of an mGlu5 Receptor Nanobody Using Physics-Based Molecular Modeling and Deep Learning Techniques.

Authors: Eshak, Floriane, Pion, Léo, Scholler, Pauline, Nevoltris, Damien, Chames, Patrick, Rondard, Philippe, Pin, Jean-Philippe, Acher, Francine C., Goupil-Lamy, Anne

Source: Journal of Chemical Information & Modeling; 6/10/2024, Vol. 64 Issue 11, p4436-4461, 26p

Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)‑2-((S)‑Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu2 Receptor Agonist.

Authors: Liu, Na, Eshak, Floriane, Malhaire, Fanny, Brabet, Isabelle, Prézeau, Laurent, Renard, Emma, Pin, Jean-Philippe, Acher, Francine C., Staudt, Markus, Bunch, Lennart

Source: Journal of Medicinal Chemistry; 1/25/2024, Vol. 67 Issue 2, p1314-1326, 13p

Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu2Receptor Agonist

Authors: Liu, Na, Eshak, Floriane, Malhaire, Fanny, Brabet, Isabelle, Prézeau, Laurent, Renard, Emma, Pin, Jean-Philippe, Acher, Francine C., Staudt, Markus, Bunch, Lennart

Source: Journal of Medicinal Chemistry; January 2024, Vol. 67 Issue: 2 p1314-1326, 13p