BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice

Authors: Sherman, Matthew E. ^a, Michalski, Jane ^{a, b}, Das, Sayan ^a, Yang, Hyojik ^a, Chandrasekaran, Lakshmi ^c, O'Meara, Timothy R. ^d, Dowling, David J. ^{d, e}, Levy, Ofer ^{d, e, f}, Barnoy, Shoshana ^c, Venkatesan, Malabi ^c, Ernst, Robert K. ^{a, ⁎}

Source: In Vaccine 19 March 2025 50

Immune profile diversity is achieved with synthetic TLR4 agonists combined with the RG1-VLP vaccine in mice

Authors: Matthews, Rebecca L. ^a, Khan, Nazneen ^a, Beckman, Bradley ^a, Sharma, Simran ^b, Dietz, Zackary ^b, Picking, William D. ^b, Izmirlian, Grant ^c, Sanders, Chelsea ^d, Stocks, Stacy M. ^d, Difilippantonio, Simone ^d, Kirnbauer, Reinhard ^e, Roden, Richard B. ^f, Pinto, Ligia A. ^g, Shoemaker, Robert H. ^h, Ernst, Robert K. ⁱ, Marshall, Jason D. ^{a, ⁎}

Source: In Vaccine 12 January 2025 44

Phenotypic and in silico characterization of carbapenem-resistant Serratia marcescens clinical strains

Authors: Ballaben, Anelise Stella ^{a, b, ⁎}, de Almeida, Otávio G.G. ^b, Ferreira, Joseane Cristina ^b, de Oliveira Garcia, Doroti ^c, Doi, Yohei ^{d, e}, Ernst, Robert K. ^f, von Zeska Kress, Marcia R. ^b, Darini, Ana Lúcia da Costa ^b

Source: In Journal of Global Antimicrobial Resistance May 2025 42:105-112

Structural Elucidation of Intact Rough-type Lipopolysaccharides Using Field Asymmetric Ion Mobility Spectrometry and Kendrick Mass Defect Plots

Authors: Mikhael, Abanoub, Hardie, Darryl, Smith, Derek, Pětrošová, Helena, Ernst, Robert K., Goodlett, David R.

Source: ANALYTICAL CHEMISTRY -WASHINGTON DC-. 95(46):16796-16800

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632795682&indx=1&recIds=ETOCRN632795682

Intranasal VLP-RBD vaccine adjuvanted with BECC470 confers immunity against Delta SARS-CoV-2 challenge in K18-hACE2-mice

Authors: Lee, Katherine S., Rader, Nathaniel A., Miller-Stump, Olivia A., Cooper, Melissa, Wong, Ting Y., Shahrier Amin, Md., Barbier, Mariette, Bevere, Justin R., Ernst, Robert K., Heath Damron, F.

Source: Vaccine. 41(34):5003-5017

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194662060.0x000001&indx=1&recIds=ETOCvdc_100194662060.0x000001

6-Bromoindirubin-3′-oxime derivatives are highly active colistin adjuvants against Klebsiella pneumoniaeElectronic supplementary information (ESI) available: Additional MIC data, hemolysis, lipid A analysis, synthetic procedures, compound characterization and spectra. See DOI: https://doi.org/10.1039/d2md00370h

Authors: Li, Haoting, Mattingly, Anne E., Smith, Richard D., Melander, Roberta J., Ernst, Robert K., Melander, Christian

Source: RSC medicinal chemistry. 14(2):247-252

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178404673.0x000001&indx=1&recIds=ETOCvdc_100178404673.0x000001

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance

Authors: O'Meara, Timothy R., Nanishi, Etsuro, McGrath, Marisa E., Barman, Soumik, Dong, Danica, Dillen, Carly, Menon, Manisha, Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Ernst, Robert K., Levy, Ofer, Frieman, Matthew B., Dowling, David J.

Source: In The Journal of Allergy and Clinical Immunology November 2023 152(5):1107-1120

Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection

Authors: Tomlinson, Kira L. ¹, Chen, Ying-Tsun ¹, Junker, Alex ¹, Urso, AndreaCarola ¹, Wong Fok Lung, Tania ¹, Ahn, Danielle ¹, Hofstaedter, Casey E. ², Baskota, Swikrity U. ³, Ernst, Robert K. ², Prince, Alice ¹, Riquelme, Sebastián A. ^{1, 4, ∗}

Source: In Cell Metabolism 3 October 2023 35(10):1767-1781

Methods of treating sepsis using anti-sepsis lipid A (ASLA) based therapeutics

Spatial lipidomics reveals biased phospholipid remodeling in acute Pseudomonas lung infection

Authors: Scott, Alison J. ^{1, 2, 4, ∗}, Ellis, Shane R. ^{2, 3}, Hofstaedter, Casey E. ¹, Heeren, Ron M.A. ², Ernst, Robert K. ^{1, ∗∗}

Source: In iScience 15 September 2023 26(9)

Physicochemical characterization of biological and synthetic forms of two lipid A-based TLR4 agonists

Authors: Hu, Gang ^a, Varisco, David J. ^b, Das, Sayan ^b, Middaugh, C. Russell ^a, Gardner, Francesca ^b, Ernst, Robert K. ^b, Picking, Wendy L. ^{a, c}, Picking, William D. ^{a, c, d, ∗}

Source: In Heliyon July 2023 9(7)

Dimeric 2-aminoimidazoles are highly active adjuvants for gram-positive selective antibiotics against Acinetobacter baumannii

Authors: Marrujo, Santiana A., Hubble, Veronica B., Yang, Jingdong, Wang, Man, Nemeth, Ansley M., Barlock, Samantha L., Juarez, Dane, Smith, Richard D., Melander, Roberta J., Ernst, Robert K., Chang, Mayland, Melander, Christian

Source: In European Journal of Medicinal Chemistry 5 May 2023 253

An In Vitro Model of the Efficacy of Breast Implant Irrigant Solutions Against Gram-Negative Infections

Authors: Ha, Michael, Ngaage, Ledibabari M., Smith, Richard D., Izac, Jerilyn R., Kim, Peter C., Singh, Devinder, Slezak, Sheri, Ernst, Robert K., Harro, Janette, Rasko, Yvonne M.

Source: Annals of plastic surgery. 89(6):679-683

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173159052.0x000001&indx=1&recIds=ETOCvdc_100173159052.0x000001

Decreasing Tryptophan and Increasing Neopterin Plasma Levels During Pregnancy are Associated with High First Trimester Porphyromonas gingivalis K-Serotype IgG Serointensity in a Cohort of Hispanic Women

Authors: Postolache, Teodor T., Upadhyaya, Sanjaya K., Spector, Anna M., Mohyuddin, Iqra, Constantine, Niel, Ernst, Robert K., Wadhawan, Abhishek, Dutra, Samia Valeria Ozorio, Dagdag, Aline, Makkar, Hina, Lowry, Christopher A., Akram, Faisal, Fuchs, Dietmar, Brenner, Lisa A., Groer, Maureen W., Reynolds, Mark A.

Source: Current topics in medicinal chemistry. 22(25):2126-2144

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168778952.0x000001&indx=1&recIds=ETOCvdc_100168778952.0x000001

Positively Charged Polyvinylidene Fluoride Membrane: A Potential Alternative for Absorbent Paper Points in Endodontics

Authors: Yeung, Wing-Yee, Tordik, Patricia A., Martinho, Frederico C., Ernst, Robert K.

Source: Journal of endodontics. 48(2):263-268

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154674994.0x000001&indx=1&recIds=ETOCvdc_100154674994.0x000001

Lipid A Structural Determination from a Single Colony

Authors: Yang, Hyojik, Smith, Richard D., Chandler, Courtney E., Johnson, J. Kristie, Jackson, Shelley N., Woods, Amina S., Scott, Alison J., Goodlett, David R., Ernst, Robert K.

Source: Analytical chemistry. 94(21):7460-7465

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629377517&indx=1&recIds=ETOCRN629377517

Site-selective modifications by lipid A phosphoethanolamine transferases linked to colistin resistance and bacterial fitness.

Authors: Schumann, Anna, Gaballa, Ahmed, Hyojik Yang, Di Yu, Ernst, Robert K., Wiedmann, Martin

Source: MSphere; Feb2025, Vol. 10 Issue 2, p1-19, 19p

Genomic characterization of lytic bacteriophages targeting genetically diverse Pseudomonas aeruginosa clinical isolates

Authors: Nordstrom, Hayley R. ¹, Evans, Daniel R. ¹, Finney, Amanda G. ¹, Westbrook, Kevin J. ¹, Zamora, Paula F. ², Hofstaedter, Casey E. ³, Yassin, Mohamed H. ¹, Pradhan, Akansha ¹, Iovleva, Alina ¹, Ernst, Robert K. ³, Bomberger, Jennifer M. ², Shields, Ryan K. ¹, Doi, Yohei ¹, Van Tyne, Daria ^{1, 4, ∗}

Source: In iScience 17 June 2022 25(6)

Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

Authors: Wong Fok Lung, Tania, Charytonowicz, Daniel, Beaumont, Kristin G., Shah, Shivang S., Sridhar, Shwetha H., Gorrie, Claire L., Mu, Andre, Hofstaedter, Casey E., Varisco, David, McConville, Thomas H., Drikic, Marija, Fowler, Brandon, Urso, Andreacarola, Shi, Wei, Fucich, Dario, Annavajhala, Medini K., Khan, Ibrahim N., Oussenko, Irina, Francoeur, Nancy, Smith, Melissa L., Stockwell, Brent R., Lewis, Ian A., Hachani, Abderrahman, Upadhyay Baskota, Swikrity, Uhlemann, Anne-Catrin, Ahn, Danielle, Ernst, Robert K., Howden, Benjamin P., Sebra, Robert, Prince, Alice

Source: In Cell Metabolism 3 May 2022 34(5):761-774

Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in Yersinia pestis

Authors: Chandler, Courtney E., Harberts, Erin M., Pelletier, Mark R., Thaipisuttikul, Iyarit, Jones, Jace W., Hajjar, Adeline M., Sahl, Jason W., Goodlett, David R., Pride, Aaron C., Rasko, David A., Trent, M. Stephen, Bishop, Russell E., Ernst, Robert K.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Sep . 117(37), 22984-22991.

Access URL: https://www.jstor.org/stable/26969229