Systematic In Vitro Evaluation of a Library of Approved and Pharmacologically Active Compounds for the Identification of Novel Candidate Drugs for KMT2A-Rearranged Leukemia

Authors: Mawar Karsa, Emma Ronca, Angelika Bongers, Anna Mariana, Ernest Moles, Timothy W. Failes, Greg M. Arndt, Laurence C. Cheung, Rishi S. Kotecha, Maria Kavallaris, Michelle Haber, Murray D. Norris, Michelle J. Henderson, Lin Xiao, Klaartje Somers

Source: Frontiers in Oncology, Vol 11 (2022)

Subject Terms: KMT2A/MLL-rearranged leukemia, infant leukemia, repurposing, high-throughput screen, NR5A1, apoptosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.779859/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/a4e7367f914c409982b8e7dce5bbe234

Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia

Authors: Patrick Connerty, Ernest Moles, Charles E. de Bock, Nisitha Jayatilleke, Jenny L. Smith, Soheil Meshinchi, Chelsea Mayoh, Maria Kavallaris, Richard B. Lock

Source: Pharmaceutics, Vol 13, Iss 10, p 1681 (2021)

Subject Terms: lipid-based nanoparticles, long non-coding RNA, RNA interference, nanomedicine, nanoparticle-assisted siRNA delivery, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/10/1681; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/2b83fb439aaf40ae8845b777116b0c33

Modeling the Distribution of Diprotic Basic Drugs in Liposomal Systems: Perspectives on Malaria Nanotherapy

Authors: Ernest Moles, Maria Kavallaris, Xavier Fernàndez-Busquets

Source: Frontiers in Pharmacology, Vol 10 (2019)

Subject Terms: partition coefficient, distribution coefficient, polyprotic drug, pH-controlled drug encapsulation, targeted drug delivery, liposomal systems, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.01064/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/7f39aa5fd53b43f98dc22522328345fb

An ImmunoPEGliposome for Targeted Antimalarial Combination Therapy at the Nanoscale

Authors: Arnau Biosca, Lorin Dirscherl, Ernest Moles, Santiago Imperial, Xavier Fernàndez-Busquets

Source: Pharmaceutics, Vol 11, Iss 7, p 341 (2019)

Subject Terms: combination therapy, immunoliposomes, malaria, nanomedicine, nanotechnology, Plasmodium, targeted drug delivery, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/11/7/341; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/dc87d6d8a9984940bcbc4f815c4efaba