Cell-state transitions and density-dependent interactions together explain the dynamics of spontaneous epithelial-mesenchymal heterogeneity

Authors: Paras Jain, Ramanarayanan Kizhuttil, Madhav B. Nair, Sugandha Bhatia, Erik W. Thompson, Jason T. George, Mohit Kumar Jolly

Source: iScience, Vol 27, Iss 7, Pp 110310- (2024)

Subject Terms: Cell biology, Mathematical biosciences, Cancer, Science

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Relation: http://www.sciencedirect.com/science/article/pii/S2589004224015359; https://doaj.org/toc/2589-0042

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Identification and characterization of TM4SF1+ tumor self-seeded cells

Authors: Haotian Yang, Haolu Wang, Yaowu He, Yang Yang, Erik W. Thompson, Di Xia, Leslie J. Burke, Lu Cao, John D. Hooper, Michael S. Roberts, Darrell H.G. Crawford, Xiaowen Liang

Source: Cell Reports, Vol 43, Iss 7, Pp 114512- (2024)

Subject Terms: CP: Cancer, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2211124724008416; https://doaj.org/toc/2211-1247

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Epidermal growth factor potentiates EGFR(Y992/1173)-mediated therapeutic response of triple negative breast cancer cells to cold atmospheric plasma-activated medium

Authors: Peiyu Wang, Renwu Zhou, Rusen Zhou, Shuo Feng, Liqian Zhao, Wenshao Li, Jinyong Lin, Aleksandra Rajapakse, Chia-Hwa Lee, Frank B. Furnari, Antony W. Burgess, Jennifer H. Gunter, Gang Liu, Kostya (Ken) Ostrikov, Derek J. Richard, Fiona Simpson, Xiaofeng Dai, Erik W. Thompson

Source: Redox Biology, Vol 69, Iss , Pp 102976- (2024)

Subject Terms: Cold atmospheric plasma, Epithelial growth factor receptor, Triple negative breast cancer, Apoptosis, Medicine (General), R5-920, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2213231723003774; https://doaj.org/toc/2213-2317

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Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer

Authors: Charlene Waryah, Joseph Cursons, Momeneh Foroutan, Christian Pflueger, Edina Wang, Ramyar Molania, Eleanor Woodward, Anabel Sorolla, Christopher Wallis, Colette Moses, Irina Glas, Leandro Magalhães, Erik W. Thompson, Liam G. Fearnley, Christine L. Chaffer, Melissa Davis, Anthony T. Papenfuss, Andrew Redfern, Ryan Lister, Manel Esteller, Pilar Blancafort

Source: Advanced Science, Vol 10, Iss 22, Pp n/a-n/a (2023)

Subject Terms: cancer epigenetics, CRISPR/dCas9 repression, epithelial‐mesenchymal transition, triple negative breast cancer, ZEB1, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/6a78b1096143434884b25f3051790583

Pan-cancer quantitation of epithelial-mesenchymal transition dynamics using parallel reaction monitoring-based targeted proteomics approach

Authors: Ankit P. Jain, Janani Sambath, Gajanan Sathe, Irene A. George, Akhilesh Pandey, Erik W. Thompson, Prashant Kumar

Source: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)

Subject Terms: Epithelial-mesenchymal transition, Pan-cancer targeted proteomics, Parallel reaction monitoring, Mass spectrometry, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/9aaef17b1f4f44e79d7d7d45d526847d

Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation

Authors: Yu Hin Tang, Anja Rockstroh, Kamil A. Sokolowski, Layla-Rose Lynam, Melanie Lehman, Erik W. Thompson, Philip A. Gregory, Colleen C. Nelson, Marianna Volpert, Brett G. Hollier

Source: Breast Cancer Research, Vol 24, Iss 1, Pp 1-17 (2022)

Subject Terms: Neuropilin, Breast cancer, Claudin-low, Triple-negative breast cancer, Cancer stem cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/1465-542X

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Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system

Authors: Razan Wafai, Elizabeth D. Williams, Emma de Souza, Peter T. Simpson, Amy E. McCart Reed, Jamie R. Kutasovic, Mark Waltham, Cameron E. Snell, Tony Blick, Erik W. Thompson, Honor J. Hugo

Source: Breast Cancer Research, Vol 22, Iss 1, Pp 1-21 (2020)

Subject Terms: Integrin, Hypoxia, Twist1, EMT, Breast cancer, Patient-derived xenograft (PDX), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/1465-542X

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Circulating Tumour Cells Indicate the Presence of Residual Disease Post-Castration in Prostate Cancer Patient-Derived Xenograft Models

Authors: Sara Hassan, Tony Blick, Jack Wood, Erik W. Thompson, Elizabeth D. Williams

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: kallikrein related peptidase 3, metastasis, circulating tumour cell, castrate-resistant prostate cancer, epithelial mesenchymal plasticity, prostate specific antigen, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.858013/full; https://doaj.org/toc/2296-634X

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GelMA, Click-Chemistry Gelatin and Bioprinted Polyethylene Glycol-Based Hydrogels as 3D Ex Vivo Drug Testing Platforms for Patient-Derived Breast Cancer Organoids

Authors: Nathalie Bock, Farzaneh Forouz, Luke Hipwood, Julien Clegg, Penny Jeffery, Madeline Gough, Tirsa van Wyngaard, Christopher Pyke, Mark N. Adams, Laura J. Bray, Laura Croft, Erik W. Thompson, Thomas Kryza, Christoph Meinert

Source: Pharmaceutics, Vol 15, Iss 1, p 261 (2023)

Subject Terms: 3D cancer model, patient-derived organoid, hydrogel, GelMA, gelatin, polyethylene glycol, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/15/1/261; https://doaj.org/toc/1999-4923

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Patient-Derived Explants as a Precision Medicine Patient-Proximal Testing Platform Informing Cancer Management

Authors: Abby R. Templeton, Penny L. Jeffery, Patrick B. Thomas, Mahasha P. J. Perera, Gary Ng, Alivia R. Calabrese, Clarissa Nicholls, Nathan J. Mackenzie, Jack Wood, Laura J. Bray, Ian Vela, Erik W. Thompson, Elizabeth D. Williams

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: precision medicine, patient-derived explants, whole exome sequencing, ex vivo, cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.767697/full; https://doaj.org/toc/2234-943X

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Applications of RNA characterisation in circulating tumour cells

Authors: Sara Hassan, Tony Blick, Elizabeth D. Williams, Erik W. Thompson

Source: Frontiers in Bioscience-Landmark, Vol 25, Iss 5, Pp 874-892 (2020)

Subject Terms: ctc, metastasis, emt, tumour heterogeneity, rna analysis, ctc score, review, Biochemistry, QD415-436, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.imrpress.com/journal/FBL/25/5/10.2741/4838; https://doaj.org/toc/2768-6701

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Receptor-Mediated Redox Imbalance: An Emerging Clinical Avenue against Aggressive Cancers

Authors: Xiaofeng Dai, Erik W. Thompson, Kostya (Ken) Ostrikov

Source: Biomolecules, Vol 12, Iss 12, p 1880 (2022)

Subject Terms: cold atmospheric plasma, redox imbalance, receptor, aggressive cancer, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/12/12/1880; https://doaj.org/toc/2218-273X

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Corrigendum: Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo

Authors: Xuan Huang, Gina Reye, Konstantin I. Momot, Tony Blick, Thomas Lloyd, Wayne D. Tilley, Theresa E. Hickey, Cameron E. Snell, Rachel K. Okolicsanyi, Larisa M. Haupt, Vito Ferro, Erik W. Thompson, Honor J. Hugo

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: mammographic density, breast cancer, heparanase, syndecan-1, NMR, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.678589/full; https://doaj.org/toc/2296-634X

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Three-Dimensional Models as a New Frontier for Studying the Role of Proteoglycans in the Normal and Malignant Breast Microenvironment

Authors: Julien Clegg, Maria K. Koch, Erik W. Thompson, Larisa M. Haupt, Priyakshi Kalita-de Croft, Laura J. Bray

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: breast cancer, proteoglycans (PGs), extracellular matrix (ECM), 3D models, tumor microenvironment (TME), Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcell.2020.569454/full; https://doaj.org/toc/2296-634X

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Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo

Authors: Xuan Huang, Gina Reye, Konstantin I. Momot, Tony Blick, Thomas Lloyd, Wayne D. Tilley, Theresa E. Hickey, Cameron E. Snell, Rachel K. Okolicsanyi, Larisa M. Haupt, Vito Ferro, Erik W. Thompson, Honor J. Hugo

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: mammographic density, breast cancer, heparanase, syndecan-1, NMR, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcell.2020.00599/full; https://doaj.org/toc/2296-634X

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Innovative Precision Gene‐Editing Tools in Personalized Cancer Medicine

Authors: Xiaofeng Dai, Pilar Blancafort, Peiyu Wang, Agustin Sgro, Erik W. Thompson, Kostya (Ken) Ostrikov

Source: Advanced Science, Vol 7, Iss 12, Pp n/a-n/a (2020)

Subject Terms: CRISPR, genome‐editing, precision medicine, transcription activator‐like effector nucleases (TALENs), zinc finger nucleases (ZFNs), Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/8f22ee66481f4b4f94ade555fc0522a2

New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression

Authors: Sugandha Bhatia, Peiyu Wang, Alan Toh, Erik W. Thompson

Source: Frontiers in Molecular Biosciences, Vol 7 (2020)

Subject Terms: EMT, EMP, stem cell, CTCs, hybrid EMT states, metastasis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmolb.2020.00071/full; https://doaj.org/toc/2296-889X

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High mammographic density in women is associated with protumor inflammation

Authors: Cecilia W. Huo, Prue Hill, Grace Chew, Paul J. Neeson, Heloise Halse, Elizabeth D. Williams, Michael A. Henderson, Erik W. Thompson, Kara L. Britt

Source: Breast Cancer Research, Vol 20, Iss 1, Pp 1-16 (2018)

Subject Terms: Mammographic density, Immune infiltration, Macrophages, Dendritic cells, PD-L1, B cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13058-018-1010-2; https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/40636973aec24781b723a6a1eaa126e6

Population Dynamics of Epithelial-Mesenchymal Heterogeneity in Cancer Cells

Authors: Paras Jain, Sugandha Bhatia, Erik W. Thompson, Mohit Kumar Jolly

Source: Biomolecules, Vol 12, Iss 3, p 348 (2022)

Subject Terms: asymmetric cell division, epithelial-mesenchymal heterogeneity, epithelial-mesenchymal plasticity, population dynamics, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/12/3/348; https://doaj.org/toc/2218-273X

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Hypoxia-induced reactive oxygen species mediate N-cadherin and SERPINE1 expression, EGFR signalling and motility in MDA-MB-468 breast cancer cells

Authors: Iman Azimi, Rosalie M. Petersen, Erik W. Thompson, Sarah J. Roberts-Thomson, Gregory R. Monteith

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/18ec8d602dea4bf788612cac5aa67919