Biological mechanisms of resilience to tau pathology in Alzheimer’s disease

Authors: Anna L. Svenningsson, Diana I. Bocancea, Erik Stomrud, Anita van Loenhoud, Frederik Barkhof, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Oskar Hansson, Rik Ossenkoppele

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-17 (2024)

Subject Terms: Alzheimer’s disease, Tau, Brain resilience, Cognitive resilience, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/30afe2ef6d474f0e87dfb76fa9c6b8d9

Phosphorylated tau in cerebrospinal fluid-derived extracellular vesicles in Alzheimer’s disease: a pilot study

Authors: Roman Sattarov, Megan Havers, Camilla Orbjörn, Erik Stomrud, Shorena Janelidze, Thomas Laurell, Niklas Mattsson-Carlgren

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

Subject Terms: Alzheimer’s disease, Extracellular vesicles, P-tau181, P-tau217, Biomarkers, Acoustic trapping, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/59e547163a534427b4267f0eb07f69ea

Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer’s disease

Authors: Anika Wuestefeld, Alexa Pichet Binette, Danielle van Westen, Olof Strandberg, Erik Stomrud, Niklas Mattsson-Carlgren, Shorena Janelidze, Ruben Smith, Sebastian Palmqvist, Hannah Baumeister, David Berron, Paul A. Yushkevich, Oskar Hansson, Nicola Spotorno, Laura E.M. Wisse

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)

Subject Terms: Tau-PET imaging, Amyloid-beta, MRI, Medial temporal lobe subregions, Aging, In vivo, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/b9abd4ab96174d0c88ed8964d092f79e

Predicting progression from subjective cognitive decline to mild cognitive impairment or dementia based on brain atrophy patterns

Authors: Ondrej Lerch, Daniel Ferreira, Erik Stomrud, Danielle van Westen, Pontus Tideman, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Jakub Hort, Oskar Hansson, Eric Westman

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-17 (2024)

Subject Terms: Structural MRI, Subjective cognitive decline, Alzheimer’s disease, Atrophy patterns, Multivariate analysis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/40514354ff8e49bc8df96ba9fc69af5a

Effects of time of the day at sampling on CSF and plasma levels of Alzheimer’ disease biomarkers

Authors: Anna Orduña Dolado, Erik Stomrud, Nicholas J. Ashton, Johanna Nilsson, Clara Quijano-Rubio, Alexander Jethwa, Wagner S. Brum, Ann Brinkmalm Westman, Henrik Zetterberg, Kaj Blennow, Shorena Janelidze, Oskar Hansson

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-10 (2024)

Subject Terms: Alzheimer’s disease, Fluid biomarkers, p-tau, Aβ, Sampling time, Diurnal variability, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/f78a34bbdde94bdab236ffea02e7059b

Associations of modifiable and non-modifiable risk factors with cognitive functions – a prospective, population-based, 17 years follow-up study of 3,229 individuals

Authors: Isabelle Glans, Katarina Nägga, Anna-Märta Gustavsson, Erik Stomrud, Peter M Nilsson, Olle Melander, Oskar Hansson, Sebastian Palmqvist

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/fbd1cc4a0a784acbaa25cf7ce5a947a7

Cerebrospinal fluid reference proteins increase accuracy and interpretability of biomarkers for brain diseases

Authors: Linda Karlsson, Jacob Vogel, Ida Arvidsson, Kalle Åström, Shorena Janelidze, Kaj Blennow, Sebastian Palmqvist, Erik Stomrud, Niklas Mattsson-Carlgren, Oskar Hansson

Source: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/83a754f4856845649154ab6fc1777235

A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings

Authors: Wagner S. Brum, Nicholas C. Cullen, Joseph Therriault, Shorena Janelidze, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Andrea L. Benedet, Eduardo R. Zimmer, Erik Stomrud, Sebastian Palmqvist, Henrik Zetterberg, Giovanni B. Frisoni, Nicholas J. Ashton, Kaj Blennow, Niklas Mattsson-Carlgren, Pedro Rosa-Neto, Oskar Hansson

Source: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/45431c464f6049b581c84b0d07def687

Comparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer’s disease in patients with mild cognitive symptoms

Authors: Ida Arvidsson, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Nicholas Cullen, Shorena Janelidze, Pontus Tideman, Anders Heyden, Karl Åström, Oskar Hansson, Niklas Mattsson-Carlgren

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)

Subject Terms: Alzheimer’s disease, Cognitive decline, Deep learning, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/49a2d49cc014492c8756c4880a8e5d5c

Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer’s Disease

Authors: Juan Lantero-Rodriguez, Gemma Salvadó, Anniina Snellman, Laia Montoliu-Gaya, Wagner S. Brum, Andrea L. Benedet, Niklas Mattsson-Carlgren, Pontus Tideman, Shorena Janelidze, Sebastian Palmqvist, Erik Stomrud, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Oskar Hansson

Source: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-22 (2024)

Subject Terms: Tau, NTA, NTA-tau, Plasma, Alzheimer’s disease, Biomarkers, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/1f03c4bcfa8843128bc55b3c29041416

Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology

Authors: Joseph Therriault, Marcel S. Woo, Gemma Salvadó, Johan Gobom, Thomas K. Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Paolo Vitali, Manuel A. Friese, Gassan Massarweh, Jean-Paul Soucy, Tharick A. Pascoal, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Serge Gauthier, Henrik Zetterberg, Oskar Hansson, Kaj Blennow, Pedro Rosa-Neto

Source: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-14 (2024)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/b47ea600285b4aea8f46ab3e27b0c3b2

Divergent functional connectivity changes associated with white matter hyperintensities

Authors: Alexander F. Santillo, Tor O. Strandberg, Nina H. Reislev, Markus Nilsson, Erik Stomrud, Nicola Spotorno, Danielle van Westen, Oskar Hansson

Source: NeuroImage, Vol 296, Iss , Pp 120672- (2024)

Subject Terms: Functional connectivity, Cognitive function, White matter hyperintensities, Diffusion mri, entropy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1053811924001678; https://doaj.org/toc/1095-9572

Access URL: https://doaj.org/article/ffa8bb1dfc934fd8b565fe36e837e2d4

The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases

Authors: Ruben Smith, Francesca Capotosti, Martin Schain, Tomas Ohlsson, Efthymia Vokali, Jerome Molette, Tanja Touilloux, Valerie Hliva, Ioannis K. Dimitrakopoulos, Andreas Puschmann, Jonas Jögi, Per Svenningsson, Mattias Andréasson, Christine Sandiego, David S. Russell, Patricia Miranda-Azpiazu, Christer Halldin, Erik Stomrud, Sara Hall, Klas Bratteby, Elina Tampio L’Estrade, Ruth Luthi-Carter, Andrea Pfeifer, Marie Kosco-Vilbois, Johannes Streffer, Oskar Hansson

Source: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8e2d2bdd4dfc4ecea2658cceed5ad9e8

Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease

Authors: Alexa Pichet Binette, Nicolai Franzmeier, Nicola Spotorno, Michael Ewers, Matthias Brendel, Davina Biel, Alzheimer’s Disease Neuroimaging Initiative, Olof Strandberg, Shorena Janelidze, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Ruben Smith, Erik Stomrud, Rik Ossenkoppele, Oskar Hansson

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d1cde27011a649659e040123199efd35

Axonal degeneration and amyloid pathology predict cognitive decline beyond cortical atrophy

Authors: Anna Linnéa Svenningsson, Erik Stomrud, Sebastian Palmqvist, Oskar Hansson, Rik Ossenkoppele

Source: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)

Subject Terms: Resilience, Cognition, Amyloid, Neurodegeneration, Aging, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/dbe1065d58df4605a6950c399cd9390f

Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer's disease

Authors: Tharick A. Pascoal, Antoine Leuzy, Joseph Therriault, Mira Chamoun, Firoza Lussier, Cecile Tissot, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Pamela C. L. Ferreira, João Pedro Ferrari‐Souza, Ruben Smith, Andrea Lessa Benedet, Serge Gauthier, Oskar Hansson, Pedro Rosa‐Neto

Source: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 1, Pp n/a-n/a (2023)

Subject Terms: Alzheimer's disease, A/T/N system, biomarker, diagnose, PET, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/2352-8729

Access URL: https://doaj.org/article/2164d28cba23488f90d144831f9de21f

The genetic regulation of protein expression in cerebrospinal fluid

Authors: Oskar Hansson, Atul Kumar, Shorena Janelidze, Erik Stomrud, Philip S Insel, Kaj Blennow, Henrik Zetterberg, Eric Fauman, Åsa K Hedman, Michael W Nagle, Christopher D Whelan, Denis Baird, Anders Mälarstig, Niklas Mattsson‐Carlgren

Source: EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)

Subject Terms: biomarkers, cerebrospinal fluid, genetic regulation, Mendelian randomization, pQTL, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/4174b4e6116f45eb86dccf005c92af0b

Genetic effects on longitudinal cognitive decline during the early stages of Alzheimer’s disease

Authors: Atul Kumar, Maryam Shoai, Sebastian Palmqvist, Erik Stomrud, John Hardy, Niklas Mattsson-Carlgren, Oskar Hansson

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/eca63dc7f9f04a0a98a3074419d85dc2

Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers

Authors: Rik Ossenkoppele, Juhan Reimand, Ruben Smith, Antoine Leuzy, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Henrik Zetterberg, the Alzheimer's Disease Neuroimaging Initiative, Philip Scheltens, Jeffrey L Dage, Femke Bouwman, Kaj Blennow, Niklas Mattsson‐Carlgren, Shorena Janelidze, Oskar Hansson

Source: EMBO Molecular Medicine, Vol 13, Iss 8, Pp 1-15 (2021)

Subject Terms: Alzheimer's disease, CSF, PET, plasma, tau, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/057a0cbad93e4950bcab674977a33f6d

A multicentre validation study of the diagnostic value of plasma neurofilament light

Authors: Nicholas J. Ashton, Shorena Janelidze, Ahmad Al Khleifat, Antoine Leuzy, Emma L. van der Ende, Thomas K. Karikari, Andrea L. Benedet, Tharick A. Pascoal, Alberto Lleó, Lucilla Parnetti, Daniela Galimberti, Laura Bonanni, Andrea Pilotto, Alessandro Padovani, Jan Lycke, Lenka Novakova, Markus Axelsson, Latha Velayudhan, Gil D. Rabinovici, Bruce Miller, Carmine Pariante, Naghmeh Nikkheslat, Susan M. Resnick, Madhav Thambisetty, Michael Schöll, Gorka Fernández-Eulate, Francisco J. Gil-Bea, Adolfo López de Munain, Ammar Al-Chalabi, Pedro Rosa-Neto, Andre Strydom, Per Svenningsson, Erik Stomrud, Alexander Santillo, Dag Aarsland, John C. van Swieten, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Abdul Hye, Oskar Hansson

Source: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5a53b0a732414b4ca05246e46c25baa3