The Bioactive Compounds of Epimedium and Their Potential Mechanism of Action in Treating Osteoporosis: A Network Pharmacology and Experimental Validation Study.

Authors: Dong, Huizhong¹ (AUTHOR), Tang, Fen¹ (AUTHOR), Zhao, Zilu¹ (AUTHOR), Huang, Wenxuan¹ (AUTHOR), Wan, Xiangyang¹ (AUTHOR), Hong, Zhanying² (AUTHOR), Liu, Ying³ (AUTHOR) liuchanger1984@163.com, Dong, Xin¹ (AUTHOR) dongxin@shu.edu.cn, Chen, Si¹ (AUTHOR) dongxin@shu.edu.cn

Source: Pharmaceuticals (14248247). Jun2024, Vol. 17 Issue 6, p706. 24p.

Subject Terms: *EPIMEDIUM, *OSTEOPOROSIS, *BIOACTIVE compounds, *CHINESE medicine

Exploring the dynamic adaptive responses of Epimedium pubescens to phosphorus deficiency by Integrated transcriptome and miRNA analysis.

Authors: Liu, Shangnian^1,2 (AUTHOR), An, Xiaojing^2,3 (AUTHOR), Xu, Chaoqun² (AUTHOR), Guo, Baolin² (AUTHOR), Li, Xianen² (AUTHOR), Chen, Caixia² (AUTHOR) cxchen@implad.ac.cn, He, Dongmei¹ (AUTHOR) hedongmei@cdutcm.edu.cn, Xu, De⁴ (AUTHOR), Li, Yi⁴ (AUTHOR)

Source: BMC Plant Biology. 5/31/2024, Vol. 24 Issue 1, p1-23. 23p.

Subject Terms: *BIOLOGICAL evolution, *EPIMEDIUM, *RNA regulation, *PHOSPHORUS, *TRANSCRIPTOMES, *ROOT growth

Advancements in the Biotransformation and Biosynthesis of the Primary Active Flavonoids Derived from Epimedium.

Authors: Zhang, Xiaoling^1,2,3 (AUTHOR), Tang, Bingling^1,2 (AUTHOR), Wen, Sijie^1,2 (AUTHOR), Wang, Yitong^1,2 (AUTHOR), Pan, Chengxue¹ (AUTHOR) pancx@zzu.edu.cn, Qu, Lingbo⁴ (AUTHOR), Yin, Yulong⁵ (AUTHOR), Wei, Yongjun² (AUTHOR) pancx@zzu.edu.cn

Source: Molecules. Oct2023, Vol. 28 Issue 20, p7173. 20p.

Subject Terms: *EPIMEDIUM, *FLAVONOIDS, *BIOCONVERSION, *MICROBIOLOGICAL synthesis, *BIOSYNTHESIS, *MICROBIAL cells

Floral morphology and development of Epimedium pubescens and Plagiorhegma dubium (Berberidaceae) and their systematic significance.

Authors: Zhang, Yu^1,2 (AUTHOR), Gong, Jing-Zhi^1,2 (AUTHOR), Gui, Chao-Xia^1,2 (AUTHOR), Xie, Si-Yu^1,2 (AUTHOR), Yang, Zhao-Ping³ (AUTHOR), Luo, Min-Rong⁴ (AUTHOR), Ning, Sui-Xia⁵ (AUTHOR), Chang, Zhao-Yang^1,2 (AUTHOR), Kang, Bing¹ (AUTHOR), Zhao, Liang^1,2 (AUTHOR) biology_zhaoliang@126.com, Craene, Louis Ronse De⁶ (AUTHOR)

Source: Botanical Journal of the Linnean Society. Sep2023, Vol. 203 Issue 1, p78-93. 16p.

Subject Terms: *FLORAL morphology, *EPIMEDIUM, *FLOWER development, *SCANNING electron microscopy, *OVULES, *CARPEL

Efficient production of icariin and baohuoside I from Epimedium Folium flavonoids by fungal α-l-rhamnosidase hydrolysing regioselectively the terminal rhamnose of epimedin C.

Authors: Zhang, Shanshan^1,2 (AUTHOR), Lu, Changning^1,2 (AUTHOR), Cao, Shiping^1,2 (AUTHOR), Li, Qi^1,2 (AUTHOR), Wu, Guangwei^1,2 (AUTHOR) gweiwu@njfu.edu.cn, Zhao, Linguo^1,2 (AUTHOR) njfu2304@163.com

Source: Biotechnology for Biofuels & Bioproducts. 6/30/2023, p1-18. 18p.

Subject Terms: *EPIMEDIUM, *RHAMNOSE, *BIOCONVERSION

Sub-chronic toxicity of an aqueous extract of Epimedium sagittatum (Sieb. Et Zucc.) Maxim. in rats.

Authors: Song, Lei^1,2,3 (AUTHOR), Zhou, Yating¹ (AUTHOR), Zhai, Yuxia¹ (AUTHOR), Huo, Xiangxiang¹ (AUTHOR), Chen, Mengying¹ (AUTHOR), Shi, Hong^1,2 (AUTHOR), Yu, Yingli^1,2,3 (AUTHOR), Zhang, Yue^1,2,3 (AUTHOR), Zhou, Kun^1,2,3 (AUTHOR)

Source: Drug & Chemical Toxicology. May2023, Vol. 46 Issue 3, p451-461. 11p.

Subject Terms: *EPIMEDIUM, *RATS, *HEART, *BIOCHEMISTRY, *ADRENAL glands, *PYRUVATES, *LIQUID chromatography, *HEART injuries

Geographic Terms: ASIA

The Effect of Epimedium Isopentenyl Flavonoids on the Broiler Gut Health Using Microbiomic and Metabolomic Analyses.

Authors: Zhang, Jiaqi^1,2 (AUTHOR), Zhao, Qingyu^1,2 (AUTHOR), Qin, Yuchang^1,2 (AUTHOR), Si, Wei^1,2 (AUTHOR), Zhang, Huiyan^1,2 (AUTHOR) zhanghuiyan@caas.cn, Zhang, Junmin^1,2 (AUTHOR) zhanghuiyan@caas.cn

Source: International Journal of Molecular Sciences. Apr2023, Vol. 24 Issue 8, p7646. 18p.

Subject Terms: *LIQUID chromatography-mass spectrometry, *EPIMEDIUM, *METABOLOMICS, *SHORT-chain fatty acids, *FLAVONOIDS

Comparative analysis of codon usage patterns in chloroplast genomes of ten Epimedium species.

Authors: Wang, Yingzhe^1,2 (AUTHOR), Jiang, Dacheng² (AUTHOR), Guo, Kun² (AUTHOR), Zhao, Lei² (AUTHOR), Meng, Fangfang² (AUTHOR), Xiao, Jinglei² (AUTHOR), Niu, Yuan³ (AUTHOR), Sun, Yunlong¹ (AUTHOR) syloong@126.com

Source: BMC Genomic Data. 1/9/2023, Vol. 24 Issue 1, p1-10. 10p.

Subject Terms: *CHLOROPLAST DNA, *EPIMEDIUM, *GENE expression, *SPECIES, *NATURAL selection, *GENE flow

Epimedium alpinum subsp. albanicum new subspecies for the flora of Kosovo.

Authors: Hashani, Zeqir¹, Mala, Xhavit² xhavitmala@hotmail.com, Maxhuni, Qenan³, Zeneli, Lulzim¹

Source: Italian Botanist. 2023, Issue 15, p1-8. 8p.

Subject Terms: *EPIMEDIUM, *SERPENTINE, *TAXONOMY, *BOTANY, *SPECIES distribution, *SUBSPECIES

Geographic Terms: KOSOVO (Republic)

A Novel 3- O -rhamnoside: 2″- O -xylosyltransferase Responsible for Terminal Modification of Prenylflavonol Glycosides in Epimedium pubescens Maxim.

Authors: Yao, Yu¹ (AUTHOR), Gu, Jiajun^1,2 (AUTHOR), Luo, Yanjiao¹ (AUTHOR), Zhang, Yixin¹ (AUTHOR), Wang, Yuanyue¹ (AUTHOR), Pang, Yongzhen³ (AUTHOR), Jia, Shangang⁴ (AUTHOR), Xu, Chaoqun¹ (AUTHOR), Li, Doudou¹ (AUTHOR), Suo, Fengmei¹ (AUTHOR), Shen, Guoan¹ (AUTHOR) gashen@implad.ac.cn, Guo, Baolin¹ (AUTHOR) gashen@implad.ac.cn

Source: International Journal of Molecular Sciences. Dec2022, Vol. 23 Issue 24, p16050. 19p.

Subject Terms: *FLAVONOL glycosides, *EPIMEDIUM, *ENZYMATIC analysis, *MOIETIES (Chemistry), *TRISACCHARIDES, *GLYCOSIDES, *GAMMA-glutamyltransferase

A systematic review on quality control of Epimedium sagittatum.

Authors: Liang Zhonghou^1,2 837137171@qq.com, Yang Sainan^1,2, Dai Bin^1,2, Li Youqing^1,2, Fan Shi^1,2

Source: Pakistan Journal of Agricultural Sciences. 2022, Vol. 59 Issue 4, p729-737. 9p.

Subject Terms: *EPIMEDIUM, *STRENGTH training, *CHINESE medicine, *HARVESTING, *HARVESTING time

Geographic Terms: CHINA

Quality differentiation of Epimedium from different harvesting periods based on LC-MS and network pharmacology.

Authors: Zhang, Jianyu¹ (AUTHOR), Chen, Yuru¹ (AUTHOR), Tang, Yuchen¹ (AUTHOR), Guo, Shubo¹ (AUTHOR), Ye, Cheng¹ (AUTHOR), Li, Wenlong^1,2,3,4 (AUTHOR) wshlwl@tjutcm.edu.cn

Source: New Journal of Chemistry. 5/28/2024, Vol. 48 Issue 20, p9020-9029. 10p.

Subject Terms: *LIQUID chromatography-mass spectrometry, *EPIMEDIUM, *CHEMICAL fingerprinting, *HIGH performance liquid chromatography, *PHARMACOLOGY, *CLUSTER analysis (Statistics)

Transcriptome Analysis on the Quality of Epimedium koreanum in Different Soil Moisture Conditions at Harvesting Stage.

Authors: Zhang, Yonggang¹ (AUTHOR) zhangyonggang@jlau.edu.cn, Wang, Dantong¹ (AUTHOR), Wu, Feng¹ (AUTHOR), Huang, Xiangdi¹ (AUTHOR), Chai, Xiaowei¹ (AUTHOR), Yang, Limin¹ (AUTHOR) yanglimin@jlau.edu.cn

Source: Genes. May2024, Vol. 15 Issue 5, p528. 15p.

Subject Terms: *SOIL moisture, *EPIMEDIUM, *FLAVONOL glycosides, *METABOLITES, *FLAVONOIDS

One new prenylated flavonoid with cytotoxic activity from Epimedium brevicornu maxim.

Authors: Zhang, Hui, Wang, YanRu, Liang, Yuhang, Zhao, Xu, Chen, Gang

Source: Natural Product Research; Feb2025, Vol. 39 Issue 4, p981-984, 4p

Subject Terms: FLAVONOIDS, CYTOTOXINS, LUNG cancer, EPIMEDIUM, CANCER cells

Dietary supplementation with Epimedium contributes to the improvement of hormone levels, gut microbiota, and serum metabolite composition in the Chinese forest musk deer (Moschus berezovskii).

Authors: Xie, Shan, Yang, Qinlin, Ying, Zaixiang, Cai, Mingcheng, Fan, Wenqiao, Gao, Hanyu, Feng, Xiaolan, Wu, Yongjiang

Source: Frontiers in Veterinary Science; 2025, p1-15, 15p

Subject Terms: HORMONE regulation, GUT microbiome, LIPID metabolism, DIETARY supplements, EPIMEDIUM

Continuous chromatography system with 6-zone and 18-column dynamic tandem connection technique for the enrichment of total flavonoids from Epimedium koreanum Nakai.

Authors: Cui, Yi, Huai, Jie, Cai, Yiting, Li, Shuai, Zhang, Weiye, Zhou, Taoyulin, Song, Yujie, Zhang, Han, Li, Shengfu, Zhuang, Linwu, Zhang, Junjie

Source: Analytical & Bioanalytical Chemistry; Jan2025, Vol. 417 Issue 3, p583-598, 16p

Subject Terms: CHEMICAL engineering, NATURAL products, CHEMICAL engineers, DYNAMICAL systems, EPIMEDIUM

Epimedium brevicornum Maxim alleviates diabetes osteoporosis by regulating AGE-RAGE signaling pathway

Authors: Shan Shan Lei, Yu Yan Wang, Xiao Wen Huang, Xu Ping Wang, Ming Gao, Bo Li

Source: Molecular Medicine, Vol 31, Iss 1, Pp 1-17 (2025)

Subject Terms: Diabetes osteoporosis (DOP), Epimedium brevicornum Maxim (EP), AGE-RAGE pathway, Bioinformatics techniques, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/a6cacadc42844c249fa579cff3c08a5b

Determination of 6 flavonol glycosides in epimedium health wine by ultra-high performance liquid chromatography

Authors: SHI Hao, MAO Qiongli, HU Yang, LI Xianzhi, YANG Qiang, LI Qiang, XIONG Xiaotong, YAN Ling, ZHU Yan

Source: Zhongguo niangzao, Vol 44, Iss 1, Pp 277-281 (2025)

Subject Terms: epimedium, health wine, flavonol glycoside, ultra-high performance liquid chromatography, Biotechnology, TP248.13-248.65, Food processing and manufacture, TP368-456

File Description: electronic resource

Relation: https://manu61.magtech.com.cn/zgnz/fileup/0254-5071/PDF/0254-5071-2025-44-1-277.pdf; https://doaj.org/toc/0254-5071

Access URL: https://doaj.org/article/2da13cd3ea73428bb4a898fe6ceb536e

Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system: current status and future perspective

Authors: Song-Po Liu, Yun-Fei Li, Dan Zhang, Chun-Yang Li, Xiao-Fang Dai, Dong-Feng Lan, Ji Cai, He Zhou, Tao Song, Yan-Yu Zhao, Zhi-Xu He, Jun Tan, Ji-Dong Zhang

Source: Asian Journal of Andrology, Vol 27, Iss 1, Pp 20-29 (2025)

Subject Terms: epimedium, icariin, infertility, male reproductive system, tumor, Diseases of the genitourinary system. Urology, RC870-923

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/aja20248; https://doaj.org/toc/1008-682X

Access URL: https://doaj.org/article/7b6d9dc048554713b4ed46d2fdafb6b3

Spatial distribution dynamics for Epimedium brevicornum Maxim. from 1970 to 2020.

Authors: Li, Yunfeng^1,2 (AUTHOR), Wang, Yan¹ (AUTHOR), Du, Xiaojuan¹ (AUTHOR), Zhao, Chunying¹ (AUTHOR), He, Ping² (AUTHOR), Meng, Fanyun² (AUTHOR) mfy@bnu.edu.cn

Source: Ecology & Evolution (20457758). Feb2024, Vol. 14 Issue 2, p1-14. 14p.

Subject Terms: *EPIMEDIUM, *SEASONAL temperature variations

Geographic Terms: SHANXI Sheng (China), HENAN Sheng (China), GANSU Sheng (China)