Non-HLA Autoantibodies Against Angiotensin II Receptor 1 (AT1R) and Endothelin A Receptor (ETAR) in Pediatric Kidney Transplantation.

Authors: Antoniello, Benedetta^1,2 (AUTHOR) benedetta.antoniello@studenti.unipd.it, Negrisolo, Susanna^1,2 (AUTHOR) susanna.negrisolo@unipd.it, Marzenta, Diana^1,3 (AUTHOR) diana.marzenta@aopd.veneto.it, Vadori, Marta^2,4 (AUTHOR), De Gaspari, Piera^1,5 (AUTHOR), Cozzi, Emanuele^2,4 (AUTHOR), Benetti, Elisa^1,2,3 (AUTHOR) elisa.benetti@aopd.veneto.it

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11817. 11p.

Subject Terms: *HLA histocompatibility antigens, *ENDOTHELIN receptors, *KIDNEY transplantation, *GRAFT rejection, *ANGIOTENSIN II

Investigation of pulmonary artery and circulating endothelin-1 expression in dogs with pulmonary hypertension secondary to myxomatous mitral valve disease.

Authors: Tangmahakul, Nattawan¹ nattawan.t@chula.ac.th, Rungsipipat, Anudep² anudep.r@chula.ac.th, Surachetpong, Sirilak Disatian¹ sirilak.d@chula.ac.th

Source: Veterinary World. Sep2024, Vol. 17 Issue 9, p2144-2151. 8p.

Subject Terms: *ENZYME-linked immunosorbent assay, *ENDOTHELIN receptors, *MITRAL valve, *PULMONARY hypertension, *PATHOLOGICAL physiology, *PULMONARY artery

Aprocitentan: a new emerging prospect in the pharmacotherapy of hypertension.

Authors: Naseralallah, Lina¹ (AUTHOR) LNaseralallah@hamad.qa, Koraysh, Somaya¹ (AUTHOR)

Source: Blood Pressure. Aug2024, Vol. 33 Issue 1, p1-13. 13p.

Subject Terms: *CLINICAL trial registries, *ENDOTHELIN receptors, *BLOOD pressure, *MEDICATION safety, *DRUG design

Targeting G protein‐coupled receptors for heart failure treatment.

Authors: Thai, Bui San¹ (AUTHOR), Chia, Ling Yeong¹ (AUTHOR), Nguyen, Anh T. N.¹ (AUTHOR), Qin, Chengxue¹ (AUTHOR), Ritchie, Rebecca H.¹ (AUTHOR), Hutchinson, Dana S.¹ (AUTHOR), Kompa, Andrew² (AUTHOR), White, Paul J.¹ (AUTHOR), May, Lauren T.¹ (AUTHOR) lauren.may@monash.edu

Source: British Journal of Pharmacology. Jul2024, Vol. 181 Issue 14, p2270-2286. 17p.

Subject Terms: *ENDOTHELIN receptors, *HEART failure, *G protein coupled receptors, *GLUCAGON-like peptide 1, *ANGIOTENSIN-receptor blockers, *PEPTIDE receptors, *TREATMENT failure

Can Combination Therapy with Endothelin Receptor Antagonist and PDE5 Inhibitors Prevent Echocardiographic Findings Suspicious for Pulmonary Arterial Hypertension? Description of a Real-Life Case Series.

Authors: Damiani, Arianna¹ (AUTHOR) arianna.damiani@unifi.it, Lepri, Gemma¹ (AUTHOR), Bonomi, Francesco¹ (AUTHOR), Fiorentini, Elisa¹ (AUTHOR), Peretti, Silvia¹ (AUTHOR), Blagojevic, Jelena¹ (AUTHOR), Bellando Randone, Silvia¹ (AUTHOR), Guiducci, Serena¹ (AUTHOR)

Source: Diagnostics (2075-4418). Jul2024, Vol. 14 Issue 14, p1526. 7p.

Subject Terms: *PULMONARY arterial hypertension, *ENDOTHELIN receptors, *PULMONARY function tests, *PHOSPHODIESTERASE inhibitors, *PHOSPHODIESTERASE-5 inhibitors

Graphene Far-Infrared Irradiation Can Effectively Relieve the Blood Pressure Level of Rat Untr-HT in Primary Hypertension.

Authors: Lu, Guanjie¹ (AUTHOR), Guo, Haotong¹ (AUTHOR), Zhang, Yi¹ (AUTHOR) luguanjie2023@163.com, Zhang, Meng¹ (AUTHOR), Zhang, Tao¹ (AUTHOR), Hu, Ge¹ (AUTHOR), Zhang, Qian¹ (AUTHOR) zhangqianbua@163.com

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 12, p6675. 13p.

Subject Terms: *ENDOTHELIN receptors, *ESSENTIAL hypertension, *BLOOD pressure, *VASCULAR smooth muscle, *PREPROENDOTHELIN, *SMOOTH muscle contraction

Hypertension and Heart Failure: From Pathophysiology to Treatment.

Authors: Gallo, Giovanna¹ (AUTHOR) giovanna.gallo@uniroma1.it, Savoia, Carmine¹ (AUTHOR) carmine.savoia@uniroma1.it

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 12, p6661. 17p.

Subject Terms: *ENDOTHELIN receptors, *HEART failure, *VENTRICULAR remodeling, *HYPERTENSION, *SMALL interfering RNA, *ANTIHYPERTENSIVE agents, *MINERALOCORTICOID receptors

The Anti-Atherosclerotic Effects of Endothelin Receptor Antagonist, Bosentan, in Combination with Atorvastatin—An Experimental Study.

Authors: Stasinopoulou, Marianna¹ (AUTHOR) mar.stasinopoulou@gmail.com, Kostomitsopoulos, Nikolaos¹ (AUTHOR) nkostom@bioacademy.gr, Kadoglou, Nikolaos P. E.² (AUTHOR) nikoskad@yahoo.com

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 12, p6614. 12p.

Subject Terms: *ATORVASTATIN, *ENDOTHELIN receptors, *HIGH-fat diet, *ELASTIN, *CARDIOVASCULAR diseases, *STREPTOZOTOCIN

Molecular Aspects of Cardiometabolic Diseases: From Etiopathogenesis to Potential Therapeutic Targets.

Authors: Bernatova, Iveta¹ (AUTHOR) iveta.bernatova@savba.sk, Bartekova, Monika² (AUTHOR) iveta.bernatova@savba.sk

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5841. 5p.

Subject Terms: *HEART metabolism disorders, *ENDOTHELIN receptors, *CALCIUM-dependent protein kinase, *DRUG target, *CARDIOVASCULAR diseases, *THERAPEUTICS

Integrated metabolomics analysis reveals mechanistic insights into variability in blood pressure response to thiazide diuretics and beta blockers.

Authors: Mehanna, Mai¹ (AUTHOR), McDonough, Caitrin W.² (AUTHOR), Smith, Steven M.³ (AUTHOR), Gong, Yan² (AUTHOR), Gums, John G.² (AUTHOR), Chapman, Arlene B.⁴ (AUTHOR), Johnson, Julie A.⁵ (AUTHOR), Cooper‐DeHoff, Rhonda M.² (AUTHOR) dehoff@cop.ufl.edu

Source: CTS: Clinical & Translational Science. May2024, Vol. 17 Issue 5, p1-8. 8p.

Subject Terms: *ENDOTHELIN receptors, *PREPROENDOTHELIN, *METABOLOMICS, *NITRIC-oxide synthases, *SPHINGOSINE-1-phosphate, *DIURETICS, *BLOOD pressure

Maximizing the Therapeutic Effect of Endothelin Receptor Antagonists in Pulmonary Fibrosis: A Paradigm for Treating the Disease.

Authors: Cantor, Jerome¹ (AUTHOR) jocantor1@gmail.com

Source: International Journal of Molecular Sciences. Apr2024, Vol. 25 Issue 8, p4184. 13p.

Subject Terms: *ENDOTHELIN receptors, *PULMONARY fibrosis, *ENDOTHELINS, *TREATMENT effectiveness, *EXTRACELLULAR matrix, *PREPROENDOTHELIN, *ELASTIN

Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.

Authors: Mazzieri, Alessio¹ (AUTHOR) alessiomazzieri90@gmail.com, Porcellati, Francesca¹ (AUTHOR) francesca.porcellati@unipg.it, Timio, Francesca² (AUTHOR) francesca.timio@ospedale.perugia.it, Reboldi, Gianpaolo² (AUTHOR) paolo.reboldi@unipg.it

Source: International Journal of Molecular Sciences. Apr2024, Vol. 25 Issue 7, p3969. 17p.

Subject Terms: *ENDOTHELIN receptors, *GLUCAGON-like peptide-1 receptor, *INDIVIDUALIZED medicine, *DRUG target, *DIABETIC nephropathies, *GLUCAGON-like peptide-1 agonists, *THERAPEUTICS, *MINERALOCORTICOID receptors

Preclinical metabolism and the disposition of vornorexant/TS‐142, a novel dual orexin 1/2 receptor antagonist for the treatment of insomnia.

Authors: Konno, Yoshihiro¹ (AUTHOR) y‐konno@taisho.co.jp, Kamigaso, Shunsuke¹ (AUTHOR), Toki, Hidetoh¹ (AUTHOR), Terasaka, Shuichi¹ (AUTHOR), Hikichi, Hirohiko² (AUTHOR), Endo, Hiromi¹ (AUTHOR), Yamaguchi, Jun‐Ichi¹ (AUTHOR), Mizuno‐Yasuhira, Akiko¹ (AUTHOR)

Source: Pharmacology Research & Perspectives. Apr2024, Vol. 12 Issue 2, p1-14. 14p.

Subject Terms: *ENDOTHELIN receptors, *ORAL drug administration, *DRUG efficacy, *HYPNOTICS, *INSOMNIA, *METABOLISM, *CEREBROSPINAL fluid

Safety of Dual Orexin Receptor Antagonist Daridorexant: A Disproportionality Analysis of Publicly Available FAERS Data.

Authors: Cicala, Giuseppe¹ (AUTHOR) gcicala@unime.it, Barbieri, Maria Antonietta¹ (AUTHOR) giuliarusso.ab@gmail.com, Russo, Giulia¹ (AUTHOR) espina@unime.it, Salvo, Francesco^2,3 (AUTHOR) francesco.salvo@u-bordeaux.fr, Spina, Edoardo¹ (AUTHOR)

Source: Pharmaceuticals (14248247). Mar2024, Vol. 17 Issue 3, p342. 15p.

Subject Terms: *ENDOTHELIN receptors, *DRUG side effects, *OREXINS, *ODDS ratio, *DATABASES

Geographic Terms: EUROPE

Autoantibodies Targeting G-Protein-Coupled Receptors: Pathogenetic, Clinical and Therapeutic Implications in Systemic Sclerosis.

Authors: Binda, Marco¹ (AUTHOR) marco.binda@studenti.unipd.it, Moccaldi, Beatrice¹ (AUTHOR), Civieri, Giovanni² (AUTHOR), Cuberli, Anna¹ (AUTHOR), Doria, Andrea¹ (AUTHOR), Tona, Francesco² (AUTHOR), Zanatta, Elisabetta¹ (AUTHOR) elisabetta.zanatta@unipd.it

Source: International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 4, p2299. 17p.

Subject Terms: *ENDOTHELIN receptors, *SYSTEMIC scleroderma, *CHEMOKINE receptors, *AUTOANTIBODIES, *CONNECTIVE tissue diseases, *CHOLINERGIC receptors, *ANGIOTENSIN I

Taming resistant hypertension: The promise of novel pharmacologic approaches and renal denervation.

Authors: Azzam, Omar^1,2 (AUTHOR), Nejad, Sayeh Heidari¹ (AUTHOR), Carnagarin, Revathy¹ (AUTHOR), Nolde, Janis M.¹ (AUTHOR), Galindo‐Kiuchi, Marcio¹ (AUTHOR), Schlaich, Markus P.^1,2,3 (AUTHOR) markus.schlaich@uwa.edu.au

Source: British Journal of Pharmacology. Feb2024, Vol. 181 Issue 3, p319-339. 21p.

Subject Terms: *ENDOTHELIN receptors, *DENERVATION, *MINERALOCORTICOID receptors, *HYPERTENSION, *ANTIHYPERTENSIVE agents, *SYMPATHETIC nervous system

Secondary cryofibrinogenemia is related to more severe microangiopathic involvement in systemic sclerosis: results from a retrospective observational study.

Authors: Sandri, Gilda^1,2,3 (AUTHOR) gilda.sandri@unimore.it, Amati, Gabriele^1,3 (AUTHOR) gabriele.amatimed@gmail.com, Spinella, Amelia¹ (AUTHOR) amelia.spinella@gmail.com, Natali, Patrizia⁴ (AUTHOR) p.natali@ausl.mo.it, Debbia, Daria⁴ (AUTHOR) da.debbia@ausl.mo.it, Orlandi, Martina^1,2,3 (AUTHOR) martina.orlandi@unimore.it, Secchi, Ottavio¹ (AUTHOR) ottavio.secchi@gmail.com, Bongiovanni, Benedetta^1,3 (AUTHOR) be.bongiovanni@gmail.com, de Pinto, Marco¹ (AUTHOR) marcodepinto1993@gmail.com, Mascia, Maria Teresa^1,2,3 (AUTHOR) mmmt.mascia@gmail.com, Giuggioli, Dilia^1,2,3 (AUTHOR) dilia.giuggioli@unimore.it

Source: Clinical Rheumatology. Mar2025, Vol. 44 Issue 3, p1173-1185. 13p.

Subject Terms: *PULMONARY arterial hypertension, *ENDOTHELIN receptors, *FISHER exact test, *SYSTEMIC scleroderma, *MEDICAL sciences

Efficacy and safety of endothelin A receptor antagonists in IgA nephropathy: a systematic review and meta-analysis.

Authors: Tian, Zhonghua¹ (AUTHOR), Yang, Yalin¹ (AUTHOR), Mei, Jixiong¹ (AUTHOR), Huang, Mingchun¹ (AUTHOR), Li, Yanyan¹ (AUTHOR), Fang, Zhie¹ (AUTHOR), Li, Yunyi¹ (AUTHOR), Tang, Ling¹ (AUTHOR), Li, Yuxia² (AUTHOR)

Source: Clinical Kidney Journal. Mar2025, Vol. 18 Issue 3, p1-12. 12p.

Subject Terms: *IGA glomerulonephritis, *ENDOTHELIN receptors, *KIDNEY injuries, *PROTEINURIA, *SAFETY, *TREATMENT effectiveness

Atrasentan in Patients with IgA Nephropathy.

Authors: Heerspink, Hiddo J. L.¹, h.j.lambers.heerspink@umcg.nl, Jardine, Meg², Kohan, Donald E.³, Lafayette, Richard A.⁴, Levin, Adeera⁵, Liew, Adrian⁶, Hong Zhang⁷, Lodha, Amit⁸, Gray, Todd⁹, Yi Wang⁸, Renfurm, Ronny¹⁰, Barratt, Jonathan¹¹

Source: New England Journal of Medicine; 2/6/2025, Vol. 392 Issue 6, p544-554, 11p

Interplay of Angiotensin Peptides, Vasopressin, and Insulin in the Heart: Experimental and Clinical Evidence of Altered Interactions in Obesity and Diabetes Mellitus.

Authors: Szczepanska-Sadowska, Ewa¹ (AUTHOR) eszczepanska@wum.edu.pl

Source: International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 2, p1310. 27p.

Subject Terms: *ENDOTHELIN receptors, *ANGIOTENSINS, *PEPTIDES, *INSULIN, *CORONARY circulation, *DIABETES, *VASOPRESSIN, *ANGIOTENSIN II