Exploring the Anti-Chagas Activity of Zanthoxylum chiloperone’s Seedlings Through Metabolomics and Protein–Ligand Docking

Authors: Ninfa Vera de Bilbao, Ryland T. Giebelhaus, Ryan P. Dias, Maria Elena Ferreira, Miguel Martínez, Lorea Velasco-Carneros, Seo Lin Nam, A. Paulina de la Mata, Jean-Didier Maréchal, Ahissan Innocent Adou, Gloria Yaluff, Elva Serna, Muriel Sylvestre, Susana Torres, Alicia Schinini, Ricardo Galeano, Alain Fournet, James J. Harynuk, Gerardo Cebrián-Torrejón

Source: Plants, Vol 14, Iss 6, p 954 (2025)

Subject Terms: canthin-6-ones, chagas disease, medicinal plants, natural products, plant metabolomics, Rutaceae, Botany, QK1-989

File Description: electronic resource

Relation: https://www.mdpi.com/2223-7747/14/6/954; https://doaj.org/toc/2223-7747

Access URL: https://doaj.org/article/3deac0f8f78b49a6b270383bd36291ea

Preclinical Studies and Drug Combination of Low-Cost Molecules for Chagas Disease

Authors: Elena Aguilera, Carina Sánchez, María Eugenia Cruces, Belén Dávila, Lucía Minini, Florencia Mosquillo, Leticia Pérez-Díaz, Elva Serna, Susana Torres, Alicia Schini, Luis Sanabria, Ninfa I. Vera de Bilbao, Gloria Yaluff, Flavio R. Zolessi, Luis Fabian Ceilas, Hugo Cerecetto, Guzmán Alvarez

Source: Pharmaceuticals, Vol 16, Iss 1, p 20 (2022)

Subject Terms: Chagas disease, pre-clinically studied, drug combination, RMN metabolomics, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/1/20; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/1e23890425284d1381d54bf2743249aa

Preclinical Studies in Anti-Trypanosomatidae Drug Development

Authors: Cintya Perdomo, Elena Aguilera, Ileana Corvo, Paula Faral-Tello, Elva Serna, Carlos Robello, Shane R. Wilkinson, Gloria Yaluff, Guzmán Alvarez

Source: Pharmaceuticals, Vol 14, Iss 7, p 644 (2021)

Subject Terms: anti-trypanosomatid, arylidene ketones, thiazolidene hydrazines, Pathogen box, veterinary isolates, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/14/7/644; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/412137f8cd824fe4af8561229996da07

In Vivo Anti-Trypanosoma cruzi Activity of Hydro-Ethanolic Extract and Isolated Active Principles from Aristeguietia glutinosa and Mechanism of Action Studies

Authors: Javier Varela, Elva Serna, Susana Torres, Gloria Yaluff, Ninfa I. Vera de Bilbao, Patricio Miño, Ximena Chiriboga, Hugo Cerecetto, Mercedes González

Source: Molecules, Vol 19, Iss 6, Pp 8488-8502 (2014)

Subject Terms: anti-T. cruzi activity, Aristeguietia glutinosa Lam., (+)-15-hydroxy-7-labden-17-al, labdane diterpenoid, 1H-NMR metabolomics, Organic chemistry, QD241-441

File Description: electronic resource

Relation: http://www.mdpi.com/1420-3049/19/6/8488; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/29fc81157eb44572a311a8706551b3e5

A Nature-Inspired Design Yields a New Class of Steroids Against Trypanosomatids

Authors: Elena Aguilera, Cintya Perdomo, Alejandra Espindola, Ileana Corvo, Paula Faral-Tello, Carlos Robello, Elva Serna, Fátima Benítez, Rocío Riveros, Susana Torres, Ninfa I. Vera de Bilbao, Gloria Yaluff, Guzmán Alvarez

Source: Molecules, Vol 24, Iss 20, p 3800 (2019)

Subject Terms: anti-t. cruzi activity in vitro and in vivo, anti-leishmania spp. activity in vitro and in vivo, cytotoxicity and genotoxicity, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/24/20/3800; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/640aa9bb0e5946caa3c7b580b6a7cb5c

Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment

Authors: Elena Aguilera, Javier Varela, Elva Serna, Susana Torres, Gloria Yaluff, Ninfa Vera de Bilbao, Hugo Cerecetto, Guzmán Alvarez, Mercedes González

Source: Memorias do Instituto Oswaldo Cruz, Vol 113, Iss 3, Pp 153-160

Subject Terms: Chagas disease, synergism, isobologram, in vivo studies, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000300153&lng=en&tlng=en; https://doaj.org/toc/1678-8060

Access URL: https://doaj.org/article/9bd06671af50451dad8407fc45126304

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