ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development

Authors: Guillaume P. Andrieu, Guillaume Hypolite, Mehdi Latiri, Estelle Balducci, Caroline Costa, Els Verhoeyen, Marianne Courgeon, Omran Allatif, Ivan Nemazanyy, Ganna Panasyuk, Kathryn Wellen, Daniel Herranz, Laurent Genestier, Elizabeth Macintyre, Vahid Asnafi, Melania Tesio

Source: Blood Advances, Vol 9, Iss 7, Pp 1670-1691 (2025)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S247395292400658X; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/741daebda57c439ea824a8518b9e1109

In vivo CAR T cell therapy against angioimmunoblastic T cell lymphoma

Authors: Adrien Krug, Aymen Saidane, Chiara Martinello, Floriane Fusil, Alexander Michels, Christian J. Buchholz, Jean-Ehrland Ricci, Els Verhoeyen

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)

Subject Terms: CD8-targeted virus envelope, CAR T, AITL, In vivo gene therapy, Pseudotyping, Lentiviral vector, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/daf8777c96c74d378e623fabf71e0eca

Engineered packaging cell line for the enhanced production of baboon-enveloped retroviral vectors

Authors: Denise Klatt, Lucia Sereni, Boya Liu, Pietro Genovese, Axel Schambach, Els Verhoeyen, David A. Williams, Christian Brendel

Source: Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102389- (2024)

Subject Terms: MT: Delivery Strategies, packaging cell line, BaEVRLess envelope, ASCT2 knockout, α-retroviral vectors, CD47 overexpression, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253124002762; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/8e2e01e0ba9340b482b868e06259719f

Dependence on mitochondrial respiration of malignant T cells reveals a new therapeutic target for angioimmunoblastic T-cell lymphoma

Authors: Adrien Krug, Rana Mhaidly, Marie Tosolini, Laura Mondragon, Gamze Tari, Adriana Martinez Turtos, Rachel Paul-Bellon, Vahid Asnafi, Sandrine Marchetti, Léa Di Mascio, Marion Travert, Frédéric Bost, Emmanuel Bachy, Rafael J. Argüello, Jean-Jacques Fournié, Philippe Gaulard, François Lemonnier, Jean-Ehrland Ricci, Els Verhoeyen

Source: Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/7cd810306c654f90b3cc436c3f70300e

CAR T cells outperform CAR NK cells in CAR-mediated effector functions in head-to-head comparison

Authors: Lukas Egli, Meike Kaulfuss, Juliane Mietz, Arianna Picozzi, Els Verhoeyen, Christian Münz, Obinna Chijioke

Source: Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-18 (2024)

Subject Terms: Chimeric antigen receptor, Adoptive cell therapy, Human T cells, Human NK cells, IFN-γ, Cytotoxicity, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-3619

Access URL: https://doaj.org/article/8f50899e7813436a9d318bb05e27875d

Inhibition of choline metabolism in an angioimmunoblastic T-cell lymphoma preclinical model reveals a new metabolic vulnerability as possible target for treatment

Authors: Adrien Krug, Marie Tosolini, Blandine Madji Hounoum, Jean-Jacques Fournié, Roger Geiger, Matteo Pecoraro, Patrick Emond, Philippe Gaulard, François Lemonnier, Jean-Ehrland Ricci, Els Verhoeyen

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)

Subject Terms: Choline, AITL, Lipid metabolism, CDP-choline pathway, CDP-ethanolamine pathway, Choline kinase, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/0685f8cd030f49b99d2ba6536610e7de

Optimisation of a primary human CAR‐NK cell manufacturing pipeline

Authors: Aline Pfefferle, Julian Contet, Kahlia Wong, Charlotte Chen, Els Verhoeyen, Chloe K Slichter, Kimberly S Schluns, Joseph Cursons, Richard Berry, Iva Nikolic, Jai Rautela, Nicholas D Huntington

Source: Clinical & Translational Immunology, Vol 13, Iss 5, Pp n/a-n/a (2024)

Subject Terms: immunotherapy, lymphocytes, NK cells, translational immunology, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2050-0068

Access URL: https://doaj.org/article/1c4ef2b2dbce494a9cb2a8585541cc59

Multimodal cartography of human lymphopoiesis reveals B and T/NK/ILC lineages are subjected to differential regulation

Authors: Kutaiba Alhaj Hussen, Emna Chabaane, Elisabeth Nelson, Shalva Lekiashvili, Samuel Diop, Seydou Keita, Bertrand Evrard, Aurélie Lardenois, Marc Delord, Els Verhoeyen, Kerstin Cornils, Zeinab Kasraian, Elizabeth A. Macintyre, Ana Cumano, David Garrick, Michele Goodhardt, Guillaume P. Andrieu, Vahid Asnafi, Frederic Chalmel, Bruno Canque

Source: iScience, Vol 26, Iss 10, Pp 107890- (2023)

Subject Terms: Biological sciences, Immunology, Components of the immune system, Cell biology, Transcriptomics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223019673; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/06171025b16245b4bbab3a99462d5ce3

S108: ATP CITRATE LYASE IS AN ESSENTIAL PLAYER OF THE METABOLIC REWIRING INDUCED BY PTEN LOSS DURING T-ALL DEVELOPMENT

Authors: Guillaume Andrieu, Estelle Balduci, Caroline Costa, Els Verhoeyen, Ivan Nemazanyy, Ganna Pannasiuk, Kathryn Wellen, Elizabeth Macintyre, Vahid Asnafi, Melania Tesio

Source: HemaSphere, Vol 7, p e6897578 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000967344.68975.78; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/4a362240788947cd8fb15ae04ae25799

Distinct subsets of multi-lymphoid progenitors support ontogeny-related changes in human lymphopoiesis

Authors: Seydou Keita, Samuel Diop, Shalva Lekiashvili, Emna Chabaane, Elisabeth Nelson, Marion Strullu, Chloé Arfeuille, Fabien Guimiot, Thomas Domet, Sophie Duchez, Bertrand Evrard, Thomas Darde, Jerome Larghero, Els Verhoeyen, Ana Cumano, Elizabeth A. Macintyre, Zeinab Kasraian, François Jouen, Michele Goodhardt, David Garrick, Frederic Chalmel, Kutaiba Alhaj Hussen, Bruno Canque

Source: Cell Reports, Vol 42, Iss 6, Pp 112618- (2023)

Subject Terms: CP: Developmental biology, CP: Immunology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723006290; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/159f2d831f9a402db5b8c2adc8fa3349

Production of CRISPRi-engineered primary human mammary epithelial cells with baboon envelope pseudotyped lentiviral vectors

Authors: Sonia Pastor, Julien Wicinski, Emmanuelle Charafe-Jauffret, Els Verhoeyen, Geoffrey Guittard, Christophe Ginestier

Source: STAR Protocols, Vol 4, Iss 1, Pp 102055- (2023)

Subject Terms: Cell Biology, Cell isolation, Flow Cytometry/Mass Cytometry, Cancer, Molecular Biology, Gene Expression, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166723000138; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/35b2daa7600e4e67ae1d01e3ab26a669

IRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune response

Authors: Adriana Martinez-Turtos, Rachel Paul, Manuel Grima-Reyes, Hussein Issaoui, Adrien Krug, Rana Mhaidly, Jozef P. Bossowski, Johanna Chiche, Sandrine Marchetti, Els Verhoeyen, Eric Chevet, Jean-Ehrland Ricci

Source: OncoImmunology, Vol 11, Iss 1 (2022)

Subject Terms: Cancer, UPR, IRE1α, XBP1s, RIDD, anti-cancer immunosurveillance, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/a17f8333685a4354820bb0d127341553

Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

Authors: Eric Vivier, Daniel Olive, Remy Castellano, Els Verhoeyen, Pierre-Louis Bernard, Rebecca Delconte, Sonia Pastor, Vladimir Laletin, Cathy Costa Da Silva, Armelle Goubard, Emmanuelle Josselin, Adrien Krug, Julien Vernerey, Raynier Devillier, Nicholas D Huntington, Jacques Nunes, Geoffrey Guittard

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 5 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/5/e004244.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/1d21d7dd603042f59b7170a17a6f2de6

An optimized measles virus glycoprotein-pseudotyped lentiviral vector production system to promote efficient transduction of human primary B cells

Authors: Eirini Vamva, Stosh Ozog, Els Verhoeyen, Richard G. James, David J. Rawlings, Bruce E. Torbett

Source: STAR Protocols, Vol 3, Iss 1, Pp 101228- (2022)

Subject Terms: Cell isolation, Flow Cytometry/Mass Cytometry, Immunology, Microbiology, Molecular Biology, Biotechnology and bioengineering, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166722001083; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/e6b7e6a73833410aad10f86653494eaf

CD46 Null Packaging Cell Line Improves Measles Lentiviral Vector Production and Gene Delivery to Hematopoietic Stem and Progenitor Cells

Authors: Stosh Ozog, Craig X. Chen, Elizabeth Simpson, Olivia Garijo, Nina D. Timberlake, Petra Minder, Els Verhoeyen, Bruce E. Torbett

Source: Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 27-39 (2019)

Subject Terms: Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050118301189; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/fddd9b144ec5464e8213e1eb8573ad39

NK cells enhance CAR-T cell antitumor efficacy by enhancing immune/tumor cells cluster formation and improving CAR-T cell fitness

Authors: Amer Najjar, Manel Juan, Lorena Pérez-Amill, Alvaro Urbano-Ispizua, Beatriz Martín-Antonio, Mireia Bachiller, Anthony Matthew Battram, Sebastian Ciro Carné, Els Verhoeyen

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/8/e002866.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/83b56dc8044d43ad9b451d4d44edf564

Baboon Envelope Pseudotyped 'Nanoblades' Carrying Cas9/gRNA Complexes Allow Efficient Genome Editing in Human T, B, and CD34+ Cells and Knock-in of AAV6-Encoded Donor DNA in CD34+ Cells

Authors: Alejandra Gutierrez-Guerrero, Maria Jimena Abrey Recalde, Philippe E. Mangeot, Caroline Costa, Ornellie Bernadin, Séverine Périan, Floriane Fusil, Gisèle Froment, Adriana Martinez-Turtos, Adrien Krug, Francisco Martin, Karim Benabdellah, Emiliano P. Ricci, Simone Giovannozzi, Rik Gijsbers, Eduard Ayuso, François-Loïc Cosset, Els Verhoeyen

Source: Frontiers in Genome Editing, Vol 3 (2021)

Subject Terms: hematopoietic stem cells, T cell, B cell, gene editing, CRISPR/Cas9, nanoblade, Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgeed.2021.604371/full; https://doaj.org/toc/2673-3439

Access URL: https://doaj.org/article/1d5485f02cd64cd39b1ee599b28883bf

Tumor cell-derived IL-10 promotes cell-autonomous growth and immune escape in diffuse large B-cell lymphoma

Authors: Kristin Stirm, Peter Leary, Katrin Bertram, Nicolás Gonzalo Núñez, Daria Wüst, Christophe Boudesco, Els Verhoeyen, Thorsten Zenz, Burkhard Becher, Thomas Menter, Alexandar Tzankov, Anne Müller

Source: OncoImmunology, Vol 10, Iss 1 (2021)

Subject Terms: lymphoma microenvironment, dlbcl mouse models, oncogenic stat3 signaling, personalized treatment, cancer immunotherapy, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/1d829b2258f141b2b3b452c988a05534

Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins

Authors: Philippe E. Mangeot, Valérie Risson, Floriane Fusil, Aline Marnef, Emilie Laurent, Juliana Blin, Virginie Mournetas, Emmanuelle Massouridès, Thibault J. M. Sohier, Antoine Corbin, Fabien Aubé, Marie Teixeira, Christian Pinset, Laurent Schaeffer, Gaëlle Legube, François-Loïc Cosset, Els Verhoeyen, Théophile Ohlmann, Emiliano P. Ricci

Source: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0bd13889c5db4e0ba26c33892287ae45

In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

Authors: Anett Pfeiffer, Frederic B Thalheimer, Sylvia Hartmann, Annika M Frank, Ruben R Bender, Simon Danisch, Caroline Costa, Winfried S Wels, Ute Modlich, Renata Stripecke, Els Verhoeyen, Christian J Buchholz

Source: EMBO Molecular Medicine, Vol 10, Iss 11, Pp 1-11 (2018)

Subject Terms: cytokine release syndrome, gene delivery, humanized mouse, T‐cell targeting, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/0d3a5818f8be4f4293451029dc69af29