Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

Authors: Hudson W Coates, Isabelle M Capell-Hattam, Ellen M Olzomer, Ximing Du, Rhonda Farrell, Hongyuan Yang, Frances L Byrne, Andrew J Brown

Source: eLife, Vol 12 (2023)

Subject Terms: Squalene monooxygenase, Cholesterol, Hypoxia, proteasome, protein degradation, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/82843; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/3f53fc512fcc4b44b302c034457a3da2

Complete inhibition of liver acetyl-CoA carboxylase activity is required to exacerbate liver tumorigenesis in mice treated with diethylnitrosamine

Authors: Riya Shrestha, Calum S. Vancuylenburg, Martina Beretta, Mingyan Zhou, Divya P. Shah, Ellen M. Olzomer, Sian L. Richards, Kyle L. Hoehn, Frances L. Byrne

Source: Cancer & Metabolism, Vol 12, Iss 1, Pp 1-10 (2024)

Subject Terms: Liver cancer, De novo lipogenesis, Acetyl-CoA carboxylase, Tumorigenesis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2049-3002

Access URL: https://doaj.org/article/a90ba229d3e74b79b98ae71a6d283af0

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

Authors: Stephanie J. Alexopoulos, Sing-Young Chen, Amanda E. Brandon, Joseph M. Salamoun, Frances L. Byrne, Christopher J. Garcia, Martina Beretta, Ellen M. Olzomer, Divya P. Shah, Ashleigh M. Philp, Stefan R. Hargett, Robert T. Lawrence, Brendan Lee, James Sligar, Pascal Carrive, Simon P. Tucker, Andrew Philp, Carolin Lackner, Nigel Turner, Gregory J. Cooney, Webster L. Santos, Kyle L. Hoehn

Source: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/49822901a6bc47aea8285786f6119e85

Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

Authors: Marin E. Nelson, Sujoy Lahiri, Jenny D. Y. Chow, Frances L. Byrne, Stefan R. Hargett, David S. Breen, Ellen M. Olzomer, Lindsay E. Wu, Gregory J. Cooney, Nigel Turner, David E. James, Jill K. Slack-Davis, Carolin Lackner, Stephen H. Caldwell, Kyle L. Hoehn

Source: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/19ef0685f5d74b788afe67c6f9e96489

Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice

Authors: Sing-Young Chen, Martina Beretta, Ellen M. Olzomer, Divya P. Shah, Derek Y.H. Wong, Stephanie J. Alexopoulos, Isabella Aleksovska, Joseph M. Salamoun, Christopher J. Garcia, Blake J. Cochran, Kerry-Anne Rye, Greg C. Smith, Frances L. Byrne, Margaret J. Morris, Webster L. Santos, James Cantley, Kyle L. Hoehn

Source: Molecular Metabolism, Vol 69, Iss , Pp 101684- (2023)

Subject Terms: Calorie restriction, Mitochondrial uncoupling, Obesity, Diabetes, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877823000182; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/e475640495114e8b9f51a21417a66099

Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)

Authors: Alexander J. Knights, Emily J. Vohralik, Peter J. Houweling, Elizabeth S. Stout, Laura J. Norton, Stephanie J. Alexopoulos, Jinfen. J. Yik, Hanapi Mat Jusoh, Ellen M. Olzomer, Kim S. Bell-Anderson, Kathryn N. North, Kyle L. Hoehn, Merlin Crossley, Kate G. R. Quinlan

Source: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c3cf746046c44c4288224f72b4e3c524

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress

Authors: Frances L. Byrne, Ellen M. Olzomer, Gabriella R. Marriott, Lake-Ee Quek, Alice Katen, Jacky Su, Marin E. Nelson, Gene Hart-Smith, Mark Larance, Veronica F. Sebesfi, Jeff Cuff, Gabriella E. Martyn, Elizabeth Childress, Stephanie J. Alexopoulos, Ivan K. Poon, Maree C. Faux, Antony W. Burgess, Glen Reid, Joshua A. McCarroll, Webster L. Santos, Kate GR. Quinlan, Nigel Turner, Daniel J. Fazakerley, Naresh Kumar, Kyle L. Hoehn

Source: Redox Biology, Vol 28, Iss , Pp - (2020)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231719308845; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/5e4c5baf666144d5a43fe60f14c4e6fb