Oleraceins from Portulaca oleracea leaves: Quali-quantitative determination and antioxidant potential

Authors: Ciro Cannavacciuolo, Assunta Napolitano, Verena M. Dirsch, Elke H. Heiss, Milena Masullo, Sonia Piacente

Source: Current Research in Food Science, Vol 10, Iss , Pp 100992- (2025)

Subject Terms: Portulaca oleracea L., Purslane, ‘Green’ extracts, Oleraceins, Cyclo-DOPA phenolic alkaloids, Antioxidant activity, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2665927125000231; https://doaj.org/toc/2665-9271

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Corrigendum: Sulforaphane diminishes moonlighting of pyruvate kinase M2 and interleukin 1β expression in M1 (LPS) macrophages

Authors: Sheyda Bahiraii, Martin Brenner, Fangfang Yan, Wolfram Weckwerth, Elke H. Heiss

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: sulforaphane, macrophages, M1 polarization, glycolysis, PKM2, interleukin 1 beta, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1395642/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/3ff9337e0d614481af415e8440a6b41e

Norbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFκB, MAPK and STAT3 activation and blocking metabolic reprogramming

Authors: Wan Li, Zhengnan Cai, Florian Schindler, Sheyda Bahiraii, Martin Brenner, Elke H. Heiss, Wolfram Weckwerth

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: norbergenin, anti-inflammation, proteomics, metabolomics, macrophages, NFκB signaling pathway, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1117638/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/1bce8259c0d547f6a3eb107e1aab0f94

Branched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Authors: Zhengnan Cai, Wan Li, Martin Brenner, Sheyda Bahiraii, Elke H. Heiss, Wolfram Weckwerth

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: macrophage polarization, tumor-associated macrophages, panomics, BCKAs Fc-gamma receptor (FCgR)-mediated phagocytosis, tumor necrosis factor alpha (TNFα)-nuclear factor kappa B (NFκB) -mediated inflammatory pathway, apoptosis, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.966158/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5152d698cb154af494edfd6ad3f492f3

LC-MS- and 1H NMR-Based Metabolomics to Highlight the Impact of Extraction Solvents on Chemical Profile and Antioxidant Activity of Daikon Sprouts (Raphanus sativus L.)

Authors: Ciro Cannavacciuolo, Antonietta Cerulli, Verena M. Dirsch, Elke H. Heiss, Milena Masullo, Sonia Piacente

Source: Antioxidants, Vol 12, Iss 8, p 1542 (2023)

Subject Terms: Raphanus sativus L., Brassicaceae, daikon, green extracts, hydroxycinnamic acid derivatives, TEAC, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/12/8/1542; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/e9b0c4454e884d3097e4296d83ac7e9b

AMPK-Mediated Phosphorylation of Nrf2 at S374/S408/S433 Favors Its βTrCP2-Mediated Degradation in KEAP1-Deficient Cells

Authors: Eleni Petsouki, Sylvia Ender, Shara Natalia Sosa Cabrera, Elke H. Heiss

Source: Antioxidants, Vol 12, Iss 8, p 1586 (2023)

Subject Terms: Nrf2, AMPK, βTrCP, E3 ubiquitin ligase, transcription factor, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/12/8/1586; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/3bb9899051ae49ae8815da092581fce8

Sulforaphane diminishes moonlighting of pyruvate kinase M2 and interleukin 1β expression in M1 (LPS) macrophages

Authors: Sheyda Bahiraii, Martin Brenner, Fangfang Yan, Wolfram Weckwerth, Elke H. Heiss

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: sulforaphane, macrophages, M1 polarization, glycolysis, PKM2, interleukin 1 beta, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.935692/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/2bdd16a2eb9642bd8caac484a9125978

Caco-2 Cells for Measuring Intestinal Cholesterol Transport - Possibilities and Limitations

Authors: Verena Hiebl, Daniel Schachner, Angela Ladurner, Elke H. Heiss, Herbert Stangl, Verena M. Dirsch

Source: Biological Procedures Online, Vol 22, Iss 1, Pp 1-18 (2020)

Subject Terms: Caco-2, Cholesterol uptake, Cholesterol efflux, ABCA1, ABCG5/G8, NPC1L1, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12575-020-00120-w; https://doaj.org/toc/1480-9222

Access URL: https://doaj.org/article/9ddfc7e53c2d4ee3b061c80f48780af7

Elevated PINK1/Parkin-Dependent Mitophagy and Boosted Mitochondrial Function Mediate Protection of HepG2 Cells from Excess Palmitic Acid by Hesperetin

Authors: Wan Li (Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna), Zhengnan Cai (Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna), Florian Schindler (Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna), Leila Afjehi-Sadat (Mass Spectrometry Centre, Faculty of Chemistry, University of Vienna), Bianca Montsch (Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna), Petra Heffeter (Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna), Elke H. Heiss (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Wolfram Weckwerth (Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna)

Availability: http://data.europeana.eu/aggregation/europeana/1300/https___phaidra_univie_ac_at_o_2070847

Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling

Authors: Zhengnan Cai (Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna), Wan Li (Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna), Sonja Hager (Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna), Jayne Louise Wilson (Center for Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna), Leila Afjehi-Sadat (Mass Spectrometry Centre, Faculty of Chemistry, University of Vienna), Elke H. Heiss (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Thomas Weichhart (Center for Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna), Petra Heffeter (Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna), Wolfram Weckwerth (Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna)

Availability: http://data.europeana.eu/aggregation/europeana/1300/https___phaidra_univie_ac_at_o_2066862

Sulforaphane impedes mitochondrial reprogramming and histone acetylation in polarizing M1 (LPS) macrophages

Authors: Sheyda Bahiraii (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Martin Brenner (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Wolfram Weckwerth (Research Platform Vienna Metabolomics Center, Research Platforms, University of Vienna), Elke H. Heiss (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna)

Availability: http://data.europeana.eu/aggregation/europeana/1300/https___phaidra_univie_ac_at_o_2067028

Short Chain (≤C4) Esterification Increases Bioavailability of Rosmarinic Acid and Its Potency to Inhibit Vascular Smooth Muscle Cell Proliferation

Authors: Tina Blažević, Gottfried Reznicek, Limin Ding, Gangqiang Yang, Patricia Haiss, Elke H. Heiss, Verena M. Dirsch, Rongxia Liu

Source: Frontiers in Pharmacology, Vol 11 (2021)

Subject Terms: vascular smooth muscle cells, rosmarinic acid, proliferation, pharmacokinetics, rosmarinic acid esters, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2020.609756/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/3664cd58cba246e888f9fe4fbd157bf1

AMPK Enhances Transcription of Selected Nrf2 Target Genes via Negative Regulation of Bach1

Authors: Katrin Fischhuber, Manuel Matzinger, Elke H. Heiss

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: AMPK, Nrf2, Bach1, gene expression, ARE sites, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcell.2020.00628/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/02129494df29457bb128401135ebf022

Characterization of Constituents with Potential Anti-Inflammatory Activity in Chinese Lonicera Species by UHPLC-HRMS Based Metabolite Profiling

Authors: Eva-Maria Pferschy-Wenzig, Sabine Ortmann, Atanas G. Atanasov, Klara Hellauer, Jürgen Hartler, Olaf Kunert, Markus Gold-Binder, Angela Ladurner, Elke H. Heiß, Simone Latkolik, Yi-Min Zhao, Pia Raab, Marlene Monschein, Nina Trummer, Bola Samuel, Sara Crockett, Jian-Hua Miao, Gerhard G. Thallinger, Valery Bochkov, Verena M. Dirsch, Rudolf Bauer

Source: Metabolites, Vol 12, Iss 4, p 288 (2022)

Subject Terms: Lonicera, honeysuckle, anti-inflammatory, metabolite profiling, UHPLC-HRMS, multivariate data analysis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/12/4/288; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/141ec5d7967b4552aed8a6e15e0ce161

Exudates of Picea abies, Pinus nigra, and Larix decidua: Chromatographic Comparison and Pro-Migratory Effects on Keratinocytes In Vitro

Authors: Thomas Goels, Elisabeth Eichenauer, Ammar Tahir, Paul Prochaska, Franziska Hoeller, Elke H. Heiß, Sabine Glasl

Source: Plants, Vol 11, Iss 5, p 599 (2022)

Subject Terms: Pinaceae exudates, Picea abies balm, Picea abies resin, Pinus nigra resin, Larix decidua balm, fingerprint comparison, Botany, QK1-989

File Description: electronic resource

Relation: https://www.mdpi.com/2223-7747/11/5/599; https://doaj.org/toc/2223-7747

Access URL: https://doaj.org/article/5eadab82e2894523998864a85d42e23f

AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes

Authors: Manuel Matzinger, Katrin Fischhuber, Daniel Pölöske, Karl Mechtler, Elke H. Heiss

Source: Redox Biology, Vol 29, Iss , Pp - (2020)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231719312777; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/0a4e9d410c3d4c549c5a87c9997283e2

Cultured rat aortic vascular smooth muscle cells do not express a functional TRPV1

Authors: Tina Blažević (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Cosmin I. Ciotu (Institute of Physiology, Center for Physiology and Pharmacology, Medical University of Vienna), Markus Gold-Binder (Institute of Physiology, Center for Physiology and Pharmacology, Medical University of Vienna), Elke H. Heiss (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Michael J. M. Fischer (Institute of Physiology, Center for Physiology and Pharmacology, Medical University of Vienna), Verena M. Dirsch (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna)

Availability: http://data.europeana.eu/aggregation/europeana/1300/https___phaidra_univie_ac_at_o_2045358

LC-MS- and 1H NMR-Based Metabolomics to Highlight the Impact of Extraction Solvents on Chemical Profile and Antioxidant Activity of Daikon Sprouts (Raphanus sativus L.)

Authors: Ciro Cannavacciuolo (Dipartimento di Farmacia, Università degli Studi di Salerno), Antonietta Cerulli (Dipartimento di Farmacia, Università degli Studi di Salerno), Verena M. Dirsch (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Elke H. Heiss (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Milena Masullo (Dipartimento di Farmacia, Università degli Studi di Salerno), Sonia Piacente (Dipartimento di Farmacia, Università degli Studi di Salerno)

Availability: http://data.europeana.eu/aggregation/europeana/1300/https___phaidra_univie_ac_at_o_2068543

AMPK-Mediated Phosphorylation of Nrf2 at S374/S408/S433 Favors Its βTrCP2-Mediated Degradation in KEAP1-Deficient Cells

Authors: Eleni Petsouki (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Sylvia Ender (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Shara Natalia Sosa Cabrera (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Elke H. Heiss (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna)

Availability: http://data.europeana.eu/aggregation/europeana/1300/https___phaidra_univie_ac_at_o_2068541

Norbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFκB, MAPK and STAT3 activation and blocking metabolic reprogramming

Authors: Wan Li (Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna), Zhengnan Cai (Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna), Florian Schindler (Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna), Sheyda Bahiraii (University of Vienna), Martin Brenner (Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna), Elke H. Heiss (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Wolfram Weckwerth (Functional and Evolutionary Ecology, Faculty of Life Sciences, University of Vienna)

Availability: http://data.europeana.eu/aggregation/europeana/1300/https___phaidra_univie_ac_at_o_2063725