Proapoptotic activity of JNK-sensitive BH3-only proteins underpins ovarian cancer response to replication checkpoint inhibitors

Authors: Annapoorna Venkatachalam, Cristina Correia, Kevin L. Peterson, Xianon Hou, Paula A. Schneider, Annabella R. Strathman, Karen S. Flatten, Chance C. Sine, Emily A. Balczewski, Cordelia D. McGehee, Melissa C. Larson, Laura N. Duffield, X. Wei Meng, Nicole D. Vincelette, Husheng Ding, Ann L. Oberg, Fergus J. Couch, Elizabeth M. Swisher, Hu Li, S. John Weroha, Scott H. Kaufmann

Source: Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)

Subject Terms: High grade serous ovarian cancer, Apoptosis, CHK1 inhibitor, ATR inhibitor, WEE1 inhibitor, BH3 proteins, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/10416db1db3e4dd388e15b58bcaf44a8

Farletuzumab ecteribulin and MORAb‐109, folate receptor alpha and mesothelin targeting antibody–drug conjugates, show activity in poor prognosis gynaecological cancer models

Authors: Ksenija Nesic, Katherine Rybinski, Gayanie Ratnayake, Gwo‐Yaw Ho, Ratana Lim, Marc Radke, Chloe Neagle, Elizabeth M. Swisher, Matthew J. Wakefield, Holly E. Barker, Keiji Furuuchi, Clare L. Scott, Cassandra J. Vandenberg

Source: Clinical and Translational Medicine, Vol 15, Iss 3, Pp n/a-n/a (2025)

Subject Terms: Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/98f6b877efe3495982837ee0ac5ea3bb

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance

Authors: Ksenija Nesic, John J. Krais, Yifan Wang, Cassandra J. Vandenberg, Pooja Patel, Kathy Q. Cai, Tanya Kwan, Elizabeth Lieschke, Gwo-Yaw Ho, Holly E. Barker, Justin Bedo, Silvia Casadei, Andrew Farrell, Marc Radke, Kristy Shield-Artin, Jocelyn S. Penington, Franziska Geissler, Elizabeth Kyran, Robert Betsch, Lijun Xu, Fan Zhang, Alexander Dobrovic, Inger Olesen, Rebecca Kristeleit, Amit Oza, Iain McNeish, Gayanie Ratnayake, Nadia Traficante, Australian Ovarian Cancer Study, Anna DeFazio, David D. L. Bowtell, Thomas C. Harding, Kevin Lin, Elizabeth M. Swisher, Olga Kondrashova, Clare L. Scott, Neil Johnson, Matthew J. Wakefield

Source: Molecular Cancer, Vol 23, Iss 1, Pp 1-10 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/8f0a9b712db94dd79db01d43d570add9

The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial

Authors: Elena Giudice, Tzu-Ting Huang, Jayakumar R. Nair, Grant Zurcher, Ann McCoy, Darryl Nousome, Marc R. Radke, Elizabeth M. Swisher, Stanley Lipkowitz, Kristen Ibanez, Duncan Donohue, Tyler Malys, Min-Jung Lee, Bernadette Redd, Elliot Levy, Shraddha Rastogi, Nahoko Sato, Jane B. Trepel, Jung-Min Lee

Source: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a32a2dc2018942d5a1dda8aa8f8851d8

The role of aberrant DNA methylation in cancer initiation and clinical impacts

Authors: Franziska Geissler, Ksenija Nesic, Olga Kondrashova, Alexander Dobrovic, Elizabeth M. Swisher, Clare L. Scott, Matthew J. Wakefield

Source: Therapeutic Advances in Medical Oncology, Vol 16 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1758-8359

Access URL: https://doaj.org/article/149fbe6f4eb449958647e023e6a32ed0

Extraordinary clinical response to ibrutinib in low-grade ovarian cancer guided by organoid drug testing

Authors: Heidi J. Gray, Payel Chatterjee, Rachele Rosati, Lauren R. Appleyard, Grace J. Durenberger, Robert L. Diaz, Hallie A. Swan, Danielle Peretti, Maddy Pollastro, Trevor Ainge, Katannya Kapeli, Shalini Pereira, Astrid L. Margossian, Kalyan Banda, Barbara A. Goff, Elizabeth M. Swisher, Brady Bernard, Christopher J. Kemp, Carla Grandori

Source: npj Precision Oncology, Vol 7, Iss 1, Pp 1-6 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2397-768X

Access URL: https://doaj.org/article/8a9cc59b3ce64630836df3b6b10cdaf8

The microtubule inhibitor eribulin demonstrates efficacy in platinum-resistant and refractory high-grade serous ovarian cancer patient-derived xenograft models

Authors: Gwo Yaw Ho, Cassandra J. Vandenberg, Ratana Lim, Elizabeth L. Christie, Dale W. Garsed, Elizabeth Lieschke, Ksenija Nesic, Olga Kondrashova, Gayanie Ratnayake, Marc Radke, Jocelyn S. Penington, Amandine Carmagnac, Valerie Heong, Elizabeth L. Kyran, Fan Zhang, Nadia Traficante, Ruby Huang, Alexander Dobrovic, Elizabeth M. Swisher, Orla McNally, Damien Kee, Matthew J. Wakefield, Anthony T. Papenfuss, David D. L. Bowtell, Holly E. Barker, Clare L. Scott

Source: Therapeutic Advances in Medical Oncology, Vol 15 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1758-8359

Access URL: https://doaj.org/article/acfd52763fdb4a6092abd9806478e071

Sertoli-Leydig cell tumor associated with a germline DICER1 pathogenic variant diagnosed during pregnancy: Considerations for treatment, surveillance, and prevention

Authors: Joyce Y. Wang, Kimberly K. Ma, Daniel J. Reiter, Ana Torvie, Elizabeth M. Swisher

Source: Gynecologic Oncology Reports, Vol 48, Iss , Pp 101215- (2023)

Subject Terms: DICER1, Genetic testing, Metachronous tumor, Post-treatment surveillance, Pregnancy, Sertoli-Leydig cell tumor, Gynecology and obstetrics, RG1-991, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S235257892300084X; https://doaj.org/toc/2352-5789

Access URL: https://doaj.org/article/23cc7612a64348009b01c66fbb113eaf

Mathematical modeling of the early modeled CA-125 longitudinal kinetics (KELIM-PARP) as a pragmatic indicator of rucaparib efficacy in patients with recurrent ovarian carcinoma in ARIEL2 & STUDY 10Research in context

Authors: Olivier Colomban, Elizabeth M. Swisher, Rebecca Kristeleit, Iain McNeish, Ronnie Shapira-Frommer, Sandra Goble, Kevin K. Lin, Lara Maloney, Gilles Freyer, Benoit You

Source: EBioMedicine, Vol 89, Iss , Pp 104477- (2023)

Subject Terms: Ovarian neoplasm, CA-125 antigen, Poly (ADP-ribose) polymerase inhibitors, Decision support techniques, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423000427; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/8424b6b7464c47abaf85ca637a1499c4

Maintenance treatment with rucaparib for recurrent ovarian carcinoma in ARIEL3, a randomized phase 3 trial: The effects of best response to last platinum‐based regimen and disease at baseline on efficacy and safety

Authors: Ana Oaknin, Amit M. Oza, Domenica Lorusso, Carol Aghajanian, Andrew Dean, Nicoletta Colombo, Johanne I. Weberpals, Andrew R. Clamp, Giovanni Scambia, Alexandra Leary, Robert W. Holloway, Margarita Amenedo Gancedo, Peter C. Fong, Jeffrey C. Goh, David M. O’Malley, Deborah K. Armstrong, Susana Banerjee, Jesus García‐Donas, Elizabeth M. Swisher, Terri Cameron, Lara Maloney, Sandra Goble, Jonathan A. Ledermann, Robert L. Coleman

Source: Cancer Medicine, Vol 10, Iss 20, Pp 7162-7173 (2021)

Subject Terms: clinical trials, gynecological oncology, medical oncology, target therapy, women's cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/2cbcf9c399a94021b6832bbcf96e807d

Barriers, interventions, and recommendations: Improving the genetic testing landscape

Authors: E. J. Dusic, Tesla Theoryn, Catharine Wang, Elizabeth M. Swisher, Deborah J. Bowen, EDGE Study Team

Source: Frontiers in Digital Health, Vol 4 (2022)

Subject Terms: cancer, genetics, primary care, population testing, genetic testing, Medicine, Public aspects of medicine, RA1-1270, Electronic computers. Computer science, QA75.5-76.95

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fdgth.2022.961128/full; https://doaj.org/toc/2673-253X

Access URL: https://doaj.org/article/d701ff9d0d284830ac2a7a03b1a0fd61

Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2)

Authors: Elizabeth M. Swisher, Tanya T. Kwan, Amit M. Oza, Anna V. Tinker, Isabelle Ray-Coquard, Ana Oaknin, Robert L. Coleman, Carol Aghajanian, Gottfried E. Konecny, David M. O’Malley, Alexandra Leary, Diane Provencher, Stephen Welch, Lee-may Chen, Andrea E. Wahner Hendrickson, Ling Ma, Prafull Ghatage, Rebecca S. Kristeleit, Oliver Dorigo, Ashan Musafer, Scott H. Kaufmann, Julia A. Elvin, Douglas I. Lin, Setsuko K. Chambers, Erin Dominy, Lan-Thanh Vo, Sandra Goble, Lara Maloney, Heidi Giordano, Thomas Harding, Alexander Dobrovic, Clare L. Scott, Kevin K. Lin, Iain A. McNeish

Source: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4c0bb318d2464bacb5fcd01f6ceefda3

Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer

Authors: Anniina Färkkilä, Doga C. Gulhan, Julia Casado, Connor A. Jacobson, Huy Nguyen, Bose Kochupurakkal, Zoltan Maliga, Clarence Yapp, Yu-An Chen, Denis Schapiro, Yinghui Zhou, Julie R. Graham, Bruce J. Dezube, Pamela Munster, Sandro Santagata, Elizabeth Garcia, Scott Rodig, Ana Lako, Dipanjan Chowdhury, Geoffrey I. Shapiro, Ursula A. Matulonis, Peter J. Park, Sampsa Hautaniemi, Peter K. Sorger, Elizabeth M. Swisher, Alan D. D’Andrea, Panagiotis A. Konstantinopoulos

Source: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/bd4459e944254dc4845c521cfcab9cf4

BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance

Authors: Yifan Wang, Andrea J. Bernhardy, Joseph Nacson, John J. Krais, Yin-Fei Tan, Emmanuelle Nicolas, Marc R. Radke, Elizabeth Handorf, Alba Llop-Guevara, Judith Balmaña, Elizabeth M. Swisher, Violeta Serra, Suraj Peri, Neil Johnson

Source: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/67c22e7b21e74d119a7920f907472b4a

Patterns and duration of primary and recurrent treatment in ovarian cancer patients with germline BRCA mutations

Authors: Soledad Jorge, Elizabeth M. Swisher, Barbara M. Norquist, Kathryn P. Pennington, Heidi J. Gray, Renata R. Urban, Rochelle L. Garcia, Kemi M. Doll

Source: Gynecologic Oncology Reports, Vol 29, Iss , Pp 113-117 (2019)

Subject Terms: Gynecology and obstetrics, RG1-991, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352578919300761; https://doaj.org/toc/2352-5789

Access URL: https://doaj.org/article/a91f6f49292e47a9ba5c9f2ca0eea309

MAGENTA (Making Genetic testing accessible): a prospective randomized controlled trial comparing online genetic education and telephone genetic counseling for hereditary cancer genetic testing

Authors: Nadine Rayes, Deborah J. Bowen, Tara Coffin, Denise Nebgen, Christine Peterson, Mark F. Munsell, Kathleen Gavin, Rebecca Lechner, Jamie Crase, Deborah Polinsky, Iris Romero, Stephanie V. Blank, Douglas A. Levine, Barbara M. Norquist, Elizabeth M. Swisher, Karen H. Lu

Source: BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)

Subject Terms: Genetic testing, Genetic counseling, Hereditary cancer, Ovarian cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-019-5868-x; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/2de4a07221254aad8fba0ebfef4e44d2

BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer

Authors: Goldie Y.L. Lui, Reid Shaw, Franz X. Schaub, Isabella N. Stork, Kay E. Gurley, Caroline Bridgwater, Robert L. Diaz, Rachele Rosati, Hallie A. Swan, Tan A. Ince, Thomas C. Harding, Vijayakrishna K. Gadi, Barbara A. Goff, Christopher J. Kemp, Elizabeth M. Swisher, Carla Grandori

Source: EBioMedicine, Vol 60, Iss , Pp 102988- (2020)

Subject Terms: Ovarian cancer, Drug combinations, Poly(ADP-ribose) Polymerase Inhibitors, Rucaparib, Dasatinib, Navitoclax, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396420303649; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/3e5e8f98aab5402f8b8ee8783a2b4b38

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Authors: Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria I. Harrell, Giada V. Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B. Pearson, John J. Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J. Hutt, Scott H. Kaufmann, Kevin K. Lin, Thomas C. Harding, Nadia Traficante, Australian Ovarian Cancer Study (AOCS), Anna deFazio, Iain A. McNeish, David D. Bowtell, Elizabeth M. Swisher, Alexander Dobrovic, Matthew J. Wakefield, Clare L. Scott

Source: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/daa72fc740814394b7993401524f3f72

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Authors: Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Radoslav Aleksandrov, Maria I. Harrell, Malini Menon, Rachel Brough, James Campbell, Jessica Frankum, Michael Ranes, Helen N. Pemberton, Rumana Rafiq, Kerry Fenwick, Amanda Swain, Sebastian Guettler, Jung-Min Lee, Elizabeth M. Swisher, Stoyno Stoynov, Kosuke Yusa, Alan Ashworth, Christopher J. Lord

Source: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1eb977c74fb546b0a7321e49be5d0643

Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas

Authors: Khyati Meghani, Walker Fuchs, Alexandre Detappe, Pascal Drané, Ewa Gogola, Sven Rottenberg, Jos Jonkers, Ursula Matulonis, Elizabeth M. Swisher, Panagiotis A. Konstantinopoulos, Dipanjan Chowdhury

Source: Cell Reports, Vol 23, Iss 1, Pp 100-111 (2018)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124718303802; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/b3d43fb7b6404de58fe771346b25edef