Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study

Authors: Michelle M. Mielke, Roger A. Fielding, Elizabeth J. Atkinson, Zaira Aversa, Marissa J. Schafer, Steven R. Cummings, Marco Pahor, Christiaan Leeuwenburgh, Nathan K. LeBrasseur

Source: The Journal of Nutrition, Health and Aging, Vol 29, Iss 5, Pp 100529- (2025)

Subject Terms: Cognition, SASP, Mobility disability, Myeloperoxidase, Matrix metalloproteinase 7, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1279770725000521; https://doaj.org/toc/1760-4788

Access URL: https://doaj.org/article/7755db23c955446a81482d5a6337e55d

Biomarkers of cellular senescence in idiopathic pulmonary fibrosis

Authors: Zaira Aversa, Elizabeth J. Atkinson, Eva M. Carmona, Thomas A. White, Amanda A. Heeren, Sarah K. Jachim, Xu Zhang, Steven R. Cummings, Sergio E. Chiarella, Andrew H. Limper, Nathan K. LeBrasseur

Source: Respiratory Research, Vol 24, Iss 1, Pp 1-13 (2023)

Subject Terms: Aging, Biomarkers, Cellular senescence, Idiopathic pulmonary fibrosis (IPF), Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/8d4a4dd058af433191e03b3e30beda89

Predicting cholangiocarcinoma in primary sclerosing cholangitis: using artificial intelligence, clinical and laboratory data

Authors: Chang Hu, Ravishankar K. Iyer, Brian D. Juran, Bryan M. McCauley, Elizabeth J. Atkinson, John E. Eaton, Ahmad H. Ali, Konstantinos N. Lazaridis

Source: BMC Gastroenterology, Vol 23, Iss 1, Pp 1-13 (2023)

Subject Terms: Primary sclerosing cholangitis, Cholangiocarcinoma, Risk factors, Artificial intelligence, Bile acids, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1471-230X

Access URL: https://doaj.org/article/dc8643afb863491789cba4a455256d9f

Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance

Authors: Xu Zhang, Vesselina M. Pearsall, Chase M. Carver, Elizabeth J. Atkinson, Benjamin D. S. Clarkson, Ethan M. Grund, Michelle Baez-Faria, Kevin D. Pavelko, Jennifer M. Kachergus, Thomas A. White, Renee K. Johnson, Courtney S. Malo, Alan M. Gonzalez-Suarez, Katayoun Ayasoufi, Kurt O. Johnson, Zachariah P. Tritz, Cori E. Fain, Roman H. Khadka, Mikolaj Ogrodnik, Diana Jurk, Yi Zhu, Tamara Tchkonia, Alexander Revzin, James L. Kirkland, Aaron J. Johnson, Charles L. Howe, E. Aubrey Thompson, Nathan K. LeBrasseur, Marissa J. Schafer

Source: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/563782268a174f9491ef229d9fd5e5e9

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

Authors: Dominik Saul, Robyn Laura Kosinsky, Elizabeth J. Atkinson, Madison L. Doolittle, Xu Zhang, Nathan K. LeBrasseur, Robert J. Pignolo, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Diana Jurk, João F. Passos, LaTonya J. Hickson, Ailing Xue, David G. Monroe, Tamara Tchkonia, James L. Kirkland, Joshua N. Farr, Sundeep Khosla

Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e07e402c5be742719a9abae3ab241ab2

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: a machine learning approach using clinical trial data

Authors: Stephanie Q. Duong, Cynthia S. Crowson, Arjun Athreya, Elizabeth J. Atkinson, John M. Davis, Kenneth J. Warrington, Eric L. Matteson, Richard Weinshilboum, Liewei Wang, Elena Myasoedova

Source: Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-11 (2022)

Subject Terms: Rheumatoid arthritis, Methotrexate, Treatment, Machine learning, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1478-6362

Access URL: https://doaj.org/article/1fb3c53bc9e040f39eefca4c09f137d0

The PSC scientific community resource: an asset for multi-omics interrogation of primary sclerosing cholangitis

Authors: Ahmad Hassan Ali, Brian D. Juran, Erik M. Schlicht, Jackie K. Bianchi, Bryan M. McCauley, Elizabeth J. Atkinson, Konstantinos N. Lazaridis

Source: BMC Gastroenterology, Vol 21, Iss 1, Pp 1-9 (2021)

Subject Terms: Cholangitis, Biobank, Pathogenesis, Exposome, Metabolome, Methylome, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1471-230X

Access URL: https://doaj.org/article/b7444afeb42948e8b5e6feb1df48ba6a

Hangboard training in advanced climbers: A randomized controlled trial

Authors: Saskia Mundry, Gino Steinmetz, Elizabeth J. Atkinson, Arndt F. Schilling, Volker R. Schöffl, Dominik Saul

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3ca7086dbe44457fbd3e44fd8d1e66a8

ST-V-Net: incorporating shape prior into convolutional neural networks for proximal femur segmentation

Authors: Chen Zhao, Joyce H. Keyak, Jinshan Tang, Tadashi S. Kaneko, Sundeep Khosla, Shreyasee Amin, Elizabeth J. Atkinson, Lan-Juan Zhao, Michael J. Serou, Chaoyang Zhang, Hui Shen, Hong-Wen Deng, Weihua Zhou

Source: Complex & Intelligent Systems, Vol 9, Iss 3, Pp 2747-2758 (2021)

Subject Terms: Quantitative computed tomography, Proximal femur, Segmentation, Deep learning, Convolutional neural networks, Electronic computers. Computer science, QA75.5-76.95, Information technology, T58.5-58.64

File Description: electronic resource

Relation: https://doaj.org/toc/2199-4536; https://doaj.org/toc/2198-6053

Access URL: https://doaj.org/article/223ea72c2a434dc7a1954511014d2658

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Authors: Megan M. Weivoda, Chee Kian Chew, David G. Monroe, Joshua N. Farr, Elizabeth J. Atkinson, Jennifer R. Geske, Brittany Eckhardt, Brianne Thicke, Ming Ruan, Amanda J. Tweed, Louise K. McCready, Robert A. Rizza, Aleksey Matveyenko, Moustapha Kassem, Thomas Levin Andersen, Adrian Vella, Matthew T. Drake, Bart L. Clarke, Merry Jo Oursler, Sundeep Khosla

Source: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/801d47b97fd94e109d4d6b51b08d8de3

Natural language processing of radiology reports for identification of skeletal site-specific fractures

Authors: Yanshan Wang, Saeed Mehrabi, Sunghwan Sohn, Elizabeth J. Atkinson, Shreyasee Amin, Hongfang Liu

Source: BMC Medical Informatics and Decision Making, Vol 19, Iss S3, Pp 23-29 (2019)

Subject Terms: Fracture identification, Natural language processing, Radiology reports, Electronic health records, Computer applications to medicine. Medical informatics, R858-859.7

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12911-019-0780-5; https://doaj.org/toc/1472-6947

Access URL: https://doaj.org/article/2083ba820d4b4bc58c2caab631a7096b

Genetic variants related to successful migraine prophylaxis with verapamil

Authors: Fred Michael Cutrer, Ann M. Moyer, Elizabeth J. Atkinson, Liguo Wang, Shulan Tian, Yanhong Wu, Ivan Garza, Carrie E. Robertson, Carey A. Huebert, Brenda E. Moore, Christopher J. Klein

Source: Molecular Genetics & Genomic Medicine, Vol 9, Iss 6, Pp n/a-n/a (2021)

Subject Terms: genomic, migraine, phospholipase‐C, prophylactic, verapamil, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/2324-9269

Access URL: https://doaj.org/article/f36d5e69928c462996755ad83923dc7f

A clinical text classification paradigm using weak supervision and deep representation

Authors: Yanshan Wang, Sunghwan Sohn, Sijia Liu, Feichen Shen, Liwei Wang, Elizabeth J. Atkinson, Shreyasee Amin, Hongfang Liu

Source: BMC Medical Informatics and Decision Making, Vol 19, Iss 1, Pp 1-13 (2019)

Subject Terms: Clinical text classification, Natural language processing, Electronic health records, Machine learning, Weak supervision, Computer applications to medicine. Medical informatics, R858-859.7

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12911-018-0723-6; https://doaj.org/toc/1472-6947

Access URL: https://doaj.org/article/e9f50da104d643909e3b307c36a1274b

Proton Pump Inhibitors and the Risk for Fracture at Specific Sites: Data Mining of the FDA Adverse Event Reporting System

Authors: Liwei Wang, Mei Li, Yuying Cao, Zhengqi Han, Xueju Wang, Elizabeth J. Atkinson, Hongfang Liu, Shreyasee Amin

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/0e2625d8f9a0451cb5f05326c1152653

Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ EBioMedicine 47 (2019) 446–456

Authors: LaTonya J. Hickson, Larissa G.P. Langhi Prata, Shane A. Bobart, Tamara K. Evans, Nino Giorgadze, Shahrukh K. Hashmi, Sandra M. Herrmann, Michael D. Jensen, Qingyi Jia, Kyra L. Jordan, Todd A. Kellogg, Sundeep Khosla, Daniel M. Koerber, Anthony B. Lagnado, Donna K. Lawson, Nathan K. LeBrasseur, Lilach O. Lerman, Kathleen M. McDonald, Travis J. McKenzie, João F. Passos, Robert J. Pignolo, Tamar Pirtskhalava, Ishran M. Saadiq, Kalli K. Schaefer, Stephen C. Textor, Stella G. Victorelli, Tammie L. Volkman, Ailing Xue, Mark A. Wentworth, Erin O. Wissler Gerdes, David B. Allison, Stephanie L. Dickinson, Keisuke Ejima, Elizabeth J. Atkinson, Marc Lenburg, Yi Zhu, Tamara Tchkonia, James L. Kirkland

Source: EBioMedicine, Vol 52, Iss , Pp - (2020)

Subject Terms: Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396419308102; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/9ed50bb390cb426aa207a5f49e49f8fb

Cellular senescence mediates fibrotic pulmonary disease

Authors: Marissa J. Schafer, Thomas A. White, Koji Iijima, Andrew J. Haak, Giovanni Ligresti, Elizabeth J. Atkinson, Ann L. Oberg, Jodie Birch, Hanna Salmonowicz, Yi Zhu, Daniel L. Mazula, Robert W. Brooks, Heike Fuhrmann-Stroissnigg, Tamar Pirtskhalava, Y. S. Prakash, Tamara Tchkonia, Paul D. Robbins, Marie Christine Aubry, João F. Passos, James L. Kirkland, Daniel J. Tschumperlin, Hirohito Kita, Nathan K. LeBrasseur

Source: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/24b84bad3904485caad4533a2d6fd946

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Authors: Cristian Pattaro, Alexander Teumer, Mathias Gorski, Audrey Y. Chu, Man Li, Vladan Mijatovic, Maija Garnaas, Adrienne Tin, Rossella Sorice, Yong Li, Daniel Taliun, Matthias Olden, Meredith Foster, Qiong Yang, Ming-Huei Chen, Tune H. Pers, Andrew D. Johnson, Yi-An Ko, Christian Fuchsberger, Bamidele Tayo, Michael Nalls, Mary F. Feitosa, Aaron Isaacs, Abbas Dehghan, Pio d’Adamo, Adebowale Adeyemo, Aida Karina Dieffenbach, Alan B. Zonderman, Ilja M. Nolte, Peter J. van der Most, Alan F. Wright, Alan R. Shuldiner, Alanna C. Morrison, Albert Hofman, Albert V. Smith, Albert W. Dreisbach, Andre Franke, Andre G. Uitterlinden, Andres Metspalu, Anke Tonjes, Antonio Lupo, Antonietta Robino, Åsa Johansson, Ayse Demirkan, Barbara Kollerits, Barry I. Freedman, Belen Ponte, Ben A. Oostra, Bernhard Paulweber, Bernhard K. Krämer, Braxton D. Mitchell, Brendan M. Buckley, Carmen A. Peralta, Caroline Hayward, Catherine Helmer, Charles N. Rotimi, Christian M. Shaffer, Christian Müller, Cinzia Sala, Cornelia M. van Duijn, Aude Saint-Pierre, Daniel Ackermann, Daniel Shriner, Daniela Ruggiero, Daniela Toniolo, Yingchang Lu, Daniele Cusi, Darina Czamara, David Ellinghaus, David S. Siscovick, Douglas Ruderfer, Christian Gieger, Harald Grallert, Elena Rochtchina, Elizabeth J. Atkinson, Elizabeth G. Holliday, Eric Boerwinkle, Erika Salvi, Erwin P. Bottinger, Federico Murgia, Fernando Rivadeneira, Florian Ernst, Florian Kronenberg, Frank B. Hu, Gerjan J. Navis, Gary C. Curhan, George B. Ehret, Georg Homuth, Stefan Coassin, Gian-Andri Thun, Giorgio Pistis, Giovanni Gambaro, Giovanni Malerba, Grant W. Montgomery, Gudny Eiriksdottir, Gunnar Jacobs, Guo Li, H-Erich Wichmann, Harry Campbell, Helena Schmidt, Henri Wallaschofski, Henry Völzke, Hermann Brenner, Heyo K. Kroemer, Holly Kramer, Honghuang Lin, I. Mateo Leach, Ian Ford, Idris Guessous, Igor Rudan, Inga Prokopenko, Ingrid Borecki, Iris M. Heid, Ivana Kolcic, Ivana Persico, J. Wouter Jukema, James F. Wilson, Janine F. Felix, Jasmin Divers, Jean-Charles Lambert, Jeanette M. Stafford, Jean-Michel Gaspoz, Jennifer A. Smith, Jessica D. Faul, Jie Jin Wang, Jingzhong Ding, Joel N. Hirschhorn, John Attia, John B. Whitfield, John Chalmers, Jorma Viikari, Josef Coresh, Joshua C. Denny, Juha Karjalainen, Jyotika K. Fernandes, Karlhans Endlich, Katja Butterbach, Keith L. Keene, Kurt Lohman, Laura Portas, Lenore J. Launer, Leo-Pekka Lyytikäinen, Loic Yengo, Lude Franke, Luigi Ferrucci, Lynda M. Rose, Lyudmyla Kedenko, Madhumathi Rao, Maksim Struchalin, Marcus E. Kleber, Margherita Cavalieri, Margot Haun, Marilyn C. Cornelis, Marina Ciullo, Mario Pirastu, Mariza de Andrade, Mark A. McEvoy, Mark Woodward, Martin Adam, Massimiliano Cocca, Matthias Nauck, Medea Imboden, Melanie Waldenberger, Menno Pruijm, Marie Metzger, Michael Stumvoll, Michele K. Evans, Michele M. Sale, Mika Kähönen, Mladen Boban, Murielle Bochud, Myriam Rheinberger, Niek Verweij, Nabila Bouatia-Naji, Nicholas G. Martin, Nick Hastie, Nicole Probst-Hensch, Nicole Soranzo, Olivier Devuyst, Olli Raitakari, Omri Gottesman, Oscar H. Franco, Ozren Polasek, Paolo Gasparini, Patricia B. Munroe, Paul M. Ridker, Paul Mitchell, Paul Muntner, Christa Meisinger, Johannes H. Smit, ICBP Consortium, AGEN Consortium, CARDIOGRAM, CHARGe-Heart Failure Group, ECHOGen Consortium, Peter Kovacs, Philipp S. Wild, Philippe Froguel, Rainer Rettig, Reedik Mägi, Reiner Biffar, Reinhold Schmidt, Rita P. S. Middelberg, Robert J. Carroll, Brenda W. Penninx, Rodney J. Scott, Ronit Katz, Sanaz Sedaghat, Sarah H. Wild, Sharon L. R. Kardia, Sheila Ulivi, Shih-Jen Hwang, Stefan Enroth, Stefan Kloiber, Stella Trompet, Benedicte Stengel, Stephen J. Hancock, Stephen T. Turner, Sylvia E. Rosas, Sylvia Stracke, Tamara B. Harris, Tanja Zeller, Tatijana Zemunik, Terho Lehtimäki, Thomas Illig, Thor Aspelund, Tiit Nikopensius, Tonu Esko, Toshiko Tanaka, Ulf Gyllensten, Uwe Völker, Valur Emilsson, Veronique Vitart, Ville Aalto, Vilmundur Gudnason, Vincent Chouraki, Wei-Min Chen, Wilmar Igl, Winfried März, Wolfgang Koenig, Wolfgang Lieb, Ruth J. F. Loos, Yongmei Liu, Harold Snieder, Peter P. Pramstaller, Afshin Parsa, Jeffrey R. O’Connell, Katalin Susztak, Pavel Hamet, Johanne Tremblay, Ian H. de Boer, Carsten A. Böger, Wolfram Goessling, Daniel I. Chasman, Anna Köttgen, W. H. Linda Kao, Caroline S. Fox

Source: Nature Communications, Vol 7, Iss 1, Pp 1-19 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5d9d63e116c24c36a1c1be4822c2160b

Sex‐Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction

Authors: Satoshi Yoshino, Rebecca Cilluffo, Megha Prasad, Patricia J. M. Best, Elizabeth J. Atkinson, Tatsuo Aoki, Julie M. Cunningham, Mariza de Andrade, Lilach O. Lerman, Amir Lerman

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 4 (2016)

Subject Terms: acetylcholine, coronary disease, endothelium, genetics, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/42922612197741ee8f42c4d2dccb8e95

Potential Extensions of the US FRAX Algorithm

Authors: L. Joseph Melton, Elizabeth J. Atkinson, Sara J. Achenbach, John A. Kanis, Terry M. Therneau, Helena Johansson, Sundeep Khosla, Shreyasee Amin

Source: Journal of Osteoporosis, Vol 2012 (2012)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2090-8059; https://doaj.org/toc/2042-0064

Access URL: https://doaj.org/article/a5854972b9b249d68fe042124ab75c4b

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