Mitochondrial priming and response to BH3 mimetics in 'one-two punch' senogenic-senolytic strategies

Authors: Júlia López, Àngela Llop-Hernández, Sara Verdura, Eila Serrano-Hervás, Eva Martinez-Balibrea, Joaquim Bosch-Barrera, Eduard Teixidor, Eugeni López-Bonet, Begoña Martin-Castillo, Josep Sardanyés, Tomás Alarcón, Ruth Lupu, Elisabet Cuyàs, Javier A. Menendez

Source: Cell Death Discovery, Vol 11, Iss 1, Pp 1-16 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/612596be0f79401e9b4c171055786f0a

Fatty acid synthase (FASN) is a tumor-cell-intrinsic metabolic checkpoint restricting T-cell immunity

Authors: Elisabet Cuyàs, Stefano Pedarra, Sara Verdura, Miguel Angel Pardo, Roderic Espin Garcia, Eila Serrano-Hervás, Àngela Llop-Hernández, Eduard Teixidor, Joaquim Bosch-Barrera, Eugeni López-Bonet, Begoña Martin-Castillo, Ruth Lupu, Miguel Angel Pujana, Josep Sardanyès, Tomás Alarcón, Javier A. Menendez

Source: Cell Death Discovery, Vol 10, Iss 1, Pp 1-17 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/cf58d85bd0c34429bd80f33b1267b08a

Fatty acid synthase (FASN) inhibition cooperates with BH3 mimetic drugs to overcome resistance to mitochondrial apoptosis in pancreatic cancer

Authors: Travis Vander Steen, Ingrid Espinoza, Cristina Duran, Guillem Casadevall, Eila Serrano-Hervás, Elisabet Cuyàs, Sara Verdura, George Kemble, Scott H. Kaufmann, Robert McWilliams, Sílvia Osuna, Daniel D. Billadeau, Javier A. Menendez, Ruth Lupu

Source: Neoplasia: An International Journal for Oncology Research, Vol 62, Iss , Pp 101143- (2025)

Subject Terms: Pancreatic cancer, Fatty acid synthase, BH3 mimetics, Gemcitabine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558625000223; https://doaj.org/toc/1476-5586

Access URL: https://doaj.org/article/ba6bc971ac2a4b7b8c3617e49f7f66c9

Fatty acid synthase (FASN) signalome: A molecular guide for precision oncology

Authors: Javier A. Menendez, Elisabet Cuyàs, Jose Antonio Encinar, Travis Vander Steen, Sara Verdura, Àngela Llop‐Hernández, Júlia López, Eila Serrano‐Hervás, Sílvia Osuna, Begoña Martin‐Castillo, Ruth Lupu

Source: Molecular Oncology, Vol 18, Iss 3, Pp 479-516 (2024)

Subject Terms: cell fate, ferroptosis, immunotherapy, metastasis, mitochondrial priming, molecular glues, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/d3a6d2c3332d4732a381d0b6a5d9a94b

Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells

Authors: Barbara Schroeder, Travis Vander Steen, Ingrid Espinoza, Chandra M. Kurapaty Venkatapoorna, Zeng Hu, Fernando Martín Silva, Kevin Regan, Elisabet Cuyàs, X. Wei Meng, Sara Verdura, Aina Arbusà, Paula A. Schneider, Karen S. Flatten, George Kemble, Joan Montero, Scott H. Kaufmann, Javier A. Menendez, Ruth Lupu

Source: Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/aa72c25e3f5c4af1a2822139760db5bf

The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer

Authors: Emily Golden, Rabab Rashwan, Eleanor A. Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyàs, Magdalena Ratajska, Iwona Kardaś, Piotr Kozlowski, Elizabeth K. M. Johnstone, Heng B. See, Ciara Duffy, Jeremy Parry, Kim A. Lagerborg, Piotr Czapiewski, Javier A. Menendez, Adam Gorczyński, Bartosz Wasag, Kevin D. G. Pfleger, Christina Curtis, Bum-Kyu Lee, Jonghwan Kim, Joseph Cursons, Nathan J. Pavlos, Wojciech Biernat, Mohit Jain, Andrew J. Woo, Andrew Redfern, Pilar Blancafort

Source: Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7a78efc95f94434186efe33c5a90c19a

Metformin: Targeting the Metabolo-Epigenetic Link in Cancer Biology

Authors: Elisabet Cuyàs, Sara Verdura, Begoña Martin-Castillo, Javier A. Menendez

Source: Frontiers in Oncology, Vol 10 (2021)

Subject Terms: metformin, metabolism, epigenetics, chromatin, cancer, diet, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2020.620641/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/606f28326ee14f8b9a3c23043e8cc37f

Clinical Management of COVID-19 in Cancer Patients with the STAT3 Inhibitor Silibinin

Authors: Joaquim Bosch-Barrera, Ariadna Roqué, Eduard Teixidor, Maria Carmen Carmona-Garcia, Aina Arbusà, Joan Brunet, Begoña Martin-Castillo, Elisabet Cuyàs, Sara Verdura, Javier A. Menendez

Source: Pharmaceuticals, Vol 15, Iss 1, p 19 (2021)

Subject Terms: SARS-CoV-2, COVID-19, STAT3, silibinin, Legalon, COVID-GRAM score, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/15/1/19; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/8b7ee1d49b544476a47992a5e8eac169

Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy

Authors: Sara Verdura, Elisabet Cuyàs, Begoña Martin-Castillo, Javier A. Menendez

Source: OncoImmunology, Vol 8, Iss 10 (2019)

Subject Terms: metformin, immunotherapy, t-cells, immune checkpoints, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/bc8541831dc8455b8c5891d4f5d61214

A multiscale model of epigenetic heterogeneity-driven cell fate decision-making.

Authors: Núria Folguera-Blasco, Rubén Pérez-Carrasco, Elisabet Cuyàs, Javier A Menendez, Tomás Alarcón

Source: PLoS Computational Biology, Vol 15, Iss 4, p e1006592 (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/b4b0e1e42f854a6f9809956b5c2bba32

Lung Cancer Management with Silibinin: A Historical and Translational Perspective

Authors: Sara Verdura, Elisabet Cuyàs, Verónica Ruiz-Torres, Vicente Micol, Jorge Joven, Joaquim Bosch-Barrera, Javier A. Menendez

Source: Pharmaceuticals, Vol 14, Iss 6, p 559 (2021)

Subject Terms: silibinin, silymarin, non-small cell lung cancer, EMT, metastasis, STAT3, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/14/6/559; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/23be91c15ee24c6eb56bdf2b44dd6fbe

The C Allele of ATM rs11212617 Associates With Higher Pathological Complete Remission Rate in Breast Cancer Patients Treated With Neoadjuvant Metformin

Authors: Elisabet Cuyàs, Maria Buxó, Maria José Ferri Iglesias, Sara Verdura, Sonia Pernas, Joan Dorca, Isabel Álvarez, Susana Martínez, Jose Manuel Pérez-Garcia, Norberto Batista-López, César A. Rodríguez-Sánchez, Kepa Amillano, Severina Domínguez, Maria Luque, Idoia Morilla, Agostina Stradella, Gemma Viñas, Javier Cortés, Jorge Joven, Joan Brunet, Eugeni López-Bonet, Margarita Garcia, Samiha Saidani, Xavier Queralt Moles, Begoña Martin-Castillo, Javier A. Menendez

Source: Frontiers in Oncology, Vol 9 (2019)

Subject Terms: metformin, breast cancer, neoadjuvancy, HER2, ATM, rs11212617, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2019.00193/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/d2338fd8195c45919755b3df06f89a20

Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation

Authors: Elisabet Cuyàs, Sara Verdura, Laura Llorach-Parés, Salvador Fernández-Arroyo, Jorge Joven, Begoña Martin-Castillo, Joaquim Bosch-Barrera, Joan Brunet, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Javier A. Menendez

Source: Frontiers in Endocrinology, Vol 9 (2018)

Subject Terms: metformin, SIRT1, aging, NAD+, NAD loss, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fendo.2018.00657/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/c7d9e1e1041d4fcb9bae970f349fbf99

Oncometabolic Nuclear Reprogramming of Cancer Stemness

Authors: Javier A. Menendez, Bruna Corominas-Faja, Elisabet Cuyàs, María G. García, Salvador Fernández-Arroyo, Agustín F. Fernández, Jorge Joven, Mario F. Fraga, Tomás Alarcón

Source: Stem Cell Reports, Vol 6, Iss 3, Pp 273-283 (2016)

Subject Terms: Oncometabolites, reprogramming, stemness, cancer, stem cells, cancer stem cells, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221367111500377X; https://doaj.org/toc/2213-6711

Access URL: https://doaj.org/article/d4eaa52a2cdb4605ad74ba3e567f2f7a

Epigenetic regulation of cell fate reprogramming in aging and disease: A predictive computational model.

Authors: Núria Folguera-Blasco, Elisabet Cuyàs, Javier A Menéndez, Tomás Alarcón

Source: PLoS Computational Biology, Vol 14, Iss 3, p e1006052 (2018)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5871006?pdf=render; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/f248b94f3c4f4f73820179955f7598e2

Active transmembrane drug transport in microgravity: a validation study using an ABC transporter model [v1; ref status: indexed, http://f1000r.es/41n]

Authors: Sergi Vaquer, Elisabet Cuyàs, Arnau Rabadán, Albert González, Felip Fenollosa, Rafael de la Torre

Source: F1000Research, Vol 3 (2014)

Subject Terms: Membranes & Sorting, Pharmacokinetics & Drug Delivery, Medicine, Science

File Description: electronic resource

Relation: http://f1000research.com/articles/3-201/v1; https://doaj.org/toc/2046-1402

Access URL: https://doaj.org/article/065e0e72eab54380b0472e779515fccc

Clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy'): the influence of gender and genetics (CYP2D6, COMT, 5-HTT).

Authors: Ricardo Pardo-Lozano, Magí Farré, Samanta Yubero-Lahoz, Brian O'Mathúna, Marta Torrens, Cristina Mustata, Clara Pérez-Mañá, Klaus Langohr, Elisabet Cuyàs, Marcel lí Carbó, Rafael de la Torre

Source: PLoS ONE, Vol 7, Iss 10, p e47599 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3480420?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/bace9d6b7b7444f5a3c29cf7e11c0bea

Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response.

Authors: Francina Fonseca, Rafael de la Torre, Laura Díaz, Antonio Pastor, Elisabet Cuyàs, Nieves Pizarro, Olha Khymenets, Magí Farré, Marta Torrens

Source: PLoS ONE, Vol 6, Iss 5, p e19527 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21589866/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/45be50da4e09408eb4c918cb3e699709

The influence of genetic and environmental factors among MDMA users in cognitive performance.

Authors: Elisabet Cuyàs, Antonio Verdejo-García, Ana Beatriz Fagundo, Olha Khymenets, Joan Rodríguez, Aida Cuenca, Susana de Sola Llopis, Klaus Langohr, Jordi Peña-Casanova, Marta Torrens, Rocío Martín-Santos, Magí Farré, Rafael de la Torre

Source: PLoS ONE, Vol 6, Iss 11, p e27206 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3217947?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/2226b97e556c4780962f8279a316e5af

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