Translational approach to assess brain injury after cardiac arrest in preclinical models: a narrative review

Authors: Francesca Motta, Marianna Cerrato, Daria De Giorgio, Alice Salimbeni, Giulia Merigo, Aurora Magliocca, Carlo Perego, Elisa R. Zanier, Giuseppe Ristagno, Francesca Fumagalli

Source: Intensive Care Medicine Experimental, Vol 13, Iss 1, Pp 1-17 (2025)

Subject Terms: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/2197-425X

Access URL: https://doaj.org/article/0fba0e46ec304d7c9ac0e12a1f831901

Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injuryResearch in context

Authors: Romit J. Samanta, Anne-Cécile Chiollaz, Edward Needham, John K. Yue, Adel Helmy, Elisa R. Zanier, Kevin K.W. Wang, Firas Kobeissy, Jussi P. Posti, Charlotte Summers, Geoffrey T. Manley, Andrew IR. Maas, Olli Tenovuo, Jean-Charles Sanchez, David K. Menon, Neeraj Badjatia, Ramon Diaz-Arrastia, Ann-Christine Duhaime, V Ramana Feeser, Shankar Gopinath, Ramesh Grandhi, Ruchira J. Ha, Dirk Keene, Christopher Madden, Michael McCrea, Randall Merchant, Laura B. Ngwenya, Richard B. Rodgers, David Schnyer, Sabrina R. Taylor, Ross Zafonte, Cecilia Ackerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Audny Anke, Gérard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Ronny Beer, Bo-Michael Bellander, Habib Benali, Maurizio Berardino, Luigi Beretta, Erta Beqiri, Morten Blaabjerg, Stine Borgen Lund, Camilla Brorsson, Andras Buki, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Ana M. Castaño-León, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Hans Clusmann, Mark Steven Coburn, Jonathan Coles, Jamie D. Cooper, Marta Correia, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Véronique De Keyser, Vincent Degos, Francesco Della Corte, Hugo den Boogert, Bart Depreitere, Đula Đilvesi, Abhishek Dixit, Jens Dreier, Guy-Loup Dulière, Ari Ercole, Erzsébet Ezer, Martin Fabricius, Kelly Foks, Shirin Frisvold, Alex Furmanov, Damien Galanaud, Dashiell Gantner, Alexandre Ghuysen, Lelde Giga, Jagoš Golubović, Pedro A. Gomez, Benjamin Gravesteijn, Francesca Grossi, Deepak Gupta, Iain Haitsma, Raimund Helbok, Eirik Helseth, Jilske Huijben, Peter J. Hutchinson, Stefan Jankowski, Faye Johnson, Mladen Karan, Angelos G. Kolias, Daniel Kondziella, Evgenios Kornaropoulos, Lars-Owe Koskinen, Noémi Kovács, Ana Kowark, Alfonso Lagares, Steven Laureys, Fiona Lecky, Didier Ledoux, Roger Lightfoot, Hester Lingsma, Andrew I.R. Maas, Alex Manara, Hugues Maréchal, Costanza Martino, Julia Mattern, Catherine McMahon, David Menon, Tomas Menovsky, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, David Nelson, Virginia Newcombe, József Nyirádi, Fabrizio Ortolano, Jean-François Payen, Vincent Perlbarg, Paolo Persona, Wilco Peul, Anna Piippo-Karjalainen, Horia Ples, Inigo Pomposo, Louis Puybasset, Andreea Rădoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Sophie Richter, Saulius Rocka, Cecilie Roe, Olav Roise, Jeffrey Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Juan Sahuquillo, Oliver Sakowitz, Renan Sanchez-Porras, Oddrun Sandrød, Kari Schirmer-Mikalsen, Rico Frederik Schou, Charlie Sewalt, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Ewout W. Steyerberg, Nino Stocchetti, Nina Sundström, Riikka Takala, Viktória Tamás, Tomas Tamosuitis, Matt Thomas, Dick Tibboel, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Andreas Unterberg, Peter Vajkoczy, Egils Valeinis, Shirley Vallance, Zoltán Vámos, Gregory Van der Steen, Jeroen T.J.M. van Dijck, Thomas A. van Essen, Roel van Wijk, Alessia Vargiolu, Emmanuel Vega, Anne Vik, Rimantas Vilcinis, Victor Volovici, Peter Vulekovic, Eveline Wiegers, Guy Williams, Stefan Winzeck, Stefan Wolf, Alexander Younsi, Frederick A. Zeiler, Agate Ziverte, Tommaso Zoerle

Source: EBioMedicine, Vol 108, Iss , Pp 105310- (2024)

Subject Terms: Traumatic brain injury, Stratified medicine, Inflammation, Clustering, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424003463; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/901234563c104cc1be5c3a073a2be5fc

Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury

Authors: Domenico Mercurio, Francesca Pischiutta, Serena Seminara, Francesca Tribuzio, Ilaria Lisi, Laura Pasetto, Valentina Bonetto, Maria-Grazia De Simoni, Wilhelm Schwaeble, Sadam Yaseen, Thomas Dudler, Elisa R. Zanier, Stefano Fumagalli

Source: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-11 (2024)

Subject Terms: Complement system, Traumatic brain injury, Pharmacology, Mannan-binding lectin-associated serine proteases, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/71c3b354a8d74e7bafc4e08a65953866

Mastering the brain in critical conditions: an update

Authors: Chiara Robba, Elisa R. Zanier, Carmen Lopez Soto, Soojin Park, Romain Sonneville, Raimund Helbolk, Aarti Sarwal, Virginia F. J. Newcombe, Mathieu van der Jagt, Jan Gunst, Tobias Gauss, Samy Figueiredo, Jacques Duranteau, Markus B. Skrifvars, Carolina Iaquaniello, Susanne Muehlschlegel, Victoria Metaxa, Claudio Sandroni, Giuseppe Citerio, Geert Meyfroidt

Source: Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-11 (2024)

Subject Terms: Acute brain injury, Outcome, Prognostication, Neuroimaging, Neuromonitoring, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/2197-425X

Access URL: https://doaj.org/article/b1ff6c78df9a4041aa8f609f3d44199b

MesenchymAl stromal cells for Traumatic bRain Injury (MATRIx): a study protocol for a multicenter, double-blind, randomised, placebo-controlled phase II trial

Authors: Elisa R. Zanier, Francesca Pischiutta, Eliana Rulli, Alessia Vargiolu, Francesca Elli, Paolo Gritti, Giuseppe Gaipa, Daniela Belotti, Gianpaolo Basso, Tommaso Zoerle, Nino Stocchetti, Giuseppe Citerio, on behalf of the MATRIx Study group

Source: Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-11 (2023)

Subject Terms: Traumatic brain injury, Mesenchymal stromal cells, Cell therapy, Neurogenesis and synaptic plasticity, Inflammation, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/2197-425X

Access URL: https://doaj.org/article/7ba941349f5048babfbfcfb645974657

Hypertonic sodium lactate infusion reduces vasopressor requirements and biomarkers of brain and cardiac injury after experimental cardiac arrest

Authors: Filippo Annoni, Fuhong Su, Lorenzo Peluso, Ilaria Lisi, Enrico Caruso, Francesca Pischiutta, Elisa Gouvea Bogossian, Bruno Garcia, Hassane Njimi, Jean-Louis Vincent, Nicolas Gaspard, Lorenzo Ferlini, Jacques Creteur, Elisa R. Zanier, Fabio Silvio Taccone

Source: Critical Care, Vol 27, Iss 1, Pp 1-13 (2023)

Subject Terms: Cardiac arrest, Resuscitation, Post-arrest, Anoxic injury, ischemia–reperfusion, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/266820e678e149ff9e0c56a5861bc030

ECoG spiking activity and signal dimension are early predictive measures of epileptogenesis in a translational mouse model of traumatic brain injury

Authors: Rossella Di Sapia, Massimo Rizzi, Federico Moro, Ilaria Lisi, Alessia Caccamo, Teresa Ravizza, Annamaria Vezzani, Elisa R. Zanier

Source: Neurobiology of Disease, Vol 185, Iss , Pp 106251- (2023)

Subject Terms: Biomarker, EEG, Epileptiform activity, Controlled cortical impact, Mouse, Seizures, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996123002668; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/9049826838b440a887921393a6737093

A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment

Authors: Francesca Pischiutta, Helena Cavaleiro, Enrico Caruso, Francesca Tribuzio, Noemi Di Marzo, Federico Moro, Firas Kobeissy, Kevin K. Wang, António J. Salgado, Elisa R. Zanier

Source: Frontiers in Cellular Neuroscience, Vol 17 (2023)

Subject Terms: traumatic brain injury, 3D in vitro model, organotypic cortical brain slices, mesenchymal stromal cells, secretome, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fncel.2023.1217987/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/00bf870a8179441d88f7b5cd517e8283

Systematic review and meta-analysis of preclinical studies testing mesenchymal stromal cells for traumatic brain injury

Authors: Francesca Pischiutta, Enrico Caruso, Alessandra Lugo, Helena Cavaleiro, Nino Stocchetti, Giuseppe Citerio, António Salgado, Silvano Gallus, Elisa R. Zanier

Source: npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2057-3995

Access URL: https://doaj.org/article/5e831e55bf7740ee91e7eb28620f1c97

Markers of blood-brain barrier disruption increase early and persistently in COVID-19 patients with neurological manifestations

Authors: Valentina Bonetto, Laura Pasetto, Ilaria Lisi, Marco Carbonara, Rosalia Zangari, Erica Ferrari, Veronica Punzi, Silvia Luotti, Nicola Bottino, Bruno Biagianti, Cristina Moglia, Giuseppe Fuda, Roberta Gualtierotti, Francesco Blasi, Ciro Canetta, Nicola Montano, Mauro Tettamanti, Giorgia Camera, Maria Grimoldi, Giulia Negro, Nicola Rifino, Andrea Calvo, Paolo Brambilla, Francesco Biroli, Alessandra Bandera, Alessandro Nobili, Nino Stocchetti, Maria Sessa, Elisa R. Zanier

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: COVID-19, neurological damages, blood-brain barrier, inflammation, blood biomarkers, critical care, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1070379/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e11f55a299534925a328cc0e40993561

In-depth characterization of a mouse model of post-traumatic epilepsy for biomarker and drug discovery

Authors: Rossella Di Sapia, Federico Moro, Marica Montanarella, Valentina Iori, Edoardo Micotti, Daniele Tolomeo, Kevin K. W. Wang, Annamaria Vezzani, Teresa Ravizza, Elisa R. Zanier

Source: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/c368fc500d214dc0983c6407ff95df79

Cognitive Assessment in SARS-CoV-2 Patients: A Systematic Review

Authors: Bruno Biagianti, Asia Di Liberto, Aiello Nicolò Edoardo, Ilaria Lisi, Letizia Nobilia, Giulia Delor de Ferrabonc, Elisa R. Zanier, Nino Stocchetti, Paolo Brambilla

Source: Frontiers in Aging Neuroscience, Vol 14 (2022)

Subject Terms: SARS-CoV-2, COVID-19, neuropsychology, psychometrics, cognitive impairment, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2022.909661/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/59f4c39fb3bb4fc191ca5b48caf4f72a

Angiotensin-(1–7) as a Potential Therapeutic Strategy for Delayed Cerebral Ischemia in Subarachnoid Hemorrhage

Authors: Filippo Annoni, Federico Moro, Enrico Caruso, Tommaso Zoerle, Fabio Silvio Taccone, Elisa R. Zanier

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: renin–angiotensin system (RAS), delayed cerebral ischemia (DCI), subarachnoid hemorrhage (SAH), anoxic injury, acute brain injury, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.841692/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f738d1b4d51a4e7495a3cdfe26c30923

C. elegans detects toxicity of traumatic brain injury generated tau

Authors: Elisa R. Zanier, Maria Monica Barzago, Gloria Vegliante, Margherita Romeo, Elena Restelli, Ilaria Bertani, Carmina Natale, Luca Colnaghi, Laura Colombo, Luca Russo, Edoardo Micotti, Luana Fioriti, Roberto Chiesa, Luisa Diomede

Source: Neurobiology of Disease, Vol 153, Iss , Pp 105330- (2021)

Subject Terms: Tau, Tauopathy, Traumatic brain injury, Caenorhabditis elegans, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996121000796; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/c73e31b43b9048b68215b54d309f0507

Intravenous infusion of human bone marrow mesenchymal stromal cells promotes functional recovery and neuroplasticity after ischemic stroke in mice

Authors: Eliana Sammali, Claudia Alia, Gloria Vegliante, Valentina Colombo, Nadia Giordano, Francesca Pischiutta, Giorgio B. Boncoraglio, Mario Barilani, Lorenza Lazzari, Matteo Caleo, Maria-Grazia De Simoni, Giuseppe Gaipa, Giuseppe Citerio, Elisa R. Zanier

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/4a8c9b8a3d0b47f0851e220fca0f3975

Brain Protection after Anoxic Brain Injury: Is Lactate Supplementation Helpful?

Authors: Filippo Annoni, Lorenzo Peluso, Elisa Gouvêa Bogossian, Jacques Creteur, Elisa R. Zanier, Fabio Silvio Taccone

Source: Cells, Vol 10, Iss 7, p 1714 (2021)

Subject Terms: cardiac arrest, ischemia-reperfusion injury, hypertonic lactate, resuscitation, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/7/1714; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/6182787b1a834ac8a08a631914692b3c

Macrophages are essential for maintaining a M2 protective response early after ischemic brain injury

Authors: Carlo Perego, Stefano Fumagalli, Elisa R. Zanier, Erika Carlino, Nicolò Panini, Eugenio Erba, Maria-Grazia De Simoni, PhD

Source: Neurobiology of Disease, Vol 96, Iss , Pp 284-293 (2016)

Subject Terms: Brain ischemic injury, Inflammation, Microglia, Macrophage depletion, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996116302339; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/30804098624246a29dfd79dc9e3ce4a7

Neuroprotection in Traumatic Brain Injury: Mesenchymal Stromal Cells can Potentially Overcome Some Limitations of Previous Clinical Trials

Authors: Marco Carbonara, Francesca Fossi, Tommaso Zoerle, Fabrizio Ortolano, Federico Moro, Francesca Pischiutta, Elisa R. Zanier, Nino Stocchetti

Source: Frontiers in Neurology, Vol 9 (2018)

Subject Terms: traumatic brain injury, mesenchymal stromal cells, brain protection, brain repair, vulnerability, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fneur.2018.00885/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/dc56587ce40e4ee3895b96a0e52f7259

Virtual Reality for Traumatic Brain Injury

Authors: Elisa R. Zanier, Tommaso Zoerle, Daniele Di Lernia, Giuseppe Riva

Source: Frontiers in Neurology, Vol 9 (2018)

Subject Terms: traumatic brain injury, virtual reality, brain protection, neurorepair, rehabilitation, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fneur.2018.00345/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/3d978d8ac7d94907a2c28bf1ddf3ef3d

Placenta-Derived Cells for Acute Brain Injury

Authors: Francesca Pischiutta, Eliana Sammali, Ornella Parolini, Hilary V. O. Carswell, Elisa R. Zanier

Source: Cell Transplantation, Vol 27 (2018)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/0963-6897; https://doaj.org/toc/1555-3892

Access URL: https://doaj.org/article/859fad2ed8af4a23aac6871d2e804296