Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

Authors: Steffen Fuchs, Clara Danßmann, Filippos Klironomos, Annika Winkler, Jörg Fallmann, Louisa-Marie Kruetzfeldt, Annabell Szymansky, Julian Naderi, Stephan H. Bernhart, Laura Grunewald, Konstantin Helmsauer, Elias Rodriguez-Fos, Marieluise Kirchner, Philipp Mertins, Kathy Astrahantseff, Christin Suenkel, Joern Toedling, Fabienne Meggetto, Marc Remke, Peter F. Stadler, Patrick Hundsdoerfer, Hedwig E. Deubzer, Annette Künkele, Peter Lang, Jörg Fuchs, Anton G. Henssen, Angelika Eggert, Nikolaus Rajewsky, Falk Hertwig, Johannes H. Schulte

Source: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e3f97aeb65a24b24bd42256f006984aa

Mutational topography reflects clinical neuroblastoma heterogeneity

Authors: Elias Rodriguez-Fos, Mercè Planas-Fèlix, Martin Burkert, Montserrat Puiggròs, Joern Toedling, Nina Thiessen, Eric Blanc, Annabell Szymansky, Falk Hertwig, Naveed Ishaque, Dieter Beule, David Torrents, Angelika Eggert, Richard P. Koche, Roland F. Schwarz, Kerstin Haase, Johannes H. Schulte, Anton G. Henssen

Source: Cell Genomics, Vol 3, Iss 10, Pp 100402- (2023)

Subject Terms: neuroblastoma, mutational signatures, cancer genomics, tumor evolution, ecDNA, complex rearrangements, Genetics, QH426-470, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666979X23002161; https://doaj.org/toc/2666-979X

Access URL: https://doaj.org/article/0df526825af642e280ef874891c577b1

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells

Authors: Mareike Berlak, Elizabeth Tucker, Mathurin Dorel, Annika Winkler, Aleixandria McGearey, Elias Rodriguez-Fos, Barbara Martins da Costa, Karen Barker, Elicia Fyle, Elizabeth Calton, Selma Eising, Kim Ober, Deborah Hughes, Eleni Koutroumanidou, Paul Carter, Reda Stankunaite, Paula Proszek, Neha Jain, Carolina Rosswog, Heathcliff Dorado-Garcia, Jan Jasper Molenaar, Mike Hubank, Giuseppe Barone, John Anderson, Peter Lang, Hedwig Elisabeth Deubzer, Annette Künkele, Matthias Fischer, Angelika Eggert, Charlotte Kloft, Anton George Henssen, Michael Boettcher, Falk Hertwig, Nils Blüthgen, Louis Chesler, Johannes Hubertus Schulte

Source: Molecular Cancer, Vol 21, Iss 1, Pp 1-19 (2022)

Subject Terms: Neuroblastoma, CRISPR screening, ALK, Resistance, NF1, NRAS, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/141d19867f1b4f5b98e903127aa48cab

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma

Authors: Konstantin Helmsauer, Maria E. Valieva, Salaheddine Ali, Rocío Chamorro González, Robert Schöpflin, Claudia Röefzaad, Yi Bei, Heathcliff Dorado Garcia, Elias Rodriguez-Fos, Montserrat Puiggròs, Katharina Kasack, Kerstin Haase, Csilla Keskeny, Celine Y. Chen, Luis P. Kuschel, Philipp Euskirchen, Verena Heinrich, Michael I. Robson, Carolina Rosswog, Joern Toedling, Annabell Szymansky, Falk Hertwig, Matthias Fischer, David Torrents, Angelika Eggert, Johannes H. Schulte, Stefan Mundlos, Anton G. Henssen, Richard P. Koche

Source: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c5b9fcaacd9648e4831d4de98b3e2479

Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Authors: Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercè Planas-Fèlix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H. Pers, Claire C. Morgan, Ignasi Moran, Goutham Atla, Juan R. González, Montserrat Puiggros, Jonathan Martí, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Aaron Leong, Varindepal Kaur, Jason Flannick, Torben Jørgensen, Allan Linneberg, Marit E. Jørgensen, Daniel R. Witte, Cramer Christensen, Ivan Brandslund, Emil V. Appel, Robert A. Scott, Jian’an Luan, Claudia Langenberg, Nicholas J. Wareham, Oluf Pedersen, Antonio Zorzano, Jose C Florez, Torben Hansen, Jorge Ferrer, Josep Maria Mercader, David Torrents

Source: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/bc0e732fc3984663bcd763ffc1af847e

Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Authors: Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercè Planas-Fèlix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H. Pers, Claire C. Morgan, Ignasi Moran, Goutham Atla, Juan R. González, Montserrat Puiggros, Jonathan Martí, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Aaron Leong, Varindepal Kaur, Jason Flannick, Torben Jørgensen, Allan Linneberg, Marit E. Jørgensen, Daniel R. Witte, Cramer Christensen, Ivan Brandslund, Emil V. Appel, Robert A. Scott, Jian’an Luan, Claudia Langenberg, Nicholas J. Wareham, Oluf Pedersen, Antonio Zorzano, Jose C Florez, Torben Hansen, Jorge Ferrer, Josep Maria Mercader, David Torrents

Source: Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/202ddca41ed244ff9a8f095f544c3220