Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

Authors: Elena Mitsi, Mariana O. Diniz, Jesús Reiné, Andrea M. Collins, Ryan E. Robinson, Angela Hyder-Wright, Madlen Farrar, Konstantinos Liatsikos, Josh Hamilton, Onyia Onyema, Britta C. Urban, Carla Solórzano, Sandra Belij-Rammerstorfer, Emma Sheehan, Teresa Lambe, Simon J. Draper, Daniela Weiskopf, Alessandro Sette, Mala K. Maini, Daniela M. Ferreira

Source: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6d44bf59f3084d30b1170569d157d5ea

Serotype 3 Experimental Human Pneumococcal Challenge (EHPC) study protocol: dose ranging and reproducibility in a healthy volunteer population (challenge 3)

Authors: Maia Lesosky, Konstantinos Liatsikos, Stephen B Gordon, Kelly Davies, Phoebe Hazenberg, Angela Hyder-Wright, Ryan E Robinson, Britta Urban, Elena Mitsi, Carla Solorzano, Daniela M Ferreira, Madlen Farrar, Ashleigh Howard, Andrea M Collins, Jaye Brunning, Hannah Fleet, Amy Bettam, Tinashe Kenny-Nyazika, Dima El Safadi

Source: BMJ Open, Vol 14, Iss 1 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/14/1/e075948.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/29c9f5f36e564dbebdfe5cbccf615b4d

Detection of SARS-CoV-2 infection by saliva and nasopharyngeal sampling in frontline healthcare workers: An observational cohort study.

Authors: Naomi F Walker, Rachel L Byrne, Ashleigh Howard, Elissavet Nikolaou, Madlen Farrar, Sharon Glynn, Katerina S Cheliotis, Ana I Cubas Atienzar, Kelly Davies, Jesús Reiné, Zalina Rashid-Gardner, Esther L German, Carla Solórzano, Tess Blandamer, Lisa Hitchins, Christopher Myerscough, Bradford D Gessner, Elizabeth Begier, Andrea M Collins, Mike Beadsworth, Stacy Todd, Helen Hill, Catherine F Houlihan, Eleni Nastouli, Emily R Adams, Elena Mitsi, Daniela M Ferreira, SAFER investigators

Source: PLoS ONE, Vol 18, Iss 1, p e0280908 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/2f8d87f300ff42ec98b0540f44bdb8b9

Comprehensive review of safety in Experimental Human Pneumococcal Challenge.

Authors: Ryan E Robinson, Christopher Myerscough, Nengjie He, Helen Hill, Wendi A Shepherd, Patricia Gonzalez-Dias, Konstantinos Liatsikos, Samuel Latham, Fred Fyles, Klara Doherty, Phoebe Hazenberg, Fathimath Shiham, Daniella Mclenghan, Hugh Adler, Vicki Randles, Seher Zaidi, Angela Hyder-Wright, Elena Mitsi, Hassan Burhan, Ben Morton, Jamie Rylance, Maia Lesosky, Stephen B Gordon, Andrea M Collins, Daniela M Ferreira

Source: PLoS ONE, Vol 18, Iss 5, p e0284399 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/5ba86a5041f341e7abc5a37ebce3456c

The nose is the best niche for detection of experimental pneumococcal colonisation in adults of all ages, using nasal wash

Authors: Elissavet Nikolaou, Esther L. German, Annie Blizard, Ashleigh Howard, Lisa Hitchins, Tao Chen, Jim Chadwick, Sherin Pojar, Elena Mitsi, Carla Solórzano, Syba Sunny, Felicity Dunne, Jenna F. Gritzfeld, Hugh Adler, Jason Hinds, Katherine A. Gould, Jamie Rylance, Andrea M. Collins, Stephen B. Gordon, Daniela M. Ferreira

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e86701c2f70341c0a89b2827ecb7542b

Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccharide vaccine on pneumococcal colonisation using the experimental human pneumococcal challenge model in healthy adults (PREVENTING PNEUMO 2)

Authors: Tao Chen, Duolao Wang, Konstantinos Liatsikos, Stephen B Gordon, Hassan Burhan, Ben Morton, Tinashe K Nyazika, Bradford D Gessner, Helen Hill, Andrea Collins, Josh Hamilton, Kelly Davies, Fred Fyles, Phoebe Hazenberg, Elizabeth Begier, Angela Hyder-Wright, Sherin Pojar, Christopher Myerscough, Jesus Reine, Ryan E Robinson, Britta Urban, Elena Mitsi, Carla Solorzano, Angela Quinn, Kaijie Pan, Annaliesa S Anderson, Christian Theilacker, Daniela M Ferreira, Kelly Convey, James Court, Madlen Farrar, Lisa Hitchins, Ashleigh Howard, Lauren Kerruish, Samuel Latham, Annabel Murphy, Elissavet Nikolaou, Angelina Peterson

Source: BMJ Open, Vol 12, Iss 7 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/12/7/e062109.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/13a7b19514ce48c68e2c73bb6ee12be9

Exploring metal availability in the natural niche of Streptococcus pneumoniae to discover potential vaccine antigens

Authors: Lucille F. van Beek, Kristin Surmann, H. Bart van den Berg van Saparoea, Diane Houben, Wouter S. P. Jong, Christian Hentschker, Thomas H. A. Ederveen, Elena Mitsi, Daniela M. Ferreira, Fred van Opzeeland, Christa E. van der Gaast – de Jongh, Irma Joosten, Uwe Völker, Frank Schmidt, Joen Luirink, Dimitri A. Diavatopoulos, Marien I. de Jonge

Source: Virulence, Vol 11, Iss 1, Pp 1310-1328 (2020)

Subject Terms: streptococcus pneumoniae, transition metals, nasal fluid, protein antigens, colonization, in vivo-mimicking, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/2150-5594; https://doaj.org/toc/2150-5608

Access URL: https://doaj.org/article/3e016418b8e44a38bee691ecfa6505c3

Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization

Authors: Simon P. Jochems, Karin de Ruiter, Carla Solórzano, Astrid Voskamp, Elena Mitsi, Elissavet Nikolaou, Beatriz F. Carniel, Sherin Pojar, Esther L. German, Jesús Reiné, Alessandra Soares-Schanoski, Helen Hill, Rachel Robinson, Angela D. Hyder-Wright, Caroline M. Weight, Pascal F. Durrenberger, Robert S. Heyderman, Stephen B. Gordon, Hermelijn H. Smits, Britta C. Urban, Jamie Rylance, Andrea M. Collins, Mark D. Wilkie, Lepa Lazarova, Samuel C. Leong, Maria Yazdanbakhsh, Daniela M. Ferreira

Source: The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/bcadd546859142bdac48336b2764f1e0

Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2

Authors: Elena Mitsi, Jesús Reiné, Britta C. Urban, Carla Solórzano, Elissavet Nikolaou, Angela D. Hyder-Wright, Sherin Pojar, Ashleigh Howard, Lisa Hitchins, Sharon Glynn, Madlen C. Farrar, Konstantinos Liatsikos, Andrea M. Collins, Naomi F. Walker, Helen C. Hill, Esther L. German, Katerina S. Cheliotis, Rachel L. Byrne, Christopher T. Williams, Ana I. Cubas-Atienzar, Tom E. Fletcher, Emily R. Adams, Simon J. Draper, David Pulido, Rohini Beavon, Christian Theilacker, Elizabeth Begier, Luis Jodar, Bradford D. Gessner, Daniela M. Ferreira

Source: The Journal of Clinical Investigation, Vol 132, Iss 7 (2022)

Subject Terms: Immunology, Virology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/b2d172fcc22a4eafaa71e455bedd326d

Influence of sex, season and environmental air quality on experimental human pneumococcal carriage acquisition: a retrospective cohort analysis

Authors: Katerina S. Cheliotis, Christopher P. Jewell, Carla Solórzano, Britta Urban, Andrea M. Collins, Elena Mitsi, Sherin Pojar, Elissavet Nikolaou, Esther L. German, Jesús Reiné, Stephen B. Gordon, Simon P. Jochems, Jamie Rylance, Daniela M. Ferreira

Source: ERJ Open Research, Vol 8, Iss 2 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://openres.ersjournals.com/content/8/2/00586-2021.full; https://doaj.org/toc/2312-0541

Access URL: https://doaj.org/article/02f21473f41241cd9746bf539d810172

Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine

Authors: Wouter A. A. de Steenhuijsen Piters, Simon P. Jochems, Elena Mitsi, Jamie Rylance, Sherin Pojar, Elissavet Nikolaou, Esther L. German, Mark Holloway, Beatriz F. Carniel, Mei Ling J. N. Chu, Kayleigh Arp, Elisabeth A. M. Sanders, Daniela M. Ferreira, Debby Bogaert

Source: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/41664ac4244044f8a670c8b1459330bb

Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine

Authors: Beatriz F. Carniel, Fernando Marcon, Jamie Rylance, Esther L. German, Seher Zaidi, Jesus Reiné, Edessa Negera, Elissavet Nikolaou, Sherin Pojar, Carla Solórzano, Andrea M. Collins, Victoria Connor, Debbie Bogaert, Stephen B. Gordon, Helder I. Nakaya, Daniela M. Ferreira, Simon P. Jochems, Elena Mitsi

Source: JCI Insight, Vol 6, Iss 4 (2021)

Subject Terms: Immunology, Vaccines, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/ac32bdcbe5794f33bcf3a38a2cdc394a

Experimental Human Challenge Defines Distinct Pneumococcal Kinetic Profiles and Mucosal Responses between Colonized and Non-Colonized Adults

Authors: Elissavet Nikolaou, Simon P. Jochems, Elena Mitsi, Sherin Pojar, Annie Blizard, Jesus Reiné, Carla Solórzano, Edessa Negera, Beatriz Carniel, Alessandra Soares-Schanoski, Victoria Connor, Hugh Adler, Seher R. Zaidi, Caz Hales, Helen Hill, Angie Hyder-Wright, Stephen B. Gordon, Jamie Rylance, Daniela M. Ferreira

Source: mBio, Vol 12, Iss 1 (2021)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2161-2129; https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/1236366ad73a46a3aea687a3e4c72662

Anti-protein immunoglobulin M responses to pneumococcus are not associated with aging

Authors: Esther L. German, Bahij Al-Hakim, Elena Mitsi, Shaun H. Pennington, Jenna F. Gritzfeld, Angie D. Hyder-Wright, Antonia Banyard, Stephen B. Gordon, Andrea M. Collins, Daniela M. Ferreira

Source: Pneumonia, Vol 10, Iss 1, Pp 1-7 (2018)

Subject Terms: IgM antibodies, Pneumococcus, Vaccines, Immune senescence, Proteins, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s41479-018-0048-3; https://doaj.org/toc/2200-6133

Access URL: https://doaj.org/article/7e4745a52a2d4a8b986ceb4ebcff2155

Human alveolar macrophages predominately express combined classical M1 and M2 surface markers in steady state

Authors: Elena Mitsi, Raphael Kamng’ona, Jamie Rylance, Carla Solórzano, J. Jesus Reiné, Henry C. Mwandumba, Daniela M. Ferreira, Kondwani C. Jambo

Source: Respiratory Research, Vol 19, Iss 1, Pp 1-4 (2018)

Subject Terms: Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12931-018-0777-0; https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/8bd8628108f5481c93da55b15ec7af9c

Single use and conventional bronchoscopes for Broncho alveolar lavage (BAL) in research: a comparative study (NCT 02515591)

Authors: Seher Raza Zaidi, Andrea M. Collins, Elena Mitsi, Jesús Reiné, Kayleigh Davies, Angela D Wright, Jessica Owugha, Richard Fitzgerald, Amitava Ganguli, Stephen B Gordon, Daniela Mulari Ferreira, Jamie Rylance

Source: BMC Pulmonary Medicine, Vol 17, Iss 1, Pp 1-5 (2017)

Subject Terms: Research Bronchoscopy, Bronchoalveolar Lavage, Single use bronchoscopes, Bronchoscopy, Bronchoalveolar lavage fluid, Lung diseases, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12890-017-0421-7; https://doaj.org/toc/1471-2466

Access URL: https://doaj.org/article/0ab3909d24a6432eb990cea59c1f4330

Saliva Alternative to Upper Respiratory Swabs for SARS-CoV-2 Diagnosis

Authors: Rachel L. Byrne, Grant A. Kay, Konstantina Kontogianni, Ghaith Aljayyoussi, Lottie Brown, Andrea M. Collins, Luis E. Cuevas, Daniela M. Ferreira, Alice J. Fraser, Gala Garrod, Helen Hill, Grant L. Hughes, Stefanie Menzies, Elena Mitsi, Sophie I. Owen, Edward I. Patterson, Christopher T. Williams, Angela Hyder-Wright, Emily R. Adams, Ana I. Cubas-Atienzar

Source: Emerging Infectious Diseases, Vol 26, Iss 11, Pp 2769-2770 (2020)

Subject Terms: SARS-CoV-2, COVID-19, RT-qPCR, swabs, saliva, respiratory infections, Medicine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/26/11/20-3283_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

Access URL: https://doaj.org/article/f8bfa2d103934611b625a409ce932d1a

Antibodies Reactive to Commensal Streptococcus mitis Show Cross-Reactivity With Virulent Streptococcus pneumoniae Serotypes

Authors: Sudhanshu Shekhar, Rabia Khan, Daniela M. Ferreira, Elena Mitsi, Esther German, Gro Herredsvela Rørvik, Dag Berild, Karl Schenck, Keehwan Kwon, Fernanda Petersen

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: Streptococcus pneumoniae, Streptococcus mitis, antibody, antigens, cross-reactivity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2018.00747/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9aa1d682264e462a87664e9fe0f97f5e