Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice

Authors: Omar Mamad, Mona Heiland, Andreas U. Lindner, Thomas D. M. Hill, Ronan M. Ronroy, Kilian Rentrup, Amaya Sanz-Rodriguez, Elena Langa, Janosch P. Heller, Oscar Moreno, Jordi Llop, Anindya Bhattacharya, James A. Palmer, Marc Ceusters, Tobias Engel, David C. Henshall

Source: Frontiers in Pharmacology, Vol 14 (2024)

Subject Terms: anti-seizure medicines, inflammation, interleukin 1β, drug-resistant epilepsy, hippocampal sclerosis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1308478/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/4fa05e1ff28e4d35a32f692bc0e2ed81

Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy

Authors: Elizabeth Brindley, Mona Heiland, Catherine Mooney, Mairead Diviney, Omar Mamad, Thomas D. M. Hill, Yan Yan, Morten T. Venø, Cristina R. Reschke, Aasia Batool, Elena Langa, Amaya Sanz-Rodriguez, Janosch P. Heller, Gareth Morris, Karen Conboy, Jørgen Kjems, Gary P. Brennan, David C. Henshall

Source: Frontiers in Molecular Neuroscience, Vol 16 (2023)

Subject Terms: electroencephalogram, diagnosis, epigenetic, hippocampus, noncoding RNA, point-of-care testing, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2023.1230942/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/5a12b88c05be4334969707b5a82ff1e7

AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome

Authors: Aoife Campbell, Gareth Morris, Albert Sanfeliu, Joana Augusto, Elena Langa, Jaideep C. Kesavan, Ngoc T. Nguyen, Ronan M. Conroy, Jesper Worm, Lukasz Kielpinski, Mads Aaboe Jensen, Meghan T. Miller, Thomas Kremer, Cristina R. Reschke, David C. Henshall

Source: Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 514-529 (2022)

Subject Terms: MT: Oligonucleotides: Therapies and Applications, microRNAs, Angelman syndrome, epilepsy, seizures, miR-134, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253122000853; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/9cfd00cc33fa406da3ff7352a705c687

Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice

Authors: Aoife Campbell, Gareth Morris, Janosch P. Heller, Elena Langa, Elizabeth Brindley, Jesper Worm, Mads Aaboe Jensen, Meghan T. Miller, David C. Henshall, Cristina R. Reschke

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/0b672bed99a647c39d8f5224165e8622

Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice

Authors: Luiz F. Almeida Silva, Cristina R. Reschke, Ngoc T. Nguyen, Elena Langa, Amaya Sanz-Rodriguez, Rogerio R. Gerbatin, Fernanda R. Temp, Mayara L. de Freitas, Ronan M. Conroy, Gary P. Brennan, Tobias Engel, David C. Henshall

Source: Molecular Brain, Vol 13, Iss 1, Pp 1-15 (2020)

Subject Terms: Antagomirs, kainic acid, Hippocampus, microRNA, Oligonucleotide, Temporal lobe epilepsy, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13041-020-00653-x; https://doaj.org/toc/1756-6606

Access URL: https://doaj.org/article/437cebdae0ed4f06ac210951c4c7a083

Altered Biogenesis and MicroRNA Content of Hippocampal Exosomes Following Experimental Status Epilepticus

Authors: Aasia Batool, Thomas D. M. Hill, Ngoc T. Nguyen, Elena Langa, Mairéad Diviney, Catherine Mooney, Gary P. Brennan, Niamh M. C. Connolly, Amaya Sanz-Rodriguez, Brenton L. Cavanagh, David C. Henshall

Source: Frontiers in Neuroscience, Vol 13 (2020)

Subject Terms: epileptogenesis, extracellular vesicle, neuroinflammation, non-coding RNA, seizure, temporal lobe epilepsy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnins.2019.01404/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/46abeaf665154000a4909c438eaf4e3c

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Cannabis intake and intussusception: an accidental association?

Authors: Alberto Fernández-Atutxa, Leticia de-Castro, Juan Antonio Arévalo-Senra, Elena Langara, José Luis Cabriada-Nuño

Source: Revista Espanola de Enfermedades Digestivas, Vol 109, Iss 2, Pp 157-159

Subject Terms: Cannabinoids, Intussusception, Abdominal pain, Intestinal occlusion, Vomiting, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082017000200016&lng=en&tlng=en; https://doaj.org/toc/1130-0108

Access URL: https://doaj.org/article/b5f628afe9594221afc7bea2334c26b5