Mast cell leukemia: clinical and molecular features and survival outcomes of patients in the ECNM Registry

Authors: Kennedy, Vanessa E., Perkins, Cecelia, Reiter, Andreas, Jawhar, Mohamad, Lübke, Johannes, Kluin-Nelemans, Hanneke C., Shomali, William, Langford, Cheryl, Abuel, Justin, Hermine, Olivier, Niedoszytko, Marek, Gorska, Aleksandra, Mital, Andrzej, Bonadonna, Patrizia, Zanotti, Roberta, Tanasi, Ilaria, Mattsson, Mattias, Hagglund, Hans, Triggiani, Massimo, Yavuz, Akif Selim, Panse, Jens, Christen, Deborah, Heizmann, Marc, Shoumariyeh, Khalid, Müller, Sabine, Elena, Chiara, Malcovati, Luca, Fiorelli, Nicolas, Wortmann, Friederike, Vucinic, Vladan, Brockow, Knut, Fokoloros, Christos, Papageorgiou, Sotirios G., Breynaert, Christine, Bullens, Dominique, Doubek, Michael, Ilerhaus, Anja, Angelova-Fischer, Irena, Solomianyi, Oleksii, Várkonyi, Judit, Sabato, Vito, Rüfer, Axel, Schug, Tanja Daniela, Hermans, Maud A. W., Fortina, Anna Belloni, Caroppo, Francesca, Bumbea, Horia, Gulen, Theo, Hartmann, Karin, Elberink, Hanneke Oude, Schwaab, Juliana, Arock, Michel, Valent, Peter, Sperr, Wolfgang R., Gotlib, Jason ^∗

Source: In Blood Advances 9 May 2023 7(9):1713-1724

Prognostic Impact of Organomegaly in Mastocytosis: An Analysis of the European Competence Network on Mastocytosis

Authors: Lübke, Johannes, Schwaab, Juliana, Christen, Deborah, Elberink, Hanneke Oude, Span, Bart, Niedoszytko, Marek, Gorska, Aleksandra, Lange, Magdalena, Gleixner, Karoline V., Hadzijusufovic, Emir, Solomianyi, Oleksii, Angelova-Fischer, Irena, Zanotti, Roberta, Bonifacio, Massimiliano, Bonadonna, Patrizia, Shoumariyeh, Khalid, von Bubnoff, Nikolas, Müller, Sabine, Perkins, Cecelia, Elena, Chiara, Malcovati, Luca, Hagglund, Hans, Mattsson, Mattias, Parente, Roberta, Varkonyi, Judit, Fortina, Anna Belloni, Caroppo, Francesca, Zink, Alexander, Brockow, Knut, Breynaert, Christine, Bullens, Dominique, Yavuz, Akif Selim, Doubek, Michael, Sabato, Vito, Schug, Tanja, Niederwieser, Dietger, Hartmann, Karin, Triggiani, Massimo, Gotlib, Jason, Hermine, Olivier, Arock, Michel, Kluin-Nelemans, Hanneke C., Panse, Jens, Sperr, Wolfgang R., Valent, Peter, Reiter, Andreas, Jawhar, Mohamad

Source: In The Journal of Allergy and Clinical Immunology: In Practice February 2023 11(2):581-590

Mast Cell Diseases in Practice and Research: Issues and Perspectives Raised by Patients and Their Recommendations to the Scientific Community and Beyond

Authors: Jennings, Susan V., Finnerty, Celeste C., Hobart, Jessica S., Martín-Martínez, Mercedes, Sinclair, Kristin A., Slee, Valerie M., Agopian, Julie, Akin, Cem, Álvarez-Twose, Ivan, Bonadonna, Patrizia, Bowman, Angela S., Brockow, Knut, Bumbea, Horia, de Haro, Claudia, Fok, Jie Shen, Hartmann, Karin, Hegmann, Nicole, Hermine, Olivier, Kalisiak, Monika, Katelaris, Constance H., Kurz, Jacqueline, Marcis, Patrizia, Mayne, David, Mendoza, David, Moussy, Alain, Mudretzkyj, Genija, Vaia, Nicoleta Nidelea, Niedoszytko, Marek, Elberink, Hanneke Oude, Orfao, Alberto, Radia, Deepti H., Rosenmeier, Sophie, Ribada, Eugenia, Schinhofen, Waltraud, Schwaab, Juliana, Siebenhaar, Frank, Triggiani, Massimo, Tripodo, Giuseppe, Velazquez, Rocio, Wielink, Yvon, Wimazal, Friedrich, Yigit, Timo, Zubrinich, Celia, Valent, Peter

Source: In The Journal of Allergy and Clinical Immunology: In Practice August 2022 10(8):2039-2051

Proposed European Competence Network on Mastocytosis—American Initiative in Mast Cell Diseases (ECNM-AIM) Response Criteria in Advanced Systemic Mastocytosis

Authors: Gotlib, Jason, Schwaab, Juliana, Shomali, William, George, Tracy I., Radia, Deepti H., Castells, Mariana, Carter, Melody C., Hartmann, Karin, Álvarez-Twose, Ivan, Brockow, Knut, Bonadonna, Patrizia, Hermine, Olivier, Niedoszytko, Marek, Hoermann, Gregor, Sperr, Wolfgang R., Elberink, Hanneke Oude, Siebenhaar, Frank, Butterfield, Joseph H., Ustun, Celalettin, Zanotti, Roberta, Triggiani, Massimo, Schwartz, Lawrence B., Lyons, Jonathan J., Orfao, Alberto, Sotlar, Karl, Horny, Hans-Peter, Arock, Michel, Metcalfe, Dean D., Akin, Cem, Lübke, Johannes, Valent, Peter, Reiter, Andreas

Source: In The Journal of Allergy and Clinical Immunology: In Practice August 2022 10(8):2025-2038

COVID-19 Vaccination in Mastocytosis: Recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM)

Authors: Bonadonna, Patrizia, Brockow, Knut, Niedoszytko, Marek, Elberink, Hanneke Oude, Akin, Cem, Nedoszytko, Boguslaw, Butterfield, Joseph H., Alvarez-Twose, Ivan, Sotlar, Karl, Schwaab, Juliana, Jawhar, Mohamad, Castells, Mariana, Sperr, Wolfgang R., Hermine, Olivier, Gotlib, Jason, Zanotti, Roberta, Reiter, Andreas, Broesby-Olsen, Sigurd, Bindslev-Jensen, Carsten, Schwartz, Lawrence B., Horny, Hans-Peter, Radia, Deepti, Triggiani, Massimo, Sabato, Vito, Carter, Melody C., Siebenhaar, Frank, Orfao, Alberto, Grattan, Clive, Metcalfe, Dean D., Arock, Michel, Gulen, Theo, Hartmann, Karin, Valent, Peter

Source: In The Journal of Allergy and Clinical Immunology: In Practice June 2021 9(6):2139-2144

Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference

Authors: Gotlib, Jason, George, Tracy I., Carter, Melody C., Austen, K. Frank, Bochner, Bruce, Dwyer, Daniel F., Lyons, Jonathan J., Hamilton, Matthew J., Butterfield, Joseph, Bonadonna, Patrizia, Weiler, Catherine, Galli, Stephen J., Schwartz, Lawrence B., Elberink, Hanneke Oude, Maitland, Anne, Theoharides, Theoharis, Ustun, Celalettin, Horny, Hans-Peter, Orfao, Alberto, Deininger, Michael, Radia, Deepti, Jawhar, Mohamad, Kluin-Nelemans, Hanneke, Metcalfe, Dean D., Arock, Michel, Sperr, Wolfgang R., Valent, Peter, Castells, Mariana, Akin, Cem

Source: In The Journal of Allergy and Clinical Immunology June 2021 147(6):2043-2052

Scoring the Risk of Having Systemic Mastocytosis in Adult Patients with Mastocytosis in the Skin

Authors: Fuchs, David, Kilbertus, Alex, Kofler, Karin, von Bubnoff, Nikolas, Shoumariyeh, Khalid, Zanotti, Roberta, Bonadonna, Patrizia, Scaffidi, Luigi, Doubek, Michael, Elberink, Hanneke Oude, Span, Lambert F.R., Hermine, Olivier, Elena, Chiara, Benvenuti, Pietro, Yavuz, Akif Selim, Brockow, Knut, Zink, Alexander, Aberer, Elisabeth, Gorska, Aleksandra, Romantowski, Jan, Hadzijusufovic, Emir, Fortina, Anna Belloni, Caroppo, Francesca, Perkins, Cecelia, Illerhaus, Anja, Panse, Jens, Vucinic, Vladan, Jawhar, Mohamad, Sabato, Vito, Triggiani, Massimo, Parente, Roberta, Bergström, Anna, Breynaert, Christine, Gotlib, Jason, Reiter, Andreas, Hartmann, Karin, Niedoszytko, Marek, Arock, Michel, Kluin-Nelemans, Hanneke C., Sperr, Wolfgang R., Greul, Rosemarie, Valent, Peter

Source: In The Journal of Allergy and Clinical Immunology: In Practice April 2021 9(4):1705-1712

MPN-524 Reductions in Indolent Systemic Mastocytosis Biomarker Burden With Avapritinib in the Registrational, Double-Blind, Placebo-Controlled PIONEER Trial

Authors: Gotlib, Jason, Castells, Mariana, Elberink, Hanneke Oude, Siebenhaar, Frank, Hartmann, Karin, Broesby-Olsen, Sigurd, George, Tracy I., Panse, Jens, Alvarez-Twose, Iván, Radia, Deepti H., Tashi, Tsewang, Livideanu, Cristina Bulai, Sabato, Vito, Van Daele, Paul, Cerquozzi, Sonia, Dybedal, Ingunn, Reiter, Andreas, Ustun, Celalettin, Schafhausen, Philippe, Bose, Prithviraj, DeAngelo, Daniel J., Rein, Lindsay, Vachhani, Pankit, Triggiani, Massimo, Rafferty, Mark, Butt, Nauman M., Oh, Stephen T., Wortmann, Friederike, Ungerstedt, Johanna, Taparia, Minakshi, Kuykendall, Andrew T., Yi, Cecilia Arana, Mattsson, Mattias, Shomali, William, Giannetti, Matthew P., Bidollari, Ilda, Lin, Hui-Min, Scherber, Robyn, Roche, Maria, Akin, Cem, Maurer, Marcus

Source: Clinical lymphoma, myeloma & leukemia. 23(S1):S398-S399

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196312913.0x000001&indx=1&recIds=ETOCvdc_100196312913.0x000001

Responses to Avapritinib in Patients Without Detectable KIT Mutations by ddPCR in Peripheral Blood Highlight Diagnostic Challenges and Opportunities in Indolent Systemic Mastocytosis

Authors: Pongdee, Thanai ¹, Vachhani, Pankit ², Tashi, Tsewang ⁰, Alvarez-Twose, Ivan ⁴, Bonadonna, Patrizia ⁵, Radia, Deepti ⁰, Elberink, Hanneke Oude ⁷, Gotlib, Jason ⁸, Cerquozzi, Sonia ⁹, Sabato, Vito ¹⁰, Dybedal, Ingunn ¹¹, Triggiani, Massimo ¹², Livideanu, Cristina Bulai ¹³, Hartmann, Karin ¹⁴, Oh, Stephen ¹⁵, Bose, Prithviraj ¹⁶, Desai, Ruchi ¹⁷, Schafhausen, Philipe ¹⁸, Maurer, Marcus ¹⁹, Siebenhaar, Frank ¹⁹, George, Tracy ²⁰, Broesby-Olsen, Sigurd ²¹, Yang, Guang ²², Erlich, Rachel ²², Lin, Hui-Min ²², Rosenzweig, Mark ²², Lampson, Benjamin ²², Akin, Cem ²³

Source: In The Journal of Allergy and Clinical Immunology February 2025 155(2) Supplement:AB315-AB315

POSTER: MPN-524 Reductions in Indolent Systemic Mastocytosis Biomarker Burden With Avapritinib in the Registrational, Double-Blind, Placebo-Controlled PIONEER Trial

Authors: Gotlib, Jason, Castells, Mariana, Elberink, Hanneke Oude, Siebenhaar, Frank, Hartmann, Karin, Broesby-Olsen, Sigurd, George, Tracy I., Panse, Jens, Alvarez-Twose, Iván, Radia, Deepti H., Tashi, Tsewang, Livideanu, Cristina Bulai, Sabato, Vito, Daele, Paul Van, Cerquozzi, Sonia, Dybedal, Ingunn, Reiter, Andreas, Ustun, Celalettin, Schafhausen, Philippe, Bose, Prithviraj, DeAngelo, Daniel J., Rein, Lindsay, Vachhani, Pankit, Triggiani, Massimo, Rafferty, Mark, Butt, Nauman M., Oh, Stephen T., Wortmann, Friederike, Ungerstedt, Johanna, Taparia, Minakshi, Kuykendall, Andrew T., Yi, Cecilia Arana, Mattsson, Mattias, Shomali, William, Giannetti, Matthew P., Bidollari, Ilda, Lin, Hui-Min, Scherber, Robyn, Roche, Maria, Akin, Cem, Maurer, Marcus

Source: Clinical lymphoma, myeloma & leukemia. 23(S1):S194-S194

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196318904.0x000001&indx=1&recIds=ETOCvdc_100196318904.0x000001

Efficacy and Safety of Avapritinib in Indolent Systemic Mastocytosis (ISM): Results from the Double Blinded Placebo-Controlled PIONEER Study

Authors: Castells, Mariana, Gotlib, Jason, Elberink, Hanneke Oude, Siebenhaar, Frank, Hartmann, Karin, Broesby-Olsen, Sigurd, George, Tracy, Panse, Jens, Alvarez-Twose, Ivan, Radia, Deepti, Tashi, Tsewang, Livideanu, Cristina Bulai, Sabato, Vito, Van Daele, Paul, Cerquozzi, Sonia, Dybedal, Ingunn, Reiter, Andreas, Pongdee, Thanai, Barete, Stéphane, Schwartz, Lawrence, Bose, Prithviraj, Triggiani, Massimo, Shomali, William, Giannetti, Matthew, Bidollari, Ilda, Lin, Hui-Min, Scherber, Robyn, Roche, Maria, Akin, Cem, Maurer, Marcus

Source: Journal of allergy and clinical immunology. 151(2):AB204-AB204

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180524174.0x000001&indx=1&recIds=ETOCvdc_100180524174.0x000001

Avapritinib versus Placebo in Indolent Systemic Mastocytosis.

Authors: Gotlib, Jason, Castells, Mariana, Elberink, Hanneke Oude, Siebenhaar, Frank, Hartmann, Karin, Broesby-Olsen, Sigurd, George, Tracy I., Panse, Jens, Alvarez-Twose, Iván, Radia, Deepti H., Tashi, Tsewang, Bulai Livideanu, Cristina, Sabato, Vito, Heaney, Mark, Van Daele, Paul, Cerquozzi, Sonia, Dybedal, Ingunn, Reiter, Andreas, Pongdee, Thanai, Barete, Stéphane

Source: NEJM Evidence; Jun2023, Vol. 2 Issue 6, p1-15, 15p

Subject Terms: THERAPEUTIC use of antineoplastic agents, DRUG efficacy, ALKALINE phosphatase, CONFIDENCE intervals, MAST cell disease, HEALTH outcome assessment, ALLELES, PLACEBOS, RANDOMIZED controlled trials, HYDROLASES, COMPARATIVE studies, DESCRIPTIVE statistics, MAST cells, QUALITY of life, STATISTICAL sampling, BONE marrow, PATIENT safety

Exploring the Spectrum of Indolent Systemic Mastocytosis: Analysis of High-Risk Disease Features in the PIONEER Study

Authors: Maurer, Marcus, Akin, Cem, Broesby-Olsen, Sigurd, Elberink, Hanneke Oude, George, Tracy, Siebenhaar, Frank, Gotlib, Jason, Radia, Deepti, Reiter, Andreas, Muñoz-González, Javier, Newberry, Kate, Lin, Hui-Min, Bidollari, Ilda, Lampson, Benjamin, Hartmann, Karin

Source: In The Journal of Allergy and Clinical Immunology February 2024 153(2) Supplement:AB238-AB238

Avapritinib Decreased Symptom Burden in Patients With Indolent Systemic Mastocytosis in the Registrational Double-Blind, Placebo-Controlled PIONEER Study

Authors: Giannetti, Matthew, Akin, Cem, Livideanu, Cristina Bulai, Sabato, Vito, Van Daele, Paul, Pongdee, Thanai, Barete, Stéphane, Vadas, Peter, Maurer, Marcus, Siebenhaar, Frank, Triggiani, Massimo, Bonadonna, Patrizia, Hartmann, Karin, Guilarte, Mar, Ogbogu, Princess, Gaudy, Caroline, Bidollari, Ilda, Green, Teresa, Lin, Hui-Min, Roche, Maria, Sullivan, Erin, Castells, Mariana, Elberink, Hanneke Oude

Source: In The Journal of Allergy and Clinical Immunology February 2024 153(2) Supplement:AB254-AB254

PIONEER: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Avapritinib in Patients with Indolent or Smoldering Systemic Mastocytosis (SM) With Symptoms Inadequately Controlled by Standard Therapy

Authors: Akin, Cem, Elberink, Hanneke Oude, Gotlib, Jason, Sabato, Vito, Hartmann, Karin, Broesby-Olsen, Sigurd, Castells, Mariana, Deininger, Michael, Heaney, Mark, George, Tracy, Radia, Deepti, Triggiani, Massimo, van Daele, Paul, DeAngelo, Daniel, Schmidt-Kittler, Oleg, Lin, Hui-Min, Morrison, Andrew, Mar, Brenton, Sibenhaar, Frank, Maurer, Marcus

Source: Journal of allergy and clinical immunology. 145(2):AB336-AB336

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129194009.0x000001&indx=1&recIds=ETOCvdc_100129194009.0x000001

Pioneer Part 2: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Evaluate Safety and Efficacy of Avapritinib in Indolent Systemic Mastocytosis

Authors: Akin, Cem ^*, Elberink, Hanneke Oude ^*, Gotlib, Jason, Sabato, Vito ^*, Hartmann, Karin ^*, Broesby-Olsen, Sigurd ^*, Castells, Mariana ^*, Tashi, Tsewang ^*, Heaney, Mark L, George, Tracy I., Siebenhaar, Frank ^*, Radia, Deepti H. ^*, Triggiani, Massimo ^*, van Daele, Paul ^*, DeAngelo, Daniel J., Alvarez-Twose, Iván ^*, Reiter, Andreas ^*, Vadas, Peter ^*, Bonadonna, Patrizia ^*, Hew, Paggy ^*, Lin, Hui-Min ^*, Roche, Maria ^*, Maurer, Marcus ^*

Source: In Blood 5 November 2020 136 Supplement 1:41-42

Pioneer: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Avapritinib in Patients with Indolent or Smoldering Systemic Mastocytosis with Symptoms Inadequately Controlled with Standard Therapy

Authors: Akin, Cem ^*, Sabato, Vito ^*, Gotlib, Jason, Castells, Mariana ^*, Deininger, Michael W., Elberink, Hanneke Oude ^*, Heaney, Mark L, van Daele, Paul ^*, Radia, Deepti ^*, Triggiani, Massimo ^*, DeAngelo, Daniel J., Alvarez-Twose, Iván ^*, Broesby-Olsen, Sigurd ^*, George, Tracy I., Hartmann, Karin ^*, Frank, Siebenhaar ^*, Reiter, Andreas, Vadas, Peter ^*, Bonadonna, Patrizia ^*, Panse, Jens P., Staubach-Renz, Petra ^*, Brockow, Knut ^*, Thaci, Diamant ^*, Lin, Hui-Min ^*, Morrison, Andrew ^*, Mar, Brenton ^*, Maurer, Marcus ^*

Source: In Blood 13 November 2019 134 Supplement 1:2950-2950

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Distinct Diagnostic and Clinical Features of Bone Marrow Mastocytosis: A Study of the Registry of the European Competence Network on Mastocytosis (ECNM)

Authors: Bonifacio, Massimiliano ^*, Bonadonna, Patrizia ^*, Elberink, Hanneke Oude ^*, van Anrooij, Björn ^*, Górska, Aleksandra ^*, Lange, Magdalena ^*, Hadzijusufovic, Emir ^*, Scaffidi, Luigi ^*, Tanasi, Ilaria ^*, Perkins, Cecelia ^*, Ferretti, Virginia Valeria ^*, Illerhaus, Anja ^*, Jakob, Thilo ^*, Parente, Roberta ^*, Jawhar, Mohamad ^*, Caroppo, Francesca ^*, Zink, Alexander ^*, Kilbertus, Alex ^*, Yavuz, Akif Selim ^*, Doubek, Michael ^*, Hagglund, Hans ^*, Panse, Jens P., Sabato, Vito ^*, Aberer, Elisabeth ^*, Jaekel, Nadja ^*, Vandenberghe, Peter, Fuchs, David ^*, Brockow, Knut ^*, Belloni Fortina, Anna ^*, Reiter, Andreas ^*, Triggiani, Massimo ^*, Shoumariyeh, Khalid ^*, Hartmann, Karin ^*, Elena, Chiara ^*, Hermine, Olivier ^*, Gotlib, Jason, Niedoszytko, Marek ^*, Kluin-Nelemans, Hanneke ^*, Sperr, Wolfgang R. ^*, Valent, Peter, Zanotti, Roberta ^*

Source: In Blood 8 December 2017 130 Supplement 1:4200-4200

Veroorzakers van allergie.

Authors: Derksen, Jan, Smithuis, Otto, van der Heide, Sicco, Terreehorst, Ingrid, Kauffman, Henk, Knol, Edward, Knulst, André, Elberink, Hanneke Oude, van Ginkel, Cees, de Waard-van der Spek, Flora, Jansen, Ad

Source: Het Allergieboek; 2010, p29-80, 52p