Harnessing artificial intelligence for prostate cancer management

Authors: Zhu, Lingxuan, Pan, Jiahua, Mou, Weiming, Deng, Longxin, Zhu, Yinjie, Wang, Yanqing, Pareek, Gyan, Hyams, Elias, Carneiro, Benedito A., Hadfield, Matthew J., El-Deiry, Wafik S., Yang, Tao, Tan, Tao, Tong, Tong, Ta, Na, Zhu, Yan, Gao, Yisha, Lai, Yancheng, Cheng, Liang, Chen, Rui, Xue, Wei

Source: In Cell Reports Medicine 16 April 2024 5(4)

Predictive and prognostic biomarkers in urological tumours

Authors: Cimadamore, Alessia, Franzese, Carmine, Di Loreto, Carla, Blanca, Ana, Lopez-Beltran, Antonio, Crestani, Alessandro, Giannarini, Gianluca, Tan, Puay Hoon, Carneiro, Benedito A., El-Deiry, Wafik S., Montironi, Rodolfo, Cheng, Liang

Source: In Pathology March 2024 56(2):228-238

Clinical activity of 9-ING-41, a small molecule selective glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in refractory adult T-Cell leukemia/lymphoma

Authors: Hsu, Andrew, Huntington, Kelsey E., De Souza, Andre, Zhou, Lanlan, Olszewski, Adam J., Makwana, Nirav P., Treaba, Diana O., Cavalcante, Ludimila, Giles, Francis J., Safran, Howard, El-Deiry, Wafik S., Carneiro, Benedito A.

Source: Cancer biology & therapy. 23(1):417-423

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167402861.0x000001&indx=1&recIds=ETOCvdc_100167402861.0x000001

Heterogeneity in Cancer.

Authors: MacDonald, William J., Purcell, Connor, Pinho-Schwermann, Maximilian, Stubbs, Nolan M., Srinivasan, Praveen R., El-Deiry, Wafik S.

Source: Cancers; Feb2025, Vol. 17 Issue 3, p441, 28p

Subject Terms: TUMOR treatment, TUMOR genetics, DRUG resistance in cancer cells, EPIGENOMICS, CELL physiology, METASTASIS, MOLECULAR biology, TUMORS, GENETIC mutation, DISEASE progression

Predicted Immunogenicity of CDK12 Biallelic Loss-of-Function Tumors Varies across Cancer Types

Authors: Elliott, Andrew, Zhang, Jian, Zhang, Qing, Swensen, Jeffrey, Martin, Daniel, Xiu, Joanne, Geynisman, Daniel M., Vaena, Daniel, Herzog, Thomas J., Holloway, Robert W., El-Deiry, Wafik S., Spetzler, David, Heath, Elisabeth, Stafford, Phillip, Korn, W. Michael

Source: In The Journal of Molecular Diagnostics December 2021 23(12):1761-1773

EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG

Authors: Zhang, Yiqun, Zhou, Lanlan, Safran, Howard, Borsuk, Robyn, Lulla, Rishi, Tapinos, Nikos, Seyhan, Attila A., El-Deiry, Wafik S.

Source: In Neoplasia August 2021 23(8):792-810

Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting

Authors: Hernández Borrero, Liz J., El-Deiry, Wafik S.

Source: In BBA - Reviews on Cancer August 2021 1876(1)

Natural Killer Cell Infiltration in Prostate Cancers Predict Improved Patient Outcomes

Authors: Zorko, Nicholas A., Makovec, Allison, Elliott, Andrew, Kellen, Samuel, Lozada, John R., Arafa, Ali T., Felices, Martin, Shackelford, Madison, Barata, Pedro, Zakharia, Yousef, Narayan, Vivek, Stein, Mark N., Zarrabi, Kevin K., Patniak, Akash, Bilen, Mehmet A., Radovich, Milan, Sledge, George, El-Deiry, Wafik S., Heath, Elisabeth I., Hoon, Dave S. B., Nabhan, Chadi, Miller, Jeffrey S., Hwang, Justin H., Antonarakis, Emmanuel S.

Source: Prostate Cancer and Prostatic Diseases; March 2025, Vol. 28 Issue: 1 p129-137, 9p

First-in-Human Phase 1b Trial of Quinacrine Plus Capecitabine in Patients With Refractory Metastatic Colorectal Cancer

Authors: Winer, Arthur, Denlinger, Crystal S., Vijayvergia, Namrata, Cohen, Steven J., Astaturov, Igor, Dotan, Efrat, Gallant, Jean-Nicolas, Wang, Edward W., Kunkel, Miriam, Lim, Bora, Harvey, Harold A., Sivik, Jeffrey, Korzekwa, Kenneth, Ruth, Karen, White, Kevin, Cooper, Harry S., Ross, Eric A., Zhou, Lanlan, El-Deiry, Wafik S.

Source: In Clinical Colorectal Cancer March 2021 20(1):e43-e52

P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9

Authors: Tian, Xiaobing, Ahsan, Nagib, Lulla, Amriti, Lev, Avital, Abbosh, Philip, Dicker, David T., Zhang, Shengliang, El-Deiry, Wafik S.

Source: In Neoplasia March 2021 23(3):304-325

Antitumorigenic effect of combination treatment with ONC201 and TRAIL in endometrial cancer in vitro and in vivo

Authors: Ray, Jocelyn E., Ralff, Marie D., Jhaveri, Aakash, Zhou, Lanlan, Dicker, David T., Ross, Eric A., El-Deiry, Wafik S.

Source: Cancer biology & therapy. 22(10-12):554-563

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137295542.0x000001&indx=1&recIds=ETOCvdc_100137295542.0x000001

Combination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo

Authors: Jhaveri, Aakash V., Zhou, Lanlan, Ralff, Marie D., Lee, Young S., Navaraj, Arunasalam, Carneiro, Benedito A., Safran, Howard, Prabhu, Varun V., Ross, Eric A., Lee, Seulki, El-Deiry, Wafik S.

Source: Cancer biology & therapy. 22(10-12):607-618

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137295523.0x000001&indx=1&recIds=ETOCvdc_100137295523.0x000001

Strategies to sensitize cancer cells to immunotherapy

Authors: George, Andrew, Sahin, Ilyas, Carneiro, Benedito A., Dizon, Don S., Safran, Howard P., El-Deiry, Wafik S.

Source: Human vaccines & immunotherapeutics. 17(8):2595-2601

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130268139.0x000001&indx=1&recIds=ETOCvdc_100130268139.0x000001

The Role of BCL-2 Proteins in the Development of Castration-resistant Prostate Cancer and Emerging Therapeutic Strategies

Authors: Soliman, Luke, De Souza, Andre, Srinivasan, Praveen, Danish, Matthew, Bertone, Paul, El-Deiry, Wafik S., Carneiro, Benedito A.

Source: American journal of clinical oncology. 44(7):374-382

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180631375.0x000001&indx=1&recIds=ETOCvdc_100180631375.0x000001

Mutations in DNA Repair Genes and Clinical Outcomes of Patients With Metastatic Colorectal Cancer Receiving Oxaliplatin or Irinotecan-containing Regimens

Authors: Marks, Eric I., Matera, Robert, Olszewski, Adam J., Yakirevich, Evgeny, El-Deiry, Wafik S., Safran, Howard, Carneiro, Benedito A.

Source: American journal of clinical oncology. 44(2):68-73

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180631057.0x000001&indx=1&recIds=ETOCvdc_100180631057.0x000001

Targeting the SMURF2-HIF1α axis: a new frontier in cancer therapy.

Authors: Youssef, Emile, Zhao, Shuai, Purcell, Connor, Olson, Gary L., El-Deiry, Wafik S.

Source: Frontiers in Oncology; 2024, p1-20, 20p

Subject Terms: METABOLIC reprogramming, TUMOR microenvironment, HYPOXIA-inducible factors, CANCER invasiveness, CLINICAL medicine, ONCOLOGY, HYPOXIA-inducible factor 1

Genomic, immunologic, and prognostic associations of TROP2 (TACSTD2) expression in solid tumors.

Authors: Morgenstern-Kaplan, Dan, Kareff, Samuel A, Trabolsi, Asaad, Rodriguez, Estelamari, Krause, Harris, Ribeiro, Jennifer R, Tan, Heng, Antonarakis, Emmanuel S, Lou, Emil, Nagasaka, Misako, Algaze, Sandra, Lenz, Heinz-Josef, Liu, Stephen V, Halmos, Balazs, Hoon, Dave S B, Seeber, Andreas, Ma, Patrick C, El-Deiry, Wafik S, Vanderwalde, Ari M, Lopes, Gilberto

Source: Oncologist; Nov2024, Vol. 29 Issue 11, pe1480-e1491, 12p

Subject Terms: PROTEINS, GENOMICS, RESEARCH funding, BREAST tumors, FISHER exact test, DNA, COLORECTAL cancer, DESCRIPTIVE statistics, MANN Whitney U Test, CHI-squared test, GENE expression, IMMUNOHISTOCHEMISTRY, KAPLAN-Meier estimator, PANCREATIC tumors, GENES, GENE expression profiling, TUMORS, TUMOR antigens, GENETIC mutation, SEQUENCE analysis, OVERALL survival, HEPATOCELLULAR carcinoma, CYCLIN-dependent kinases

Geographic Terms: ARIZONA

ONC201 and imipridones: Anti-cancer compounds with clinical efficacy

Authors: Prabhu, Varun Vijay, Morrow, Sara, Rahman Kawakibi, Abed, Zhou, Lanlan, Ralff, Marie, Ray, Jocelyn, Jhaveri, Aakash, Ferrarini, Isacco, Lee, Young, Parker, Cassandra, Zhang, Yiqun, Borsuk, Robyn, Chang, Wen-I, Honeyman, Joshua N., Tavora, Fabio, Carneiro, Benedito, Raufi, Alexander, Huntington, Kelsey, Carlsen, Lindsey, Louie, Anna, Safran, Howard, Seyhan, Attila A., Tarapore, Rohinton S., Schalop, Lee, Stogniew, Martin, Allen, Joshua E., Oster, Wolfgang, El-Deiry, Wafik S.

Source: In Neoplasia December 2020 22(12):725-744

Molecular characteristics of BRCA1/2 and PALB2 mutations in pancreatic ductal adenocarcinoma

Authors: Seeber, Andreas, Zimmer, Kai, Kocher, Florian, Puccini, Alberto, Xiu, Joanne, Nabhan, Chadi, Elliott, Andrew, Goldberg, Richard M., Grothey, Axel, Shields, Anthony F., Battaglin, Francesca, El-Deiry, Wafik S., Philip, Philip A., Marshall, John L., Hall, Michael, Korn, W. Michael, Lenz, Heinz-Josef, Wolf, Dominik, Feistritzer, Clemens, Spizzo, Gilbert

Source: In ESMO Open 2020 5(6)

Molecular profile of BRCA-mutated biliary tract cancers

Authors: Spizzo, Gilbert, Puccini, Alberto, Xiu, Joanne, Goldberg, Richard M., Grothey, Axel, Shields, Anthony F., Arora, Sukeshi Patel, Khushman, Moh’d, Salem, Mohamed E., Battaglin, Francesca, Baca, Yasmine, El-Deiry, Wafik S., Philip, Philip A., Nassem, Madiha, Hall, Michael, Marshall, John L., Kocher, Florian, Amann, Arno, Wolf, Dominik, Korn, W. Michael, Lenz, Heinz-Josef, Seeber, Andreas

Source: In ESMO Open 2020 5(3)