The effect of lactate dehydrogenase-A inhibition on intracellular nucleotides and mitochondrial respiration in pancreatic cancer cells

Authors: Franczak, Marika, Kutryb-Zajac, Barbara, El Hassouni, Btissame, Giovannetti, Elisa, Granchi, Carlotta, Minutolo, Filippo, Smolenski, Ryszard T., Peters, Godefridus J.

Source: Nucleosides, nucleotides & nucleic acids. 41(12):1375-1385

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189313997.0x000001&indx=1&recIds=ETOCvdc_100189313997.0x000001

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

Authors: El Hassouni, Btissame, Granchi, Carlotta, Vallés-Martí, Andrea, Supadmanaba, I Gede Putu, Bononi, Giulia, Tuccinardi, Tiziano, Funel, Niccola, Jimenez, Connie R., Peters, Godefridus J., Giovannetti, Elisa, Minutolo, Filippo

Source: In Seminars in Cancer Biology February 2020 60:238-248

The role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment

Authors: Buckens, Oscar J, El Hassouni, Btissame, Giovannetti, Elisa, Peters, Godefridus J

Source: Expert opinion on investigational drugs. 29(6):567-582

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110698626.0x000001&indx=1&recIds=ETOCvdc_100110698626.0x000001

Exploring Splicing Modulation as an Innovative Approach to Combat Pancreatic Cancer: SF3B1 Emerges as a Prognostic Indicator and Therapeutic Target.

Authors: Sciarrillo, Rocco, Terrana, Francesca, Comandatore, Annalisa, Supadmanaba, I. Gede Putu, Bing Wang, El Hassouni, Btissame, Mantini, Giulia, Jansen, Gerrit, Avan, Amir, Carbone, Daniela, Diana, Patrizia, Peters, Godefridus J., Morelli, Luca, Cloos, Jacqueline, Assaraf, Yehuda G., Giovannetti, Elisa

Source: International Journal of Biological Sciences; 2024, Vol. 20 Issue 9, p3173-3184, 12p

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma

Authors: Sciarrillo, Rocco, Wojtuszkiewicz, Anna, El Hassouni, Btissame, Funel, Niccola, Gandellini, Paolo, Lagerweij, Tonny, Buonamici, Silvia, Blijlevens, Maxime, Zeeuw van der Laan, Eveline A., Zaffaroni, Nadia, Deraco, Marcello, Kusamura, Shigeki, Würdinger, Tom, Peters, Godefridus J., Molthoff, Carla F.M., Jansen, Gerrit, Kaspers, Gertjan J.L., Cloos, Jacqueline, Giovannetti, Elisa

Source: In EBioMedicine January 2019 39:215-225

MicroRNAs as a drug resistance mechanism to targeted therapies in EGFR-mutated NSCLC: Current implications and future directions

Authors: Leonetti, Alessandro, Assaraf, Yehuda G., Veltsista, Paraskevi D., El Hassouni, Btissame, Tiseo, Marcello, Giovannetti, Elisa

Source: In Drug Resistance Updates January 2019 42:1-11

Targeting the Ribosome Biogenesis Key Molecule Fibrillarin to Avoid Chemoresistance

Authors: El Hassouni, Btissame, Sarkisjan, Dzjemma, Vos, J. Chris, Giovannetti, Elisa, Peters, Godefridus J.

Source: Current medicinal chemistry. 26(33):6020-6032

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094348707.0x000001&indx=1&recIds=ETOCvdc_100094348707.0x000001

RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment

Authors: Balboni, Beatrice, El Hassouni, Btissame, Honeywell, Richard J., Sarkisjan, Dzjemma, Giovannetti, Elisa, Poore, Julie, Heaton, Callie, Peterson, Christine, Benaim, Ely, Lee, Young B., Kim, Deog J., Peters, Godefridus J.

Source: Expert opinion on investigational drugs. 28(4):311-322

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100078265580.0x000001&indx=1&recIds=ETOCvdc_100078265580.0x000001

Pharmacogenetics of treatments for pancreatic cancer

Authors: El Hassouni, Btissame, Li Petri, Giovanna, Liu, Daniel S.K., Cascioferro, Stella, Parrino, Barbara, Hassan, Waqar, Diana, Patrizia, Ali, Asif, Frampton, Adam E, Giovannetti, Elisa

Source: Expert opinion on drug metabolism and toxicology. 15(6):437-447

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100106462400.0x000001&indx=1&recIds=ETOCvdc_100106462400.0x000001

Antibiotics and Adverse Events in Patients with Pancreatic Cancer Treated with Gemcitabine: Looking for Novel Clinical and Preclinical Insights

Authors: El Hassouni, Btissame, Gregori, Alessandro, Puik, Jisce R., Deng, Dongmei, Kazemier, Geert, Giovannetti, Elisa

Source: Oncologist. 26(12):e2306-e2307

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137011003.0x000001&indx=1&recIds=ETOCvdc_100137011003.0x000001

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds.

Authors: Li Petri, Giovanna^1,2 (AUTHOR), El Hassouni, Btissame¹ (AUTHOR), Sciarrillo, Rocco^1,3,4 (AUTHOR), Funel, Niccola⁵ (AUTHOR), Mantini, Giulia^1,6 (AUTHOR), Zeeuw van der Laan, Eveline A.¹ (AUTHOR), Cascioferro, Stella² (AUTHOR), Avan, Amir^1,7 (AUTHOR), Zucali, Paolo Andrea⁸ (AUTHOR), Zaffaroni, Nadia⁹ (AUTHOR), Lagerweij, Tonny¹⁰ (AUTHOR), Parrino, Barbara² (AUTHOR), Smid, Kees¹ (AUTHOR), Deraco, Marcello¹¹ (AUTHOR), Granchi, Carlotta¹² (AUTHOR), Braczko, Alicja¹³ (AUTHOR), Smolenski, Ryszard T.¹³ (AUTHOR), Matherly, Larry H.¹⁴ (AUTHOR), Jansen, Gerrit¹⁵ (AUTHOR), Assaraf, Yehuda G.¹⁶ (AUTHOR)

Source: British Journal of Cancer. Aug2020, Vol. 123 Issue 4, p644-656. 13p.

Proteomic analysis of gemcitabine-resistant pancreatic cancer cells reveals that microtubule-associated protein 2 upregulation associates with taxane treatment.

Authors: Le Large, Tessa Ya Sung, El Hassouni, Btissame, Funel, Niccola, Kok, Bart, Piersma, Sander R., Pham, Thang V., Olive, Kenneth P., Kazemier, Geert, van Laarhoven, Hanneke W.M., Jimenez, Connie R., Bijlsma, Maarten F., Giovannetti, Elisa

Source: Therapeutic Advances in Medical Oncology; 5/10/2019, Vol. 11, p1-17, 17p

Gemcitabine resistant pancreatic cancer cells are sensitive to paclitaxel treatment

Authors: Le Large, Tessa, El Hassouni, Btissame, Kazemier, Geert, van Laarhoven, Hanneke, Jimenez, Connie, Bijlsma, Maarten, Giovannetti, Elisa

Source: Pancreatology. 17(3):S42-S42

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100050923914.0x000001&indx=1&recIds=ETOCvdc_100050923914.0x000001

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CX-5461 Inhibits Pancreatic Ductal Adenocarcinoma Cell Growth, Migration and Induces DNA Damage.

Authors: El Hassouni, Btissame¹ (AUTHOR) b.elhassouni@amsterdamumc.nl, Mantini, Giulia¹ (AUTHOR) g.mantini@amsterdamumc.nl, Immordino, Benoît¹ (AUTHOR) benoit-immordino@hotmail.com, Peters, Godefridus J.^1,2 (AUTHOR) gj.peters@amsterdamumc.nl, Giovannetti, Elisa^1,3 (AUTHOR) elisa.giovannetti@gmail.com, Diana, Patrizia (AUTHOR)

Source: Molecules. Dec2019, Vol. 24 Issue 24, p4445. 1p. 3 Charts, 3 Graphs.

Subject Terms: *DNA damage, *CELL growth, *DOUBLE-strand DNA breaks, *ORGANELLE formation, *RIBOSOMES, *CANCER cell migration

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Dynamic Evaluation of Circulating miRNA Profile in EGFR -Mutated NSCLC Patients Treated with EGFR-TKIs.

Authors: Leonetti, Alessandro, Capula, Mjriam, Minari, Roberta, Mazzaschi, Giulia, Gregori, Alessandro, El Hassouni, Btissame, Papini, Filippo, Bordi, Paola, Verzè, Michela, Avan, Amir, Tiseo, Marcello, Giovannetti, Elisa

Source: Cells (2073-4409); Jun2021, Vol. 10 Issue 6, p1520-1520, 1p

Subject Terms: EPIDERMAL growth factor receptors, MICRORNA, NON-small-cell lung carcinoma, KINASE inhibitors, DISEASE progression

RX-3117 (Fluorocyclopentenyl-Cytosine)-Mediated Down-Regulation of DNA Methyltransferase 1 Leads to Protein Expression of Tumor-Suppressor Genes and Increased Functionality of the Proton-Coupled Folate Carrier.

Authors: Sarkisjan, Dzjemma, Julsing, Joris R., El Hassouni, Btissame, Honeywell, Richard J., Kathmann, Ietje, Matherly, Larry H., Lee, Young B., Kim, Deog J., Peters, Godefridus J.

Source: International Journal of Molecular Sciences; 4/15/2020, Vol. 21 Issue 8, p2717-2717, 1p, 1 Diagram, 2 Charts, 2 Graphs

Subject Terms: P16 gene, TUMOR suppressor genes, DNA methyltransferases, PROTEIN expression, FOLIC acid, GENE expression, GENETIC regulation

3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma.

Authors: Cascioferro, Stella, Li Petri, Giovanna, Parrino, Barbara, El Hassouni, Btissame, Carbone, Daniela, Arizza, Vincenzo, Perricone, Ugo, Padova, Alessandro, Funel, Niccola, Peters, Godefridus J., Cirrincione, Girolamo, Giovannetti, Elisa, Diana, Patrizia

Source: Molecules; 1/15/2020, Vol. 25 Issue 2, p329, 1p, 2 Diagrams, 2 Charts, 2 Graphs

Subject Terms: THIADIAZOLES, ANTINEOPLASTIC agents, ADENOCARCINOMA, ANIMAL models in research, PANCREATIC diseases, CELL lines