Leptomeningeal collaterals regulate reperfusion in ischemic stroke and rescue the brain from futile recanalization

Authors: Binder, Nadine Felizitas, El Amki, Mohamad, Glück, Chaim, Middleham, William, Reuss, Anna Maria, Bertolo, Adrien, Thurner, Patrick, Deffieux, Thomas, Lambride, Chryso, Epp, Robert, Handelsmann, Hannah-Lea, Baumgartner, Philipp, Orset, Cyrille, Bethge, Philipp, Kulcsar, Zsolt, Aguzzi, Adriano, Tanter, Mickael, Schmid, Franca, Vivien, Denis, Wyss, Matthias Tasso, Luft, Andreas, Weller, Michael, Weber, Bruno, Wegener, Susanne

Source: In Neuron 1 May 2024 112(9):1456-1472

Vascular Response to Spreading Depolarization Predicts Stroke Outcome

Authors: Binder, Nadine Felizitas, Glück, Chaim, Middleham, William, Alasoadura, Michael, Pranculeviciute, Nikolete, Wyss, Matthias Tasso, Chuquet, Julien, Weber, Bruno, Wegener, Susanne, El Amki, Mohamad

Source: Stroke. 53(4):1386-1395

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Transcranial Cortex-Wide Imaging of Murine Ischemic Perfusion With Large-Field Multifocal Illumination Microscopy.

Authors: Chen, Zhenyue, Zhou, Quanyu, Droux, Jeanne, Liu, Yu-Hang, Glück, Chaim, Gezginer, Irmak, Wyss, Matthias, Yoshihara, Hikari A.I., Kindler, Diana Rita, Weber, Bruno, Wegener, Susanne, El Amki, Mohamad, Razansky, Daniel

Source: Stroke (00392499); Jan2025, Vol. 56 Issue 1, p170-182, 13p

Circle of Willis variants and their association with outcome in patients with middle cerebral artery‐M1‐occlusion stroke

Authors: Westphal, Laura P., Lohaus, Niklas, Winklhofer, Sebastian, Manzolini, Christian, Held, Ulrike, Steigmiller, Klaus, Hamann, Janne M., El Amki, Mohamad, Dobrocky, Tomas, Panos, Leonidas D., Kaesmacher, Johannes, Fischer, Urs, Heldner, Mirjam R., Luft, Andreas R., Gralla, Jan, Arnold, Marcel, Wiest, Roland, Wegener, Susanne

Source: European journal of neurology. 28(11):3682-3691

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139821096.0x000001&indx=1&recIds=ETOCvdc_100139821096.0x000001

Bessel beam optical coherence microscopy enables multiscale assessment of cerebrovascular network morphology and function.

Authors: Glandorf, Lukas^1,2, Wittmann, Bastian³, Droux, Jeanne⁴, Glück, Chaim¹, Weber, Bruno¹, Wegener, Susanne⁴, El Amki, Mohamad⁴, Leitgeb, Rainer⁵, Menze, Bjoern³, Razansky, Daniel^1,2, daniel.razansky@uzh.ch

Source: Light: Science & Applications; 11/11/2024, Vol. 13 Issue 1, p1-14, 14p

Crossed Cerebellar Diaschisis Indicates Hemodynamic Compromise in Ischemic Stroke Patients

Authors: von Bieberstein, Lita, van Niftrik, Christiaan Hendrik Bas, Sebök, Martina, El Amki, Mohamad, Piccirelli, Marco, Stippich, Christoph, Regli, Luca, Luft, Andreas R., Fierstra, Jorn, Wegener, Susanne

Source: Translational stroke research. 12(1):39-48

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194145191.0x000001&indx=1&recIds=ETOCvdc_100194145191.0x000001

Urantide Improves Cardiac Function, Modulates Systemic Cytokine Response, and Increases Survival in A Murine Model of Endotoxic Shock

Authors: Clavier, Thomas, Besnier, Emmanuel, Maucotel, Julie, Arabo, Arnaud, Desrues, Laurence, El Amki, Mohamad, Perzo, Nicolas, Richard, Vincent, Tamion, Fabienne, Gandolfo, Pierrick, Dubois, Martine, Castel, Hélène, Compère, Vincent

Source: Shock. 54(4):574-582

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181579101.0x000001&indx=1&recIds=ETOCvdc_100181579101.0x000001

Pia-FLOW: Deciphering hemodynamic maps of the pial vascular connectome and its response to arterial occlusion.

Authors: Glück, Chaim, Quanyu Zhou, Droux, Jeanne, Zhenyue Chen, Glandorf, Lukas, Wegener, Susanne, Razansky, Daniel, Weber, Bruno, El Amki, Mohamad

Source: Proceedings of the National Academy of Sciences of the United States of America; 7/9/2024, Vol. 121 Issue 28, p1-9, 15p

Subject Terms: ARTERIAL occlusions, HEMODYNAMICS, FLUID dynamics, FLOW velocity, BONE marrow

Association between vasoactive peptide urotensin II in plasma and cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a potential therapeutic target

Authors: Clavier, Thomas, Mutel, Alexandre, Desrues, Laurence, Lefevre-Scelles, Antoine, Gastaldi, Gioia, El Amki, Mohamad, Dubois, Martine, Melot, Anthony, Wurtz, Véronique, Curey, Sophie

Source: Journal of neurosurgery. 131(4):1278-1288

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN621579689&indx=1&recIds=ETOCRN621579689

Cortex-wide transcranial localization microscopy with fluorescently labeled red blood cells.

Authors: Zhou, Quanyu, Glück, Chaim, Tang, Lin, Glandorf, Lukas, Droux, Jeanne, El Amki, Mohamad, Wegener, Susanne, Weber, Bruno, Razansky, Daniel, Chen, Zhenyue

Source: Nature Communications; 4/25/2024, Vol. 15 Issue 1, p1-11, 11p

Subject Terms: ERYTHROCYTES, CEREBRAL angiography, MICROSCOPY, FLOW velocity, SPATIAL resolution, CEREBRAL circulation

Hypothalamic, thalamic and hippocampal lesions in the mouse MCAO model: Potential involvement of deep cerebral arteries?

Authors: El Amki, Mohamad, Clavier, Thomas, Perzo, Nicolas, Bernard, René, Guichet, Pierre-Olivier, Castel, Hélène

Source: In Journal of Neuroscience Methods 30 October 2015 254:80-85

Long-Lasting Cerebral Vasospasm, Microthrombosis, Apoptosis and Paravascular Alterations Associated with Neurological Deficits in a Mouse Model of Subarachnoid Hemorrhage

Authors: El Amki, Mohamad, Dubois, Martine, Lefevre-Scelles, Antoine, Magne, Nicolas, Roussel, Mélanie, Clavier, Thomas, Guichet, Pierre-Olivier, Gérardin, Emmanuel, Compère, Vincent, Castel, Hélène

Source: Molecular neurobiology. 55(4):2763-2779

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128588510.0x000001&indx=1&recIds=ETOCvdc_100128588510.0x000001

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke

Authors: Orset, Cyrille, Haelewyn, Benoit, Allan, Stuart M., Ansar, Saema, Campos, Francesco, Cho, Tae Hee, Durand, Anne, El Amki, Mohamad, Fatar, Marc, Garcia-Yébenes, Isaac, Gauberti, Maxime, Grudzenski, Saskia, Lizasoain, Ignacio, Lo, Eng, Macrez, Richard, Margaill, Isabelle, Maysami, Samaneh, Meairs, Stephen, Nighoghossian, Norbert, Orbe, Josune, Paramo, Jose Antonio, Parienti, Jean-Jacques, Rothwell, Nancy J., Rubio, Marina, Waeber, Christian, Young, Alan R., Touzé, Emmanuel, Vivien, Denis

Source: Stroke. 47(5):1312-1318

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100030739719.0x000001&indx=1&recIds=ETOCvdc_100030739719.0x000001

The role of leptomeningeal collaterals in redistributing blood flow during stroke.

Authors: Epp, Robert, Glück, Chaim, Binder, Nadine Felizitas, El Amki, Mohamad, Weber, Bruno, Wegener, Susanne, Jenny, Patrick, Schmid, Franca

Source: PLoS Computational Biology; 10/23/2023, Vol. 19 Issue 10, p1-33, 33p, 3 Diagrams, 2 Graphs

Subject Terms: COLLATERAL circulation, BLOOD flow, ANTERIOR cerebral artery, STROKE, CEREBRAL arteries, ISCHEMIC stroke, BLOOD flow measurement, ARTERIAL occlusions

Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke

Authors: El Amki, Mohamad, Glück, Chaim, Binder, Nadine, Middleham, William, Wyss, Matthias T., Weiss, Tobias, Meister, Hanna, Luft, Andreas, Weller, Michael, Weber, Bruno, Wegener, Susanne

Source: Cell reports. 33(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115601628.0x000001&indx=1&recIds=ETOCvdc_100115601628.0x000001

Ultrasound trapping and navigation of microrobots in the mouse brain vasculature.

Authors: Del Campo Fonseca, Alexia, Glück, Chaim, Droux, Jeanne, Ferry, Yann, Frei, Carole, Wegener, Susanne, Weber, Bruno, El Amki, Mohamad, Ahmed, Daniel

Source: Nature Communications; 9/21/2023, Vol. 14 Issue 1, p1-14, 14p

Subject Terms: MICROROBOTS, BLOOD vessels, MICROBUBBLE diagnosis, OSMOTIC pressure, BRAIN anatomy, ULTRASONIC imaging

Resolving the Smoking Paradox: No Evidence for Smoking-Induced Preconditioning in Large Vessel Occlusion Stroke.

Authors: Widmer, Roni E., Bink, Andrea, Hamann, Janne, Herzog, Lisa, El Amki, Mohamad, Sarikaya, Hakan, Kulcsar, Zsolt, Luft, Andreas R., Wegener, Susanne

Source: European Neurology; 2023, Vol. 86 Issue 5, p325-333, 9p

Subject Terms: STROKE, STROKE patients, DISEASE risk factors, SMOKING

Experimental modeling of recombinant tissue plasminogen activator effects after ischemic stroke

Authors: El Amki, Mohamad, Lerouet, Dominique, Coqueran, Bérard, Curis, Emmanuel, Orset, Cyrille, Vivien, Denis, Plotkine, Michel, Marchand-Leroux, Catherine, Margaill, Isabelle

Source: In Experimental Neurology December 2012 238(2):138-144

Deep optoacoustic localization microangiography of ischemic stroke in mice.

Authors: Deán-Ben, Xosé Luís, Robin, Justine, Nozdriukhin, Daniil, Ni, Ruiqing, Zhao, Jim, Glück, Chaim, Droux, Jeanne, Sendón-Lago, Juan, Chen, Zhenyue, Zhou, Quanyu, Weber, Bruno, Wegener, Susanne, Vidal, Anxo, Arand, Michael, El Amki, Mohamad, Razansky, Daniel

Source: Nature Communications; 6/16/2023, Vol. 14 Issue 1, p1-11, 11p

Subject Terms: ISCHEMIC stroke, BLOOD cells, LIGHT absorption, HIGH resolution imaging, CEREBRAL hemispheres

Sensorimotor stroke alters hippocampo-thalamic network activity

Authors: Baumgartner, Philipp, El Amki, Mohamad, Bracko, Oliver, Luft, Andreas R., Wegener, Susanne

Source: Scientific reports. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131118854.0x000001&indx=1&recIds=ETOCvdc_100131118854.0x000001