The Role of Pharmacometrics in Advancing the Therapies for Autoimmune Diseases

Authors: Artur Świerczek, Dominika Batko, Elżbieta Wyska

Source: Pharmaceutics, Vol 16, Iss 12, p 1559 (2024)

Subject Terms: pharmacometrics, autoimmune diseases, personalized medicine, PBPK modeling, PK/PD modeling, disease progression modeling, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/12/1559; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/97ee800ee34c46878e8e266b87dc039d

Pharmacokinetics and Quantitative Structure–Pharmacokinetics Relationship Study of Xanthine Derivatives with Antidepressant, Anti-Inflammatory, and Analgesic Activity in Rats

Authors: Artur Świerczek, Małgorzata Szafarz, Agnieszka Cios, Jan Kobierski, Krzysztof Pociecha, Daniel Attard Saliba, Grażyna Chłoń-Rzepa, Elżbieta Wyska

Source: Pharmaceutics, Vol 16, Iss 11, p 1463 (2024)

Subject Terms: quantitative structure–pharmacokinetics relationship, multivariate data analysis, regression analysis, methylxanthines, 7- and 7,8-substituted theophylline derivatives, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/11/1463; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/4901f3712d704e1bacafaa5777f5162f

Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins

Authors: Szczepan Mogilski, Monika Kubacka, Artur Świerczek, Elżbieta Wyska, Katarzyna Szczepańska, Jacek Sapa, Katarzyna Kieć-Kononowicz, Dorota Łażewska

Source: Pharmaceuticals, Vol 16, Iss 10, p 1481 (2023)

Subject Terms: pain, pruritus, itch, histamine H3 receptor, sigma receptors, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/10/1481; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/6cd04dd7b53146d69e2538b00099cbd6

Combined hyperforin and lanicemine treatment instead of ketamine or imipramine restores behavioral deficits induced by chronic restraint stress and dietary zinc restriction in mice

Authors: Bartłomiej Pochwat, Paulina Misztak, Julia Masternak, Ewa Bączyńska, Krystian Bijata, Matylda Roszkowska, Monika Bijata, Jakub Włodarczyk, Małgorzata Szafarz, Elżbieta Wyska, Bożena Muszyńska, Agata Krakowska, Włodzimierz Opoka, Gabriel Nowak, Bernadeta Szewczyk

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: refractory depression, ketamine, hyperforin and lanicemine, zinc deficiency, chronic stress, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.933364/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/b358d4e3043d414eb1864ae94ad23e41

Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment

Authors: Mateusz Pieróg, Katarzyna Socała, Dorota Nieoczym, Elżbieta Wyska, Małgorzata Samorek-Pieróg, Piotr Wlaź

Source: Molecules, Vol 28, Iss 9, p 3810 (2023)

Subject Terms: caproic acid, caprylic acid, lauric acid, metformin, mice, seizures, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/9/3810; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/865b190ff2b3427693b829fd7330aba0

Pharmacokinetic/Pharmacodynamic Evaluation of a New Purine-2,6-Dione Derivative in Rodents with Experimental Autoimmune Diseases

Authors: Artur Świerczek, Krzysztof Pociecha, Hanna Plutecka, Marietta Ślusarczyk, Grażyna Chłoń-Rzepa, Elżbieta Wyska

Source: Pharmaceutics, Vol 14, Iss 5, p 1090 (2022)

Subject Terms: disease progression modeling, phosphodiesterase inhibitors, rheumatoid arthritis, multiple sclerosis, autoimmune hepatitis, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/5/1090; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/6229171f68fc4b698ffb605466b18254

Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation

Authors: Katarzyna Wójcik-Pszczoła, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Bruno Ferreira, Paulina Koczurkiewicz-Adamczyk, Elżbieta Pękala, Elżbieta Wyska, Krzysztof Pociecha, Reinoud Gosens

Source: Pharmaceuticals, Vol 15, Iss 4, p 423 (2022)

Subject Terms: phosphodiesterase inhibitors, alveolar epithelial type II cells, transforming growth factor type β, asthma, lung fibrosis, airway remodeling, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/15/4/423; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/a628a0c1f9554f039d360a1729feea03

Effect of Ellagic Acid on Seizure Threshold in Two Acute Seizure Tests in Mice

Authors: Mateusz Pieróg, Katarzyna Socała, Elżbieta Wyska, Ewa Poleszak, Piotr Wlaź

Source: Molecules, Vol 26, Iss 16, p 4841 (2021)

Subject Terms: ellagic acid, mice, seizure models, pentylenetetrazole, seizure threshold, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/16/4841; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/7228f5d331df4b79a82fedb328412274

PK/PD Modeling of the PDE7 Inhibitor—GRMS-55 in a Mouse Model of Autoimmune Hepatitis

Authors: Artur Świerczek, Hanna Plutecka, Marietta Ślusarczyk, Grażyna Chłoń-Rzepa, Elżbieta Wyska

Source: Pharmaceutics, Vol 13, Iss 5, p 597 (2021)

Subject Terms: disease progression modeling, phosphodiesterase inhibitors, cytokines, concanavalin A-induced hepatitis, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/5/597; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/609c476067c8494e8b794168fc7ec429

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.