Enhancing dementia prediction: A 19-year validation of the CAIDE risk score with insulin resistance and APOE ε4 integration in a population-based cohort

Authors: Pietilä, Elina ^{a, b, ∗}, Löyttyniemi, Eliisa ^c, Koskinen, Seppo ^d, Lehtisalo, Jenni ^d, Viitanen, Matti ^{e, f}, Rinne, Juha O. ^{a, b, g}, Jula, Antti ^h, Ekblad, Laura L. ^{a, b, e}

Source: In The Journal of Prevention of Alzheimer's Disease February 2025 12(2)

Cognitively healthy APOE4/4 carriers show white matter impairment associated with serum NfL and amyloid-PET

Authors: Tato-Fernández, Claudia, Ekblad, Laura L., Pietilä, Elina, Saunavaara, Virva, Helin, Semi, Parkkola, Riitta, Zetterberg, Henrik, Blennow, Kaj, Rinne, Juha O., Snellman, Anniina

Source: In Neurobiology of Disease March 2024 192

Midlife insulin resistance, APOE genotype, and change in late-life brain beta-amyloid accumulation – A 5-year follow-up [11C]PIB-PET study

Authors: Pietilä, Elina, Snellman, Anniina, Tuisku, Jouni, Helin, Semi, Viitanen, Matti, Jula, Antti, Rinne, Juha O., Ekblad, Laura L.

Source: In Neurobiology of Disease January 2024 190

Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer's disease

Authors: Snellman, Anniina, Ekblad, Laura L., Ashton, Nicholas J., Karikari, Thomas K., Lantero-Rodriguez, Juan, Pietilä, Elina, Koivumäki, Mikko, Helin, Semi, Karrasch, Mira, Zetterberg, Henrik, Blennow, Kaj, Rinne, Juha O.

Source: In Neurobiology of Disease July 2023 183

Association of Midlife Inflammatory Markers With Cognitive Performance at 10-Year Follow-up

Authors: Kipinoinen, Teemu, Toppala, Sini, Rinne, Juha O., Viitanen, Matti H., Jula, Antti M., Ekblad, Laura L.

Source: Neurology. 99(20):e2294-e2302

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173127664.0x000001&indx=1&recIds=ETOCvdc_100173127664.0x000001

Proteomic correlates of cortical thickness in cognitively normal individuals with normal and abnormal cerebrospinal fluid beta-amyloid1-42

Authors: Ekblad, Laura L., Visser, Pieter Jelle, Tijms, Betty M.

Source: In Neurobiology of Aging November 2021 107:42-52

SV2A PET shows hippocampal synaptic loss in cognitively unimpaired APOE ε4/ε4 homozygotes.

Authors: Snellman, Anniina, Tuisku, Jouni, Koivumäki, Mikko, Wahlroos, Saara, Aarnio, Richard, Rajander, Johan, Karrasch, Mira, Ekblad, Laura L., Rinne, Juha O.

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2024, Vol. 20 Issue 12, p8802-8813, 12p

Midlife insulin resistance, APOE genotype, and change in late‐life brain amyloid accumulation – a 5‐year follow‐up 11C‐PIB‐PET study

Authors: Pietilä, Elina M., Ekblad, Laura L., Snellman, Anniina, Toppala, Sini, Tuisku, Jouni, Helin, Semi, Viitanen, Matti, Jula, Antti, Rinne, Juha O.

Source: Alzheimer's & dementia. 19(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186172316.0x000001&indx=1&recIds=ETOCvdc_100186172316.0x000001

APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly.

Authors: Snellman, Anniina^1,2 (AUTHOR) aepakk@utu.fi, Ekblad, Laura L.¹ (AUTHOR), Tuisku, Jouni¹ (AUTHOR), Koivumäki, Mikko¹ (AUTHOR), Ashton, Nicholas J.^2,3,4,5 (AUTHOR), Lantero-Rodriguez, Juan² (AUTHOR), Karikari, Thomas K.^2,6 (AUTHOR), Helin, Semi¹ (AUTHOR), Bucci, Marco^1,7,8 (AUTHOR), Löyttyniemi, Eliisa⁹ (AUTHOR), Parkkola, Riitta¹⁰ (AUTHOR), Karrasch, Mira¹¹ (AUTHOR), Schöll, Michael^2,12,13 (AUTHOR), Zetterberg, Henrik^{2,13,14,15,16} (AUTHOR), Blennow, Kaj^2,14 (AUTHOR), Rinne, Juha O.^1,17 (AUTHOR)

Source: Alzheimer's Research & Therapy. 4/4/2023, Vol. 15 Issue 1, p1-15. 15p.

Subject Terms: *GLIAL fibrillary acidic protein, *APOLIPOPROTEIN E, *TRANSLOCATOR proteins, *POSITRON emission tomography, *NEUROINFLAMMATION

Associations between CSF proteins and medial temporal lobe atrophy across the AD continuum

Authors: Ekblad, Laura L., Visser, Pieter Jelle, Tijms, Betty M.

Source: Alzheimer's & dementia. 17(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138979302.0x000001&indx=1&recIds=ETOCvdc_100138979302.0x000001

Chronic low‐grade inflammation predicts greater decline in verbal fluency and word‐list learning on 10 years' follow‐up

Authors: Kipinoinen, Teemu, Toppala, Sini, Viitanen, Matti, Rinne, Juha O., Jula, Antti, Ekblad, Laura L.

Source: Alzheimer's & dementia. 17(10)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153939807.0x000001&indx=1&recIds=ETOCvdc_100153939807.0x000001

Insulin resistance and body mass index are associated with TSPO PET in cognitively unimpaired elderly.

Authors: Ekblad, Laura L¹ (AUTHOR) llekbl@utu.fi, Tuisku, Jouni¹ (AUTHOR), Koivumäki, Mikko¹ (AUTHOR), Helin, Semi¹ (AUTHOR), Rinne, Juha O^1,2 (AUTHOR), Snellman, Anniina¹ (AUTHOR)

Source: Journal of Cerebral Blood Flow & Metabolism. Sep2023, Vol. 43 Issue 9, p1588-1600. 13p.

Impaired Early Insulin Response to Glucose Load Predicts Episodic Memory Decline: A 10-Year Population-Based Cohort Follow-Up of 45–74-Year-Old Men and Women.

Authors: Toppala, Sini^1,2 (AUTHOR) satopp@utu.fi, Ekblad, Laura L.¹ (AUTHOR), Viitanen, Matti^3,4 (AUTHOR), Rinne, Juha O.^1,5 (AUTHOR), Jula, Antti⁶ (AUTHOR)

Source: Journal of Alzheimer's Disease. 2023, Vol. 92 Issue 1, p349-359. 11p.

Subject Terms: *EPISODIC memory, *INSULIN, *GLUCOSE tolerance tests, *OLDER men, *MIDDLE-aged men, *HYPERGLYCEMIA

INSULIN RESISTANCE IS ASSOCIATED WITH A DECLINE IN VERBAL FLUENCY DURING 11 YEARS OF FOLLOW-UP

Authors: Ekblad, Laura L., Rinne, Juha O., Puukka, Pauli J., Laine, Hanna, Ahtiluoto, Satu, Sulkava, Raimo, Viitanen, Matti, Jula, Antti

Source: Alzheimer's & dementia. 15(7):P806-P807

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093005690.0x000001&indx=1&recIds=ETOCvdc_100093005690.0x000001

Midlife insulin resistance, APOE genotype, and change in late‐life brain amyloid accumulation – a 5‐year follow‐up ¹¹C‐PIB‐PET study.

Authors: Pietilä, Elina M., Ekblad, Laura L., Snellman, Anniina, Toppala, Sini, Tuisku, Jouni, Helin, Semi, Viitanen, Matti, Jula, Antti, Rinne, Juha O.

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Jun2023 Supplement 1, Vol. 19, p1-3, 3p

ASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer's Disease – Study Protocol and Baseline Characteristics.

Authors: Snellman, Anniina, Ekblad, Laura L., Koivumäki, Mikko, Lindgrén, Noora, Tuisku, Jouni, Perälä, Merja, Kallio, Lila, Lehtonen, Riina, Saunavaara, Virva, Saunavaara, Jani, Oikonen, Vesa, Aarnio, Richard, Löyttyniemi, Eliisa, Parkkola, Riitta, Karrasch, Mira, Zetterberg, Henrik, Blennow, Kaj, Rinne, Juha O.

Source: Frontiers in Neurology; 2/9/2022, Vol. 13, p1-14, 14p

Subject Terms: DISEASE risk factors, AMYLOID plaque, POSITRON emission tomography, CEREBROSPINAL fluid examination, MAGNETIC resonance imaging, NEUROINFLAMMATION

Company/Entity: GOTEBORGS universitet

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum

Authors: Jansen, Willemijn J., Janssen, Olin, Tijms, Betty M., Vos, Stephanie J. B., Ossenkoppele, Rik, Visser, Pieter Jelle, Aarsland, Dag, Alcolea, Daniel, Altomare, Daniele, von Arnim, Christine, Baiardi, Simone, Baldeiras, Ines, Barthel, Henryk, Bateman, Randall J., Van Berckel, Bart, Binette, Alexa Pichet, Blennow, Kaj, Boada, Merce, Boecker, Henning, Bottlaender, Michel, den Braber, Anouk, Brooks, David J., Van Buchem, Mark A., Camus, Vincent, Carill, Jose Manuel, Cerman, Jiri, Chen, Kewei, Chételat, Gaël, Chipi, Elena, Cohen, Ann D., Daniels, Alisha, Delarue, Marion, Didic, Mira, Drzezga, Alexander, Dubois, Bruno, Eckerström, Marie, Ekblad, Laura L., Engelborghs, Sebastiaan, Epelbaum, Stéphane, Fagan, Anne M., Fan, Yong, Fladby, Tormod, Fleisher, Adam S., Van der Flier, Wiesje M., Förster, Stefan, Fortea, Juan, Frederiksen, Kristian Steen, Freund-Levi, Yvonne, Frings, Lars, Frisoni, Giovanni B., Fröhlich, Lutz, Gabryelewicz, Tomasz, Gertz, Hermann-Josef, Gill, Kiran Dip, Gkatzima, Olymbia, Gómez-Tortosa, Estrella, Grimmer, Timo, Guedj, Eric, Habeck, Christian G., Hampel, Harald, Handels, Ron, Hansson, Oskar, Hausner, Lucrezia, Hellwig, Sabine, Heneka, Michael T., Herukka, Sanna-Kaisa, Hildebrandt, Helmut, Hodges, John, Hort, Jakub, Huang, Chin-Chang, Iriondo, Ane Juaristi, Itoh, Yoshiaki, Ivanoiu, Adrian, Jagust, William J., Jessen, Frank, Johannsen, Peter, Johnson, Keith A., Kandimalla, Ramesh, Kapaki, Elisabeth N., Kern, Silke, Kilander, Lena, Klimkowicz-Mrowiec, Aleksandra, Klunk, William E., Koglin, Norman, Kornhuber, Johannes, Kramberger, Milica G., Kuo, Hung-Chou, Van Laere, Koen, Landau, Susan M., Landeau, Brigitte, Lee, Dong Young, de Leon, Mony, Leyton, Cristian E., Lin, Kun-Ju, Lleó, Alberto, Löwenmark, Malin, Madsen, Karine, Maier, Wolfgang, Marcusson, Jan, Marquié, Marta, Martinez-Lage, Pablo, Maserejian, Nancy, Mattsson, Niklas, de Mendonça, Alexandre, Meyer, Philipp T., Miller, Bruce L., Minatani, Shinobu, Mintun, Mark A., Mok, Vincent C. T., Molinuevo, Jose Luis, Morbelli, Silvia Daniela, Morris, John C., Mroczko, Barbara, Na, Duk L., Newberg, Andrew, Nobili, Flavio, Nordberg, Agneta, Olde Rikkert, Marcel G. M., de Oliveira, Catarina Resende, Olivieri, Pauline, Orellana, Adela, Paraskevas, George, Parchi, Piero, Pardini, Matteo, Parnetti, Lucilla, Peters, Oliver, Poirier, Judes, Popp, Julius, Prabhakar, Sudesh, Rabinovici, Gil D., Ramakers, Inez H., Rami, Lorena, Reiman, Eric M., Rinne, Juha O., Rodrigue, Karen M., Rodríguez-Rodriguez, Eloy, Roe, Catherine M., Rosa-Neto, Pedro, Rosen, Howard J., Rot, Uros, Rowe, Christopher C., Rüther, Eckart, Ruiz, Agustín, Sabri, Osama, Sakhardande, Jayant, Sánchez-Juan, Pascual, Sando, Sigrid Botne, Santana, Isabel, Sarazin, Marie, Scheltens, Philip, Schröder, Johannes, Selnes, Per, Seo, Sang Won, Silva, Dina, Skoog, Ingmar, Snyder, Peter J., Soininen, Hilkka, Sollberger, Marc, Sperling, Reisa A., Spiru, Luisa, Stern, Yaakov, Stomrud, Erik, Takeda, Akitoshi, Teichmann, Marc, Teunissen, Charlotte E., Thompson, Louisa I., Tomassen, Jori, Tsolaki, Magda, Vandenberghe, Rik, Verbeek, Marcel M., Verhey, Frans R. J., Villemagne, Victor, Villeneuve, Sylvia, Vogelgsang, Jonathan, Waldemar, Gunhild, Wallin, Anders, Wallin, Åsa K., Wiltfang, Jens, Wolk, David A., Yen, Tzu-Chen, Zboch, Marzena, Zetterberg, Henrik

Source: JAMA Neurology; March 2022, Vol. 79 Issue: 3 p228-243, 16p

Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [¹¹C]PBR28 in Elderly Individuals Without Dementia.

Authors: Toppala, Sini, Ekblad, Laura L., Tuisku, Jouni, Helin, Semi, Johansson, Jarkko J., Laine, Hanna, Löyttyniemi, Eliisa, Marjamäki, Päivi, Blennow, Kaj, Zetterberg, Henrik, Jula, Antti, Viitanen, Matti, Rinne, Juha O.

Source: Neurology; 3/23/2021, Vol. 96 Issue 12, pe1608-e1619, 12p

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MIDLIFE INSULIN RESISTANCE AND LATE-LIFE COGNITION, BRAIN AMYLOID ACCUMULATION, AND CEREBROVASCULAR LESIONS

Authors: Ekblad, Laura L., Toppala, Sini, Lotjonen, Jyrki, Karrasch, Mira, Johansson, Jarkko, Helin, Semi, Puukka, Pauli, Laine, Hanna, Jula, Antti, Viitanen, Matti, Rinne, Juha O.

Source: Alzheimer's & dementia. 14(7):P613-P613

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100069584828.0x000001&indx=1&recIds=ETOCvdc_100069584828.0x000001