Resazurin dye is an in vivo sensor of kidney tubular function

Authors: Martinez, Shirely Acosta ^{1, 19}, Karel, Isaac Z. ^{1, 19}, Silvaroli, Josie A. ^{1, 19}, Ahmed, Eman ¹, Kim, Ji Young ¹, Stayton, Amanda ², Patel, Prisha S. ², Afjal, Mohammad Amir ², Horton, Thomas ², Bohmer, Margaret ¹, Vanichapol, Thitinee ³, Sander, Veronika ³, Andrade, Gabriel Mayoral ⁴, Allison, Corynne Vermillion ¹, Mondal, Milon ¹, Thorson, Victoria C. ¹, Partey, Alexandra ¹, Nimkar, Kartik ¹, Williams, Victoria ⁵, Quimby, Jessica ⁶, Ganesan, Latha ⁷, Madhavan, Sethu M. ⁷, Davidson, Alan J. ³, Peterson, Blake R. ⁸, Adebiyi, Adebowale ⁹, Rao, Reena ^{10, 11}, Sweet, Douglas H. ¹², Singh, Prabhleen ¹³, Bennett, Kevin M. ¹⁴, Zepeda-Orozco, Diana ⁴, Mallipattu, Sandeep K. ^{15, 16}, Eisenmann, Eric D. ¹, Sparreboom, Alex ¹, Rovin, Brad H. ⁷, Bajwa, Amandeep ^{2, 17, 18, ∗}, Pabla, Navjot S. ^{1, ∗}

Source: In Kidney International March 2025 107(3):508-520

Pharmacokinetic assessment of low dose decitabine in combination therapies: Development and validation of a sensitive UHPLC-MS/MS method for murine plasma analysis

Authors: Anabtawi, Nadeen, Drabison, Thomas, Jin, Yan, Eisenmann, Eric D., Sparreboom, Alex, Govindarajan, Rajgopal, Baker, Sharyn D., Ahmed, Eman

Source: In Journal of Chromatography B 15 July 2024 1242

Vincristine Disposition and Neurotoxicity Are Unchanged in Humanized CYP3A5 Mice

Authors: Li, Yang, Kazuki, Yasuhiro, Drabison, Thomas, Kobayashi, Kaoru, Fujita, Ken-ichi, Xu, Yue, Jin, Yan, Ahmed, Eman, Li, Junan, Eisenmann, Eric D., Baker, Sharyn D., Cavaletti, Guido, Sparreboom, Alex, Hu, Shuiying ^*

Source: In Drug Metabolism and Disposition February 2024 52(2):80-85

Exploring pharmacokinetics of talazoparib in ABCB1/ABCG2-deficient mice using a novel UHPLC-MS/MS method

Authors: Talebi, Zahra ^a, Garrison, Dominique A. ^b, Eisenmann, Eric D. ^a, Parmar, Kalindi ^c, Shapiro, Geoffrey I. ^{c, d}, Rudek, Michelle A. ^{b, e}, Sparreboom, Alex ^{a, ∗∗}, Jin, Yan ^{a, ∗}

Source: In Heliyon November 2023 9(11)

Determination of the endogenous OATP1B biomarkers glycochenodeoxycholate-3-sulfate and chenodeoxycholate-24-glucuronide in human and mouse plasma by a validated UHPLC-MS/MS method

Authors: Jin, Yan, Li, Yang, Eisenmann, Eric D., Figg, William D., Baker, Sharyn D., Sparreboom, Alex, Hu, Shuiying

Source: In Journal of Chromatography B 1 November 2022 1210

Boosting the oral bioavailability of anticancer drugs through intentional drug–drug interactions

Authors: Eisenmann, Eric D., Talebi, Zahra, Sparreboom, Alex, Baker, Sharyn D.

Source: Basic & clinical pharmacology & toxicology. 130:23-35

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138800233.0x000001&indx=1&recIds=ETOCvdc_100138800233.0x000001

BMX kinase mediates gilteritinib resistance in FLT3-mutated AML through microenvironmental factors

Authors: Buelow, Daelynn R. ^*, Bhatnagar, Bhavana ^*, Orwick, Shelley J., Jeon, Jae Yoon, Eisenmann, Eric D., Stromatt, Jack C., Pabla, Navjot Singh, Blachly, James S., Baker, Sharyn D. ^*, Blaser, Bradley W. ^*

Source: In Blood Advances 13 September 2022 6(17):5049-5060

Targeting OCT3 attenuates doxorubicin-induced cardiac injury

Authors: Huang, Kevin M., Thomas, Megan Zavorka, Magdy, Tarek, Eisenmann, Eric D., Uddin, Muhammad Erfan, DiGiacomo, Duncan F., Pan, Alexander, Keiser, Markus, Otter, Marcus, Xia, Sherry H., Li, Yang, Jin, Yan, Fu, Qiang, Gibson, Alice A., Bonilla, Ingrid M., Carnes, Cynthia A., Corps, Kara N., Coppola, Vincenzo, Smith, Sakima A., Addison, Daniel, Nies, Anne T., Bundschuh, Ralf, Chen, Taosheng, Lustberg, Maryam B., Wang, Joanne, Oswald, Stefan, Campbell, Moray J., Yan, Pearlly S., Baker, Sharyn D., Hu, Shuiying, Burridge, Paul W., Sparreboom, Alex

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Feb 01. 118(5), 1-9.

Access URL: https://www.jstor.org/stable/27006166

Nucleoside Reverse Transcriptase Inhibitor (NRTI)-Induced Neuropathy and Mitochondrial Toxicity: Limitations of the Poly-γ Hypothesis and the Potential Roles of Autophagy and Drug Transport.

Authors: Haynes, John, Joshi, Arnav, Larue, Ross C., Eisenmann, Eric D., Govindarajan, Rajgopal

Source: Pharmaceutics; Dec2024, Vol. 16 Issue 12, p1592, 20p

Subject Terms: HIGHLY active antiretroviral therapy, NUCLEOSIDE reverse transcriptase inhibitors, PERIPHERAL neuropathy, HIV, HIV infections

Development and validation of a sensitive UHPLC-MS/MS analytical method for venetoclax in mouse plasma, and its application to pharmacokinetic studies

Authors: Eisenmann, Eric D., Jin, Yan, Weber, Robert H., Sparreboom, Alex, Baker, Sharyn D.

Source: In Journal of Chromatography B 1 September 2020 1152

TP-0903 Is Active in Preclinical Models of Acute Myeloid Leukemia with TP53 Mutation/Deletion.

Authors: Eisenmann, Eric D.¹ (AUTHOR), Stromatt, Jack C.¹ (AUTHOR), Fobare, Sydney² (AUTHOR), Huang, Kevin M.¹ (AUTHOR), Buelow, Daelynn R.¹ (AUTHOR), Orwick, Shelley¹ (AUTHOR), Jeon, Jae Yoon¹ (AUTHOR), Weber, Robert H.¹ (AUTHOR), Larsen, Bill¹ (AUTHOR), Mims, Alice S.² (AUTHOR), Hertlein, Erin³ (AUTHOR), Byrd, John C.³ (AUTHOR), Baker, Sharyn D.¹ (AUTHOR) baker.2480@osu.edu

Source: Cancers. Jan2023, Vol. 15 Issue 1, p29. 14p.

Subject Terms: *BIOLOGICAL models, *IN vitro studies, *GENETIC mutation, *XENOGRAFTS, *DNA, *IN vivo studies, *PROTEIN kinase inhibitors, *PHOSPHOTRANSFERASES, *ANIMAL experimentation, *ANTINEOPLASTIC agents, *APOPTOSIS, *CELL cycle proteins, *CELL survival, *IMMUNOBLOTTING, *DECITABINE, *TUMOR suppressor genes, *RESEARCH funding, *CELL lines, *MICE, *OVERALL survival, *PHARMACODYNAMICS

Myocardial hypersensitivity to ischemic injury is not reversed by clonidine or propranolol in a predator-based rat model of posttraumatic stress disorder

Authors: Rorabaugh, Boyd R., Bui, Albert D., Seeley, Sarah L., Eisenmann, Eric D., Rose, Robert M., Johnson, Brandon L., Huntley, Madelaine R., Heikkila, Megan E., Zoladz, Phillip R.

Source: In Progress in Neuropsychopharmacology & Biological Psychiatry 8 March 2019 89:117-124

Darolutamide does not interfere with OATP‐mediated uptake of docetaxel.

Authors: Buck, Stefan A. J., Talebi, Zahra, Drabison, Thomas, Jin, Yan, Gibson, Alice A., Hu, Peng, de Bruijn, Peter, de Ridder, Corrina M. A., Stuurman, Debra, Hu, Shuiying, van Weerden, Wytske M., Koolen, Stijn L. W., de Wit, Ronald, Sparreboom, Alex, Mathijssen, Ron H. J., Eisenmann, Eric D.

Source: International Journal of Cancer; Jul2024, Vol. 155 Issue 2, p314-323, 10p

Subject Terms: DOCETAXEL, ANDROGEN receptors, PROSTATE cancer patients, DRUG interactions

MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia.

Authors: Uddin, Muhammad Erfan¹ (AUTHOR) uddin.33@osu.edu, Eisenmann, Eric D.¹ (AUTHOR) eisenmann.11@buckeyemail.osu.edu, Li, Yang¹ (AUTHOR) li.10991@osu.edu, Huang, Kevin M.¹ (AUTHOR) huang.2834@buckeyemail.osu.edu, Garrison, Dominique A.¹ (AUTHOR) garrison.220@buckeyemail.osu.edu, Talebi, Zahra¹ (AUTHOR) talebi.9@osu.edu, Gibson, Alice A.¹ (AUTHOR) gibson.972@osu.edu, Jin, Yan¹ (AUTHOR) jin.1134@osu.edu, Nepal, Mahesh¹ (AUTHOR) nepal.17@osu.edu, Bonilla, Ingrid M.² (AUTHOR) ingrid.bonilla4@upr.edu, Fu, Qiang¹ (AUTHOR) pkpdfu@gmail.com, Sun, Xinxin¹ (AUTHOR) xinxin224@gmail.com, Millar, Alec³ (AUTHOR) alec.miller@midwestern.edu, Tarasov, Mikhail³ (AUTHOR) tarasov.4@osu.edu, Jay, Christopher E.⁴ (AUTHOR) jayce@mymail.vcu.edu, Cui, Xiaoming⁵ (AUTHOR) xiaoming.cui@novartis.com, Einolf, Heidi J.⁵ (AUTHOR) heidi.einolf@novartis.com, Pelis, Ryan M.⁵ (AUTHOR) ryan.pelis@novartis.com, Smith, Sakima A.^6,7 (AUTHOR) sakima.smith@osumc.edu, Radwański, Przemysław B.^3,7 (AUTHOR) radwanski.2@osu.edu

Source: International Journal of Molecular Sciences. Aug2022, Vol. 23 Issue 15, p8607-8607. 19p.

Subject Terms: *PROARRHYTHMIA, *VENTRICULAR arrhythmia, *ARRHYTHMIA, *ATRIAL flutter, *DRUG interactions, *ATRIAL fibrillation, *ORGANIC cation transporters

Interaction of Antifungal Drugs with CYP3A- and OATP1B-Mediated Venetoclax Elimination.

Authors: Eisenmann, Eric D.¹ (AUTHOR) eisenmann.11@osu.edu, Garrison, Dominique A.¹ (AUTHOR) garrison.220@buckeyemail.osu.edu, Talebi, Zahra¹ (AUTHOR) talebi.9@osu.edu, Jin, Yan¹ (AUTHOR) jin.1134@osu.edu, Silvaroli, Josie A.¹ (AUTHOR) silvaroli.1@buckeyemail.osu.edu, Kim, Jin-Gyu¹ (AUTHOR) kim.6182@buckeyemail.osu.edu, Sparreboom, Alex¹ (AUTHOR) sparreboom.1@osu.edu, Savona, Michael R.² (AUTHOR) michael.savona@vumc.org, Mims, Alice S.³ (AUTHOR) alice.mims@osumc.edu, Baker, Sharyn D.¹ (AUTHOR) baker.2480@osu.edu

Source: Pharmaceutics. Apr2022, Vol. 14 Issue 4, pN.PAG-N.PAG. 16p.

Subject Terms: *DRUG interactions, *VENETOCLAX, *CYTOCHROME P-450 CYP3A, *HEMATOLOGIC malignancies, *ANTIFUNGAL agents, *KETOCONAZOLE, *ITRACONAZOLE

Predator-based psychosocial stress model of PTSD differentially influences voluntary ethanol consumption depending on methodology

Authors: Zoladz, Phillip R., Eisenmann, Eric D., Rose, Robert M., Kohls, Brooke A., Johnson, Brandon L., Robinson, Kiera L., Heikkila, Megan E., Mucher, Kasey E., Huntley, Madelaine R.

Source: Alcohol. 70:33-41

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100060175749.0x000001&indx=1&recIds=ETOCvdc_100060175749.0x000001

Sex-dependent effects of sleep deprivation on myocardial sensitivity to ischemic injury

Authors: Zoladz, Phillip R., Krivenko, Anna, Eisenmann, Eric D., Bui, Albert D., Seeley, Sarah L., Fry, Megan E., Johnson, Brandon L., Rorabaugh, Boyd R.

Source: Stress. 19(2):264-268

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100104044742.0x000001&indx=1&recIds=ETOCvdc_100104044742.0x000001

Sex-dependent effects of chronic psychosocial stress on myocardial sensitivity to ischemic injury

Authors: Rorabaugh, Boyd R., Krivenko, Anna, Eisenmann, Eric D., Bui, Albert D., Seeley, Sarah, Fry, Megan E., Lawson, Joseph D., Stoner, Lauren E., Johnson, Brandon L., Zoladz, Phillip R.

Source: Stress. 18(6):645-653

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100104044637.0x000001&indx=1&recIds=ETOCvdc_100104044637.0x000001

Itraconazole-Induced Increases in Gilteritinib Exposure Are Mediated by CYP3A and OATP1B.

Authors: Garrison, Dominique A., Jin, Yan, Talebi, Zahra, Hu, Shuiying, Sparreboom, Alex, Baker, Sharyn D., Eisenmann, Eric D.

Source: Molecules; Oct2022, Vol. 27 Issue 20, p6815-N.PAG, 14p

Subject Terms: BORTEZOMIB, CYTOCHROME P-450 CYP3A, PROTEIN-tyrosine kinase inhibitors, DRUG absorption, ACUTE myeloid leukemia, DRUG interactions, ITRACONAZOLE

Resazurin dye is an in vivosensor of kidney tubular function

Authors: Martinez, Shirely Acosta, Karel, Isaac Z., Silvaroli, Josie A., Ahmed, Eman, Kim, Ji Young, Stayton, Amanda, Patel, Prisha S., Afjal, Mohammad Amir, Horton, Thomas, Bohmer, Margaret, Vanichapol, Thitinee, Sander, Veronika, Andrade, Gabriel Mayoral, Allison, Corynne Vermillion, Mondal, Milon, Thorson, Victoria C., Partey, Alexandra, Nimkar, Kartik, Williams, Victoria, Quimby, Jessica, Ganesan, Latha, Madhavan, Sethu M., Davidson, Alan J., Peterson, Blake R., Adebiyi, Adebowale, Rao, Reena, Sweet, Douglas H., Singh, Prabhleen, Bennett, Kevin M., Zepeda-Orozco, Diana, Mallipattu, Sandeep K., Eisenmann, Eric D., Sparreboom, Alex, Rovin, Brad H., Bajwa, Amandeep, Pabla, Navjot S.

Source: Kidney International; 20250101, Issue: Preprints