Antigen presentation safeguards the integrity of the hematopoietic stem cell pool

Authors: Hernández-Malmierca, Pablo, Vonficht, Dominik, Schnell, Alexandra, Uckelmann, Hannah J., Bollhagen, Alina, Mahmoud, Mohamed A.A., Landua, Sophie-Luise, van der Salm, Elise, Trautmann, Christine L., Raffel, Simon, Grünschläger, Florian, Lutz, Raphael, Ghosh, Michael, Renders, Simon, Correia, Nádia, Donato, Elisa, Dixon, Karin O., Hirche, Christoph, Andresen, Carolin, Robens, Claudia, Werner, Paula S., Boch, Tobias, Eisel, David, Osen, Wolfram, Pilz, Franziska, Przybylla, Adriana, Klein, Corinna, Buchholz, Frank, Milsom, Michael D., Essers, Marieke A.G., Eichmüller, Stefan B., Hofmann, Wolf-Karsten, Nowak, Daniel, Hübschmann, Daniel, Hundemer, Michael, Thiede, Christian, Bullinger, Lars, Müller-Tidow, Carsten, Armstrong, Scott A., Trumpp, Andreas, Kuchroo, Vijay K., Haas, Simon

Source: In Cell Stem Cell 5 May 2022 29(5):760-775

A transplantable tumor model allowing investigation of NY-BR-1-specific T cell responses in HLA-DRB1*0401 transgenic mice

Authors: Das, Krishna, Eisel, David, Vormehr, Mathias, Müller-Decker, Karin, Hommertgen, Adriane, Jäger, Dirk, Zörnig, Inka, Feuerer, Markus, Kopp-Schneider, Annette, Osen, Wolfram, Eichmüller, Stefan

Source: BMC cancer. 19(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191723274.0x000001&indx=1&recIds=ETOCvdc_100191723274.0x000001

An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation

Authors: Muik, Alexander, Altintas, Isil, Gieseke, Friederike, Schoedel, Kristina B, Burm, Saskia M, Toker, Aras, Salcedo, Theodora W., Verzijl, Dennis, Eisel, David, Grunwitz, Christian, Kranz, Lena M, Vormehr, Mathias, Satijn, David P.E., Diken, Mustafa, Kreiter, Sebastian, Sasser, Kate, Ahmadi, Tahamtan, Türeci, Özlem, Breij, Esther C.W., Jure-Kunkel, Maria, Sahin, Ugur

Source: Oncoimmunology. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168532643.0x000001&indx=1&recIds=ETOCvdc_100168532643.0x000001

Radiation-induced alterations in immunogenicity of a murine pancreatic ductal adenocarcinoma cell line

Authors: Schröter, Philipp, Hartmann, Laura, Osen, Wolfram, Baumann, Daniel, Offringa, Rienk, Eisel, David, Debus, Jürgen, Eichmüller, Stefan B., Rieken, Stefan

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130093258.0x000001&indx=1&recIds=ETOCvdc_100130093258.0x000001

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

Authors: Herster, Franziska, Bittner, Zsofia, Archer, Nathan K., Dickhöfer, Sabine, Eisel, David, Eigenbrod, Tatjana, Knorpp, Thomas, Schneiderhan-Marra, Nicole, Löffler, Markus W., Kalbacher, Hubert, Vierbuchen, Tim, Heine, Holger, Miller, Lloyd S., Hartl, Dominik, Freund, Lukas, Schäkel, Knut, Heister, Martin, Ghoreschi, Kamran, Weber, Alexander N. R.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131058313.0x000001&indx=1&recIds=ETOCvdc_100131058313.0x000001

Reprogramming of macrophages employing gene regulatory and metabolic network models.

Authors: Hörhold, Franziska¹ (AUTHOR), Eisel, David^2,3 (AUTHOR), Oswald, Marcus¹ (AUTHOR), Kolte, Amol¹ (AUTHOR), Röll, Daniela¹ (AUTHOR), Osen, Wolfram² (AUTHOR), Eichmüller, Stefan B.² (AUTHOR), König, Rainer¹ (AUTHOR) rainer.koenig@uni-jena.de

Source: PLoS Computational Biology. 2/25/2020, Vol. 16 Issue 2, p1-27. 27p. 1 Color Photograph, 2 Diagrams, 4 Graphs.

Subject Terms: *GENE regulatory networks, *MACROPHAGES, *METABOLIC models, *IMMUNOLOGIC diseases, *TRANSCRIPTION factors

Generation of murine tumor cell lines deficient in MHC molecule surface expression using the CRISPR/Cas9 system.

Authors: Das, Krishna¹, Eisel, David¹, Lenkl, Clarissa¹, Goyal, Ashish², Diederichs, Sven^2,3, Dickes, Elke¹, Osen, Wolfram¹, Eichmüller, Stefan B.¹ s.eichmueller@dkfz.de

Source: PLoS ONE. 3/16/2017, Vol. 12 Issue 3, p1-19. 19p.

Subject Terms: *GENETICS of breast cancer, *BREAST cancer immunology, *MAJOR histocompatibility complex, *CANCER cells, *CRISPRS, *PLASMIDS

BNT162b vaccines protect rhesus macaques from SARS-CoV-2

Authors: Vogel, Annette B., Kanevsky, Isis, Che, Ye, Swanson, Kena A., Muik, Alexander, Vormehr, Mathias, Kranz, Lena M., Walzer, Kerstin C., Hein, Stephanie, Güler, Alptekin, Loschko, Jakob, Maddur, Mohan S., Ota-Setlik, Ayuko, Tompkins, Kristin, Cole, Journey, Lui, Bonny G., Ziegenhals, Thomas, Plaschke, Arianne, Eisel, David, Dany, Sarah C., Fesser, Stephanie, Erbar, Stephanie, Bates, Ferdia, Schneider, Diana, Jesionek, Bernadette, Sänger, Bianca, Wallisch, Ann-Kathrin, Feuchter, Yvonne, Junginger, Hanna, Krumm, Stefanie A., Heinen, André P., Adams-Quack, Petra, Schlereth, Julia, Schille, Stefan, Kröner, Christoph, de la Caridad Güimil Garcia, Ramón, Hiller, Thomas, Fischer, Leyla, Sellers, Rani S., Choudhary, Shambhunath, Gonzalez, Olga, Vascotto, Fulvia, Gutman, Matthew R., Fontenot, Jane A., Hall-Ursone, Shannan, Brasky, Kathleen, Griffor, Matthew C., Han, Seungil, Su, Andreas A. H., Lees, Joshua A., Nedoma, Nicole L., Mashalidis, Ellene H., Sahasrabudhe, Parag V., Tan, Charles Y., Pavliakova, Danka, Singh, Guy, Fontes-Garfias, Camila, Pride, Michael, Scully, Ingrid L., Ciolino, Tara, Obregon, Jennifer, Gazi, Michal, Carrion, Ricardo, Alfson, Kendra J., Kalina, Warren V., Kaushal, Deepak, Shi, Pei-Yong, Klamp, Thorsten, Rosenbaum, Corinna, Kuhn, Andreas N., Türeci, Özlem, Dormitzer, Philip R., Jansen, Kathrin U., Sahin, Ugur

Source: Nature; 20210101, Issue: Preprints p1-7, 7p

Cognate Interaction With CD4⁺ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype.

Authors: Eisel, David, Das, Krishna, Dickes, Elke, König, Rainer, Osen, Wolfram, Eichmüller, Stefan B.

Source: Frontiers in Immunology; 2/22/2019, p1-12, 12p

Subject Terms: T cells, SUPPRESSOR cells, TH1 cells, T cell differentiation, TUMOR antigens

Correction: Generation of murine tumor cell lines deficient in MHC molecule surface expression using the CRISPR/Cas9 system.

Authors: Das, Krishna, Eisel, David, Lenkl, Clarissa, Goyal, Ashish, Diederichs, Sven, Dickes, Elke, Osen, Wolfram, Eichmüller, Stefan B.

Source: PLoS ONE. 12/19/2018, Vol. 13 Issue 12, p1-2. 2p.

Subject Terms: *CRISPRS, *MAJOR histocompatibility complex

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