Cells and signals of the leukemic microenvironment that support progression of T-cell acute lymphoblastic leukemia (T-ALL).

Authors: Lyu, Aram, Nam, Seo Hee, Humphrey, Ryan S., Horton, Terzah M., Ehrlich, Lauren I. R.

Source: Experimental & Molecular Medicine EMM; Nov2024, Vol. 56 Issue 11, p2337-2347, 11p

Consensus tissue domain detection in spatial omics data using multiplex image labeling with regional morphology (MILWRM).

Authors: Kaur, Harsimran, Heiser, Cody N., McKinley, Eliot T., Ventura-Antunes, Lissa, Harris, Coleman R., Roland, Joseph T., Farrow, Melissa A., Selden, Hilary J., Pingry, Ellie L., Moore, John F., Ehrlich, Lauren I. R., Shrubsole, Martha J., Spraggins, Jeffrey M., Coffey, Robert J., Lau, Ken S., Vandekar, Simon N.

Source: Communications Biology; 10/30/2024, Vol. 7 Issue 1, p1-12, 12p

Subject Terms: TRANSCRIPTOMES, LYMPH nodes, DATA science, IMMUNOFLUORESCENCE, POLYPS

The initial age‐associated decline in early T‐cell progenitors reflects fewer pre‐thymic progenitors and altered signals in the bone marrow and thymus microenvironments

Authors: Srinivasan, Jayashree, Vasudev, Anusha, Shasha, Carolyn, Selden, Hilary J., Perez, Encarnacion, LaFleur, Bonnie, Sinari, Shripad A., Krueger, Andreas, Richie, Ellen R., Ehrlich, Lauren I. R.

Source: Aging cell. 22(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195104883.0x000001&indx=1&recIds=ETOCvdc_100195104883.0x000001

Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice.

Authors: Machado Araujo, Alessandra, Dekker, Joseph D., Garrison, Kendra, Zhe Su, Rhee, Catherine, Zicheng Hu, Bum-Kyu Lee, Osorio, Daniel, Lee, Jiwon, Iyer, Vishwanath R., Ehrlich, Lauren I. R., Georgiou, George, Ippolito, Gregory, Yi, Stephen, Tucker, Haley O.

Source: eLife; 9/13/2024, p1-19, 19p

Central tolerance is impaired in the middle‐aged thymic environment

Authors: Lancaster, Jessica N., Keatinge‐Clay, Damaris E., Srinivasan, Jayashree, Li, Yu, Selden, Hilary J., Nam, Seohee, Richie, Ellen R., Ehrlich, Lauren I. R.

Source: Aging cell. 21(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153523253.0x000001&indx=1&recIds=ETOCvdc_100153523253.0x000001

Detecting T cell activation using a varying dimension Bayesian model

Authors: Hu, Zicheng, Lancaster, Jessica N, Ehrlich, Lauren I. R., Müller, Peter

Source: Journal of applied statistics. 45(4):697-713

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100063197260.0x000001&indx=1&recIds=ETOCvdc_100063197260.0x000001

IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition.

Authors: Haslund-Gourley, Benjamin S., Woloszczuk, Kyra, Hou, Jintong, Connors, Jennifer, Cusimano, Gina, Bell, Mathew, Taramangalam, Bhavani, Fourati, Slim, Mege, Nathan, Bernui, Mariana, Altman, Matthew C., Krammer, Florian, van Bakel, Harm, Ozonoff, Al, Ehrlich, Lauren I. R., Melamed, Esther, Sesma, Ana Fernandez, Simon, Viviana, Pulendran, Bali, Nadeau, Kari C.

Source: Nature Communications; 1/9/2024, Vol. 15 Issue 1, p1-19, 19p

Subject Terms: SARS-CoV-2, IMMUNOGLOBULIN M, COVID-19

Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation

Authors: Triplett, Todd A., Cardenas, Kim T., Lancaster, Jessica N., Hu, Zicheng, Selden, Hilary J., Jasso, Guadalupe J., Balasubramanyam, Sadhana, Chan, Kathy, Li, LiQi, Chen, Xi, Marcogliese, Andrea N., Davé, Utpal P., Love, Paul E., Ehrlich, Lauren I. R.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Feb . 113(8), E1016-E1025.

Access URL: https://www.jstor.org/stable/26467861

Analysis of Thymocyte Migration, Cellular Interactions, and Activation by Multiphoton Fluorescence Microscopy of Live Thymic Slices

Authors: Lancaster, Jessica N., Ehrlich, Lauren I. R.

Source: Methods in molecular biology. 1591:9-26

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN610813597&indx=1&recIds=ETOCRN610813597

Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused Secretion

Authors: Nath, Shubhankar, Christian, Laura, Tan, Sarah Youngsun, Ki, Sanghee, Ehrlich, Lauren I. R., Poenie, Martin

Source: Journal of immunology. 197(6):2090-2101

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN607970852&indx=1&recIds=ETOCRN607970852

Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia.

Authors: Lyu, Aram, Humphrey, Ryan S., Nam, Seo Hee, Durham, Tyler A., Hu, Zicheng, Arasappan, Dhivya, Horton, Terzah M., Ehrlich, Lauren I. R.

Source: Nature Communications; 10/7/2023, Vol. 14 Issue 1, p1-17, 17p

Subject Terms: LYMPHOBLASTIC leukemia, CELL adhesion, INSULIN receptors, ACUTE leukemia, FOCAL adhesion kinase, INTEGRINS, MYELOID cells, T cells, MYELOID differentiation factor 88

CCR4 promotes medullary entry and thymocyte-dendritic cell interactions required for central tolerance

Authors: Hu, Zicheng, Lancaster, Jessica N., Sasiponganan, Chayanit, Ehrlich, Lauren I. R.

Source: Journal of experimental medicine. 212(11):1947-1966

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN603282927&indx=1&recIds=ETOCRN603282927

CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance.

Authors: Yu Li, Tipan, Pablo Guaman, Selden, Hilary J., Srinivasan, Jayashree, Hale, Laura P., Ehrlich, Lauren I. R.

Source: eLife; 7/6/2023, p1-30, 30p

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Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment

Authors: Singarapu, Nandini, Ma, Keyue, Reeh, Kaitlin A. G., Shen, Jianjun, Lancaster, Jessica N., Yi, Song, Xie, Huafeng, Orkin, Stuart H., Manley, Nancy R., Ehrlich, Lauren I. R., Jiang, Ning, Richie, Ellen R.

Source: Scientific reports. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131142862.0x000001&indx=1&recIds=ETOCvdc_100131142862.0x000001

Comprehensive methylome map of lineage commitment from haematopoietic progenitors.

Authors: Ji, Hong, Ehrlich, Lauren I. R., Seita, Jun

Source: Nature; September 16 2010, Vol. 467, p338-342, 5p

Age-Related Changes in Thymic Central Tolerance.

Authors: Srinivasan, Jayashree, Lancaster, Jessica N., Singarapu, Nandini, Hale, Laura P., Ehrlich, Lauren I. R., Richie, Ellen R.

Source: Frontiers in Immunology; 4/22/2021, Vol. 11, pN.PAG-N.PAG, 24p

Subject Terms: REGULATORY T cells, EPITHELIAL cells, ANTIGEN presenting cells, CELL physiology, T cells

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