Synthesis and in vitro evaluation of novel compounds and discovery of a promising iodine-125 radioligand for purinergic P2X7 receptor (P2X7R)

Authors: Qiu, Lin ^a, Wang, Jinzhi ^a, Tewari, Manju ^b, Rensing, Derek T. ^a, Egan, Terrance M. ^b, Perlmutter, Joel S. ^{a, c}, Tu, Zhude ^{a, ⁎}

Source: In Bioorganic & Medicinal Chemistry 1 February 2025 118

P2X Receptors

Authors: Nicke, Annette, Grutter, Thomas, Egan, Terrance M.

Contributors: Bhattacharjee, Arin, book editor

Source: The Oxford Handbook of Neuronal Ion Channels.

Availability: https://doi.org/10.1093/oxfordhb/9780190669164.013.7

Using Whole-Cell Electrophysiology and Patch-Clamp Photometry to Characterize P2X7 Receptor Currents

Authors: Liang, Xin, Janks, Laura, Egan, Terrance M.

Source: Methods in molecular biology. 2510:217-238

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629710010&indx=1&recIds=ETOCRN629710010

Ca2+ flux through splice variants of the ATP-gated ionotropic receptor P2X7 is regulated by its cytoplasmic N terminus

Alternate Title: Regulated Ca2+ current of P2X7 receptors (English)

Authors: Liang, Xin, Samways, Damien S.K., Cox, Jane, Egan, Terrance M.

Source: In Journal of Biological Chemistry 16 August 2019 294(33):12521-12533

Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease

Authors: Jin, Hongjun, Han, Junbin, Resing, Derek, Liu, Hui, Yue, Xuyi, Miller, Rebecca L., Schoch, Kathleen M., Miller, Timothy M., Perlmutter, Joel S., Egan, Terrance M., Tu, Zhude

Source: In European Journal of Pharmacology 5 February 2018 820:8-17

P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease

Authors: Sáez-Orellana, Francisco, Fuentes-Fuentes, María C., Godoy, Pamela A., Silva-Grecchi, Tiare, Panes, Jessica D., Guzmán, Leonardo, Yévenes, Gonzalo E, Gavilán, Javiera, Egan, Terrance M., Aguayo, Luis G., Fuentealba, Jorge

Source: In Neuropharmacology January 2018 128:366-378

ATP-Gated P2X7 Receptors Require Chloride Channels To Promote Inflammation in Human Macrophages

Authors: Janks, Laura, Sprague, Randy S., Egan, Terrance M.

Source: Journal of immunology. 202(3):883-898

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN618887337&indx=1&recIds=ETOCRN618887337

HSP90 Regulation of P2X7 Receptor Function Requires an Intact Cytoplasmic C-Terminus

Authors: Migita, Keisuke ^*, Ozaki, Taku, Shimoyama, Shuji, Yamada, Junko, Nikaido, Yoshikazu, Furukawa, Tomonori, Shiba, Yuko, Egan, Terrance M., Ueno, Shinya

Source: In Molecular Pharmacology August 2016 90(2):116-126

Modulation of Microglial Function by ATP-Gated P2X7 Receptors: Studies in Rat, Mice and Human.

Authors: Tewari, Manju, Michalski, Stephanie, Egan, Terrance M.

Source: Cells (2073-4409); Jan2024, Vol. 13 Issue 2, p161, 27p

Subject Terms: ION channels, CENTRAL nervous system, NATURAL immunity, PURINERGIC receptors, MICROGLIA, MICE, IMMUNE response

Quantifying Ca2+ Current and Permeability in ATP-gated P2X7 Receptors

Authors: Liang, Xin, Samways, Damien S.K., Wolf, Kyle, Bowles, Elizabeth A., Richards, Jennifer P., Bruno, Jonathan, Dutertre, Sébastien ^**, DiPaolo, Richard J., Egan, Terrance M.

Source: In Journal of Biological Chemistry 20 March 2015 290(12):7930-7942

Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response

Authors: Han, Junbin, Liu, Hui, Liu, Chunling, Jin, Hongjun, Perlmutter, Joel S., Egan, Terrance M., Tu, Zhude

Source: Nuclear medicine communications. 38(5):372-382

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100043591465.0x000001&indx=1&recIds=ETOCvdc_100043591465.0x000001

Allosteric Modulation of Ca2+ flux in Ligand-gated Cation Channel (P2X4) by Actions on Lateral Portals

Authors: Samways, Damien S.K., Khakh, Baljit S., Egan, Terrance M.

Source: In Journal of Biological Chemistry 2 March 2012 287(10):7594-7602

Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors)

Authors: Samways, Damien S. K., Khakh, Baljit S., Dutertre, Sébastien, Egan, Terrance M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2011 Aug . 108(33), 13800-13805.

Access URL: https://www.jstor.org/stable/27979278

Native and recombinant ASIC1a receptors conduct negligible Ca 2+ entry

Authors: Samways, Damien S.K., Harkins, Amy B., Egan, Terrance M.

Source: In Cell Calcium 2009 45(4):319-325

Tunable Calcium Current through TRPV1 Receptor Channels

Authors: Samways, Damien S.K., Khakh, Baljit S., Egan, Terrance M.

Source: In Journal of Biological Chemistry 14 November 2008 283(46):31274-31278

A central role for P2X7 receptors in human microglia

Authors: Janks, Laura, Sharma, Cristian V. R., Egan, Terrance M.

Source: Journal of neuroinflammation. 15(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127940528.0x000001&indx=1&recIds=ETOCvdc_100127940528.0x000001

On the Role of the First Transmembrane Domain in Cation Permeability and Flux of the ATP-gated P2X2 Receptor

Authors: Samways, Damien S.K., Migita, Keisuke, Li, Zhiyuan, Egan, Terrance M.

Source: In Journal of Biological Chemistry 22 February 2008 283(8):5110-5117

Functional expression of mammalian receptors and membrane channels in different cells

Authors: Eifler, Nora, Duckely, Myriam, Sumanovski, Lazar T., Egan, Terrance M., Oksche, Alexander, Konopka, James B., Lüthi, Anita, Engel, Andreas, Werten, Paul J.L.

Source: In Journal of Structural Biology 2007 159(2):179-193

Acidic Amino Acids Impart Enhanced Ca2+ Permeability and Flux in Two Members of the ATP-gated P2X Receptor Family.

Authors: Samways, Damien S. K., Egan, Terrance M.

Source: Journal of General Physiology; March 2007, Vol. 129 Issue 3, p245-256, 12p

Contribution of Transmembrane Regions to ATP-gated P2X2 Channel Permeability Dynamics

Authors: Khakh, Baljit S. ^{‡, §}, Egan, Terrance M. ^{‡, ¶}

Source: In Journal of Biological Chemistry 18 February 2005 280(7):6118-6129