Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells

Authors: Matias I Autio, Efthymios Motakis, Arnaud Perrin, Talal Bin Amin, Zenia Tiang, Dang Vinh Do, Jiaxu Wang, Joanna Tan, Shirley Suet Lee Ding, Wei Xuan Tan, Chang Jie Mick Lee, Adrian Kee Keong Teo, Roger SY Foo

Source: eLife, Vol 13 (2024)

Subject Terms: genomic safe harbour, targeted transgene expression, cell therapy, human embryonic stem cells, landing pad cassette, gene therapy, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/79592; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/6b5c6b6b01aa44959f46ae8b1df90239

A pragmatic randomised controlled trial of preferred intensity exercise in depressed adult women in the United Kingdom: secondary analysis of individual variability of depression

Authors: Ioannis D. Morres, Anton Hinton-Bayre, Efthymios Motakis, Tim Carter, Patrick Callaghan

Source: BMC Public Health, Vol 19, Iss 1, Pp 1-11 (2019)

Subject Terms: Exercise, Preferred intensity, Depression, Individual clinical significance, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12889-019-7238-7; https://doaj.org/toc/1471-2458

Access URL: https://doaj.org/article/0fb1180ef971460cb5331779945604d7

C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution

Authors: Tsukasa Kouno, Jonathan Moody, Andrew Tae-Jun Kwon, Youtaro Shibayama, Sachi Kato, Yi Huang, Michael Böttcher, Efthymios Motakis, Mickaël Mendez, Jessica Severin, Joachim Luginbühl, Imad Abugessaisa, Akira Hasegawa, Satoshi Takizawa, Takahiro Arakawa, Masaaki Furuno, Naveen Ramalingam, Jay West, Harukazu Suzuki, Takeya Kasukawa, Timo Lassmann, Chung-Chau Hon, Erik Arner, Piero Carninci, Charles Plessy, Jay W. Shin

Source: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/2b223db146cd404e9768769b7c47b35c

Dimethyl sulfoxide (DMSO) enhances direct cardiac reprogramming by inhibiting the bromodomain of coactivators CBP/p300

Authors: Lim, Choon Kiat, Efthymios, Motakis, Tan, Wilson, Autio, Matias Ilmari, Tiang, Zenia, Li, Peter Yiqing, Foo, Roger Sik Yin

Source: In Journal of Molecular and Cellular Cardiology November 2021 160:15-26

Prioritizing Candidates of Post–Myocardial Infarction Heart Failure Using Plasma Proteomics and Single-Cell Transcriptomics

Authors: Chan, Mark Y., Efthymios, Motakis, Tan, Sock Hwee, Pickering, John W., Troughton, Richard, Pemberton, Christopher, Ho, Hee-Hwa, Prabath, Joseph-Francis, Drum, Chester L., Ling, Lieng Hsi, Soo, Wern-Miin, Chai, Siang-Chew, Fong, Alan, Oon, Yen-Yee, Loh, Joshua P., Lee, Chi-Hang, Foo, Roger S.Y., Ackers-Johnson, Matthew Andrew, Pilbrow, Anna, Richards, A. Mark

Source: Circulation. 142(15):1408-1421

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150445018.0x000001&indx=1&recIds=ETOCvdc_100150445018.0x000001

Robust CTCF-Based Chromatin Architecture Underpins Epigenetic Changes in the Heart Failure Stress–Gene Response

Authors: Lee, Dominic Paul, Tan, Wilson Lek Wen, Anene-Nzelu, Chukwuemeka George, Lee, Chang Jie Mick, Li, Peter Yiqing, Luu, Tuan Danh Anh, Chan, Cheryl Xueli, Tiang, Zenia, Ng, Shi Ling, Huang, Xingfan, Efthymios, Motakis, Autio, Matias I., Jiang, Jianming, Fullwood, Melissa Jane, Prabhakar, Shyam, Lieberman Aiden, Erez, Foo, Roger Sik-Yin

Source: Circulation. 139(16):1937-1956

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188862088.0x000001&indx=1&recIds=ETOCvdc_100188862088.0x000001

Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia.

Authors: Selvaraji, Sharmelee, Efthymios, Motakis, Sik Yin Foo, Roger, Fann, David Y., Kim Peng Lai, Mitchell, Li Hsian Chen, Christopher, Kah Leong Lim, Arumugam, Thiruma V.

Source: Theranostics; 2022, Vol. 12 Issue 7, p3007-3023, 17p

Abstract 13282: Prioritization of Post-Myocardial Infarction Heart Failure Targets Using Large-Scale Plasma Proteomics and Genome-Wide Single-Cardiac Cell Transcriptomics

Authors: Chan, Mark Y, Efthymios, Motakis, Tan, Sock-hwee, Johnson, Matthew A, See, Kelvin, Pickering, John, Troughton, Richard, Pemberton, Chris J, Ho, Hee Hwa, Ling, Lieng, Soo, Wern Miin, Drum, Chester L, Chai, Siang Chew, Fong, Alan, Loh, Joshua, Lee, Chi Hang, Foo, Roger, Pilbrow, Anna P, Richards, Arthur M

Source: Circulation (Ovid); November 2019, Vol. 140 Issue: Supplement 1 pA13282-A13282, 1p