Trading amino acids at the aphid– Buchnera symbiotic interface

Authors: Feng, Honglin, Edwards, Noel, Anderson, Catriona M. H., Althaus, Mike, Duncan, Rebecca P., Hsu, Yu-Ching, Luetje, Charles W., Price, Daniel R. G., Wilson, Alex C. C., Thwaites, David T.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Aug 01. 116(32), 16003-16011.

Access URL: https://www.jstor.org/stable/26848457

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4

Authors: Myers, Stephanie M., Miller, Duncan C., Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth H., Blackburn, Timothy J., Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Hardcastle, Ian R., Harnor, Suzannah J., Heptinstall, Amy B., Lochhead, Pamela A., Martin, Mathew P., Martin, Nick C., Newell, David R., Owen, Paul J., Pang, Leon C., Reuillon, Tristan, Rigoreau, Laurent J.M., Thomas, Huw D., Tucker, Julie A., Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin E.M., Wedge, Stephen R., Cano, Celine

Source: In European Journal of Medicinal Chemistry 15 September 2019 178:530-543

Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB 0,+) Selectively Reduces Access for Cationic Amino Acids and Derivatives.

Authors: Anderson, Catriona M. H.¹ (AUTHOR) catriona.anderson@ncl.ac.uk, Edwards, Noel² (AUTHOR), Watson, Andrew K.² (AUTHOR), Althaus, Mike^1,3 (AUTHOR), Thwaites, David T.² (AUTHOR) catriona.anderson@ncl.ac.uk

Source: Biomolecules (2218-273X). Oct2022, Vol. 12 Issue 10, pN.PAG-N.PAG. 19p.

Subject Terms: *AMINO acid derivatives, *NITRIC-oxide synthases, *AMINO acid residues, *AMINO acids, *PROTEIN transport

Molecular genetic investigations identify new clinical phenotypes associated with BCS1L-related mitochondrial disease

Authors: Oláhová, Monika, Berti, Camilla Ceccatelli, Collier, Jack J, Alston, Charlotte L, Jameson, Elisabeth, Jones, Simon A, Edwards, Noel, He, Langping, Chinnery, Patrick F, Horvath, Rita, Goffrini, Paola, Taylor, Robert W, Sayer, John A

Source: Human molecular genetics. 28(22):3766-3776

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100100510377.0x000001&indx=1&recIds=ETOCvdc_100100510377.0x000001

Bialleleic PKD1 mutations underlie early-onset autosomal dominant polycystic kidney disease in Saudi Arabian families

Authors: Al-Hamed, Mohamed H., Alsahan, Nada, Rice, Sarah J., Edwards, Noel, Nooreddeen, Eman, Alotaibi, Maha, Kurdi, Wesam, Alnemer, Maha, Altaleb, Naderah, Ali, Wafa, Al-Numair, Nouf, Almejaish, Najd, Sayer, John A., Imtiaz, Faiqa

Source: Pediatric nephrology. 34(9):1615-1623

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125313084.0x000001&indx=1&recIds=ETOCvdc_100125313084.0x000001

ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition

Authors: Alkanderi, Sumaya, Molinari, Elisa, Shaheen, Ranad, Elmaghloob, Yasmin, Stephen, Louise A., Sammut, Veronica, Ramsbottom, Simon A., Srivastava, Shalabh, Cairns, George, Edwards, Noel, Rice, Sarah J., Ewida, Nour, Alhashem, Amal, White, Kathryn, Miles, Colin G., Steel, David H., Alkuraya, Fowzan S., Ismail, Shehab, Sayer, John A.

Source: American journal of human genetics. 103(4):612-620

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093375313.0x000001&indx=1&recIds=ETOCvdc_100093375313.0x000001

Resculpting the binding pocket of APC superfamily LeuT-fold amino acid transporters

Authors: Edwards, Noel, Anderson, Catriona M. H., Conlon, Nichola J., Watson, Andrew K., Hall, Rebecca J., Cheek, Timothy R., Embley, T. Martin, Thwaites, David T.

Source: Cellular and molecular life sciences. 75(5):921-938

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125355436.0x000001&indx=1&recIds=ETOCvdc_100125355436.0x000001

Clinical and Genetic Analysis of Patients with Cystinuria in the United Kingdom

Authors: Rhodes, Hannah L., Yarram-Smith, Laura, Rice, Sarah J., Tabaksert, Ayla, Edwards, Noel, Hartley, Alice, Woodward, Mark N., Smithson, Sarah L., Tomson, Charles, Welsh, Gavin I.

Source: Clinical journal of the American Society of Nephrology. 10(7):1235-1245

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN601992058&indx=1&recIds=ETOCRN601992058

Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2)

Authors: Edwards, Noel, Anderson, Catriona M.H., Gatfield, Kelly M., Jevons, Mark P., Ganapathy, Vadivel, Thwaites, David T.

Source: In BBA - Biomembranes January 2011 1808(1):260-270

Transport of the Photodynamic Therapy Agent 5-Aminolevulinic Acid by Distinct H+-Coupled Nutrient Carriers Coexpressed in the Small Intestine

Authors: Anderson, Catriona M.H., Jevons, Mark, Thangaraju, Muthusamy, Edwards, Noel, Conlon, Nichola J., Woods, Steven, Ganapathy, Vadivel, Thwaites, David T. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics January 2010 332(1):220-228

Missense Variants in GFRA1 and NPNT Are Associated with Congenital Anomalies of the Kidney and Urinary Tract.

Authors: Al-Hamed, Mohamed H., Sayer, John A., Alsahan, Nada, Edwards, Noel, Ali, Wafaa, Tulbah, Maha, Imtiaz, Faiqa

Source: Genes; Oct2022, Vol. 13 Issue 10, pN.PAG-N.PAG, 8p

Subject Terms: MISSENSE mutation, URINARY organs, DYSPLASIA, HUMAN abnormalities, CONGENITAL disorders, KIDNEY development

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.

Authors: Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy, Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian, Harnor, Suzannah J., Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew P., Martin, Nick C., Myers, Stephanie, Newell, David R., Noble, Richard A., Phillips, Nicole, Rigoreau, Laurent

Source: Journal of Medicinal Chemistry; 5/12/2022, Vol. 65 Issue 9, p6513-6540, 28p

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

Trading amino acids at the aphid-Buchnera symbiotic interface.

Authors: Honglin Feng¹, Edwards, Noel², Anderson, Catriona M. H.², Althaus, Mike³, Duncan, Rebecca P.^1,4, Yu-Ching Hsu¹, Luetje, Charles W.⁵, Price, Daniel R. G.^1,6, Wilson, Alex C. C.¹ acwilson@miami.edu, Thwaites, David T.² d.t.thwaites@ncl.ac.uk

Source: Proceedings of the National Academy of Sciences of the United States of America. 8/6/2019, Vol. 116 Issue 32, p16003-16011. 9p.

Subject Terms: *AMINO acids, *ESSENTIAL amino acids, *PEA aphid, *CARRIER proteins, *BIOLOGICAL transport

This result is not displayed to guests.
Login for full access.

Clinical, biochemical, and pathophysiological analysis of SLC34A1 mutations.

Authors: Fearn, Amy, Allison, Benjamin, Rice, Sarah J., Edwards, Noel, Halbritter, Jan, Bourgeois, Soline, Pastor‐Arroyo, Eva M., Hildebrandt, Friedhelm, Tasic, Velibor, Wagner, Carsten A., Hernando, Nati, Sayer, John A., Werner, Andreas

Source: Physiological Reports; Jun2018, Vol. 6 Issue 12, p1-1, 7p

Subject Terms: PATHOLOGICAL physiology, XENOPUS, CELL surface display, PHOSPHATE esters, ACIDOSIS

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

A novel LMX1B mutation in a family with end-stage renal disease of 'unknown cause'.

Authors: Edwards, Noel^1,2, Rice, Sarah J.^1,2, Raman, Shreya³, Hynes, Ann Marie¹, Srivastava, Shalabh¹, Moore, Iain⁴, Al-Hamed, Mohamed¹, Xu, Yaobo¹, Santibanez-Koref, Mauro¹, Thwaites, David T.², Gale, Daniel P.⁵, Sayer, John A.¹ john.sayer@ncl.ac.uk

Source: Clinical Kidney Journal. Feb2015, Vol. 8 Issue 1, p113-119. 7p.

Subject Terms: *CHRONIC kidney failure, *NAIL-patella syndrome, *GENETIC transcription, *KIDNEY diseases, *HEMATURIA, *PROTEINURIA, *DIAGNOSIS