An In-Silico Study on Integrated Mechanisms of Mechano-Electric Coupling in Ischaemic Arrhythmogenesis

Authors: Timmermann, Viviane, Wall, Samuel T., Sundnes, Joakim, Lawen, Tarek, Baumeister, Peter A., Quinn, T. Alexander, McCulloch, Andrew D., Edwards, Andrew G.

Subject Terms: Physics - Biological Physics

Access URL: http://arxiv.org/abs/2312.06535

The sodium/glucose cotransporter 2 inhibitor Empagliflozin inhibits long QT 3 late sodium currents in a mutation specific manner

Authors: Lunsonga, Lynn C. ^a, Fatehi, Mohammad ^a, Long, Wentong ^a, Barr, Amy J. ^a, Gruber, Brittany ^a, Chattopadhyay, Arkapravo ^b, Barakat, Khaled ^b, Edwards, Andrew G. ^c, Light, Peter E. ^{a, ⁎}

Source: In Journal of Molecular and Cellular Cardiology January 2025 198:99-111

Gating kinetics and pharmacological properties of small-conductance Ca2+-activated potassium channels

Authors: van Herck, Ilsbeth G.M., Seutin, Vincent, Bentzen, Bo H., Marrion, Neil V., Edwards, Andrew G.

Source: In Biophysical Journal 4 April 2023 122(7):1143-1157

Arrhythmogenic Current Generation by Myofilament-Triggered Ca2+ Release and Sarcomere Heterogeneity

Authors: Timmermann, Viviane, Edwards, Andrew G., Wall, Samuel T., Sundnes, Joakim, McCulloch, Andrew D.

Source: In Biophysical Journal 17 December 2019 117(12):2471-2485

Arrhythmogenic influence of mutations in a myocyte-based computational model of the pulmonary vein sleeve.

Authors: Jæger, Karoline Horgmo¹ (AUTHOR) karolihj@simula.no, Edwards, Andrew G.¹ (AUTHOR), Giles, Wayne R.^1,2 (AUTHOR), Tveito, Aslak¹ (AUTHOR)

Source: Scientific Reports. 11/13/2022, Vol. 12 Issue 1, p1-18. 18p.

Subject Terms: *PULMONARY veins, *ARRHYTHMIA, *ATRIAL arrhythmias, *ACTION potentials, *ION channels, *ATRIAL fibrillation, *CYTOSKELETAL proteins

An integrative appraisal of mechano-electric feedback mechanisms in the heart

Authors: Timmermann, Viviane, Dejgaard, Lars A., Haugaa, Kristina H., Edwards, Andrew G., Sundnes, Joakim, McCulloch, Andrew D., Wall, Samuel T.

Source: In Progress in Biophysics and Molecular Biology November 2017 130 Part B:404-417

Computing rates of Markov models of voltage-gated ion channels by inverting partial differential equations governing the probability density functions of the conducting and non-conducting states

Authors: Tveito, Aslak, Lines, Glenn T., Edwards, Andrew G., McCulloch, Andrew

Source: In Mathematical Biosciences July 2016 277:126-135

Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

Authors: Morotti, Stefano, McCulloch, Andrew D., Bers, Donald M., Edwards, Andrew G., Grandi, Eleonora

Source: In Journal of Molecular and Cellular Cardiology July 2016 96:63-71

A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes.

Authors: Jæger, Karoline Horgmo¹ (AUTHOR) karolihj@simula.no, Edwards, Andrew G.^1,2 (AUTHOR), Giles, Wayne R.^1,3 (AUTHOR), Tveito, Aslak¹ (AUTHOR)

Source: PLoS Computational Biology. 8/12/2021, Vol. 17 Issue 8, p1-24. 24p. 4 Charts, 8 Graphs.

Subject Terms: *ION channels, *MEMBRANE potential, *POTASSIUM channels, *MUSCLE cells, *ARRHYTHMIA, *MEMBRANE proteins, *HEART beat, *ADULTS

Slow Calcium-Depolarization-Calcium waves may initiate fast local depolarization waves in ventricular tissue

Authors: Tveito, Aslak, Lines, Glenn Terje, Edwards, Andrew G., Maleckar, Mary M., Michailova, Anushka, Hake, Johan, McCulloch, Andrew

Source: In Progress in Biophysics and Molecular Biology October-November 2012 110(2-3):295-304

Instabilities of the resting state in a mathematical model of calcium handling in cardiac myocytes

Authors: Tveito, Aslak, Lines, Glenn Terje, Hake, Johan, Edwards, Andrew G.

Source: In Mathematical Biosciences April 2012 236(2):97-107

32 - Calcium Signaling in Cardiomyocyte Models With Realistic Geometries

Authors: Edwards, Andrew G., van den Brink, Jonas, McCulloch, Andrew D.

Source: In Zipes and Jalife's Cardiac Electrophysiology Edition: Eighth Edition. 2022:362-375

Mechanisms of spontaneous Ca²⁺ release‐mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca²⁺‐handling protein variation.

Authors: Zhang, Xianwei, Smith, Charlotte E. R., Morotti, Stefano, Edwards, Andrew G., Sato, Daisuke, Louch, William E., Ni, Haibo, Grandi, Eleonora

Source: Journal of Physiology; Jul2023, Vol. 601 Issue 13, p2685-2710, 26p

Subject Terms: TAT protein, ARRHYTHMIA, RYANODINE receptors, ATRIAL fibrillation, SARCOPLASMIC reticulum

Mechanisms of spontaneous Ca²⁺ release‐mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse‐axial tubule variation.

Authors: Zhang, Xianwei, Ni, Haibo, Morotti, Stefano, Smith, Charlotte E. R., Sato, Daisuke, Louch, William E., Edwards, Andrew G., Grandi, Eleonora

Source: Journal of Physiology; Jul2023, Vol. 601 Issue 13, p2655-2683, 29p

Subject Terms: CELL receptors, ARRHYTHMIA, RYANODINE receptors, ATRIAL fibrillation, INTRACELLULAR calcium

Properties of cardiac conduction in a cell-based computational model.

Authors: Jæger, Karoline Horgmo¹, Edwards, Andrew G.¹, McCulloch, Andrew², Tveito, Aslak¹ aslak@simula.no

Source: PLoS Computational Biology. 5/31/2019, Vol. 15 Issue 5, p1-35. 35p. 2 Color Photographs, 3 Diagrams, 1 Chart, 12 Graphs.

Subject Terms: *CARDIAC arrest, *HEART cells, *HEART conduction system, *COMPUTATIONAL acoustics, *SODIUM channels

Optical input system and method

Optical input system and method

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Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure.

Authors: Xin Shen, van den Brink, Jonas, Bergan-Dahl, Anna, Kolstad, Terje R., Norden, Einar S., Yufeng Hou, Laasmaa, Martin, Aguilar-Sanchez, Yuriana, Quick, Ann P., Espe, Emil K. S., Sjaastad, Ivar, Wehrens, Xander H. T., Edwards, Andrew G., Soeller, Christian, Louch, William E.

Source: eLife; 8/25/2022, p1-26, 26p

Validating the Arrhythmogenic Potential of High‑, Intermediate‑, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System.

Authors: Charwat, Verena¹ (AUTHOR), Charrez, Bérénice¹ (AUTHOR), Siemons, Brian A.¹ (AUTHOR), Finsberg, Henrik² (AUTHOR), Jæger, Karoline H.² (AUTHOR), Edwards, Andrew G.² (AUTHOR), Huebsch, Nathaniel¹ (AUTHOR), Wall, Samuel² (AUTHOR), Miller, Evan³ (AUTHOR), Tveito, Aslak² (AUTHOR), Healy, Kevin E.^1,4 (AUTHOR) kehealy@berkeley.edu

Source: ACS Pharmacology & Translational Science. 8/12/2022, Vol. 5 Issue 8, p652-667. 16p.