Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regulated

Authors: Nicolás Martínez-Calle, Marien Pascual, Raquel Ordoñez, Edurne San José Enériz, Marta Kulis, Estíbaliz Miranda, Elisabeth Guruceaga, Víctor Segura, María José Larráyoz, Beatriz Bellosillo, María José Calasanz, Carles Besses, José Rifón, José I. Martín-Subero, Xabier Agirre, Felipe Prosper

Source: Haematologica, Vol 104, Iss 8 (2019)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9005; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/92c068858094471b9449973937dec2fd

Explainable artificial intelligence for precision medicine in acute myeloid leukemia

Authors: Marian Gimeno, Edurne San José-Enériz, Sara Villar, Xabier Agirre, Felipe Prosper, Angel Rubio, Fernando Carazo

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: biomarkers, treatment selection, assignation problem, explainable artificial intelligence, drug repositioning, large-scale screening, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.977358/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/91f44e62426944cb9d8b24cbc157b7d0

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

Authors: Antonio Garcia-Gomez, Tianlu Li, Carlos de la Calle-Fabregat, Javier Rodríguez-Ubreva, Laura Ciudad, Francesc Català-Moll, Gerard Godoy-Tena, Montserrat Martín-Sánchez, Laura San-Segundo, Sandra Muntión, Xabier Morales, Carlos Ortiz-de-Solórzano, Julen Oyarzabal, Edurne San José-Enériz, Manel Esteller, Xabier Agirre, Felipe Prosper, Mercedes Garayoa, Esteban Ballestar

Source: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/97c0cd9d38aa419d8042bda6761115e0

BOSO: A novel feature selection algorithm for linear regression with high-dimensional data.

Authors: Luis V Valcárcel, Edurne San José-Enériz, Xabier Cendoya, Ángel Rubio, Xabier Agirre, Felipe Prósper, Francisco J Planes

Source: PLoS Computational Biology, Vol 18, Iss 5, p e1010180 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/fa1e683e8c0745dc9fa3c36ab0a72911

Inhibiting Histone and DNA Methylation Improves Cancer Vaccination in an Experimental Model of Melanoma

Authors: Lien De Beck, Robin Maximilian Awad, Veronica Basso, Noelia Casares, Kirsten De Ridder, Yannick De Vlaeminck, Alessandra Gnata, Cleo Goyvaerts, Quentin Lecocq, Edurne San José-Enériz, Stefaan Verhulst, Ken Maes, Karin Vanderkerken, Xabier Agirre, Felipe Prosper, Juan José Lasarte, Anna Mondino, Karine Breckpot

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: melanoma, cancer vaccination, dendritic cell vaccination, adoptive T cell therapies, epigenetic targeted therapy, histone and DNA methylation/demethylation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.799636/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f6044c9296d648419688c29e75e4e1a4

A network-based approach to integrate nutrient microenvironment in the prediction of synthetic lethality in cancer metabolism.

Authors: Iñigo Apaolaza, Edurne San José-Enériz, Luis V Valcarcel, Xabier Agirre, Felipe Prosper, Francisco J Planes

Source: PLoS Computational Biology, Vol 18, Iss 3, p e1009395 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/077e783ad3e448e29da2dd4895c48394

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies

Authors: Edurne San José-Enériz, Xabier Agirre, Obdulia Rabal, Amaia Vilas-Zornoza, Juan A. Sanchez-Arias, Estibaliz Miranda, Ana Ugarte, Sergio Roa, Bruno Paiva, Ander Estella-Hermoso de Mendoza, Rosa María Alvarez, Noelia Casares, Victor Segura, José I. Martín-Subero, François-Xavier Ogi, Pierre Soule, Clara M. Santiveri, Ramón Campos-Olivas, Giancarlo Castellano, Maite Garcia Fernandez de Barrena, Juan Roberto Rodriguez-Madoz, Maria José García-Barchino, Juan Jose Lasarte, Matias A Avila, Jose Angel Martinez-Climent, Julen Oyarzabal, Felipe Prosper

Source: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/286f3156e84448249eb1c05f274be064

Dual epigenetic modifiers for cancer therapy

Authors: Edurne San José-Enériz, Obdulia Rabal, Xabier Agirre, Julen Oyarzabal, Felipe Prosper

Source: Molecular & Cellular Oncology, Vol 4, Iss 4 (2017)

Subject Terms: cancer, dnmt, drug discovery, epigenetic, g9a, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2372-3556

Access URL: https://doaj.org/article/6448d806d3ac4e1986b11b5499a30ee8

An automated network-based tool to search for metabolic vulnerabilities in cancer

Authors: Luis V. Valcárcel, Edurne San José-Enériz, Raquel Ordoñez, Iñigo Apaolaza, Danel Olaverri-Mendizabal, Naroa Barrena, Ana Valcárcel, Leire Garate, Jesús San Miguel, Antonio Pineda-Lucena, Xabier Agirre, Felipe Prósper, Francisco J. Planes

Source: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c4d4832b44504993870e80bfa11472fa

Epigenetic-based differentiation therapy for Acute Myeloid Leukemia

Authors: Edurne San José-Enériz, Naroa Gimenez-Camino, Obdulia Rabal, Leire Garate, Estibaliz Miranda, Nahia Gómez-Echarte, Fernando García, Stella Charalampopoulou, Elena Sáez, Amaia Vilas-Zornoza, Patxi San Martín-Uriz, Luis V. Valcárcel, Naroa Barrena, Diego Alignani, Luis Esteban Tamariz-Amador, Ana Pérez-Ruiz, Sebastian Hilscher, Mike Schutkowski, Ana Alfonso-Pierola, Nicolás Martinez-Calle, María José Larrayoz, Bruno Paiva, María José Calasanz, Javier Muñoz, Marta Isasa, José Ignacio Martin-Subero, Antonio Pineda-Lucena, Julen Oyarzabal, Xabier Agirre, Felipe Prósper

Source: Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c19f4277205c445384d53303bce19ff2

BET inhibitors down-regulate the expression of the essential lncRNA SMILO in multiple myeloma through regulation of the transcription factor FLI1

Authors: Nahia Gómez-Echarte, Edurne San José-Enériz, Arantxa Carrasco-León, Naroa Barrena, Estibaliz Miranda, Leire Garate, Beatriz García-Torre, Sandra Alonso-Moreno, Naroa Gimenez-Camino, Estibaliz Urizar-Compains, Danel Olaverri-Mendizabal, Paula Aguirre-Ruiz, Beñat Ariceta, Luis-Esteban Tamariz-Amador, Paula Rodriguez-Otero, Francisco J. Planes, Laura Belver, José Ignacio Martín-Subero, Felipe Prosper, Xabier Agirre

Source: Haematologica, Vol 999, Iss 1 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11766; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/d9ad4eb37a8149279d2b82a9df1dfc5d

Modulation of tumor microenvironment by targeting histone acetylation in bladder cancer

Authors: Sandra P. Nunes, Lucia Morales, Carolina Rubio, Ester Munera-Maravilla, Iris Lodewijk, Cristian Suárez-Cabrera, Victor G. Martínez, Mercedes Pérez-Escavy, Miriam Pérez-Crespo, Miguel Alonso Sánchez, Esther Montesinos, Edurne San José-Enériz, Xabier Agirre, Felipe Prósper, Antonio Pineda-Lucena, Rui Henrique, Marta Dueñas, Margareta P. Correia, Carmen Jerónimo, Jesús M. Paramio

Source: Cell Death Discovery, Vol 10, Iss 1, Pp 1-15 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/2e7cebeed11f4705be37c46da8ae9498