Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis

Authors: Ionescu, Rosana-Bristena, Nicaise, Alexandra M., Reisz, Julie A., Williams, Eleanor C., Prasad, Pranathi, Willis, Cory M., Simões-Abade, Madalena B.C., Sbarro, Linda, Dzieciatkowska, Monika, Stephenson, Daniel, Suarez Cubero, Marta, Rizzi, Sandra, Pirvan, Liviu, Peruzzotti-Jametti, Luca, Fossati, Valentina, Edenhofer, Frank, Leonardi, Tommaso, Frezza, Christian, Mohorianu, Irina, D’Alessandro, Angelo, Pluchino, Stefano

Source: In Cell Stem Cell 7 November 2024 31(11):1574-1590

Truncated variants of MAGEL2 are involved in the etiologies of the Schaaf-Yang and Prader-Willi syndromes

Authors: Heimdörfer, David, Vorleuter, Alexander, Eschlböck, Alexander, Spathopoulou, Angeliki, Suarez-Cubero, Marta, Farhan, Hesso, Reiterer, Veronika, Spanjaard, Melanie, Schaaf, Christian P., Huber, Lukas A., Kremser, Leopold, Sarg, Bettina, Edenhofer, Frank, Geley, Stephan, de Araujo, Mariana E.G., Huettenhofer, Alexander

Source: In The American Journal of Human Genetics 11 July 2024 111(7):1383-1404

Recommendations, guidelines, and best practice for the use of human induced pluripotent stem cells for neuropharmacological studies of neuropsychiatric disorders

Authors: Dutan Polit, Lucia, Eidhof, Ilse, McNeill, Rhiannon V., Warre-Cornish, Katherine M., Yde Ohki, Cristine Marie, Walter, Natalie Monet, Sala, Carlo, Verpelli, Chiara, Radtke, Franziska, Galderisi, Silvana, Mucci, Armida, Collo, Ginetta, Edenhofer, Frank, Castrén, Maija L., Réthelyi, János M., Ejlersen, Morten, Hohmann, Sonja Simone, Ilieva, Mirolyuba S., Lukjanska, Renate, Matuleviciute, Rugile, Michel, Tanja Maria, de Vrij, Femke M.S., Kushner, Steven A., Lendemeijer, Bas, Kittel-Schneider, Sarah, Ziegler, Georg C., Gruber-Schoffnegger, Doris, Pasterkamp, R. Jeroen, Kasri, Amal, Potier, Marie-Claude, Knoblich, Jürgen A., Brüstle, Oliver, Peitz, Michael, Pich, Emilio Merlo, Harwood, Adrian J., Abranches, Elsa, Falk, Anna, Vernon, Anthony C., Grünblatt, Edna, Srivastava, Deepak P.

Source: In Neuroscience Applied 2023 2

ADHD‐associated PARK2 copy number variants: A pilot study on gene expression and effects of supplementary deprivation in patient‐derived cell lines

Authors: Radtke, Franziska, Palladino, Viola Stella, McNeill, Rhiannon V., Chiocchetti, Andreas G., Haslinger, Denise, Leyh, Matthias, Gersic, Danijel, Frank, Markus, Grünewald, Lena, Klebe, Stephan, Brüstle, Oliver, Günther, Katharina, Edenhofer, Frank, Kranz, Thorsten M., Reif, Andreas, Kittel‐Schneider, Sarah

Source: American journal of medical genetics.Part B.Neuropsychiatric genetics. 189(7-8):257-270

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159361825.0x000001&indx=1&recIds=ETOCvdc_100159361825.0x000001

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Authors: Mertens, Jerome, Herdy, Joseph R., Traxler, Larissa, Schafer, Simon T., Schlachetzki, Johannes C.M., Böhnke, Lena, Reid, Dylan A., Lee, Hyungjun, Zangwill, Dina, Fernandes, Diana P., Agarwal, Ravi K., Lucciola, Raffaella, Zhou-Yang, Lucia, Karbacher, Lukas, Edenhofer, Frank, Stern, Shani, Horvath, Steve, Paquola, Apua C.M., Glass, Christopher K., Yuan, Shauna H., Ku, Manching, Szücs, Attila, Goldstein, Lawrence S.B., Galasko, Douglas, Gage, Fred H.

Source: In Cell Stem Cell 2 September 2021 28(9):1533-1548

Modeling early phenotypes of Parkinson's disease by age-induced midbrain-striatum assembloids.

Authors: Barmpa, Kyriaki, Saraiva, Claudia, Lopez-Pigozzi, Diego, Gomez-Giro, Gemma, Gabassi, Elisa, Spitz, Sarah, Brandauer, Konstanze, Rodriguez Gatica, Juan E., Antony, Paul, Robertson, Graham, Sabahi-Kaviani, Rahman, Bellapianta, Alessandro, Papastefanaki, Florentia, Luttge, Regina, Kubitscheck, Ulrich, Salti, Ahmad, Ertl, Peter, Bortolozzi, Mario, Matsas, Rebecca, Edenhofer, Frank

Source: Communications Biology; 11/23/2024, Vol. 7 Issue 1, p1-19, 19p

Subject Terms: PARKINSON'S disease, SUBSTANTIA nigra, SYNAPTOGENESIS, PROGERIN, MESENCEPHALON, DOPAMINERGIC neurons

Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice

Authors: Braga, Alice, Bandiera, Sara, Verheyen, Jeroen, Hamel, Regan, Rutigliani, Carola, Edenhofer, Frank, Smith, Jayden Aaron, Pluchino, Stefano

Source: In Molecular Therapy 2 December 2020 28(12):2677-2690

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Development of a bioreactor system for pre‐endothelialized cardiac patch generation with enhanced viscoelastic properties by combined collagen I compression and stromal cell culture

Authors: Krziminski, Carolin, Kammann, Sebastian, Hansmann, Jan, Edenhofer, Frank, Dandekar, Gudrun, Walles, Heike, Leistner, Marcus

Source: Journal of tissue engineering and regenerative medicine. 14(12):1749-1762

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111930279.0x000001&indx=1&recIds=ETOCvdc_100111930279.0x000001

Single-cell Profiling of Reprogrammed Human Neural Stem Cells Unveils High Similarity to Neural Progenitors in the Developing Central Nervous System.

Authors: Spathopoulou, Angeliki, Podlesnic, Martina, De Gaetano, Laura, Kirsch, Elena Marie, Tisch, Marcel, Finotello, Francesca, Aigner, Ludwig, Günther, Katharina, Edenhofer, Frank

Source: Stem Cell Reviews & Reports; Jul2024, Vol. 20 Issue 5, p1325-1339, 15p

Subject Terms: NEURAL stem cells, EMBRYONIC stem cells, HUMAN stem cells, CENTRAL nervous system, SOMATIC cells

Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells

Authors: Thier, Marc Christian, Hommerding, Oliver, Panten, Jasper, Pinna, Roberta, García-González, Diego, Berger, Thomas, Wörsdörfer, Philipp, Assenov, Yassen, Scognamiglio, Roberta, Przybylla, Adriana, Kaschutnig, Paul, Becker, Lisa, Milsom, Michael D., Jauch, Anna, Utikal, Jochen, Herrmann, Carl, Monyer, Hannah, Edenhofer, Frank, Trumpp, Andreas

Source: In Cell Stem Cell 3 January 2019 24(1):166-182

Metabolic substrate shift in human induced pluripotent stem cells during cardiac differentiation: Functional assessment using in vitro radionuclide uptake assay

Authors: Nose, Naoko, Werner, Rudolf A., Ueda, Yuichiro, Günther, Katharina, Lapa, Constantin, Javadi, Mehrbod S., Fukushima, Kazuhito, Edenhofer, Frank, Higuchi, Takahiro

Source: In International Journal of Cardiology 15 October 2018 269:229-234

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation

Authors: Peruzzotti-Jametti, Luca, Bernstock, Joshua D., Vicario, Nunzio, Costa, Ana S.H., Kwok, Chee Keong, Leonardi, Tommaso, Booty, Lee M., Bicci, Iacopo, Balzarotti, Beatrice, Volpe, Giulio, Mallucci, Giulia, Manferrari, Giulia, Donegà, Matteo, Iraci, Nunzio, Braga, Alice, Hallenbeck, John M., Murphy, Michael P., Edenhofer, Frank, Frezza, Christian, Pluchino, Stefano

Source: In Cell Stem Cell 1 March 2018 22(3):355-368

Next‐generation disease modeling with direct conversion: a new path to old neurons

Authors: Traxler, Larissa, Edenhofer, Frank, Mertens, Jerome

Source: FEBS letters. 593(23):3316-3337

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094317281.0x000001&indx=1&recIds=ETOCvdc_100094317281.0x000001

Take the shortcut – direct conversion of somatic cells into induced neural stem cells and their biomedical applications

Authors: Erharter, Anita, Rizzi, Sandra, Mertens, Jerome, Edenhofer, Frank

Source: FEBS letters. 593(23):3353-3369

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094317269.0x000001&indx=1&recIds=ETOCvdc_100094317269.0x000001

Generation of the human induced pluripotent stem cell line (IBKMOLi002-A) from PBMCs of a patient carrying the heterozygous L271H mutation of the voltage-gated calcium channel subunit Cav1.3-encoding CACNA1D gene

Authors: Tisch, Marcel, Carmen De Mingo Alemany, María, Suarez-Cubero, Marta, Fauth, Christine, Defrancesco, Michaela, Zschocke, Johannes, Günther, Katharina, Edenhofer, Frank

Source: Stem cell research. 61

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188122283.0x000001&indx=1&recIds=ETOCvdc_100188122283.0x000001

Ability of the Hydrophobic FGF and Basic TAT Peptides to Promote Cellular Uptake of Recombinant Cre Recombinase: A Tool for Efficient Genetic Engineering of Mammalian Genomes

Authors: Peitz, Michael, Pfannkuche, Kurt, Rajewsky, Klaus, Edenhofer, Frank

Source: Proceedings of the National Academy of Sciences of the United States of America, 2002 Apr 01. 99(7), 4489-4494.

Access URL: https://www.jstor.org/stable/3058331

Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells

Authors: Appelt-Menzel, Antje, Cubukova, Alevtina, Günther, Katharina, Edenhofer, Frank, Piontek, Jörg, Krause, Gerd, Stüber, Tanja, Walles, Heike, Neuhaus, Winfried, Metzger, Marco

Source: In Stem Cell Reports 11 April 2017 8(4):894-906

The vascular adventitia: An endogenous, omnipresent source of stem cells in the body

Authors: Wörsdörfer, Philipp, Mekala, Subba Rao, Bauer, Jochen, Edenhofer, Frank, Kuerten, Stefanie, Ergün, Süleyman

Source: In Pharmacology and Therapeutics March 2017 171:13-29

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