Glutamate plus glutamine to GABA ratio as a predictor of ketamine response in treatment-resistant depression: A double-blind, randomized, open-label extension study

Authors: Ohtani, Yohei ^{a, b}, Tani, Hideaki ^{a, ⁎}, Honda, Shiori ^{a, c}, Nomoto-Takahashi, Kie ^a, Yatomi, Taisuke ^a, Yonezawa, Kengo ^a, Tomiyama, Sota ^a, Nagai, Nobuhiro ^{a, b}, Kusudo, Keisuke ^a, Moriyama, Sotaro ^a, Noda, Yoshihiro ^a, Koike, Shinsuke ^{d, e, f}, Edden, Richard A.E. ^{g, h}, Uchida, Hiroyuki ^a, Nakajima, Shinichiro ^{a, ⁎}

Source: In Journal of Affective Disorders 15 August 2025 383:354-362

Magnetic resonance spectroscopy and the menstrual cycle: A multi-centre assessment of menstrual cycle effects on GABA & GSH

Authors: Song, Yulu ^{a, b}, Prisciandaro, James J. ^c, Apšvalka, Dace ^d, Bernard, Mae ^e, Berrington, Adam ^f, Castelo-Branco, Miguel ^g, Britton, Mark K. ^h, Correia, Marta M. ^d, Cuypers, Koen ^{i, j, k}, Domagalik, Aleksandra ^l, Dydak, Ulrike ^{m, n}, Duncan, Niall W. ^{o, p}, Dwyer, Gerard E. ^{q, r}, Gong, Tao ^{s, t}, Greenhouse, Ian ^{u, v}, Hat, Katarzyna ^{w, x}, Hehl, Melina ^{i, j, k, y}, Honda, Shiori ^z, Horton, Chris ^u, Hui, Steve C.N. ^{aa, ab, ac}, Jackson, Stephen R. ^{ad, ae, af}, Jones, Daniella L. ^ag, Klan, Maren S. ^{o, p}, Lyoo, In Kyoon ^ah, Mada, Marius O. ^d, McNamara, Bronte V. ^{o, p}, Mullins, Paul G. ^e, Muska, Emlyn ^{h, ai}, Nakajima, Shinichiro ^{x, aj}, Nishio, Hayami ^u, Pereira, Andreia C. ^g, Porges, Eric C. ^{h, ai}, Rowsell, Michelle ^{d, e}, Ruopp, Rubi ^u, Shortell, Destin D. ^{h, ai}, Smith, Caitlin M. ^ad, Swinnen, Stephan ^{j, k}, Šušnjar, Antonia ^ak, Tseng, Lin-Yuan ^{o, p}, Violante, Ines R. ^al, Yoon, Sujung ^ah, Edden, Richard A.E. ^{a, b}, Dyke, Katherine ^{ad, ⁎}

Source: In Journal of Neuroscience Methods June 2025 418

Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol

Authors: Dean, Douglas C., III, Tisdall, M Dylan, Wisnowski, Jessica L., Feczko, Eric, Gagoski, Borjan, Alexander, Andrew L., Edden, Richard A.E., Gao, Wei, Hendrickson, Timothy J., Howell, Brittany R., Huang, Hao, Humphreys, Kathryn L., Riggins, Tracy, Sylvester, Chad M., Weldon, Kimberly B., Yacoub, Essa, Ahtam, Banu, Beck, Natacha, Banerjee, Suchandrima, Boroday, Sergiy, Caprihan, Arvind, Caron, Bryan, Carpenter, Samuel, Chang, Yulin, Chung, Ai Wern, Cieslak, Matthew, Clarke, William T., Dale, Anders, Das, Samir, Davies-Jenkins, Christopher W., Dufford, Alexander J., Evans, Alan C., Fesselier, Laetitia, Ganji, Sandeep K., Gilbert, Guillaume, Graham, Alice M., Gudmundson, Aaron T., Macgregor-Hannah, Maren, Harms, Michael P., Hilbert, Tom, Hui, Steve C.N., Irfanoglu, M. Okan, Kecskemeti, Steven, Kober, Tobias, Kuperman, Joshua M., Lamichhane, Bidhan, Landman, Bennett A., Lecour-Bourcher, Xavier, Lee, Erik G., Li, Xu, MacIntyre, Leigh, Madjar, Cecile, Manhard, Mary Kate, Mayer, Andrew R., Mehta, Kahini, Moore, Lucille A., Murali-Manohar, Saipavitra, Navarro, Cristian, Nebel, Mary Beth, Newman, Sharlene D., Newton, Allen T., Noeske, Ralph, Norton, Elizabeth S., Oeltzschner, Georg, Ongaro-Carcy, Regis, Ou, Xiawei, Ouyang, Minhui, Parrish, Todd B., Pekar, James J., Pengo, Thomas, Pierpaoli, Carlo, Poldrack, Russell A., Rajagopalan, Vidya, Rettmann, Dan W., Rioux, Pierre, Rosenberg, Jens T., Salo, Taylor, Satterthwaite, Theodore D., Scott, Lisa S., Shin, Eunkyung, Simegn, Gizeaddis, Simmons, W. Kyle, Song, Yulu, Tikalsky, Barry J., Tkach, Jean, van Zijl, Peter C.M., Vannest, Jennifer, Versluis, Maarten, Zhao, Yansong, Zöllner, Helge J., Fair, Damien A., Smyser, Christopher D., Elison, Jed T.

Source: In Developmental Cognitive Neuroscience December 2024 70

Integrated Short-TE and Hadamard-edited Multi-Sequence (ISTHMUS) for advanced MRS

Authors: Hui, Steve C.N., Murali-Manohar, Saipavitra, Zöllner, Helge J., Hupfeld, Kathleen E., Davies-Jenkins, Christopher W., Gudmundson, Aaron T., Song, Yulu, Yedavalli, Vivek, Wisnowski, Jessica L., Gagoski, Borjan, Oeltzschner, Georg, Edden, Richard A.E.

Source: In Journal of Neuroscience Methods September 2024 409

The Trajectory of Prefrontal GABA Levels in Initially Antipsychotic-Naïve Patients With Psychosis During 2 Years of Treatment and Associations With Striatal Cerebral Blood Flow and Outcome

Authors: Bojesen, Kirsten Borup, Rostrup, Egill, Sigvard, Anne Korning, Mikkelsen, Mark, Edden, Richard A.E., Ebdrup, Bjørn Hylsebeck, Glenthøj, Birte

Source: In Biological Psychiatry: Cognitive Neuroscience and Neuroimaging July 2024 9(7):703-713

MRS study on the correlation between frontal GABA+/Glx ratio and abnormal cognitive function in medication-naive patients with narcolepsy

Authors: Gao, Yanan ^a, Liu, Yanting ^a, Zhao, Sihui ^a, Liu, Yishu ^{b, c}, Zhang, Chen ^d, Hui, Steve ^{e, f}, Mikkelsen, Mark ^{e, f}, Edden, Richard A.E. ^{e, f}, Meng, Xiao ^g, Yu, Bing ^{a, ⁎}, Xiao, Li ^{b, c, ⁎⁎}

Source: In Sleep Medicine July 2024 119:1-8

Association between hearing ability and cortical morphology in the elderly: multiparametric mapping, cognitive relevance, and neurobiological underpinnings

Authors: Qiu, Xiaofan, Yang, Jing, Hu, Xin, Li, Junle, Zhao, Min, Ren, Fuxin, Weng, Xuchu, Edden, Richard A.E., Gao, Fei, Wang, Jinhui

Source: In eBioMedicine June 2024 104

Brain extended and closed forms glutathione levels decrease with age and extended glutathione is associated with visuospatial memory

Authors: Hu, Xin, Pan, Keyu, Zhao, Min, Lv, Jiali, Wang, Jing, Zhang, Xiaofeng, Liu, Yuxi, Song, Yulu, Gudmundson, Aaron T., Edden, Richard A.E., Ren, Fuxin, Zhang, Tao, Gao, Fei

Source: In NeuroImage June 2024 293

Neurotransmitter levels in the basal ganglia are associated with intracortical circuit activity of the primary motor cortex in healthy humans

Authors: Remahi, Sarah ^{a, b}, Mabika, Madora ^c, Côté, Samantha ^{a, b, d}, Iorio-Morin, Christian ^{a, e}, Near, Jamie ^f, Hui, Steve C.N. ^g, Edden, Richard A.E. ^g, Théoret, Hugo ^h, Whittingstall, Kevin ^{a, d}, Lepage, Jean-François ^{a, b, ⁎}

Source: In Progress in Neuropsychopharmacology & Biological Psychiatry 8 February 2024 129

Glutamate and GABA levels in the anterior cingulate cortex in treatment resistant first episode psychosis patients

Authors: van der Pluijm, Marieke, Alting, Maartje, Schrantee, Anouk, Edden, Richard A.E., Booij, Jan, de Haan, Lieuwe, van de Giessen, Elsmarieke

Source: In Schizophrenia Research February 2024 264:471-478

Meta-analysis and open-source database for in vivo brain Magnetic Resonance spectroscopy in health and disease

Authors: Gudmundson, Aaron T., Koo, Annie, Virovka, Anna, Amirault, Alyssa L., Soo, Madelene, Cho, Jocelyn H., Oeltzschner, Georg, Edden, Richard A.E., Stark, Craig E.L.

Source: In Analytical Biochemistry 1 September 2023 676

Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis

Authors: Li, Ning, Ma, Wen, Ren, Fuxin, Li, Xiao, Li, Fuyan, Zong, Wei, Wu, Lili, Dai, Zongrui, Hui, Steve C.N., Edden, Richard A.E., Li, Muwei, Gao, Fei

Source: In NeuroImage March 2023 268

Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity

Authors: Hupfeld, Kathleen E., Zöllner, Helge J., Oeltzschner, Georg, Hyatt, Hayden W., Herrmann, Olivia, Gallegos, Jessica, Hui, Steve C.N., Harris, Ashley D., Edden, Richard A.E., Tsapkini, Kyrana

Source: In Neurobiology of Aging February 2023 122:65-75

Neurometabolic timecourse of healthy aging

Authors: Gong, Tao, Hui, Steve C.N., Zöllner, Helge J., Britton, Mark, Song, Yulu, Chen, Yufan, Gudmundson, Aaron T., Hupfeld, Kathleen E., Davies-Jenkins, Christopher W., Murali-Manohar, Saipavitra, Porges, Eric C., Oeltzschner, Georg, Chen, Weibo, Wang, Guangbin, Edden, Richard A.E.

Source: In NeuroImage 1 December 2022 264

Multimodal assessment of the GABA system in patients with fragile-X syndrome and neurofibromatosis of type 1

Authors: Lacroix, Angelina, Proteau-Lemieux, Mélodie, Côté, Samantha, Near, Jamie, Hui, Steve C.N., Edden, Richard A.E., Lippé, Sarah, Çaku, Artuela, Corbin, François, Lepage, Jean-François

Source: In Neurobiology of Disease November 2022 174

The role of MRS-assessed GABA in human behavioral performance

Authors: Li, Hong, Heise, Kirstin-Friederike, Chalavi, Sima, Puts, Nicolaas A.J., Edden, Richard A.E., Swinnen, Stephan P.

Source: In Progress in Neurobiology May 2022 212

Frequency drift in MR spectroscopy at 3T

Authors: Hui, Steve C.N., Mikkelsen, Mark, Zöllner, Helge J., Ahluwalia, Vishwadeep, Alcauter, Sarael, Baltusis, Laima, Barany, Deborah A., Barlow, Laura R., Becker, Robert, Berman, Jeffrey I., Berrington, Adam, Bhattacharyya, Pallab K., Blicher, Jakob Udby, Bogner, Wolfgang, Brown, Mark S., Calhoun, Vince D., Castillo, Ryan, Cecil, Kim M., Choi, Yeo Bi, Chu, Winnie C.W., Clarke, William T., Craven, Alexander R., Cuypers, Koen, Dacko, Michael, de la Fuente-Sandoval, Camilo, Desmond, Patricia, Domagalik, Aleksandra, Dumont, Julien, Duncan, Niall W., Dydak, Ulrike, Dyke, Katherine, Edmondson, David A., Ende, Gabriele, Ersland, Lars, Evans, C. John, Fermin, Alan S.R., Ferretti, Antonio, Fillmer, Ariane, Gong, Tao, Greenhouse, Ian, Grist, James T., Gu, Meng, Harris, Ashley D., Hat, Katarzyna, Heba, Stefanie, Heckova, Eva, Hegarty, John P., II, Heise, Kirstin-Friederike, Honda, Shiori, Jacobson, Aaron, Jansen, Jacobus F.A., Jenkins, Christopher W., Johnston, Stephen J., Juchem, Christoph, Kangarlu, Alayar, Kerr, Adam B., Landheer, Karl, Lange, Thomas, Lee, Phil, Levendovszky, Swati Rane, Limperopoulos, Catherine, Liu, Feng, Lloyd, William, Lythgoe, David J., Machizawa, Maro G., MacMillan, Erin L., Maddock, Richard J., Manzhurtsev, Andrei V., Martinez-Gudino, María L., Miller, Jack J., Mirzakhanian, Heline, Moreno-Ortega, Marta, Mullins, Paul G., Nakajima, Shinichiro, Near, Jamie, Noeske, Ralph, Nordhøy, Wibeke, Oeltzschner, Georg, Osorio-Duran, Raul, Otaduy, Maria C.G., Pasaye, Erick H., Peeters, Ronald, Peltier, Scott J., Pilatus, Ulrich, Polomac, Nenad, Porges, Eric C., Pradhan, Subechhya, Prisciandaro, James Joseph, Puts, Nicolaas A, Rae, Caroline D., Reyes-Madrigal, Francisco, Roberts, Timothy P.L., Robertson, Caroline E., Rosenberg, Jens T., Rotaru, Diana-Georgiana, O'Gorman Tuura, Ruth L, Saleh, Muhammad G., Sandberg, Kristian, Sangill, Ryan, Schembri, Keith, Schrantee, Anouk, Semenova, Natalia A., Singel, Debra, Sitnikov, Rouslan, Smith, Jolinda, Song, Yulu, Stark, Craig, Stoffers, Diederick, Swinnen, Stephan P., Tain, Rongwen, Tanase, Costin, Tapper, Sofie, Tegenthoff, Martin, Thiel, Thomas, Thioux, Marc, Truong, Peter, van Dijk, Pim, Vella, Nolan, Vidyasagar, Rishma, Vovk, Andrej, Wang, Guangbin, Westlye, Lars T., Wilbur, Timothy K., Willoughby, William R., Wilson, Martin, Wittsack, Hans-Jörg, Woods, Adam J., Wu, Yen-Chien, Xu, Junqian, Lopez, Maria Yanez, Yeung, David K.W., Zhao, Qun, Zhou, Xiaopeng, Zupan, Gasper, Edden, Richard A.E.

Source: In NeuroImage 1 November 2021 241

Hippocampal and striatal responses during motor learning are modulated by prefrontal cortex stimulation

Authors: Gann, Mareike A., King, Bradley R., Dolfen, Nina, Veldman, Menno P., Chan, Kimberly L., Puts, Nicolaas A.J., Edden, Richard A.E., Davare, Marco, Swinnen, Stephan P., Mantini, Dante, Robertson, Edwin M., Albouy, Geneviève

Source: In NeuroImage 15 August 2021 237

Simultaneous quantification of GABA, Glx and GSH in the neonatal human brain using magnetic resonance spectroscopy

Authors: Yanez Lopez, Maria, Price, Anthony N., Puts, Nicolaas A.J., Hughes, Emer J., Edden, Richard A.E., McAlonan, Grainne M., Arichi, Tomoki, De Vita, Enrico

Source: In NeuroImage June 2021 233

Comparison of methods for spectral alignment and signal modelling of GABA-edited MR spectroscopy data

Authors: Rideaux, Reuben, Mikkelsen, Mark, Edden, Richard A.E.

Source: In NeuroImage 15 May 2021 232