Enhancing Breast Cancer Drug Development: Predicting Bioac-tivity and ADMET Properties of ERα Targeting Compounds through Machine Learning

Authors: Lin, Shaolong, Liu, Ruoyu, Yang, Qiuzhi, LIu, Baoquan

Source: 2023 5th International Conference on Machine Learning, Big Data and Business Intelligence (MLBDBI) Machine Learning, Big Data and Business Intelligence (MLBDBI), 2023 5th International Conference on. :58-62 Dec, 2023

Relation: 2023 5th International Conference on Machine Learning, Big Data and Business Intelligence (MLBDBI)

Estrogen receptor alpha (ERα) regulates PARN-mediated nuclear deadenylation and gene expression in breast cancer cells

Authors: Sophia Varriano, Amy Yu, Yu Qing Xu, Devorah M. Natelson, Anthony Ramadei, Frida E. Kleiman

Source: RNA Biology, Vol 21, Iss 1, Pp 1090-1099 (2024)

Subject Terms: Breast cancer, deadenylation, estrogen receptor alpha (ERα), mRNA 3’ end processing, PARN deadenylase, post-transcriptional regulation, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1547-6286; https://doaj.org/toc/1555-8584

Access URL: https://doaj.org/article/7d1a054dec2749678b78a2be4e5caf14

A possible important regulatory role of estrogen in obstructive sleep apnea hypoventilation syndrome

Authors: Pinyi Zhou, Hongmei Li, Hongyan Li, Yan Chen, Yunhui Lv

Source: Frontiers in Medicine, Vol 12 (2025)

Subject Terms: sleep apnea, obstructive, CIH, estrogen, ERα, HIF-1α, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2025.1369393/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/f30a2bfc46a5473195ffbd40f29f06cc

New Approach Methodologies (NAMs) to assess killer whale (Orcinus orca) estrogen receptor alpha (ERα) transactivation potencies by DDTs and their risks

Authors: Dave Arthur R. Robledo, Takahito Kumagawa, Mari Ochiai, Hisato Iwata

Source: Ecotoxicology and Environmental Safety, Vol 291, Iss , Pp 117761- (2025)

Subject Terms: Killer whales, DDTs, Estrogen receptor α (ERα), Endocrine disruption, New Approach Methodologies (NAMs), Risk assessment, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0147651325000971; https://doaj.org/toc/0147-6513

Access URL: https://doaj.org/article/c113aa87b2484dffb09de9db8b54d667

Comprehensive three-dimensional microCT and signaling analysis reveal the teratogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on craniofacial bone development in mice

Authors: Xiao-ming Wang, Cai-ming Qin, Dou Li, Xin-ran Xu, Xiao-jing Pan, Hui Xue

Source: Ecotoxicology and Environmental Safety, Vol 290, Iss , Pp 117743- (2025)

Subject Terms: TCDD, Craniofacial bone, Osteogenesis, Cleft palate, AhR/ ERα cross-talk, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S014765132500079X; https://doaj.org/toc/0147-6513

Access URL: https://doaj.org/article/9df8783caa504390b2d9473097d8d798

Estrogen receptor α aggravates intestinal inflammation via promoting the activation of NLRP3 inflammasome

Authors: Gao, Zhangshan, Ding, Chenchen, Huang, Xi, Liu, Yapei, Fan, Wentao, Song, Suquan ^⁎

Source: In International Immunopharmacology 25 December 2024 143 Part 2

USP36 promotes tumorigenesis and tamoxifen resistance in breast cancer by deubiquitinating and stabilizing ERα

Authors: Ting Zhuang, Shuqing Zhang, Dongyi Liu, Zhongbo Li, Xin Li, Jiaoyan Li, Penghe Yang, Chenmiao Zhang, Jiayao Cui, Mingxi Fu, Fangyu Shen, Lei Yuan, Zhao Zhang, Peng Su, Jian Zhu, Huijie Yang

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)

Subject Terms: USP36, ERα, Breast cancer, Ubiquitin, Stability, Tamoxifen resistance, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/768a7bedac244ef4a0d279eea2a13216

Screening of estrogen receptor activity of per- and polyfluoroalkyl substances based on deep learning and in vivo assessment

Authors: Pang, Xudi, Lu, Miao, Yang, Ying, Cao, Huiming ^⁎, Sun, Yuzhen, Zhou, Zhen, Wang, Ling ^⁎⁎, Liang, Yong

Source: In Environmental Pollution 15 March 2025 369

FOXF2 expression triggered by endocrine therapy orchestrates therapeutic resistance through reorganization of chromatin architecture in breast cancer

Authors: Zhang, Rui ^{a, b}, Jiang, Wen-Jing ^a, Zhao, Shuai ^a, Kang, Li-Juan ^a, Wang, Qing-Shan ^{a, b}, Feng, Yu-Mei ^{a, b, ⁎}

Source: In Cancer Letters 1 March 2025 612

Upregulation of p52-ZER6 (ZNF398) increases reactive oxygen species by suppressing metallothionein-3 in neuronal cells

Authors: Kwag, Eunsang ^{a, b, 1}, Park, Soo Jeong ^{a, b, 1}, Lee, Jee-Ho ^{a, b}, Lee, Ji-Yeong ^{a, b}, Khang, Rin ^a, Shin, Joo-Ho ^{a, b, c, ⁎}

Source: In Biochemical and Biophysical Research Communications 8 February 2025 748

METTL14-mediated m6A modification enhances USP22-ERα axis to drive breast cancer malignancy

Authors: Xuefen Zhuang, Shusha Yin, Ji Cheng, Wenshuang Sun, Zesen Fang, Yujie Xiang, E.-ying Peng, Yu Yao, Yuting Li, Xiaoyue He, Li Lu, Yuanfei Deng, Hongbiao Huang, Gengxi Cai, Yuning Liao

Source: Pharmacological Research, Vol 210, Iss , Pp 107509- (2024)

Subject Terms: Breast cancer, M6A, METTL14, USP22, ERα, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661824004547; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/4dd97e35639a44e29eb502baa5034181

Design, synthesis, and biological evaluation of novel PROTACs compounds with good ERα degradation ability

Authors: Yang, Xueqian ^{a, b}, Zheng, Xiangnan ^b, Liu, Cheng ^b, Zheng, Jiaqing ^b, Dong, Xu ^b, Ren, Wengang ^b, Zhang, Tao ^b, Lou, Hongxiang ^{a, ⁎}, Fan, Peihong ^{a, ⁎, 1}

Source: In Bioorganic & Medicinal Chemistry 1 May 2025 122

GENERATION AND CHARACTERIZATION OF POLYCLONAL ANTIBODIES SPECIFIC TO HUMAN ESTROGEN RECEPTOR ERα

Authors: A.V. Mazov, І. V. Kroupskaya

Source: Biotechnologia Acta, Vol 17, Iss 3, Pp 59-65 (2024)

Subject Terms: human estrogen receptor α (erα), cloning, expression of recombinant proteins, antibodies, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://biotechnology.kiev.ua/images/BTA/2024/3_2024/Mazov_3_2024.pdf; https://doaj.org/toc/2410-7751; https://doaj.org/toc/2410-776X

Access URL: https://doaj.org/article/21266af512704648b41579d9bd35bcee

Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling

Authors: Qing Zhao, Junjie Feng, Fubin Liu, Qianxin Liang, Manlin Xie, Jiaming Dong, Yanfang Zou, Jiali Ye, Guilong Liu, Yue Cao, Zhaodi Guo, Hongzhi Qiao, Lei Zheng, Kewei Zhao

Source: Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 2210-2227 (2024)

Subject Terms: Rhizoma Drynariae-derived nanovesicles, Bone marrow mesenchymal stem cells, Bone targeting, Osteogenic differentiation, ERα signaling, Naringin, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383524000431; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/18a0acbe3c9445bba0ac9c444acf0a4c

Selective impact of ALK and MELK inhibition on ERα stability and cell proliferation in cell lines representing distinct molecular phenotypes of breast cancer

Authors: Stefania Bartoloni, Sara Pescatori, Fabrizio Bianchi, Manuela Cipolletti, Filippo Acconcia

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)

Subject Terms: MELK, ALK, ERα, Breast cancer, 17β-estradiol, Personalized medicine approach, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/71a103b4fd424bdba5771f8600dcacd8

Mitigation of letrozole induced polycystic ovarian syndrome associated inflammatory response and endocrinal dysfunction by Vitex negundo seeds

Authors: Tarun Kumar Kar, Sananda Sil, Angshita Ghosh, Ananya Barman, Sandip Chattopadhyay

Source: Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-16 (2024)

Subject Terms: Polycystic ovarian syndrome, Vitex Nigundo ethanolic extract, Letrozole, NR3C4, ERα, Androgen, Gynecology and obstetrics, RG1-991

File Description: electronic resource

Relation: https://doaj.org/toc/1757-2215

Access URL: https://doaj.org/article/b64c4a05e16b4d388a029469acccdd9a

AutoDock and molecular dynamics-based therapeutic potential prediction of flavonoids for primary Sjögren's syndrome

Authors: Tianjiao Mao, Bo Chen, Wei Wei, Guiping Chen, Zhuoyuan Liu, Lihong Wu, Xiaomeng Li, Janak L. Pathak, Jiang Li

Source: Heliyon, Vol 10, Iss 13, Pp e33860- (2024)

Subject Terms: Primary Sjögren syndrome, Flavonoids, ERα, Molecular docking, Homology modeling, Molecular dynamics simulations, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024098918; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/ef49a9c2401944c89f2b11b4e6e5b8b5

UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5

Authors: Juan Li, Yu Liang, Shijie Zhou, Jie Chen, Chihua Wu

Source: Breast Cancer Research, Vol 26, Iss 1, Pp 1-15 (2024)

Subject Terms: UCHL1, KLF5, EGFR, TET1, TET3, ERα, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/8114d1c29c9742ba9e3d9518415e6f37

High estrogen during ovarian stimulation induced loss of maternal imprinted methylation that is essential for placental development via overexpression of TET2 in mouse oocytes

Authors: Xueyan Lu, Jiaqin Mao, Chenxi Qian, Hui Lei, Fei Mu, Huijun Sun, Song Yan, Zheng Fang, Jie Lu, Qian Xu, Jie Dong, Danjie Su, Jingjing Wang, Ni Jin, Shuqiang Chen, Xiaohong Wang

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)

Subject Terms: DNA methylation, Ovarian stimulation, Parthenogenetic activation, Parthenogenetic embryonic stem cells, ERα, TET2, MEST, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/192cf402b75b463bacbf6e0a519ae401

An estrogen-regulated long non-coding RNA NCALD promotes luminal breast cancer proliferation by activating GRHL2

Authors: Yue Meng, Dianrong Zhou, Ying Luo, Jierong Chen, Hui Li

Source: Cancer Cell International, Vol 24, Iss 1, Pp 1-15 (2024)

Subject Terms: Luminal breast cancer, LncRNA NCALD, LncRNA, GRHL2, ERα, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/2eb9eb9b2bbf42d9b3cfefadf36fdab6