From Genetics to Neuroinflammation: The Impact of ApoE4 on Microglial Function in Alzheimer's Disease.

Authors: Dias, Daniela¹ (AUTHOR) daniela.dias@i3s.up.pt, Portugal, Camila Cabral¹ (AUTHOR), Relvas, João¹ (AUTHOR), Socodato, Renato¹ (AUTHOR) renato.socodato@ibmc.up.pt

Source: Cells (2073-4409). Feb2025, Vol. 14 Issue 4, p243. 25p.

Subject Terms: *GENETIC risk score, *APOLIPOPROTEIN E4, *LIPID metabolism, *APOLIPOPROTEIN E, *SMALL molecules

Discovery of Isobavachin, a Natural Flavonoid, as an Apolipoprotein E4 (ApoE4) Structure Corrector for Alzheimer's Disease.

Authors: Patil, Sachin P.^1,2 (AUTHOR) spatil@widener.edu, Kuehn, Bella R.^1,2 (AUTHOR), McCullough, Christina¹ (AUTHOR), Bates, Dean^1,2 (AUTHOR), Hazim, Hadil¹ (AUTHOR), Diallo, Mamadou¹ (AUTHOR), Francois, Naomie¹ (AUTHOR)

Source: Molecules. Feb2025, Vol. 30 Issue 4, p940. 19p.

Subject Terms: *GENETIC risk score, *APOLIPOPROTEIN E4, *APOLIPOPROTEIN E, *MOLECULES, *ALZHEIMER'S disease

Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice.

Authors: Lin, Yingbin¹ (AUTHOR) lyb6566@fjmu.edu.cn, Luo, Xinqun¹ (AUTHOR), Wang, Fangyu¹ (AUTHOR), Cai, Huange² (AUTHOR), Lin, Yuanxiang¹ (AUTHOR), Kang, Dezhi¹ (AUTHOR), Fang, Wenhua¹ (AUTHOR) fang.wenhua@qq.com

Source: Biology of Sex Differences. 1/20/2025, Vol. 16 Issue 1, p1-10. 10p.

Subject Terms: *DISEASE risk factors, *APOLIPOPROTEIN E4, *HYPOGLYCEMIA, *MEDICAL sciences, *APOLIPOPROTEIN E, *METFORMIN

The Effect of APOE ε4 on Alzheimer's Disease Fluid Biomarkers: A Cross‐Sectional Study Based on the COAST.

Authors: Zhao, Bote^1,2,3 (AUTHOR), Zang, Peixi^1,4 (AUTHOR), Quan, Meina^1,2,3 (AUTHOR), Wang, Qianqian^1,2,3 (AUTHOR), Guo, Dongmei^1,2,3 (AUTHOR), Jia, Jianping^1,2,3 (AUTHOR) jjp@ccmu.edu.cn, Wang, Wei^1,2,3 (AUTHOR) wangwei76@xwhosp.org

Source: CNS Neuroscience & Therapeutics. Jan2025, Vol. 31 Issue 1, p1-12. 12p.

Subject Terms: *APOLIPOPROTEIN E4, *ALZHEIMER'S disease, *NEUROINFLAMMATION, *DIAGNOSIS methods, *LIPID metabolism, *CEREBROSPINAL fluid examination, *BIOMARKERS

Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Aging Apolipoprotein E4 Mice Alters Their Brains' Inflammatory Profiles.

Authors: Huynh, Thao N.¹ (AUTHOR) thao.n.huynh.gr@dartmouth.edu, Fikse, Emma N.² (AUTHOR), De La Torre, Adrianna L.¹ (AUTHOR), Havrda, Matthew C.² (AUTHOR), Chang, Catherine C. Y.¹ (AUTHOR) catherine.chang@dartmouth.edu, Chang, Ta Yuan¹ (AUTHOR) catherine.chang@dartmouth.edu

Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 24, p13690. 20p.

Subject Terms: *APOLIPOPROTEIN E4, *APOLIPOPROTEIN E, *LIPID rafts, *ALZHEIMER'S disease, *MACROMOLECULES, *ACYLTRANSFERASES

TREM2 R47H variant and risk for Alzheimer's disease: assessment in a Greek population and updated meta-analysis.

Authors: Rikos, Dimitrios^1,2 (AUTHOR), Siokas, Vasileios^1,2 (AUTHOR), Mentis, Alexios-Fotios A.^1,2,3 (AUTHOR), Aloizou, Athina-Maria^1,2 (AUTHOR), Liampas, Ioannis^1,2 (AUTHOR), Tsouris, Zisis^1,2 (AUTHOR), Peristeri, Eleni^1,2 (AUTHOR), Stamati, Polyxeni^1,2 (AUTHOR), Hadjigeorgiou, Georgios M.^1,2,4 (AUTHOR), Dardiotis, Efthimios^1,2 (AUTHOR) edar@med.uth.gr

Source: International Journal of Neuroscience. Jul2024, Vol. 134 Issue 7, p786-794. 9p.

Subject Terms: *DISEASE risk factors, *APOLIPOPROTEIN E4, *ALZHEIMER'S disease

Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4‐induced brain pathology.

Authors: Miller, Brendan¹ (AUTHOR), Kim, Su‐Jeong¹ (AUTHOR), Cao, Kevin¹ (AUTHOR), Mehta, Hemal H.¹ (AUTHOR), Thumaty, Neehar¹ (AUTHOR), Kumagai, Hiroshi¹ (AUTHOR), Iida, Tomomitsu¹ (AUTHOR), McGill, Cassandra¹ (AUTHOR), Pike, Christian J.¹ (AUTHOR), Nurmakova, Kamila² (AUTHOR), Levine, Zachary A.^2,3 (AUTHOR), Sullivan, Patrick M.⁴ (AUTHOR), Yen, Kelvin¹ (AUTHOR), Ertekin‐Taner, Nilüfer⁵ (AUTHOR), Atzmon, Gil^6,7 (AUTHOR), Barzilai, Nir⁶ (AUTHOR), Cohen, Pinchas¹ (AUTHOR) hassy@usc.edu

Source: Aging Cell. Jul2024, Vol. 23 Issue 7, p1-13. 13p.

Subject Terms: *APOLIPOPROTEIN E4, *APOLIPOPROTEIN E, *BRAIN diseases, *MOLECULAR pathology, *DISEASE risk factors, *PEPTIDES

FLIM Imaging Reveals a Toxicogenic Interaction between Amyloid-β and Apolipoprotein-E.

Authors: Dey, Arpan¹ (AUTHOR), Verma, Aditi¹ (AUTHOR), Bhaskar, Uchit² (AUTHOR), Sarkar, Bidyut³ (AUTHOR), Kallianpur, Mamata¹ (AUTHOR), Vishvakarma, Vicky¹ (AUTHOR), Das, Anand Kant^1,4 (AUTHOR), Garai, Kanchan⁵ (AUTHOR), Mukherjee, Odity² (AUTHOR), Ishii, Kunihiko³ (AUTHOR), Tahara, Tahei³ (AUTHOR), Maiti, Sudipta¹ (AUTHOR)

Source: Indian Journal of Medical & Paediatric Oncology. 2024 Supplement 1, Vol. 45, pS1-S16. 16p.

Subject Terms: *AMYLOID plaque, *APOLIPOPROTEIN E4, *OLIGOMERS, *DRUG discovery

Microglial Transforming Growth Factor-β Signaling in Alzheimer's Disease.

Authors: Vidovic, Natascha¹ (AUTHOR) natascha.vidovic@uni-bielefeld.de, Spittau, Björn¹ (AUTHOR) bjoern.spittau@uni-bielefeld.de

Source: International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 6, p3090. 20p.

Subject Terms: *ALZHEIMER'S disease, *APOLIPOPROTEIN E4, *APOLIPOPROTEIN E, *MYELOID cells, *CELL receptors, *MICROGLIA, *NEURODEGENERATION

Leading determinants of incident dementia among individuals with and without the apolipoprotein E ε4 genotype: a retrospective cohort study.

Authors: Ye, Siting^1,2 (AUTHOR), Roccati, Eddy³ (AUTHOR), Wang, Wei⁴ (AUTHOR), Zhu, Zhuoting^5,6,7 (AUTHOR), Kiburg, Katerina⁷ (AUTHOR), Huang, Yu^5,6 (AUTHOR), Zhang, Xueli⁵ (AUTHOR), Zhang, Xiayin^5,6 (AUTHOR), Liu, Jiahao⁷ (AUTHOR), Tang, Shulin⁵ (AUTHOR), Hu, Yijun⁵ (AUTHOR), Ge, Zongyuan⁸ (AUTHOR), Yu, Honghua⁵ (AUTHOR) yuhonghua@gdph.org.cn, He, Mingguang^4,5,7 (AUTHOR) mingguang_he@yahoo.com, Shang, Xianwen^5,6,7,9 (AUTHOR) xianwen.shang@unimelb.edu.au

Source: BMC Neurology. 2/20/2024, Vol. 24 Issue 1, p1-13. 13p.

Subject Terms: *APOLIPOPROTEIN E, *APOLIPOPROTEIN E4, *DISEASE risk factors, *MEDICAL record linkage, *DEMENTIA, *INCOME

Geographic Terms: UNITED Kingdom

ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9.

Authors: Ghosh, Shamasree¹ (AUTHOR) shamasree.ghosh@umu.se, Tamilselvi, Shanmugam¹ (AUTHOR) tamilselvi.shanmugam@umu.se, Williams, Chloe² (AUTHOR) chloe.williams@umu.se, Jayaweera, Sanduni W.³ (AUTHOR) sanduni.jayakodi@umu.se, Iashchishyn, Igor A.¹ (AUTHOR) igor.iashchishyn@umu.se, Šulskis, Darius⁴ (AUTHOR) darius.sulskis@gmc.vu.lt, Gilthorpe, Jonathan D.² (AUTHOR) jonathan.gilthorpe@umu.se, Olofsson, Anders³ (AUTHOR) anders.olofsson@umu.se, Smirnovas, Vytautas⁴ (AUTHOR) vytautas.smirnovas@bti.vu.lt, Svedružić, Željko M.⁵ (AUTHOR), Morozova-Roche, Ludmilla A.¹ (AUTHOR) ludmilla.morozova-roche@umu.se

Source: International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 4, p2114. 21p.

Subject Terms: *APOLIPOPROTEIN E, *APOLIPOPROTEIN E4, *AMYLOID, *AMINO acid residues, *ALZHEIMER'S disease, *CALCIUM-binding proteins, *PROTEINS

Quantitative electroencephalography (qEEG), apolipoprotein A-I (APOA-I), and apolipoprotein epsilon 4 (APOE ɛ4) alleles for the diagnosis of mild cognitive impairment and Alzheimer's disease.

Authors: Niu, Xiaoqian^1,2 (AUTHOR), Wang, Yuye^1,3 (AUTHOR), Zhang, Xiangfei¹ (AUTHOR), Wang, Yu^1,2 (AUTHOR), Shao, Wen¹ (AUTHOR), Chen, Leian^1,3 (AUTHOR), Yang, Ziyuan^1,2 (AUTHOR), Peng, Dantao^1,2,3 (AUTHOR) pengdantao2000@163.com

Source: Neurological Sciences. Feb2024, Vol. 45 Issue 2, p547-556. 10p.

Subject Terms: *APOLIPOPROTEIN E4, *MILD cognitive impairment, *APOLIPOPROTEIN A, *ALZHEIMER'S disease, *AMNESTIC mild cognitive impairment, *APOLIPOPROTEIN E, *EXECUTIVE function

Cortisol and 10‐Year Cognitive Decline in Older People From the General Population.

Authors: Amendola, Simone¹ (AUTHOR) amend.sim@gmail.com, Ouanes, Sami^2,3 (AUTHOR), Zullo, Leonardo⁴ (AUTHOR), Rabl, Miriam¹ (AUTHOR), Pistis, Giorgio⁵ (AUTHOR), Castelao, Enrique⁵ (AUTHOR), Marques‐Vidal, Pedro⁶ (AUTHOR), Vaucher, Julien^7,8 (AUTHOR), von Gunten, Armin² (AUTHOR), Preisig, Martin⁴ (AUTHOR), Popp, Julius^1,2 (AUTHOR) julius.popp@uzh.ch

Source: European Journal of Neurology. Mar2025, Vol. 32 Issue 3, p1-13. 13p.

Subject Terms: *OLDER people, *APOLIPOPROTEIN E4, *LONGITUDINAL method, *HYDROCORTISONE, *MINI-Mental State Examination, *COGNITION disorders

Daily fluid intake and brain amyloid deposition: A cohort study.

Authors: Kim, Jee Wook^1,2 (AUTHOR), Byun, Min Soo^3,4 (AUTHOR), Yi, Dahyun⁵ (AUTHOR), Jung, Joon Hyung⁶ (AUTHOR), Kong, Nayeong⁷ (AUTHOR), Chang, Yoon Young⁸ (AUTHOR), Jung, Gijung⁵ (AUTHOR), Ahn, Hyejin⁵ (AUTHOR), Lee, Jun-Young^4,9 (AUTHOR), Kang, Koung Mi¹⁰ (AUTHOR), Sohn, Chul-Ho¹⁰ (AUTHOR), Lee, Yun-Sang¹¹ (AUTHOR), Kim, Yu Kyeong¹² (AUTHOR), Lee, Dong Young^3,4,5 (AUTHOR) selfpsy@snu.ac.kr

Source: Journal of Alzheimer's Disease. Mar2025, Vol. 104 Issue 1, p138-149. 12p.

Subject Terms: *APOLIPOPROTEIN E, *APOLIPOPROTEIN E4, *ALZHEIMER'S disease, *DRINKING (Physiology), *OLDER people

Sex-specific effects of apolipoprotein E ε4 genotype on longitudinal hippocampal atrophy in amnestic mild cognitive impairment over a 2-year evaluation period.

Authors: Park, Chang Hyun^1,2 (AUTHOR), Lee, Hyunji^2,3 (AUTHOR), Lee, Young-Min^2,3,4 (AUTHOR) psyleekr@naver.com, Lee, Byung-Dae^2,3,4 (AUTHOR), Moon, Eunsoo^2,3,4 (AUTHOR), Suh, Hwagyu^2,3 (AUTHOR), Kim, Kyungwon^2,3 (AUTHOR), Kim, Hak-Jin^2,4,5 (AUTHOR), Shim, Hwanwook^2,3,4 (AUTHOR), Pak, Kyoungjune^2,4,6 (AUTHOR), Choi, Kyung-Un^2,4,7 (AUTHOR), Kim, Chang-Seok^1,8 (AUTHOR)

Source: Journal of Alzheimer's Disease. Feb2025, Vol. 103 Issue 4, p1269-1276. 8p.

Subject Terms: *AMNESTIC mild cognitive impairment, *APOLIPOPROTEIN E4, *TWO-way analysis of variance, *MILD cognitive impairment, *APOLIPOPROTEIN E

Effect of genetic and vascular risk factors on rates of cognitive decline in early-onset and late-onset Alzheimer's disease.

Authors: Li, Yunyi¹ (AUTHOR), Sanjay, Apoorva Bharthur² (AUTHOR), Manchella, Mohit³ (AUTHOR), Mishra, Aryan⁴ (AUTHOR), Logan, Paige E² (AUTHOR), Kim, Hee Jin^2,5 (AUTHOR), Risacher, Shannon L^6,7 (AUTHOR), Gao, Sujuan^1,6 (AUTHOR), Apostolova, Liana G^2,6 (AUTHOR) lapostol@iu.edu

Source: Journal of Alzheimer's Disease. Feb2025, Vol. 103 Issue 3, p920-930. 11p.

Subject Terms: *DISEASE risk factors, *APOLIPOPROTEIN E4, *ALZHEIMER'S disease, *APOLIPOPROTEIN E, *CEREBRAL atrophy

Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status.

Authors: Reas, Emilie T.¹ (AUTHOR) ereas@health.ucsd.edu, Triebswetter, Curtis¹ (AUTHOR), Banks, Sarah J.¹ (AUTHOR), McEvoy, Linda K.^2,3 (AUTHOR)

Source: Alzheimer's Research & Therapy. 1/11/2024, Vol. 16, p1-12. 12p.

Subject Terms: *APOLIPOPROTEIN E4, *OLDER people, *APOLIPOPROTEIN E, *COGNITIVE aging, *ENTORHINAL cortex, *MILD cognitive impairment

Geographic Terms: SAN Diego (Calif.)

Company/Entity: UNIVERSITY of California, San Francisco

Identification of female-enriched and disease-associated microglia (FDAMic) contributes to sexual dimorphism in late-onset Alzheimer's disease.

Authors: Wu, Deng¹ (AUTHOR), Bi, Xiaoman² (AUTHOR), Chow, Kim Hei-Man^1,3,4 (AUTHOR) heimanchow@cuhk.edu.hk

Source: Journal of Neuroinflammation. 1/4/2024, Vol. 21 Issue 1, p1-21. 21p.

Subject Terms: *ALZHEIMER'S disease, *APOLIPOPROTEIN E4, *SEXUAL dimorphism, *HORMONE therapy, *MICROGLIA, *ESTROGEN receptors

Ginkgo biloba extract mitigates the neurotoxicity of AlCl3 in alzheimer rat's model: role of apolipoprotein E4 and clusterin genes in stimulating ROS generation and apoptosis.

Authors: Batawi, Ashwaq H.¹ (AUTHOR) abatawi@kau.edu.sa

Source: International Journal of Neuroscience. 2024, Vol. 134 Issue 1, p34-44. 11p.

Subject Terms: *APOLIPOPROTEIN E4, *ACETYLCHOLINESTERASE, *APOLIPOPROTEIN E, *CLUSTERIN, *ALZHEIMER'S disease, *GINKGO, *GENE targeting

Thirty Risk Factors for Alzheimer's Disease Unified by a Common Neuroimmune–Neuroinflammation Mechanism.

Authors: Weaver, Donald F.¹ (AUTHOR) donald.weaver@uhnresearch.ca

Source: Brain Sciences (2076-3425). Jan2024, Vol. 14 Issue 1, p41. 25p.

Subject Terms: *DISEASE risk factors, *APOLIPOPROTEIN E4, *ALZHEIMER'S disease