Malaria elimination challenges in countries approaching the last mile: a discussion among regional stakeholders

Authors: Dysoley Lek, Manash Shrestha, Karma Lhazeen, Tobgyel Tobgyel, Shashi Kandel, Gokarna Dahal, Yadu Chandra Ghimire, Bijaya Shrestha, Prakash Ghimire, Phone Si Hein, Thomas J. Peto, James J. Callery, Rupam Tripura, Lorenz von Seidlein, Chanaki Amaratunga, Caroline A. Lynch, Arjen M. Dondorp, Bipin Adhikari

Source: Malaria Journal, Vol 23, Iss 1, Pp 1-12 (2024)

Subject Terms: Last mile, Challenges in malaria elimination, Cambodia, Nepal, Bhutan, Outbreaks, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2875

Access URL: https://doaj.org/article/54b4ebd96139483d9255d3218daa6b6e

Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background

Authors: Sourav Nayak, Thomas J. Peto, Michal Kucharski, Rupam Tripura, James J. Callery, Duong Tien Quang Huy, Mathieu Gendrot, Dysoley Lek, Ho Dang Trung Nghia, Rob W. van der Pluijm, Nguyen Dong, Le Thanh Long, Ranitha Vongpromek, Huy Rekol, Nguyen Hoang Chau, Olivo Miotto, Mavuto Mukaka, Mehul Dhorda, Lorenz von Seidlein, Mallika Imwong, Xavier Roca, Nicholas P. J. Day, Nicholas J. White, Arjen M. Dondorp, Zbynek Bozdech

Source: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/29b3bb4812894fb0b0a2f1767eeb054b

Impact of targeted drug administration and intermittent preventive treatment for forest goers using artesunate–pyronaridine to control malaria outbreaks in Cambodia

Authors: Dysoley Lek, Nguon Sokomar, Top Samphornarann, Jeanne Rideout, Saad El-Din Hassan, Tol Bunkea, Saing Sam Ath, Rothpisey Seng, John Hustedt, Thomas J. Peto, Jayme Hughes, Ke Kimmen, Khoy Dy, Bipin Adhikari

Source: Tropical Medicine and Health, Vol 52, Iss 1, Pp 1-9 (2024)

Subject Terms: Targeted drug administration, Intermittent preventive treatment, Outbreak response, forest goers, Artesunate–pyronaridine, Cambodia, Arctic medicine. Tropical medicine, RC955-962

File Description: electronic resource

Relation: https://doaj.org/toc/1349-4147

Access URL: https://doaj.org/article/a145482b60ce43cabc2a2f16a78e5416

A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance

Authors: John Kane, Xue Li, Sudhir Kumar, Katrina A. Button-Simons, Katelyn M. Vendrely Brenneman, Haley Dahlhoff, Mackenzie A. C. Sievert, Lisa A. Checkley, Douglas A. Shoue, Puspendra P. Singh, Biley A. Abatiyow, Meseret T. Haile, Shalini Nair, Ann Reyes, Rupam Tripura, Thomas J. Peto, Dysoley Lek, Angana Mukherjee, Stefan H. I. Kappe, Mehul Dhorda, Standwell C. Nkhoma, Ian H. Cheeseman, Ashley M. Vaughan, Timothy J. C. Anderson, Michael T. Ferdig

Source: mBio, Vol 15, Iss 7 (2024)

Subject Terms: malaria, Plasmodium falciparum, genetic cross, piperaquine, drug resistance evolution, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/b191e5641f084dea867745f9b4a6c1b8

Radical cure for Plasmodium vivax malaria after G6PD qualitative testing in four provinces in Cambodia, results from Phase I implementation

Authors: Dysoley Lek, Yu-Cheng Tsai, Jillian Hirano, Siv Sovannaroth, Voeurng Bunreth, Prak Vonn, Or Vannthen, Tol Bunkea, Top Samphornarann, Nguon Sokomar, Mak Sarath, Soy Ty Kheang, Evelyn Wong, Michelle K. Burbach, Jayme Hughes, Huy Rekol

Source: Malaria Journal, Vol 23, Iss 1, Pp 1-13 (2024)

Subject Terms: Malaria, Radical cure, Cambodia, Plasmodium vivax, Glucose-6-phosphate dehydrogenase, 8-aminoquinoline, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2875

Access URL: https://doaj.org/article/2c7c141c70024d6f81d5a5f299896045

Using serological diagnostics to characterize remaining high-incidence pockets of malaria in forest-fringe Cambodia

Authors: Mathilde Grimée, Costanza Tacoli, Mirco Sandfort, Thomas Obadia, Aimee R. Taylor, Amélie Vantaux, Leanne J. Robinson, Dysoley Lek, Rhea J. Longley, Ivo Mueller, Jean Popovici, Michael T. White, Benoît Witkowski

Source: Malaria Journal, Vol 23, Iss 1, Pp 1-12 (2024)

Subject Terms: Plasmodium vivax, Serology, Risk stratification, Forest, Cambodia, Greater Mekong Subregion, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2875

Access URL: https://doaj.org/article/c12ecb854bd64b19b26118c1d6c8b064

Strategies for deploying triple artemisinin-based combination therapy in the Greater Mekong Subregion

Authors: Freek de Haan, Chanaki Amaratunga, Van Anh Cao Thi, Long Heng Orng, Manithong Vonglokham, Thieu Nguyen Quang, Dysoley Lek, Wouter P. C. Boon, Arjen M. Dondorp, Ellen H. M. Moors

Source: Malaria Journal, Vol 22, Iss 1, Pp 1-11 (2023)

Subject Terms: Triple artemisinin-based combination therapy (TACT), Implementation strategies, Antimalarial resistance, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2875

Access URL: https://doaj.org/article/526225ade12843e383855c84cd96d85c

Correction: Expanding the role of village malaria workers in Cambodia: Implementation and evaluation of four health education packages.

Authors: Mipharny Betrian, Dafne Umans, Moul Vanna, Sam Ol, Bipin Adhikari, Chan Davoeung, James J Callery, Yok Sovann, Thomas J Peto, Richard J Maude, Rob W van der Pluijm, Voeurng Bunreth, Martin P Grobusch, Michèle van Vugt, Yoel Lubell, Lorenz von Seidlein, Arjen M Dondorp, Siv Sovannaroth, Dysoley Lek, Rupam Tripura

Source: PLoS ONE, Vol 19, Iss 12, p e0315636 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b9b84bac9cab435986d9f79afa653670

Implementation of Glucose-6-Phosphate Dehydrogenase (G6PD) testing for Plasmodium vivax case management, a mixed method study from Cambodia.

Authors: Sarah A Cassidy-Seyoum, Keoratha Chheng, Phal Chanpheakdey, Agnes Meershoek, Michelle S Hsiang, Lorenz von Seidlein, Rupam Tripura, Bipin Adhikari, Benedikt Ley, Ric N Price, Dysoley Lek, Nora Engel, Kamala Thriemer

Source: PLOS Global Public Health, Vol 4, Iss 7, p e0003476 (2024)

Subject Terms: Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/2767-3375

Access URL: https://doaj.org/article/b899c555495b4fda90cbd9ac7dfc78e2

An active and targeted survey reveals asymptomatic malaria infections among high-risk populations in Mondulkiri, Cambodia

Authors: Dyna Doum, David J. Mclver, John Hustedt, Jeffrey Hii, Siv Sovannaroth, Dysoley Lek, Jason H. Richardson, Allison Tatarsky, Neil F. Lobo

Source: Malaria Journal, Vol 22, Iss 1, Pp 1-11 (2023)

Subject Terms: Malaria, Asymptomatic, Blood spots, Prevalence, PCR, Plasmodium, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2875

Access URL: https://doaj.org/article/c4c92cc22bbb46c0ac6a83c7603a642b

Efficacy of three anti-malarial regimens for uncomplicated Plasmodium falciparum malaria in Cambodia, 2009–2011: a randomized controlled trial and brief review

Authors: Dysoley Lek, Agus Rachmat, Dustin Harrison, Geoffrey Chin, Suwanna Chaoratanakawee, David Saunders, Didier Menard, William O. Rogers

Source: Malaria Journal, Vol 21, Iss 1, Pp 1-17 (2022)

Subject Terms: Uncomplicated falciparum malaria, Cambodia, Antimalarial resistance, Randomized clinical trial, Therapeutic efficacy, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2875

Access URL: https://doaj.org/article/e2910843bfe04e7b95aafa4cbbf51a08

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

Authors: Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak, Jaishree Tripathi, Nicholas J. White, Nicholas P. J. Day, Abul Faiz, Aung Pyae Phyo, Chanaki Amaratunga, Dysoley Lek, Elizabeth A. Ashley, François Nosten, Frank Smithuis, Hagai Ginsburg, Lorenz von Seidlein, Khin Lin, Mallika Imwong, Kesinee Chotivanich, Mayfong Mayxay, Mehul Dhorda, Hoang Chau Nguyen, Thuy Nhien Thanh Nguyen, Olivo Miotto, Paul N. Newton, Podjanee Jittamala, Rupam Tripura, Sasithon Pukrittayakamee, Thomas J. Peto, Tran Tinh Hien, Arjen M. Dondorp, Zbynek Bozdech

Source: Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/2819f6d4f533428085849ed66f62dc4e

Expanding the role of village malaria workers in Cambodia: Implementation and evaluation of four health education packages.

Authors: Mipharny Betrian, Dafne Umans, Moul Vanna, Sam Ol, Bipin Adhikari, Chan Davoeung, James J Callery, Yok Sovann, Thomas J Peto, Richard J Maude, Rob W van der Pluijm, Voeunrung Bunreth, Martin P Grobusch, Michèle van Vugt, Yoel Lubell, Lorenz von Seidlein, Arjen M Dondorp, Siv Sovannaroth, Dysoley Lek, Rupam Tripura

Source: PLoS ONE, Vol 18, Iss 9, p e0283405 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/424d0f37a7e44d739aed1c25c4c628c5

Anopheles ecology, genetics and malaria transmission in northern Cambodia

Authors: Amélie Vantaux, Michelle M. Riehle, Eakpor Piv, Elise J. Farley, Sophy Chy, Saorin Kim, Anneli G. Corbett, Rachel L. Fehrman, Anais Pepey, Karin Eiglmeier, Dysoley Lek, Sovannaroth Siv, Ivo Mueller, Kenneth D. Vernick, Benoit Witkowski

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/0269045c833d476d9a8093d6977299af

Forest malaria in Cambodia: the occupational and spatial clustering of Plasmodium vivax and Plasmodium falciparum infection risk in a cross-sectional survey in Mondulkiri province, Cambodia

Authors: Mirco Sandfort, Amélie Vantaux, Saorin Kim, Thomas Obadia, Anaïs Pepey, Soazic Gardais, Nimol Khim, Dysoley Lek, Michael White, Leanne J. Robinson, Benoit Witkowski, Ivo Mueller

Source: Malaria Journal, Vol 19, Iss 1, Pp 1-12 (2020)

Subject Terms: Forest, Occupational risk, Spatial, Vivax, Hotspots, Cambodia, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12936-020-03482-4; https://doaj.org/toc/1475-2875

Access URL: https://doaj.org/article/4f30aaf46fbe493991690b40545854f7

Tools to accelerate falciparum malaria elimination in Cambodia: a meeting report

Authors: Dysoley Lek, James J. Callery, Chea Nguon, Mark Debackere, Siv Sovannaroth, Rupam Tripura, Marius Wojnarski, Patrice Piola, Soy Ty Khean, Kylie Manion, Sokomar Nguon, Amber Kunkel, Lieven Vernaeve, Thomas J. Peto, Emily Dantzer, Chan Davoeung, William Etienne, Arjen M. Dondorp, Luciano Tuseo, Lorenz von Seidlein, Jean-Olivier Guintran

Source: Malaria Journal, Vol 19, Iss 1, Pp 1-12 (2020)

Subject Terms: Cambodia, Case detection, Forest malaria, Malaria elimination, Mass drug administration, Plasmodium falciparum, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12936-020-03197-6; https://doaj.org/toc/1475-2875

Access URL: https://doaj.org/article/680d51b7f8a04bcea04c4603c466d6f8

Optimizing bulk segregant analysis of drug resistance using Plasmodium falciparum genetic crosses conducted in humanized mice

Authors: Katelyn Vendrely Brenneman, Xue Li, Sudhir Kumar, Elizabeth Delgado, Lisa A. Checkley, Douglas A. Shoue, Ann Reyes, Biley A. Abatiyow, Meseret T. Haile, Rupam Tripura, Tom Peto, Dysoley Lek, Katrina A. Button-Simons, Stefan H.I. Kappe, Mehul Dhorda, François Nosten, Standwell C. Nkhoma, Ian H. Cheeseman, Ashley M. Vaughan, Michael T. Ferdig, Tim J.C. Anderson

Source: iScience, Vol 25, Iss 4, Pp 104095- (2022)

Subject Terms: Biological sciences, Genomics, Parasitology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222003650; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/92955e99b1f54ae581be8c1979028447

G6PD testing and radical cure for Plasmodium vivax in Cambodia: A mixed methods implementation study.

Authors: Soy Ty Kheang, Rosemarie Ridley, Eng Ngeth, Por Ir, Pengby Ngor, Siv Sovannaroth, Dysoley Lek, Somaly Phon, Neeraj Kak, Shunmay Yeung

Source: PLoS ONE, Vol 17, Iss 10, p e0275822 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/512c26bf87864e0da2e32bca0edbb385

Forest work and its implications for malaria elimination: a qualitative study

Authors: Nou Sanann, Thomas J. Peto, Rupam Tripura, James J. Callery, Chea Nguon, Thanh Mai Bui, Stephanie D. Nofal, Lorenz von Seidlein, Dysoley Lek, Arjen M. Dondorp, Phaik Yeong Cheah, Christopher Pell

Source: Malaria Journal, Vol 18, Iss 1, Pp 1-11 (2019)

Subject Terms: Malaria, Elimination, Forest, Greater Mekong Sub-region, Qualitative, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12936-019-3008-3; https://doaj.org/toc/1475-2875

Access URL: https://doaj.org/article/a8d563c006e54b0c94ff394277e0f088

Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination

Authors: Christopher G Jacob, Nguyen Thuy-Nhien, Mayfong Mayxay, Richard J Maude, Huynh Hong Quang, Bouasy Hongvanthong, Viengxay Vanisaveth, Thang Ngo Duc, Huy Rekol, Rob van der Pluijm, Lorenz von Seidlein, Rick Fairhurst, François Nosten, Md Amir Hossain, Naomi Park, Scott Goodwin, Pascal Ringwald, Keobouphaphone Chindavongsa, Paul Newton, Elizabeth Ashley, Sonexay Phalivong, Rapeephan Maude, Rithea Leang, Cheah Huch, Le Thanh Dong, Kim-Tuyen Nguyen, Tran Minh Nhat, Tran Tinh Hien, Hoa Nguyen, Nicole Zdrojewski, Sara Canavati, Abdullah Abu Sayeed, Didar Uddin, Caroline Buckee, Caterina I Fanello, Marie Onyamboko, Thomas Peto, Rupam Tripura, Chanaki Amaratunga, Aung Myint Thu, Gilles Delmas, Jordi Landier, Daniel M Parker, Nguyen Hoang Chau, Dysoley Lek, Seila Suon, James Callery, Podjanee Jittamala, Borimas Hanboonkunupakarn, Sasithon Pukrittayakamee, Aung Pyae Phyo, Frank Smithuis, Khin Lin, Myo Thant, Tin Maung Hlaing, Parthasarathi Satpathi, Sanghamitra Satpathi, Prativa K Behera, Amar Tripura, Subrata Baidya, Neena Valecha, Anupkumar R Anvikar, Akhter Ul Islam, Abul Faiz, Chanon Kunasol, Eleanor Drury, Mihir Kekre, Mozam Ali, Katie Love, Shavanthi Rajatileka, Anna E Jeffreys, Kate Rowlands, Christina S Hubbart, Mehul Dhorda, Ranitha Vongpromek, Namfon Kotanan, Phrutsamon Wongnak, Jacob Almagro Garcia, Richard D Pearson, Cristina V Ariani, Thanat Chookajorn, Cinzia Malangone, T Nguyen, Jim Stalker, Ben Jeffery, Jonathan Keatley, Kimberly J Johnson, Dawn Muddyman, Xin Hui S Chan, John Sillitoe, Roberto Amato, Victoria Simpson, Sonia Gonçalves, Kirk Rockett, Nicholas P Day, Arjen M Dondorp, Dominic P Kwiatkowski, Olivo Miotto

Source: eLife, Vol 10 (2021)

Subject Terms: malaria, genetic surveillance, drug resistance, asia, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/62997; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/b9ea0c3fbc464263ad577b4b2da14f13