FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

Authors: Wieder, Nicolas, Fried, Juliana Coraor, Kim, Choah, Sidhom, Eriene-Heidi, Brown, Matthew R., Marshall, Jamie L., Arevalo, Carlos, Dvela-Levitt, Moran, Kost-Alimova, Maria, Sieber, Jonas, Gabriel, Katlyn R., Pacheco, Julian, Clish, Clary, Abbasi, Hamdah Shafqat, Singh, Shantanu, Rutter, Justine C., Therrien, Martine, Yoon, Haejin, Lai, Zon Weng, Baublis, Aaron, Subramanian, Renuka, Devkota, Ranjan, Small, Jonnell, Sreekanth, Vedagopuram, Han, Myeonghoon, Lim, Donghyun, Carpenter, Anne E., Flannick, Jason, Finucane, Hilary, Haigis, Marcia C., Claussnitzer, Melina, Sheu, Eric, Stevens, Beth, Wagner, Bridget K., Choudhary, Amit, Shaw, Jillian L., Pablo, Juan Lorenzo, Greka, Anna

Source: In Cell Metabolism 2 May 2023 35(5):887-905

A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies

Authors: Dvela-Levitt, Moran, Shaw, Jillian L., Greka, Anna

Source: In Trends in Molecular Medicine April 2021 27(4):394-409

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

Authors: Dvela-Levitt, Moran, Kost-Alimova, Maria, Emani, Maheswarareddy, Kohnert, Eva, Thompson, Rebecca, Sidhom, Eriene-Heidi, Rivadeneira, Ana, Sahakian, Nareh, Roignot, Julie, Papagregoriou, Gregory, Montesinos, Monica S., Clark, Abbe R., McKinney, David, Gutierrez, Juan, Roth, Mark, Ronco, Lucienne, Elonga, Esther, Carter, Todd A., Gnirke, Andreas, Melanson, Michelle, Hartland, Kate, Wieder, Nicolas, Hsu, Jane C.-H., Deltas, Constantinos, Hughey, Rebecca, Bleyer, Anthony J., Kmoch, Stanislav, Živná, Martina, Barešova, Veronika, Kota, Savithri, Schlondorff, Johannes, Heiman, Myriam, Alper, Seth L., Wagner, Florence, Weins, Astrid, Golub, Todd R., Lander, Eric S., Greka, Anna

Source: In Cell 25 July 2019 178(3):521-535

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

Authors: Zhou, Yiming, Castonguay, Philip, Sidhom, Eriene-Heidi, Clark, Abbe R., Dvela-Levitt, Moran, Kim, Sookyung, Sieber, Jonas, Wieder, Nicolas, Jung, Ji Yong, Andreeva, Svetlana, Reichardt, Jana, Dubois, Frank, Hoffmann, Sigrid C., Basgen, John M., Montesinos, Mónica S., Weins, Astrid, Johnson, Ashley C., Lander, Eric S., Garrett, Michael R., Hopkins, Corey R., Greka, Anna

Source: Science, 2017 Dec 01. 358(6368), 1332-1336.

Access URL: https://www.jstor.org/stable/26401050

Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress

Authors: Sieber, Jonas, Wieder, Nicolas, Ostrosky-Frid, Mauricio, Dvela-Levitt, Moran, Aygün, Ozan, Udeshi, Namrata D., Carr, Steven A., Greka, Anna

Source: In Journal of Biological Chemistry 17 November 2017 292(46):18878-18885

Involvement of the Na + , K + -ATPase α1 Isoform and Endogenous Cardiac Steroids in Depression- and Manic-like Behaviors.

Authors: Horesh, Noa, Pelov, Ilana, Pogodin, Ilana, Zannadeh, Hiba, Rosen, Haim, Mikhrina, Anastasiia Leonidovna, Dvela-Levitt, Moran, Sampath, Vishnu Priya, Lichtstein, David

Source: International Journal of Molecular Sciences; Feb2024, Vol. 25 Issue 3, p1644, 13p

Subject Terms: MEMBRANE transport proteins, CURIOSITY, BIPOLAR disorder, CELL membranes, BINDING sites, POTASSIUM channels

Elucidation of a novel mechanism for faulty protein retention and a therapeutic strategy for facilitated lysosomal removal

Authors: Dvela‐Levitt, Moran, Alimova, Maria, Kohnert, Eva, Emani, Maheswarareddy, Sidhom, Eriene, Bleyer, Anthony, Kmoch, Stanislav, Alper, Seth, Greka, Anna

Source: FASEB journal. 35

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123850637.0x000001&indx=1&recIds=ETOCvdc_100123850637.0x000001

A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury

Authors: Kost-Alimova, Maria, Sidhom, Eriene-Heidi, Satyam, Abhigyan, Chamberlain, Brian T., Dvela-Levitt, Moran, Melanson, Michelle, Alper, Seth L., Santos, Jean, Gutierrez, Juan, Subramanian, Ayshwarya, Byrne, Patrick J., Grinkevich, Elizabeth, Reyes-Bricio, Estefanía, Kim, Choah, Clark, Abbe R., Watts, Andrew J.B., Thompson, Rebecca, Marshall, Jamie, Pablo, Juan Lorenzo, Coraor, Juliana, Roignot, Julie, Vernon, Katherine A., Keller, Keith, Campbell, Alissa, Emani, Maheswarareddy, Racette, Matthew, Bazua-Valenti, Silvana, Padovano, Valeria, Weins, Astrid, McAdoo, Stephen P., Tam, Frederick W.K., Ronco, Luciene, Wagner, Florence, Tsokos, George C., Shaw, Jillian L., Greka, Anna

Source: In Cell Reports Medicine 17 November 2020 1(8)

Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors.

Authors: Bazua-Valenti, Silvana, Brown, Matthew R., Zavras, Jason, Khursigara, Magdalena Riedl, Grinkevich, Elizabeth, Sidhom, Eriene-Heidi, Keller, Keith H., Racette, Matthew, Dvela-Levitt, Moran, Quintanova, Catarina, Demirci, Hasan, Sewerin, Sebastian, Goss, Alissa C., Lin, John, Hyery Yoo, Jacome, Alvaro S. Vaca, Papanastasiou, Malvina, Udeshi, Namrata, Carr, Steven A., Himmerkus, Nina

Source: Journal of Clinical Investigation. 12/16/2024, Vol. 134 Issue 24, p1-17. 18p.

Opening New Routes for Kidney Therapy

Authors: Kinstlinger, Sara, Dvela-Levitt, Moran

Source: Journal of the American Society of Nephrology; 20240101, Issue: Preprints

Misprocessing of Alpha-Galactosidase A, Endoplasmic Reticulum Stress, and the Unfolded Protein Response

Authors: Živná, Martina, Dostálová, Gabriela, Barešová, Veronika, Mušálková, Dita, Svojšová, Klára, Meiseles, Doria, Kinstlinger, Sara, Kuchař, Ladislav, Asfaw, Befekadu, Poupětová, Helena, Vlášková, Hana, Kmochová, Tereza, Vyleťal, Petr, Hartmannová, Hana, Hodaňová, Kateřina, Stránecký, Viktor, Steiner-Mrázová, Lenka, Hnízda, Aleš, Živný, Jan, Radina, Martin, Votruba, Miroslav, Sovová, Jana, Trešlová, Helena, Stolnaja, Larisa, Reková, Petra, Roblová, Lenka, Honsová, Eva, Rychlík, Ivan, Dvela-Levitt, Moran, Bleyer, Anthony J., Linhart, Aleš, Sikora, Jakub, Kmoch, Stanislav

Source: Journal of the American Society of Nephrology; 20240101, Issue: Preprints

This result is not displayed to guests.
Login for full access.

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.

Authors: Yiming Zhou^1,2, Castonguay, Philip^1,2, Sidhom, Eriene-Heidi^1,2, Clark, Abbe R.^1,2, Dvela-Levitt, Moran^1,2, Sookyung Kim^1,2, Sieber, Jonas^1,2, Wieder, Nicolas^1,2, Ji Yong Jung^1,3, Andreeva, Svetlana¹, Reichardt, Jana¹, Dubois, Frank¹, Hoffmann, Sigrid C.⁴, Basgen, John M.⁵, Montesinos, Mónica S.^1,2, Weins, Astrid^1,6, Johnson, Ashley C.⁷, Lander, Eric S.², Garrett, Michael R.⁷, Hopkins, Corey R.⁸

Source: Science; 12/8/2017, Vol. 358 Issue 6368, p1332-1336, 5p

This result is not displayed to guests.
Login for full access.