Activation of Sphingosine-1-Phosphate Receptor 1 in the Spinal Cord Produces Mechanohypersensitivity Through the Activation of Inflammasome and IL-1β Pathway

Authors: Doyle, Timothy M. ^*, Chen, Zhoumou ^*, Durante, Mariaconcetta ^*, Salvemini, Daniela ^*

Source: In The Journal of Pain August 2019 20(8):956-964

2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents

Authors: Chiaramonte, Niccolò, Bua, Silvia, Ferraroni, Marta, Nocentini, Alessio, Bonardi, Alessandro, Bartolucci, Gianluca, Durante, Mariaconcetta, Lucarini, Laura, Chiapponi, Donata, Dei, Silvia, Manetti, Dina, Teodori, Elisabetta, Gratteri, Paola, Masini, Emanuela, Supuran, Claudiu T., Romanelli, Maria Novella

Source: In European Journal of Medicinal Chemistry 10 May 2018 151:363-375

Fructose liquid and solid formulations differently affect gut integrity, microbiota composition and related liver toxicity: a comparative in vivo study

Authors: Mastrocola, Raffaella, Ferrocino, Ilario, Liberto, Erica, Chiazza, Fausto, Cento, Alessia Sofia, Collotta, Debora, Querio, Giulia, Nigro, Debora, Bitonto, Valeria, Cutrin, Juan Carlos, Rantsiou, Kalliopi, Durante, Mariaconcetta, Masini, Emanuela, Aragno, Manuela, Cordero, Chiara, Cocolin, Luca, Collino, Massimo

Source: In The Journal of Nutritional Biochemistry May 2018 55:185-199

Role of histamine H4 receptor ligands in bleomycin-induced pulmonary fibrosis

Authors: Lucarini, Laura, Pini, Alessandro, Rosa, Arianna Carolina, Lanzi, Cecilia, Durante, Mariaconcetta, Chazot, Paul Louis, Krief, Stéphane, Schreeb, Annemarie, Stark, Holger, Masini, Emanuela

Source: In Pharmacological Research September 2016 111:740-748

HYDAMTIQ, a selective PARP‐1 inhibitor, improves bleomycin‐induced lung fibrosis by dampening the TGF‐β/SMAD signalling pathway

Authors: Lucarini, Laura, Durante, Mariaconcetta, Lanzi, Cecilia, Pini, Alessandro, Boccalini, Giulia, Calosi, Laura, Moroni, Flavio, Masini, Emanuela, Mannaioni, Guido

Source: Journal of cellular and molecular medicine. 21(2):324-335

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115979412.0x000001&indx=1&recIds=ETOCvdc_100115979412.0x000001

New furoxan derivatives for the treatment of ocular hypertension

Authors: Blangetti, Marco, Rolando, Barbara, Chegaev, Konstantin, Guglielmo, Stefano, Lazzarato, Loretta, Durante, Mariaconcetta, Masini, Emanuela, Almirante, Nicoletta, Bastia, Elena, Impagnatiello, Francesco, Fruttero, Roberta, Gasco, Alberto

Source: Bioorganic & medicinal chemistry letters. 27(3):479-483

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100042046306.0x000001&indx=1&recIds=ETOCvdc_100042046306.0x000001

Role of histamine H4 receptor in the anti-inflammatory pathway of glucocorticoid-induced leucin zipper (GILZ) in a model of lung fibrosis.

Authors: Sgambellone, Silvia, Febo, Marta, Durante, Mariaconcetta, Marri, Silvia, Villano, Serafina, Bereshchenko, Oxana, Migliorati, Graziella, Masini, Emanuela, Riccardi, Carlo, Bruscoli, Stefano, Lucarini, Laura

Source: Inflammation Research; Nov2023, Vol. 72 Issue 10/11, p2037-2052, 16p

Subject Terms: PULMONARY fibrosis, HISTAMINE receptors, HISTAMINERGIC mechanisms, AIR resistance, AIRWAY resistance (Respiration), INSUFFLATION

Adenosine A3 agonists reverse neuropathic pain via T cell-mediated production of IL-10.

Authors: Durante, Mariaconcetta^1,2, Squillace, Silvia^1,3,4, Lauro, Filomena^1,3,5, Giancotti, Luigino Antonio^1,3, Coppi, Elisabetta², Cherchi, Federica², Di Cesare Mannelli, Lorenzo², Ghelardini, Carla², Kolar, Grant^3,6, Wahlman, Carrie¹, Opejin, Adeleye⁷, Cuiying Xiao⁸, Reitman, Marc L.⁸, Tosh, Dilip K.⁸, Hawiger, Daniel⁷, Jacobson, Kenneth A.⁸, Salvemini, Daniela^1,3 daniela.salvemini@health.slu.edu, Xiao, Cuiying⁸ (AUTHOR)

Source: Journal of Clinical Investigation. 4/1/2021, Vol. 131 Issue 7, p1-6. 6p.

Subject Terms: *DORSAL root ganglia, *ADENOSINES, *METHYL aspartate receptors, *KNOCKOUT mice, *CYTOKINES

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The Histamine H 4 Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A 3 Receptor Agonist IB-MECA: Role of CD4 + T Cells.

Authors: Micheli, Laura¹ (AUTHOR), Durante, Mariaconcetta¹ (AUTHOR), Lucarini, Elena¹ (AUTHOR) laura.micheli@unifi.it, Sgambellone, Silvia¹ (AUTHOR), Lucarini, Laura¹ (AUTHOR), Di Cesare Mannelli, Lorenzo¹ (AUTHOR) lorenzo.mannelli@unifi.it, Ghelardini, Carla¹ (AUTHOR), Masini, Emanuela¹ (AUTHOR)

Source: Biomolecules (2218-273X). Oct2021, Vol. 11 Issue 10, p1447. 1p.

Subject Terms: *HISTAMINE receptors, *NEURALGIA, *INTERLEUKIN-10, *ADENOSINES, *LABORATORY mice, *T cells

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Effect of Mediterranean Diet Enriched in High Quality Extra Virgin Olive Oil on Oxidative Stress, Inflammation and Gut Microbiota in Obese and Normal Weight Adult Subjects.

Authors: Luisi, Maria Luisa Eliana, Lucarini, Laura, Biffi, Barbara, Rafanelli, Elena, Pietramellara, Giacomo, Durante, Mariaconcetta, Vidali, Sofia, Provensi, Gustavo, Madiai, Sara, Gheri, Chiara Francesca, Masini, Emanuela, Ceccherini, Maria Teresa

Source: Frontiers in Pharmacology; 11/15/2019, Vol. 10, p1-9, 9p

Subject Terms: MEDITERRANEAN diet, OLIVE oil, OXIDATIVE stress, GUT microbiome, CLINICAL trial registries, LACTIC acid bacteria

Effects of PARP-1 Deficiency and Histamine H4 Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice.

Authors: Durante, Mariaconcetta, Sgambellone, Silvia, Lanzi, Cecilia, Nardini, Patrizia, Pini, Alessandro, Moroni, Flavio, Masini, Emanuela, Lucarini, Laura

Source: Frontiers in Pharmacology; 5/16/2019, pN.PAG-N.PAG, 13p

Subject Terms: HISTAMINE receptors, PULMONARY fibrosis, IDIOPATHIC pulmonary fibrosis, MYOFIBROBLASTS, INTERSTITIAL lung diseases, THERAPEUTICS

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Effects of New NSAID-CAI Hybrid Compounds in Inflammation and Lung Fibrosis.

Authors: Lucarini, Laura¹ (AUTHOR) laura.lucarini@unifi.it, Durante, Mariaconcetta¹ (AUTHOR) silvia.sgambellone@unifi.it, Sgambellone, Silvia¹ (AUTHOR) cecilia.lanzi@unifi.it, Lanzi, Cecilia¹ (AUTHOR) elisabetta.bigagli@unifi.it, Bigagli, Elisabetta¹ (AUTHOR) emanuela.masini@unifi.it, Akgul, Ozlem² (AUTHOR) ozlem.akgul@ege.edu.tr, Masini, Emanuela¹ (AUTHOR), Supuran, Claudiu T.³ (AUTHOR) claudiu.supuran@unifi.it, Carta, Fabrizio³ (AUTHOR) fabrizio.carta@unifi.it

Source: Biomolecules (2218-273X). Sep2020, Vol. 10 Issue 9, p1307-1307. 1p.

Subject Terms: *PULMONARY fibrosis, *PNEUMONIA, *BLOOD platelet aggregation, *CARBONIC anhydrase inhibitors, *LUNG diseases, *FORMYLATION

A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Is Protective in a Rat Model of Transient Cerebral Ischemia.

Authors: Dettori, Ilaria, Gaviano, Lisa, Melani, Alessia, Lucarini, Laura, Durante, Mariaconcetta, Masini, Emanuela, Pedata, Felicita

Source: Frontiers in Pharmacology; 10/29/2018, pN.PAG-N.PAG, 11p

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HYDAMTIQ, a selective PARP-1 inhibitor, improves bleomycin-induced lung fibrosis by dampening the TGF-β/ SMAD signalling pathway.

Authors: Lucarini, Laura, Durante, Mariaconcetta, Lanzi, Cecilia, Pini, Alessandro, Boccalini, Giulia, Calosi, Laura, Moroni, Flavio, Masini, Emanuela, Mannaioni, Guido

Source: Journal of Cellular & Molecular Medicine; Feb2017, Vol. 21 Issue 2, p324-335, 12p

Subject Terms: POLYMERASES, BLEOMYCIN, FIBROSIS, LUNG diseases, TRANSFORMING growth factors