The IRG1-itaconate axis protects from cholesterol-induced inflammation and atherosclerosis.

Authors: Cyr, Yannick, Bozal, Fazli K., Barcia Durán, José Gabriel, Newman, Alexandra A. C., Amadori, Letizia, Smyrnis, Panagiotis, Gourvest, Morgane, Das, Dayasagar, Gildea, Michael, Kaur, Ravneet, Zhang, Tracy, Wang, Kristin M., Von Itter, Richard, Schlegel, P. Martin, Dupuis, Samantha D., Sanchez, Bernard F., Schmidt, Ann Marie, Fisher, Edward A., van Solingen, Coen, Giannarelli, Chiara

Source: Proceedings of the National Academy of Sciences of the United States of America; 4/9/2024, Vol. 121 Issue 15, p1-12, 30p

Subject Terms: MONONUCLEAR leukocytes, ATHEROSCLEROSIS, DRUG discovery, THERAPEUTICS, GLOBAL burden of disease