Operational effectiveness of tafenoquine and primaquine for the prevention of Plasmodium vivax recurrence in Brazil: a retrospective observational study

Authors: Brito, Marcelo ^*, Rufatto, Rosilene ^*, Brito-Sousa, José Diego, Murta, Felipe, Sampaio, Vanderson, Balieiro, Patrícia, Baía-Silva, Djane, Castro, Vanessa, Alves, Brenda, Alencar, Aline, Duparc, Stephan, Grewal Daumerie, Penny, Borghini-Fuhrer, Isabelle, Jambert, Elodie, Peterka, Cássio, Edilson Lima, Francisco, Jr, Carvalho Maia, Leonardo, Lucena Cruz, Catherine, Maciele, Bruna, Vasconcelos, Mariana, Machado, Myrna, Augusto Figueira, Elder, Alcirley Balieiro, Antônio, Batista Pereira, Dhelio, Lacerda, Marcus ^*

Source: In The Lancet Infectious Diseases June 2024 24(6):629-638

A pharmacometrics approach to assess the feasibility of capillary microsampling to replace venous sampling in clinical studies: Tafenoquine case study

Authors: Bachhav, Sagar S., Taylor, Maxine, Martin, Ana, Green, Justin A., Duparc, Stephan, Rolfe, Katie, Sharma, Hema, Tan, Lionel K., Goyal, Navin

Source: British journal of clinical pharmacology. 89(3):1187-1197

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175774793.0x000001&indx=1&recIds=ETOCvdc_100175774793.0x000001

Efficacy, Safety, Tolerability, and Pharmacokinetics of MMV390048 in Acute Uncomplicated Malaria

Authors: Mohammed, Rezika, Asres, Mezgebu Silamsaw, Gudina, Esayas Kebede, Adissu, Wondimagegn, Johnstone, Hilary, Marrast, Anne Claire, Donini, Cristina, Duparc, Stephan, Yilma, Daniel

Source: American journal of tropical medicine and hygiene. 108(1):81-84

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631060607&indx=1&recIds=ETOCRN631060607

Community health workers in clinical research at the example of a phase IIIb/ IV antimalarial drug trial conducted in five African countries

Authors: Groger, Mirjam, Lutete, Gaston Tona, Assi, Serge-Brice, Bigoga, Jude D., Ntamabyaliro, Nsengi Y., Arbe-Barnes, Sarah, Shin, Jangsik, Adegnika, Ayola A., Ntoumi, Francine, Kremsner, Peter G., Ramharter, Michael, Duparc, Stephan, Borghini-Fuhrer, Isabelle, Mombo-Ngoma, Ghyslain

Source: In International Journal of Infectious Diseases December 2023 137:114-117

Tafenoquine co-administered with dihydroartemisinin–piperaquine for the radical cure of Plasmodium vivax malaria (INSPECTOR): a randomised, placebo-controlled, efficacy and safety study

Authors: Sutanto, Inge ^*, Soebandrio, Amin ^*, Ekawati, Lenny L, Chand, Krisin, Noviyanti, Rintis, Satyagraha, Ari Winasti, Subekti, Decy, Santy, Yulia Widya, Crenna-Darusallam, Chelzie, Instiaty, Instiaty, Budiman, Waras, Prasetya, Catur Bidik, Lardo, Soroy, Elyazar, Iqbal, Duparc, Stephan, Cedar, Eve, Rolfe, Katie, Fernando, Disala, Berni, Alessandro, Jones, Siôn, Kleim, Jörg-Peter, Fletcher, Kim, Sharma, Hema, Martin, Ana, Taylor, Maxine, Goyal, Navin, Green, Justin A, Tan, Lionel K ^*, Baird, J Kevin

Source: In The Lancet Infectious Diseases October 2023 23(10):1153-1163

Safety and efficacy of four drug regimens versus standard-of-care for the treatment of symptomatic outpatients with COVID-19: A randomised, open-label, multi-arm, phase 2 clinical trial

Authors: Chandiwana, Nomathemba, Kruger, Chelsea, Johnstone, Hilary, Chughlay, Mohamed Farouk, Ju, Chung, Kim, Byungsu, Dineka, Yengiwe, Arbe-Barnes, Sarah, Miller, Robert, Owen, Andrew, Hill, Andrew, Windgassen, Daniel, Abla, Nada, Marrast, Anne Claire, Duparc, Stephan, Francois Venter, Willem Daniel

Source: In eBioMedicine December 2022 86

Tafenoquine exposure assessment, safety, and relapse prevention efficacy in children with Plasmodium vivax malaria: open-label, single-arm, non-comparative, multicentre, pharmacokinetic bridging, phase 2 trial

Authors: Vélez, Iván D, Hien, Tran T, Green, Justin A, Martin, Ana, Sharma, Hema, Rousell, Victoria M, Breton, John J, Ernest, Terry B, Rolfe, Katie, Taylor, Maxine, Mohamed, Khadeeja, Jones, Siôn W, Chau, Nguyen Hoang, Hoa, Nhu Thi, Duparc, Stephan, Tan, Lionel K, Goyal, Navin

Source: Lancet.Child & adolescent health. 6(2):86-95

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183223876.0x000001&indx=1&recIds=ETOCvdc_100183223876.0x000001

Active Pharmacovigilance for Primaquine Radical Cure of Plasmodium vivax Malaria in Odisha, India

Authors: Anvikar, Anupkumar R., Sahu, Prajyoti, Pradhan, Madan M., Sharma, Supriya, Ahmed, Naseem, Yadav, Chander P., Pradhan, Sreya, Duparc, Stephan, Daumerie, Penny Grewal, Valecha, Neena

Source: American journal of tropical medicine and hygiene. 106(3):831-840

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628881065&indx=1&recIds=ETOCRN628881065

Effectiveness of pyronaridine-artesunate against Plasmodium malariae, Plasmodium ovale spp, and mixed-Plasmodium infections: a post-hoc analysis of the CANTAM-Pyramax trial

Authors: Groger, Mirjam, Tona Lutete, Gaston, Mombo-Ngoma, Ghyslain, Ntamabyaliro, Nsengi Y, Kahunu Mesia, Gauthier, Muena Mujobu, Trésor Bodjick, Dimessa Mbadinga, Lia Betty, Zoleko Manego, Rella, Egger-Adam, Diane, Borghini-Fuhrer, Isabelle, Shin, Jangsik, Miller, Robert, Arbe-Barnes, Sarah, Duparc, Stephan, Ramharter, Michael ^*

Source: In The Lancet Microbe August 2022 3(8):e598-e605

Addressing health equity for breastfeeding women: primaquine for Plasmodium vivax radical cure.

Authors: Abla, Nada, Marrast, Anne Claire, Jambert, Elodie, Richardson, Naomi, Duparc, Stephan, Almond, Lisa, Rowland Yeo, Karen, Pan, Xian, Tarning, Joel, Zhao, Ping, Culpepper, Janice, Waitt, Catriona, Koldeweij, Charlotte, Cole, Susan, Butler, Andrew S., Khier, Sonia, Möhrle, Jörg J., El Gaaloul, Myriam

Source: Malaria Journal; 9/27/2024, Vol. 23 Issue 1, p1-12, 12p

Subject Terms: WOMEN'S health, PLASMODIUM vivax, MATERNAL exposure, DISEASE relapse, BREAST milk

Efficacy and Safety of Fosmidomycin–Piperaquine as Nonartemisinin-Based Combination Therapy for Uncomplicated Falciparum Malaria : A Single-Arm, Age De-escalation Proof-of-Concept Study in Gabon

Authors: Mombo-Ngoma, Ghyslain, Remppis, Jonathan, Sievers, Moritz, Manego, Rella Zoleko, Endamne, Lilian, Kabwende, Lumeka, Veletzky, Luzia, Nguyen, The Trong, Groger, Mirjam, Lötsch, Felix, Mischlinger, Johannes, Flohr, Lena, Kim, Johanna, Cattaneo, Chiara, Hutchinson, David, Duparc, Stephan, Moehrle, Joerg, Velavan, Thirumalaisamy P., Lell, Bertrand, Ramharter, Michael, Adegnika, Ayola Akim, Mordmüller, Benjamin, Kremsner, and Peter G.

Source: Clinical Infectious Diseases, 2018 Jun . 66(12), 1823-1830.

Access URL: https://www.jstor.org/stable/26526315

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

Authors: Llanos-Cuentas, Alejandro, Casapia, Martin, Chuquiyauri, Raúl, Hinojosa, Juan-Carlos, Kerr, Nicola, Rosario, Maria, Toovey, Stephen, Arch, Robert H, Phillips, Margaret A, Rozenberg, Felix D, Bath, Jade, Ng, Caroline L, Cowell, Annie N, Winzeler, Elizabeth A, Fidock, David A, Baker, Mark, Möhrle, Jörg J, Hooft van Huijsduijnen, Rob, Gobeau, Nathalie, Araeipour, Nada, Andenmatten, Nicole, Rückle, Thomas, Duparc, Stephan

Source: In The Lancet Infectious Diseases August 2018 18(8):874-883

Pyronaridine–artesunate or dihydroartemisinin–piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial

Authors: Sagara, Issaka, Beavogui, Abdoul Habib, Zongo, Issaka, Soulama, Issiaka, Borghini-Fuhrer, Isabelle, Fofana, Bakary, Traore, Aliou, Diallo, Nouhoum, Diakite, Hamadoun, Togo, Amadou H, Koumare, Sekou, Keita, Mohamed, Camara, Daouda, Somé, Anyirékun F, Coulibaly, Aboubacar S, Traore, Oumar B, Dama, Souleymane, Goita, Siaka, Djimde, Moussa, Bamadio, Amadou, Dara, Niawanlou, Maiga, Hamma, Sidibe, Bouran, Dao, Francois, Coulibaly, Moctar, Alhousseini, Mohamed Lamine, Niangaly, Hamidou, Sangare, Boubou, Diarra, Modibo, Coumare, Samba, Kabore, Moïse J T, Ouattara, San Maurice, Barry, Aissata, Kargougou, Désiré, Diarra, Amidou, Henry, Noelie, Soré, Harouna, Bougouma, Edith C, Thera, Ismaila, Compaore, Yves D, Sutherland, Colin J, Sylla, Malick Minkael, Nikiema, Frederic, Diallo, Mamadou Saliou, Dicko, Alassane, Picot, Stephane, Borrmann, Steffen, Duparc, Stephan, Miller, Robert M, Doumbo, Ogobara K, Shin, Jangsik, Gil, Jose Pedro, Björkman, Anders, Ouedraogo, Jean-Bosco, Sirima, Sodiomon B, Djimde, Abdoulaye A

Source: In The Lancet 7-13 April 2018 391(10128):1378-1390

Randomized Placebo-Controlled Trial Evaluating the Ophthalmic Safety of Single-Dose Tafenoquine in Healthy Volunteers

Authors: Ackert, Jessica, Mohamed, Khadeeja, Slakter, Jason S., El-Harazi, Sherif, Berni, Alessandro, Gevorkyan, Hakop, Hardaker, Elizabeth, Hussaini, Azra, Jones, Siôn W., Koh, Gavin C. K. W., Patel, Jyoti, Rasmussen, Scott, Kelly, Deborah S., Barañano, David E., Thompson, John T., Warren, Keith A., Sergott, Robert C., Tonkyn, John, Wolstenholme, Allen, Coleman, Hanna, Yuan, Alex, Duparc, Stephan, Green, Justin A.

Source: Drug safety. 42(9):1103-1114

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130225513.0x000001&indx=1&recIds=ETOCvdc_100130225513.0x000001

Partnering to fight malaria in India: Past, present and future

Authors: Samby, Kirandeep, Ramachandruni, Hanu, Banerji, Jaya, Burrows, Jeremy N., Daumerie, Penny Grewal, van Huijsduijnen, Rob A. M. Hooft, Duparc, Stephan, Wells, Timothy N. C.

Source: Journal of vector borne diseases. 56(1):15-24

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN621857537&indx=1&recIds=ETOCRN621857537

A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation

Authors: Murphy, Sean C., Duke, Elizabeth R., Shipman, Kelly J., Jensen, Ryan L., Fong, Youyi, Ferguson, Sue, Janes, Holly E., Gillespie, Kevin, Seilie, Annette M., Hanron, Amelia E., Rinn, Laurie, Fishbaugher, Matthew, VonGoedert, Tracie, Fritzen, Emma, Kappe, Stefan H., Chang, Ming, Sousa, Jason C., Marcsisin, Sean R., Chalon, Stephan, Duparc, Stephan, Kerr, Nicola, Möhrle, Jörg J., Andenmatten, Nicole, Rueckle, Thomas, Kublin, James G.

Source: The Journal of Infectious Diseases, 2018 Mar 01. 217(5), 693-702.

Access URL: https://www.jstor.org/stable/26494762

Defining the next generation of severe malaria treatment: a target product profile.

Authors: Achan, Jane, Barry, Aïssata, Leroy, Didier, Kamara, George, Duparc, Stephan, Kaszubska, Wiweka, Gandhi, Preetam, Buffet, Bénédicte, Tshilab, Patrick, Ogutu, Bernhards, Taylor, Terrie, Krishna, Sanjeev, Richardson, Naomi, Ramachandruni, Hanu, Rietveld, Hans

Source: Malaria Journal; 6/5/2024, Vol. 23 Issue 1, p1-16, 16p

Subject Terms: MALARIA, RESOURCE-limited settings, ARTEMISININ derivatives, DRUG resistance, ARTEMISININ

Geographic Terms: SOUTHEAST Asia

Optimal balance of benefit versus risk for tafenoquine in the treatment of Plasmodium vivax malaria.

Authors: Sharma, Raman, Sharma, Hema, Jones, Siôn, Borghini-Fuhrer, Isabelle, Domingo, Gonzalo J., Gibson, Rachel A., Rolfe, Katie, Tan, Lionel, Fiţa, Ioana Gabriela, Chen, Chao, Bird, Panayota, Pingle, Anup, Duparc, Stephan

Source: Malaria Journal; 5/13/2024, Vol. 23 Issue 1, p1-6, 6p

Subject Terms: GLUCOSE-6-phosphate dehydrogenase deficiency, PLASMODIUM vivax, MALARIA, COLLECTIVE efficacy, GLUCOSE-6-phosphate dehydrogenase, HEMOLYTIC anemia

Geographic Terms: EAST Asia, OCEANIA

Company/Entity: WORLD Health Organization

Multiple-level stakeholder engagement in malaria clinical trials: addressing the challenges of conducting clinical research in resource-limited settings

Authors: Mtove, George, Kimani, Joshua, Kisinza, William, Makenga, Geofrey, Mangesho, Peter, Duparc, Stephan, Nakalembe, Miriam, Phiri, Kamija, Orrico, Russell, Rojo, Ricardo, Vandenbroucke, Pol

Source: Trials. 19(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161527413.0x000001&indx=1&recIds=ETOCvdc_100161527413.0x000001

Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria

Authors: Macintyre, Fiona, Ramachandruni, Hanu, Burrows, Jeremy, Holm, René, Thomas, Anna, Möhrle, Jörg, Duparc, Stephan, Hooft van Huijsduijnen, Rob, Greenwood, Brian, Gutteridge, Winston, Wells, Timothy, Kaszubska, Wiweka

Source: Malaria journal. 17(1):1-18

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185395468.0x000001&indx=1&recIds=ETOCvdc_100185395468.0x000001