Molecular design of the γδT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing

Authors: Mallis, Robert J., Duke-Cohan, Jonathan S., Das, Dibyendu Kumar, Akitsu, Aoi, Luoma, Adrienne M., Banik, Debasis, Stephens, Hannah M., Tetteh, Paul W., Castro, Caitlin D., Krahnke, Sophie, Hussey, Rebecca E., Lawney, Brian, Brazin, Kristine N., Reche, Pedro A., Hwang, Wonmuk, Adams, Erin J., Lang, Matthew J., Reinherz, Ellis L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Jun . 118(26), 1-12.

Access URL: https://www.jstor.org/stable/27040813

Biophysical and Structural Features of αβT‐Cell Receptor Mechanosensing: A Paradigmatic Shift in Understanding T‐Cell Activation.

Authors: Mallis, Robert J., Brazin, Kristine N., Duke‐Cohan, Jonathan S., Akitsu, Aoi, Stephens, Hanna M., Chang‐Gonzalez, Ana C., Masi, Daniel J., Kirkpatrick, Evan H., Holliday, Elizabeth L., Feng, Yinnian, Zienkiewicz, Katarzyna J., Lee, Jonathan J., Cinella, Vincenzo, Uberoy, Kaveri I., Tan, Kemin, Wagner, Gerhard, Arthanari, Haribabu, Hwang, Wonmuk, Lang, Matthew J., Reinherz, Ellis L.

Source: Immunological Reviews; Jan2025, Vol. 329 Issue 1, p1-28, 28p

Subject Terms: T cell receptors, T cells, MECHANICAL behavior of materials, CELLULAR signal transduction, THERAPEUTICS, MECHANOTRANSDUCTION (Cytology), STRUCTURAL dynamics, IMMUNE recognition

Linking a mutation to survival in wild mice

Authors: Barrett, Rowan D. H., Laurent, Stefan, Mallarino, Ricardo, Pfeifer, Susanne P., Xu, Charles C. Y., Foll, Matthieu, Wakamatsu, Kazumasa, Duke-Cohan, Jonathan S., Jensen, Jeffrey D., Hoekstra, Hopi E.

Source: Science, 2019 Feb 01. 363(6426), 499-504.

Access URL: https://www.jstor.org/stable/26588397

The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations

Authors: Brazin, Kristine N., Mallis, Robert J., Boeszoermenyi, Andras, Feng, Yinnian, Yoshizawa, Akihiro, Reche, Pedro A., Kaur, Pavanjeet, Bi, Kevin, Hussey, Rebecca E., Duke-Cohan, Jonathan S., Song, Likai, Wagner, Gerhard, Arthanari, Haribabu, Lang, Matthew J., Reinherz, Ellis L.

Source: In Immunity 20 November 2018 49(5):829-841

NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology

Authors: Mallis, Robert J., Brazin, Kristine N., Duke-Cohan, Jonathan S., Hwang, Wonmuk, Wang, Jia-huai, Wagner, Gerhard, Arthanari, Haribabu, Lang, Matthew J., Reinherz, Ellis L.

Source: Journal of biomolecular NMR. 73(6-7):319-332

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127705193.0x000001&indx=1&recIds=ETOCvdc_100127705193.0x000001

Semaphorin 3E Alleviates Hallmarks of House Dust Mite–Induced Allergic Airway Disease

Authors: Movassagh, Hesam, Shan, Lianyu, Duke-Cohan, Jonathan S., Halayko, Andrew J., Uzonna, Jude E., Gounni, Abdelilah S.

Source: In The American Journal of Pathology July 2017 187(7):1566-1576

Does DPP-IV Inhibition Offer New Avenues for Therapeutic Intervention in Malignant Disease?

Authors: Busek, Petr¹ (AUTHOR) petr.busek2@lf1.cuni.cz, Duke-Cohan, Jonathan S.² (AUTHOR) jonathan_duke-cohan@dfci.harvard.edu, Sedo, Aleksi¹ (AUTHOR) petr.busek2@lf1.cuni.cz

Source: Cancers. May2022, Vol. 14 Issue 9, pN.PAG-N.PAG. 28p.

Subject Terms: *INSULIN therapy, *THERAPEUTICS, *DISEASE progression, *HYPERGLYCEMIA, *GRAFT versus host disease, *GLUCAGON-like peptide 1, *BIOAVAILABILITY, *HYPOGLYCEMIC agents, *IMMUNE system, *TYPE 2 diabetes, *STROMAL cells, *CHEMOKINES, *CELL surface antigens, *HEMATOPOIETIC stem cell transplantation, *ENZYME inhibitors, *CHEMOPREVENTION, *IMMUNODIAGNOSIS, TUMOR prevention

Attractin (DPPT-L), a Member of the CUB Family of Cell Adhesion and Guidance Proteins, is Secreted by Activated Human T Lymphocytes and Modulates Immune Cell Interactions

Authors: Duke-Cohan, Jonathan S., Gu, Jijie, McLaughlin, Daniel F., Xu, Yuhui, Freeman, Gordon J., Schlossman, Stuart F.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1998 Sep . 95(19), 11336-11341.

Access URL: https://www.jstor.org/stable/46308

Pre-T Cell Receptors (Pre-TCRs) Leverage Vβ Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands

Authors: Das, Dibyendu Kumar ^{‡, 1}, Mallis, Robert J. ^{§, 1}, Duke-Cohan, Jonathan S. ^{‖, ¶}, Hussey, Rebecca E. ^¶, Tetteh, Paul W. ^{¶, ‖}, Hilton, Mark ^‡, Wagner, Gerhard ^§, Lang, Matthew J. ^{‡, **, 2}, Reinherz, Ellis L. ^{¶, ‖, 3}

Source: In Journal of Biological Chemistry 2 December 2016 291(49):25292-25305

Pre-TCR ligand binding impacts thymocyte development before αβTCR expression

Authors: Mallis, Robert J., Bai, Ke, Arthanari, Haribabu, Hussey, Rebecca E., Handley, Maris, Li, Zhenhai, Chingozha, Loice, Duke-Cohan, Jonathan S., Lu, Hang, Wang, Jia-Huai, Zhu, Cheng, Wagner, Gerhard, Reinherz, Ellis L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Jul 01. 112(27), 8373-8378.

Access URL: https://www.jstor.org/stable/26463713

Chemorepellent Semaphorin 3E Negatively Regulates Neutrophil Migration In Vitro and In Vivo

Authors: Movassagh, Hesam, Saati, Abeer, Nandagopal, Saravanan, Mohammed, Ashfaque, Tatari, Nazanin, Shan, Lianyu, Duke-Cohan, Jonathan S., Fowke, Keith R., Lin, Francis, Gounni, Abdelilah S.

Source: Journal of immunology. 198(3):1023-1033

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN609752292&indx=1&recIds=ETOCRN609752292

Post-developmental extracellular proteoglycan maintenance in attractin-deficient mice.

Authors: Azouz, Abdallah¹ (AUTHOR), Duke-Cohan, Jonathan S.^2,3 (AUTHOR) Jonathan_Duke-Cohan@dfci.harvard.edu

Source: BMC Research Notes. 6/24/2020, Vol. 13 Issue 1, p1-4. 4p. 3 Diagrams.

Subject Terms: *PROXIMAL kidney tubules, *KIDNEY tubules, *SECRETORY granules, *EXTRACELLULAR matrix, *MICE

Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation

Authors: Patsoukis, Nikolaos, Duke-Cohan, Jonathan S., Chaudhri, Apoorvi, Aksoylar, Halil-Ibrahim, Wang, Qi, Council, Asia, Berg, Anders, Freeman, Gordon J., Boussiotis, Vassiliki A.

Source: Communications biology. 3(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164353744.0x000001&indx=1&recIds=ETOCvdc_100164353744.0x000001

Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis

Authors: Choi, Young I., Duke-Cohan, Jonathan S., Chen, Wei, Liu, Baoyu, Rossy, Jérémie, Tabarin, Thibault, Ju, Lining, Gui, Jingang, Gaus, Katharina, Zhu, Cheng, Reinherz, Ellis L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Jan 01. 111(1), 379-384.

Access URL: https://www.jstor.org/stable/23770552

Immunogenicity of recombinant Modified Vaccinia Ankara following a single or multi-dose vaccine regimen in rhesus monkeys

Authors: Grandpre, Lauren E., Duke-Cohan, Jonathan S., Ewald, Bonnie A., Devoy, Colleen, Barouch, Dan H., Letvin, Norman L., Reinherz, Ellis L., Baden, Lindsey R., Dolin, Raphael, Seaman, Michael S.

Source: In Vaccine 2009 27(10):1549-1556

The heterogeneity of human antibody responses to vaccinia virus revealed through use of focused protein arrays

Authors: Duke-Cohan, Jonathan S., Wollenick, Kristin, Witten, Elizabeth A., Seaman, Michael S., Baden, Lindsey R., Dolin, Raphael, Reinherz, Ellis L.

Source: In Vaccine 2009 27(8):1154-1165

Role of CD26/Dipeptidyl Peptidase IV in Human Immunodeficiency Virus Type 1 Infection and Apoptosis

Authors: Morimoto, Chikao, Lord, Carol I., Zhang, Chonghui, Duke-Cohan, Jonathan S., Letvin, Norman L., Schlossman, Stuart F.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1994 Oct 01. 91(21), 9960-9964.

Access URL: https://www.jstor.org/stable/2365742

Regulation of CD4-p56 lck -associated Phosphatidylinositol 3-kinase (PI 3-kinase) and Phosphatidylinositol 4-kinase (PI 4-kinase)

Authors: Prasad, K. V. S., Kapeller, Rosana, Janssen, Ottmar, Duke-Cohan, Jonathan S., Repke, Heinrich, Cantley, Lewis C., Rudd, Christopher E.

Source: Philosophical Transactions: Biological Sciences, 1993 Oct . 342(1299), 35-42.

Access URL: https://www.jstor.org/stable/55859

PlexinD1 Glycoprotein Controls Migration of Positively Selected Thymocytes into the Medulla

Authors: Choi, Young I., Duke-Cohan, Jonathan S., Ahmed, Wesam B., Handley, Maris A., Mann, Fanny, Epstein, Jonathan A., Clayton, Linda K., Reinherz, Ellis L.

Source: In Immunity 2008 29(6):888-898

Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation.

Authors: Duke-Cohan, Jonathan S., Akitsu, Aoi, Mallis, Robert J., Messier, Cameron M., Lizotte, Patrick H., Aster, Jon C., Hwang, Wonmuk, Lang, Matthew J., Reinherz, Ellis L.

Source: Nature; Jan2023, Vol. 613 Issue 7944, p565-574, 10p