Therapeutic advances in the targeting of ROR1 in hematological cancers

Authors: Adrian-Bogdan Tigu, Raluca Munteanu, Cristian Moldovan, Drula Rares, David Kegyes, Radu Tomai, Vlad Moisoiu, Gabriel Ghiaur, Ciprian Tomuleasa, Hermann Einsele, Diana Gulei, Carlo M. Croce

Source: Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/c92b9a0c66d743f0a6597e40769c6711

Design and preclinical testing of an anti‐CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia

Authors: Tigu, Adrian Bogdan, Constantinescu, Catalin Sorin, Teodorescu, Patric, Kegyes, David, Munteanu, Raluca, Feder, Richard, Peters, Mareike, Pralea, Ioana, Iuga, Cristina, Cenariu, Diana, Marcu, Andra, Tanase, Alina, Colita, Anca, Drula, Rares, Bergthorsson, Jon Thor, Greiff, Victor, Dima, Delia, Selicean, Cristina, Rus, Ioana, Zdrenghea, Mihnea, Gulei, Diana, Ghiaur, Gabriel, Tomuleasa, Ciprian

Source: Journal of cellular and molecular medicine. 27(19):2864-2875

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194623057.0x000001&indx=1&recIds=ETOCvdc_100194623057.0x000001

RNA sequencing suggests that non‐coding RNAs play a role in the development of acquired haemophilia

Authors: Tigu, Adrian Bogdan, Hotea, Ionut, Drula, Rares, Zimta, Alina‐Andreea, Dirzu, Noemi, Santa, Maria, Constantinescu, Catalin, Dima, Delia, Bergthorsson, Jon Thor, Greiff, Victor, Gulei, Diana, Coriu, Daniel, Serban, Margit, Mahlangu, Johnny, Tomuleasa, Ciprian

Source: Journal of cellular and molecular medicine. 27(13):1790-1796

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187501996.0x000001&indx=1&recIds=ETOCvdc_100187501996.0x000001

Proteasome inhibition in combination with immunotherapies: State-of-the-Art in multiple myeloma

Authors: Kegyes, David, Gulei, Diana, Drula, Rares, Cenariu, Diana, Tigu, Bogdan, Dima, Delia, Tanase, Alina, Badelita, Sorina, Buzoianu, Anca-Dana, Ciurea, Stefan, Ghiaur, Gabriel, Terpos, Evangelos, Ciechanover, Aaron, Einsele, Hermann, Tomuleasa, Ciprian

Source: In Blood Reviews September 2023 61

Exploiting the ubiquitin system in myeloid malignancies. From basic research to drug discovery in MDS and AML

Authors: Drula, Rares, Iluta, Sabina, Gulei, Diana, Iuga, Cristina, Dima, Delia, Ghiaur, Gabriel, Buzoianu, Anca Dana, Ciechanover, Aaron, Tomuleasa, Ciprian

Source: In Blood Reviews November 2022 56

MicroRNAs: where brilliance, perseverance, and ambition converged.

Authors: Drula, Rares¹, Calin, George A.^1,2,3 gcalin@mdanderson.org

Source: Journal of Clinical Investigation. 1/16/2025, Vol. 135 Issue 2, p1-4. 4p.

Subject Terms: *SMALL interfering RNA, *LIFE sciences, *SCIENTIFIC knowledge, *MOLECULAR genetics, *GENE expression

circFOXO3: Going around the mechanistic networks in cancer by interfering with miRNAs regulatory networks

Authors: Drula, Rares, Pirlog, Radu, Trif, Monica, Slaby, Ondrej, Braicu, Cornelia, Berindan-Neagoe, Ioana

Source: In BBA - Molecular Basis of Disease 1 May 2021 1867(5)

Single low‐dose decitabine as frontline therapy of acute myeloid leukaemia, with venetoclax salvage.

Authors: Jitaru, Ciprian, Peters, Mareike Cathrina, Aggarwal, Lovisha, Bancos, Anamaria, Tigu, Adrian Bogdan, Cenariu, Diana, Selicean, Cristina, Pasca, Sergiu, Moisoiu, Vlad, Rotariu, Petra, Santa, Maria, Iluta, Sabina, Drula, Rares, Kegyes, David, Kurtus, Aranka, Zdrenghea, Mihnea, Gondek, Lukasz, Tomuleasa, Ciprian, Ghiaur, Gabriel

Source: Journal of Cellular & Molecular Medicine; Oct2024, Vol. 28 Issue 20, p1-5, 5p

Subject Terms: HEMATOPOIETIC stem cells, DRUG synergism, ACUTE myeloid leukemia, POISONS, OLDER patients

Investigating Circular RNAs Using qRT-PCR; Roundup of Optimization and Processing Steps.

Authors: Drula, Rares¹ (AUTHOR), Braicu, Cornelia¹ (AUTHOR) braicucornelia@yahoo.com, Chira, Sergiu¹ (AUTHOR), Berindan-Neagoe, Ioana¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Mar2023, Vol. 24 Issue 6, p5721. 16p.

Subject Terms: *CIRCULAR RNA, *NON-coding RNA, *REGULATOR genes, *PROTEIN expression, *GENE expression, *DATABASES

RNA methylation sequencing shows different gene expression signatures for response to azacytidine therapy in high‐grade myelodysplastic syndromes.

Authors: Gulei, Diana, Moisoiu, Vlad, Kegyes, David, Drula, Rares, Iluta, Sabina, Tigu, Adrian Bogdan, Nistor, Madalina, Jitaru, Ciprian, Bancos, Anamaria, Rotariu, Petra, Popovici, Corina, Dima, Delia, Tomai, Radu, Rus, Ioana, Constantinescu, Catalin, Munteanu, Raluca, Cenariu, Diana, Sezerman, Ugur, Zdrenghea, Mihnea, Cermak, Jaroslav

Source: Journal of Cellular & Molecular Medicine; Sep2024, Vol. 28 Issue 18, p1-10, 10p

Subject Terms: NUCLEOTIDE sequencing, RNA methylation, MYELODYSPLASTIC syndromes, ACUTE myeloid leukemia, GENE expression

Critical function of circular RNAs in lung cancer

Authors: Drula, Rares, Braicu, Cornelia, Harangus, Antonia, Nabavi, Seyed M., Trif, Monica, Slaby, Ondrej, Ionescu, Calin, Irimie, Alexandru, Berindan‐Neagoe, Ioana

Source: Wiley interdisciplinary reviews.RNA. 11(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108025161.0x000001&indx=1&recIds=ETOCvdc_100108025161.0x000001

Chapter 2 - microRNA in cancer: An overview

Authors: Drula, Rares ^*, Mohapatra, Swati ^*, Calin, George A.

Source: In MicroRNA in Human Malignancies 2022:21-28

17β-estradiol promotes extracellular vesicle release and selective miRNA loading in ERα-positive breast cancer.

Authors: Drula, Rares^1,2, Pardini, Barbara^3,4 barbara.pardini@iigm.it, Xiao Fu^5,6, Cruz De Los Santos, Mireia^5,7, Jurj, Ancuta^1,2, Lan Pang¹, El-Daly, Sherien M.^5,8, Fabris, Linda¹, Knutsen, Erik^5,9,10, Dragomir, Mihnea P.^5,11,12,13, Bayraktar, Recep¹, Yongfeng Li^5,14, Meng Chen¹, Del Vecchio, Filippo¹⁵, Berland, Léa^5,16, Dae, Jessica^5,17, Fan, Daniel^1,17, Masayoshi Shimizu¹, Tran, Anh M.^5,18, Barzi, Mercedes¹⁹

Source: Proceedings of the National Academy of Sciences of the United States of America. 6/6/2023, Vol. 120 Issue 23, p1-11. 56p.

Subject Terms: *EXTRACELLULAR vesicles, *BREAST cancer, *GENE expression, *MICRORNA, *ELECTRIC vehicle industry

Low-Dose Decitabine Plus Venetoclax As Frontline Treatment of Acute Myeloid Leukemia

Authors: Peters, Mareike, Jitaru, Ciprian, Bancos, Anamaria, Tigu, Adrian Bogdan, Cenariu, Diana, Selicean, Cristina, Moisoiu, Vlad, Rotariu, Petra, Santa, Maria, Iluta, Sabina, Drula, Rares, Kegyes, David, Zdrenghea, Mihnea, Tomuleasa, Ciprian, Ghiaur, Gabriel

Source: In Transplantation and Cellular Therapy February 2024 30(2) Supplement:S113-S114

Preclinical Evaluation of an Anti-CD41 CAR T Cell in Acute Megakaryoblastic Leukemia on in Vitro and In Vivo Models

Authors: Tigu, Adrian Bogdan, Constantinescu, Catalin, Teodorescu, Patric, Kegyes, David, Munteanu, Raluca, Feder, Richard, Peters, Mareike, Pralea, Ioana, Iuga, Cristina, Cenariu, Diana, Marcu, Andra, Tanase, Alina Daniela, Colita, Anca, Drula, Rares, Bergthorsson, Jon Thor, Greiff, Victor, Dima, Delia, Selicean, Cristina, Rus, Ioana, Zdrenghea, Mihnea, Gulei, Diana, Ghiaur, Gabriel, Tomuleasa, Ciprian

Source: In Transplantation and Cellular Therapy February 2024 30(2) Supplement:S99-S99

CLL Cell-Derived Exosomes Impair Immune Function and Normal Hematopoiesis in CLL

Authors: Veletic, Ivo, Harris, David M., Rozovski, Uri, Li, Ping, Liu, Zhiming, Manshouri, Taghi, Bertilaccio, Maria Teresa S., Calin, George A., Drula, Rares-Constantin, Takahashi, Koichi, Furudate, Ken, Muftuoglu, Muharrem, Hossain, Anwar, Ferrajoli, Alessandra, Burger, Jan A., Jain, Nitin, Wierda, William G., Verstovsek, Srdan, Keating, Michael J., Estrov, Zeev

Source: In Blood 2 November 2023 142 Supplement 1:3264-3264

Contributors

Authors: Akanksha, Samuel, Allione, Alessandra, Álvarez-Perez, Juan Carlos, Andrades, Alvaro, Arenas, Alberto M., Baliñas-Gavira, Carlos, Barth, Dominik A., Bielowski, Anna, Biswas, Roopa, Boeri, Mattia, Broseghini, Elisabetta, Calin, George A., Calura, Enrica, Casalone, Elisabetta, Constâncio, Vera, Cosentino, Giulia, Costa, Marina C., Croce, Carlo M., Cuadros, Marta, Cutucache, Christine E., Davidson, Ben, Dika, Emi, Dilmac, Sayra, Dragomir, Mihnea P., Drula, Rares, Enguita, Francisco J., Feng, Zhaohui, Ferracin, Manuela, Fornari, Francesca, Fortunato, Orazio, Gabriel, André F., García, Daniel J., Gramantieri, Laura, Henrique, Rui, Hu, Wenwei, Iorio, Marilena V., Jerónimo, Carmen, Kamboj, Sakshi, Kumar, Manoj, Lawrie, Charles Henderson, Leitão, Ana Lúcia, Liu, Juan, Lovat, Francesca, Masatti, Laura, Matullo, Giuseppe, Medina, Pedro P., Mohapatra, Swati, Moisoiu, Vlad, Negrini, Massimo, Nguyen, Vu Hong Loan, Anderson O’Brien, Jacob, Ozpolat, Bulent, Pardini, Barbara, Patiño-Mercau, Juan Rodrigo, Pazzaglia, Laura, Peinado, Paola, Pekarsky, Yuri, Peng, Chun, Petrescu, George E.D., Pichler, Martin, Plantamura, Ilaria, Reich, Reuven, Rodriguez, Maria Isabel, Romualdi, Chiara, Sanjuan-Hidalgo, Juan, Scotlandi, Katia, Shankaraiah, Ram C., Slaby, Ondrej, Solé, Carla, Soni, Dharmendra Kumar, Sozzi, Gabriella, Thakur, Anamika, Veronese, Angelo, Visone, Rosa, Vychytilova-Faltejskova, Petra, Zhang, Cen

Source: In MicroRNA in Human Malignancies 2022:xi-xiv

The Roles of the Colon Cancer Associated Transcript 2 (CCAT2) Long Non-Coding RNA in Cancer: A Comprehensive Characterization of the Tumorigenic and Molecular Functions.

Authors: Pirlog, Radu^1,2 (AUTHOR) gcalin@mdanderson.org, Drula, Rares^1,2 (AUTHOR) drula.rares@gmail.com, Nutu, Andreea¹ (AUTHOR) andreeanutu.an@gmail.com, Calin, George Adrian² (AUTHOR), Berindan-Neagoe, Ioana¹ (AUTHOR) ioananeagoe29@gmail.com

Source: International Journal of Molecular Sciences. Nov2021, Vol. 22 Issue 22, p12491. 1p.

Subject Terms: *NON-coding RNA, *COLON cancer, *RNA-binding proteins, *LINCRNA, *MICRORNA, *TRANSCRIPTION factors

MicroRNAs from Liquid Biopsy Derived Extracellular Vesicles: Recent Advances in Detection and Characterization Methods.

Authors: Drula, Rares^1,2 (AUTHOR) RCDrula@mdanderson.org, Ott, Leonie Florence^1,3 (AUTHOR) RCDrula@mdanderson.org, Berindan-Neagoe, Ioana² (AUTHOR), Pantel, Klaus³ (AUTHOR), Calin, George A.¹ (AUTHOR)

Source: Cancers. Aug2020, Vol. 12 Issue 8, p2009-2009. 1p.

Subject Terms: *TUMOR diagnosis, *CARCINOGENESIS, *BIOMARKERS, *CELL communication, *CELL separation, *EXTRACELLULAR space, *MESSENGER RNA, *POLYMERASE chain reaction, *TRANSCRIPTION factors, *REVERSE transcriptase polymerase chain reaction, *MICRORNA, *EXOSOMES, BODY fluid examination

5-Azacytidine treatment inhibits the development of lung cancer models via epigenetic reprogramming and activation of cellular pathways with anti-tumor activity.

Authors: Munteanu, Raluca Andrada¹, Moldovan, Cristian Silviu¹, Tigu, Adrian Bogdan¹, Drula, Rares¹, Feder, Richard¹, Magdo, Lorand², Jurj, Ancuta², Raduly, Lajos², Budisan, Liviuta², Pirlog, Radu², Moldovan, Alin¹, Zimta, Alina-Andreea¹, Braicu, Cornelia², Preda, Alexandra^3,4, Munteanu, Vlad⁵, Romitan, Mihai¹, Gulei, Diana¹ diana.c.gulei@gmail.com, Ciuleanu, Tudor Eliade^3,4

Source: Medicine & Pharmacy Reports: Clujul Medical. 2024, Vol. 97 Issue 4, p488-506. 19p.

Subject Terms: *NON-small-cell lung carcinoma, *TREATMENT effectiveness, *IONIZING radiation, *DNA methylation, *LUNG cancer