Early influenza virus exposure shapes the B cell response to influenza vaccination in individuals 50 years later

Authors: Spangler, Abby ^{1, 3}, Shimberg, Geoffrey D. ^{1, 3}, Mantus, Grace E. ¹, Malek, Rory ¹, Cominsky, Lauren Y. ¹, Tsybovsky, Yaroslav ², Li, Ning ², Gillespie, Rebecca A. ¹, Ravichandran, Michelle ¹, Creanga, Adrian ¹, Raab, Julie E. ¹, Gajjala, Suprabhath R. ¹, Mendoza, Floreliz ¹, Houser, Katherine V. ¹, Dropulic, Lesia ¹, McDermott, Adrian B. ¹, Kanekiyo, Masaru ¹, Andrews, Sarah F. ^{1, 4, ∗}

Source: In Immunity 11 March 2025 58(3):728-744

Low-dose intravenous and subcutaneous CIS43LS monoclonal antibody for protection against malaria (VRC 612 Part C): a phase 1, adaptive trial

Authors: Lyke, Kirsten E, Berry, Andrea A, Mason, Kaitlin, Idris, Azza H, O'Callahan, Mark, Happe, Myra, Strom, Larisa, Berkowitz, Nina M, Guech, Mercy, Hu, Zonghui, Castro, Mike, Basappa, Manjula, Wang, Lu, Low, Kwang, Holman, LaSonji A, Mendoza, Floreliz, Gordon, Ingelise J, Plummer, Sarah H, Trofymenko, Olga, Strauss, Kathleen S, Joshi, Sudhaunshu, Shrestha, Biraj, Adams, Matthew, Chagas, Andrezza Campos, Murphy, Jittawadee R, Stein, Judy, Hickman, Somia, McDougal, Andrew, Lin, Bob, Narpala, Sandeep R, Vazquez, Sandra, Serebryannyy, Leonid, McDermott, Adrian, Gaudinski, Martin R, Capparelli, Edmund V, Coates, Emily E, Wu, Richard L, Ledgerwood, Julie E, Dropulic, Lesia K, Seder, Robert A

Source: Lancet infectious diseases. 23(5):578-588

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187708300.0x000001&indx=1&recIds=ETOCvdc_100187708300.0x000001

Low-dose intravenous and subcutaneous CIS43LS monoclonal antibody for protection against malaria (VRC 612 Part C): a phase 1, adaptive trial

Authors: Young, Cheryl, Boyce, Colleen, Winkler, Jennifer, Holian, Susan, Greenberg, Nancy, George, Shirley, Kwon, Alyson, Dorsey, Brenda, Da Costa, Ana Raquel, Witt, William, Grays, Daryl, Gapasin, Arren, Bernal, Paula, Floyd, Jeffrey, Goldstein, Eric, Howe, Leslie, Lee, Myounghee, Marron, Jennifer, Brooks, Kelly, Turek, Lisa, Farley, Patricia, Frels, Shantel, Booth, Delores, Gall, Jason, Carlton, Kevin, Albright, Gabriela, Amharref, Nadia, Atallah, Kandace, Banappagari, Sashikanth, Bastani, Niutish, Blackstock, Daniel, Boonyaratanakornkit, Bobby, Carey, Elizabeth, Charlton, Adam, Chaudhuri, Rajoshi, Caringal, Alegria M., Chen, Mingzhong, Chen, Peifeng, Cheng, Wei, Gowetski, Daniel, Gulla, Krishana, Hastings, Erica, Horwitz, Joe, Ivleva, Vera, Kordella, Dan, Kueltzo, Lisa A., Lagler, Sara, Le, Matt, Lee, James, Lei, Paula, Li, Yile, Nagy, Attila, Patel, Aakash, Runsewe, Peyi, Shadrick, Will, Shetty, Shamitha, Wang, Hairong, Webber, Calvin, Vejzagic, Farah, Yang, Yoo-Jung, Lyke, Kirsten E ^*, Berry, Andrea A, Mason, Kaitlin, Idris, Azza H, O'Callahan, Mark, Happe, Myra, Strom, Larisa, Berkowitz, Nina M, Guech, Mercy, Hu, Zonghui, Castro, Mike, Basappa, Manjula, Wang, Lu, Low, Kwang, Holman, LaSonji A, Mendoza, Floreliz, Gordon, Ingelise J, Plummer, Sarah H, Trofymenko, Olga, Strauss, Kathleen S, Joshi, Sudhaunshu, Shrestha, Biraj, Adams, Matthew, Chagas, Andrezza Campos, Murphy, Jittawadee R, Stein, Judy, Hickman, Somia, McDougal, Andrew, Lin, Bob, Narpala, Sandeep R, Vazquez, Sandra, Serebryannyy, Leonid, McDermott, Adrian, Gaudinski, Martin R, Capparelli, Edmund V, Coates, Emily E, Wu, Richard L, Ledgerwood, Julie E, Dropulic, Lesia K, Seder, Robert A

Source: In The Lancet Infectious Diseases May 2023 23(5):578-588

Clinical exome sequencing of 1000 families with complex immune phenotypes: Toward comprehensive genomic evaluations

Authors: Similuk, Morgan N., Yan, Jia, Ghosh, Rajarshi, Oler, Andrew J., Franco, Luis M., Setzer, Michael R., Kamen, Michael, Jodarski, Colleen, DiMaggio, Thomas, Davis, Joie, Gore, Rachel, Jamal, Leila, Borges, Adrienne, Gentile, Nicole, Niemela, Julie, Lowe, Chenery, Jevtich, Kathleen, Yu, Yunting, Hullfish, Haley, Hsu, Amy P., Hong, Celine, Littel, Patricia, Seifert, Bryce A., Milner, Joshua, Johnston, Jennifer J., Cheng, Xi, Li, Zhiwen, Veltri, Daniel, Huang, Ke, Kaladi, Krishnaveni, Barnett, Jason, Zhang, Lingwen, Vlasenko, Nikita, Fan, Yongjie, Karlins, Eric, Ganakammal, Satishkumar Ranganathan, Gilmore, Robert, Tran, Emily, Yun, Alvin, Mackey, Joseph, Yazhuk, Svetlana, Lack, Justin, Kuram, Vasudev, Cao, Wenjia, Huse, Susan, Frank, Karen, Fahle, Gary, Rosenzweig, Sergio, Su, Yan, Hwang, SuJin, Bi, Weimin, Bennett, John, Myles, Ian A., De Ravin, Suk See, Fuss, Ivan, Strober, Warren, Bielekova, Bibiana, Almeida de Jesus, Adriana, Goldbach-Mansky, Raphaela, Williamson, Peter, Kumar, Kelly, Dempsy, Caeden, Frischmeyer-Guerrerio, Pamela, Fisch, Robin, Bolan, Hyejeong, Metcalfe, Dean D., Komarow, Hirsh, Carter, Melody, Druey, Kirk M., Sereti, Irini, Dropulic, Lesia, Klion, Amy D., Khoury, Paneez, O' Connell, Elise M., Holland-Thomas, Nicole C., Brown, Thomas, McDermott, David H., Murphy, Philip M., Bundy, Vanessa, Keller, Michael D., Peng, Christine, Kim, Helen, Norman, Stephanie, Delmonte, Ottavia M., Kang, Elizabeth, Su, Helen C., Malech, Harry, Freeman, Alexandra, Zerbe, Christa, Uzel, Gulbu, Bergerson, Jenna R.E., Rao, V. Koneti, Olivier, Kenneth N., Lyons, Jonathan J., Lisco, Andrea, Cohen, Jeffrey I., Lionakis, Michail S., Biesecker, Leslie G., Xirasagar, Sandhya, Notarangelo, Luigi D., Holland, Steven M., Walkiewicz, Magdalena A.

Source: In The Journal of Allergy and Clinical Immunology October 2022 150(4):947-954

Vaccination with different group 2 influenza subtypes alters epitope targeting and breadth of hemagglutinin stem–specific human B cells.

Authors: Mantus, Grace E., Chopde, Ankita J., Gorman, Jason, Cominsky, Lauren Y., Ourahmane, Amine, Creanga, Adrian, Shimberg, Geoffrey D., Gillespie, Rebecca A., Van Wazer, David J., Zhou, Tongqing, Gajjala, Suprabhath R., Williams, Connor, Maestle, Emma, Reed, Douglas S., Serebryannyy, Leonid, Costner, Pamela, Holman, Lasonji, Casazza, Joseph P., Koup, Richard A., Dropulic, Lesia K.

Source: Science Translational Medicine; 1/1/2025, Vol. 17 Issue 779, p1-13, 13p

Subject Terms: SEASONAL influenza, ANTIBODY formation, B cells, VACCINE development, INFLUENZA viruses

SASH3 variants cause a novel form of X-linked combined immunodeficiency with immune dysregulation

Authors: Delmonte, Ottavia M., Bergerson, Jenna R.E., Kawai, Tomoki, Kuehn, Hye Sun, McDermott, David H., Cortese, Irene, Zimmermann, Michael T., Dobbs, A. Kerry, Bosticardo, Marita, Fink, Danielle, Majumdar, Shamik, Palterer, Boaz, Pala, Francesca, Dsouza, Nikita R., Pouzolles, Marie, Taylor, Naomi, Calvo, Katherine R., Daley, Stephen R., Velez, Daniel, Agharahimi, Anahita, Myint-Hpu, Katherine, Dropulic, Lesia K., Lyons, Jonathan J., Holland, Steven M., Freeman, Alexandra F., Ghosh, Rajarshi, Similuk, Morgan B., Niemela, Julie E., Stoddard, Jennifer, Kuhns, Douglas B., Urrutia, Raul, Rosenzweig, Sergio D., Walkiewicz, Magdalena A., Murphy, Philip M., Notarangelo, Luigi D. ^*

Source: In Blood 23 September 2021 138(12):1019-1033

SARS-CoV-2–specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein

Authors: Keller, Michael D. ^*, Harris, Katherine M. ^*, Jensen-Wachspress, Mariah A., Kankate, Vaishnavi V., Lang, Haili, Lazarski, Christopher A., Durkee-Shock, Jessica, Lee, Ping-Hsien, Chaudhry, Kajal, Webber, Kathleen, Datar, Anushree, Terpilowski, Madeline, Reynolds, Emily K., Stevenson, Eva M., Val, Stephanie, Shancer, Zoe, Zhang, Nan, Ulrey, Robert, Ekanem, Uduak, Stanojevic, Maja, Geiger, Ashley, Liang, Hua, Hoq, Fahmida, Abraham, Allistair A., Hanley, Patrick J., Cruz, C. Russell, Ferrer, Kathleen, Dropulic, Lesia, Gangler, Krista, Burbelo, Peter D., Jones, R. Brad, Cohen, Jeffrey I., Bollard, Catherine M. ^*

Source: In Blood 17 December 2020 136(25):2905-2917

A Randomized, Double-Blinded, Placebo-Controlled, Phase 1 Study of a Replication-Defective Herpes Simplex Virus (HSV) Type 2 Vaccine, HSV529, in Adults With or Without HSV Infection

Authors: Dropulic, Lesia K., Oestreich, Makinna C., Pietz, Harlan L., Laing, Kerry J., Hunsberger, Sally, Lumbard, Keith, Garabedian, Doreen, Turk, Siu Ping, Chen, Aiying, Hornung, Ronald L., Seshadri, Chetan, Smith, Malisa T., Hosken, Nancy A., Phogat, Sanjay, Chang, Lee-Jah, Koelle, David M., Wang, Kening, Cohen, Jeffrey I.

Source: The Journal of Infectious Diseases, 2019 Sep . 220(6), 990-1000.

Access URL: https://www.jstor.org/stable/26758798

Association of GATA2 Deficiency With Severe Primary Epstein-Barr Virus (EBV) Infection and EBV-associated Cancers

Authors: Cohen, Jeffrey I., Dropulic, Lesia, Hsu, Amy P., Zerbe, Christa S., Krogmann, Tammy, Dowdell, Kennichi, Hornung, Ronald L., Lovell, Jana, Hardy, Nancy, Hickstein, Dennis, Cowen, Edward W., Calvo, Katherine R., Pittaluga, Stefania, Holland, Steven M.

Source: Clinical Infectious Diseases, 2016 Jul 01. 63(1), 41-47.

Access URL: https://www.jstor.org/stable/26371577

Periodic Illness Associated With Epstein-Barr Virus: A New Diagnosis After a 22-Year Follow-up

Authors: Dropulic, Lesia K., Ali, Mir A., Ombrello, Amanda K., Cohen, Jeffrey I.

Source: Clinical Infectious Diseases, 2016 Jun . 62(12), 1613-1614.

Access URL: https://www.jstor.org/stable/26371810

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subset

Authors: Mace, Emily M., Hsu, Amy P., Monaco-Shawver, Linda, Makedonas, George, Rosen, Joshua B., Dropulic, Lesia, Cohen, Jeffrey I., Frenkel, Eugene P., Bagwell, John C., Sullivan, John L., Biron, Christine A., Spalding, Christine, Zerbe, Christa S., Uzel, Gulbu, Holland, Steven M., Orange, Jordan S. ^*

Source: In Blood 4 April 2013 121(14):2669-2677

Severe Viral Infections and Primary Immunodeficiencies

Authors: Dropulic, Lesia K., Cohen, Jeffrey I.

Source: Clinical Infectious Diseases, 2011 Nov 01. 53(9), 897-909.

Access URL: http://dx.doi.org/10.1093/cid/cir610

Coronavirus-Specific T-Cells Can be Rapidly Expanded from Convalescent Donors for Potential Clinical Use

Authors: Keller, Michael D., Harris, Katherine M., Conway, Susan, Durkee-Shock, Jessica, Jensen-Wachspress, Mariah, Kankate, Vaishnavi V, Lang, Haili, Lazarski, Christopher, Lee, Ping-Hsien, Chaudhry, Kajal, Webber, Kathleen, Datar, Anushree, Cohen, Jeffrey I., Jones, R. Brad, Cruz, Russell, Hoq, Fahmida, Bollard, Cath M., Hanley, Patrick J., Abraham, Alister, Stanojevic, Maja, Terpilowski, Madeline, Reynolds, Emily K, Stevenson, Eva, Val, Stephanie, Shancer, Zoe, Zhang, Nan, Geiger, Ashley, Liang, Hua, Dropulic, Lesia, Burbelo, Peter, Gangler, Krista

Source: Transplantation and Cellular Therapy. 27(S):S70-S71

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135943732.0x000001&indx=1&recIds=ETOCvdc_100135943732.0x000001

Comparison of Levels of Nasal, Salivary, and Plasma Antibody to Severe Acute Respiratory Syndrome Coronavirus 2 During Natural Infection and After Vaccination.

Authors: Cohen, Jeffrey I¹ jcohen@niaid.nih.gov, Dropulic, Lesia¹, Wang, Kening¹, Gangler, Krista¹, Morgan, Kayla², Liepshutz, Kelly³, Krogmann, Tammy¹, Ali, Mir A¹, Qin, Jing⁴, Wang, Jing⁵, Vogel, Joshua S¹, Lei, Yona¹, Suzuki-Williams, Lui P¹, Spalding, Chris⁶, Palmore, Tara N⁶, Burbelo, Peter D⁷

Source: Clinical Infectious Diseases. 4/15/2023, Vol. 76 Issue 8, p1391-1399. 9p.

Subject Terms: *SARS-CoV-2, *COVID-19, *IMMUNIZATION, *SALIVA, *COVID-19 vaccines, *PRECIPITIN tests, *NASAL mucosa, *RESEARCH funding, *DESCRIPTIVE statistics, *VIRAL antibodies

Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine.

Authors: Foo Cheung, Apps, Richard, Dropulic, Lesia, Kotliarov, Yuri, Jinguo Chen, Jordan, Tristan, Langweiler, Marc, Candia, Julian, Biancotto, Angelique, Kyu Lee Han, Rachmaninoff, Nicholas, Pietz, Harlan, Kening Wang, Tsang, John S., Cohen, Jeffrey I.

Source: eLife; 1/17/2023, p1-21, 21p

Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load

Authors: Humeau, Laurent M ^*, Binder, Gwendolyn K ^*, Lu, Xiaobin, Slepushkin, Vladimir, Merling, Randall, Echeagaray, Patricia, Pereira, Mario, Slepushkina, Tatiana, Barnett, Scott, Dropulic, Lesia K, Carroll, Richard, Levine, Bruce L, June, Carl H, Dropulic, Boro

Source: In Molecular Therapy June 2004 9(6):902-913

West Nile Virus Encephalitis in a Kidney Transplant Recipient

Authors: Shepherd, James C. ^{a, *}, Subramanian, Aruna ^a, Montgomery, Robert A. ^c, Samaniego, Milagros D. ^b, Gong, Gary ^d, Bergmann, Amy ^e, Blythe, David ^e, Dropulic, Lesia ^a

Source: In American Journal of Transplantation May 2004 4(5):830-833

Serum and Cervicovaginal Fluid Antibody Profiling in Herpes Simplex Virus-Seronegative Recipients of the HSV529 Vaccine.

Authors: Wang, Kening¹ (AUTHOR), Dropulic, Lesia¹ (AUTHOR), Bozekowski, Joel² (AUTHOR), Pietz, Harlan L¹ (AUTHOR), Jegaskanda, Sinthujan¹ (AUTHOR), Dowdell, Kennichi¹ (AUTHOR), Vogel, Joshua S¹ (AUTHOR), Garabedian, Doreen¹ (AUTHOR), Oestreich, Makinna¹ (AUTHOR), Nguyen, Hanh¹ (AUTHOR), Ali, Mir A¹ (AUTHOR), Lumbard, Keith³ (AUTHOR), Hunsberger, Sally⁴ (AUTHOR), Reifert, Jack² (AUTHOR), Haynes, Winston A² (AUTHOR), Sawyer, Jaymie R² (AUTHOR), Shon, John C² (AUTHOR), Daugherty, Patrick S² (AUTHOR), Cohen, Jeffrey I¹ (AUTHOR) jcohen@niaid.nih.gov

Source: Journal of Infectious Diseases. Nov2021, Vol. 224 Issue 9, p1509-1519. 11p.

Subject Terms: *HERPES simplex, *HERPES genitalis, *VIRAL proteins, *KILLER cells, *HERPES simplex virus, *HERPES genitalis prevention, *HERPES simplex prevention, *PROTEINS, *VIRAL vaccines, *IMMUNIZATION, *VIRAL antibodies, *HERPESVIRUSES, *ANTIGENS

Patients With Natural Killer (NK) Cell Chronic Active Epstein-Barr Virus Have Immature NK Cells and Hyperactivation of PI3K/Akt/mTOR and STAT1 Pathways.

Authors: Howe, Matthew K, Dowdell, Kennichi, Kuehn, Hye Sun, Li, Qingxue, Hart, Geoffrey T, Garabedian, Doreen, Liepshutz, Kelly, Hsu, Amy P, Su, Hua, Niemela, Julie E, Stoddard, Jennifer L, Uzel, Gulbu, Shereck, Evan, Schulz, Laura, Feldman, Tatyana, Rosenzweig, Sergio D, Long, Eric O, Dropulic, Lesia, Cohen, Jeffrey I

Source: Journal of Infectious Diseases; 10/1/2020, Vol. 222 Issue 7, p1170-1179, 10p

Subject Terms: KILLER cells, EPSTEIN-Barr virus, BLOOD cells, VIRAL genomes, B cells, CHRONIC diseases, CELLULAR signal transduction, TRANSFERASES, LYMPHOPROLIFERATIVE disorders, T cells, EPSTEIN-Barr virus diseases, CARRIER proteins, PHOSPHORYLATION, LONGITUDINAL method

73 - Coronavirus-Specific T-Cells Can be Rapidly Expanded from Convalescent Donors for Potential Clinical Use

Authors: Keller, Michael D., Harris, Katherine M., Conway, Susan, Durkee-Shock, Jessica, Jensen-Wachspress, Mariah, Kankate, Vaishnavi V, Lang, Haili, Lazarski, Christopher, Lee, Ping-Hsien, Chaudhry, Kajal, Webber, Kathleen, Datar, Anushree, Cohen, Jeffrey I., Jones, R. Brad, Cruz, Russell, Hoq, Fahmida, Bollard, Cath M., Hanley, Patrick J., Abraham, Alister, Stanojevic, Maja, Terpilowski, Madeline, Reynolds, Emily K, Stevenson, Eva, Val, Stephanie, Shancer, Zoe, Zhang, Nan, Geiger, Ashley, Liang, Hua, Dropulic, Lesia, Burbelo, Peter, Gangler, Krista

Source: In Transplantation and Cellular Therapy March 2021 27(3) Supplement:S70-S71