A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

Authors: Pal, Sharmistha, Kaplan, Jakub P., Nguyen, Huy, Stopka, Sylwia A., Savani, Milan R., Regan, Michael S., Nguyen, Quang-De, Jones, Kristen L., Moreau, Lisa A., Peng, Jingyu, Dipiazza, Marina G., Perciaccante, Andrew J., Zhu, Xiaoting, Hunsel, Bradley R., Liu, Kevin X., Alexandrescu, Sanda, Drissi, Rachid, Filbin, Mariella G., McBrayer, Samuel K., Agar, Nathalie Y.R., Chowdhury, Dipanjan, Haas-Kogan, Daphne A.

Source: In Cancer Cell 12 September 2022 40(9):957-972

OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes

Authors: Liao, Yunfei, Luo, Zaili, Deng, Yaqi, Zhang, Feng, Rao, Rohit, Wang, Jiajia, Xu, Lingli, Kumar, Shiva Senthil, Sengupta, Satarupa, DeWire-Schottmiller, Mariko, Berry, Kalen, Garrett, Matthew, Fouladi, Maryam, Drissi, Rachid, Lu, Qing Richard

Source: Neuro-oncology. 23(7):1183-1196

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Characteristics of patients ≥10 years of age with diffuse intrinsic pontine glioma: a report from the International DIPG/DMG Registry

Authors: Erker, Craig, Lane, Adam, Chaney, Brooklyn, Leary, Sarah, Minturn, Jane E, Bartels, Ute, Packer, Roger J, Dorris, Kathleen, Gottardo, Nicholas G, Warren, Katherine E, Broniscer, Alberto, Kieran, Mark W, Zhu, Xiaoting, White, Peter, Dexheimer, Phillip J, Black, Katie, Asher, Anthony, DeWire, Mariko, Hansford, Jordan R, Gururangan, Sridharan, Nazarian, Javad, Ziegler, David S, Sandler, Eric, Bartlett, Allison, Goldman, Stewart, Shih, Chie-Schin, Hassall, Tim, Dholaria, Hetal, Bandopadhayay, Pratiti, Samson, Yvan, Monje, Michelle, Fisher, Paul G, Dodgshun, Andrew, Parkin, Sarah, Chintagumpala, Murali, Tsui, Karen, Gass, David, Larouche, Valerie, Broxson, Emmett, Garcia Lombardi, Mercedes, Wang, Stacie Shiqi, Ma, Jie, Hawkins, Cynthia, Hamideh, Dima, Wagner, Lars, Koschmann, Carl, Fuller, Christine, Drissi, Rachid, Jones, Blaise V, Leach, James, Fouladi, Maryam

Source: Neuro-oncology. 24(1):141-152

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165412088.0x000001&indx=1&recIds=ETOCvdc_100165412088.0x000001

Accuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry

Authors: Lazow, Margot A, Fuller, Christine, DeWire, Mariko, Lane, Adam, Bandopadhayay, Pratiti, Bartels, Ute, Bouffet, Eric, Cheng, Sylvia, Cohen, Kenneth J, Cooney, Tabitha M, Coven, Scott L, Dholaria, Hetal, Diez, Blanca, Dorris, Kathleen, El-ayadi, Moatasem, El-Sheikh, Ayman, Fisher, Paul G, Fonseca, Adriana, Garcia Lombardi, Mercedes, Greiner, Robert J, Goldman, Stewart, Gottardo, Nicholas, Gururangan, Sridharan, Hansford, Jordan R, Hassall, Tim, Hawkins, Cynthia, Kilburn, Lindsay, Koschmann, Carl, Leary, Sarah E, Ma, Jie, Minturn, Jane E, Monje-Deisseroth, Michelle, Packer, Roger, Samson, Yvan, Sandler, Eric S, Sevlever, Gustavo, Tinkle, Christopher L, Tsui, Karen, Wagner, Lars M, Zaghloul, Mohamed, Ziegler, David S, Chaney, Brooklyn, Black, Katie, Asher, Anthony, Drissi, Rachid, Fouladi, Maryam, Jones, Blaise V, Leach, James L

Source: Neuro-oncology. 24(5):821-833

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A phase I/II study of ribociclib following radiation therapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)

Authors: DeWire, Mariko, Fuller, Christine, Hummel, Trent R., Chow, Lionel M. L., Salloum, Ralph, de Blank, Peter, Pater, Luke, Lawson, Sarah, Zhu, Xiaoting, Dexheimer, Phil, Carle, Adam C., Kumar, Shiva Senthil, Drissi, Rachid, Stevenson, Charles B., Lane, Adam, Breneman, John, Witte, David, Jones, Blaise V., Leach, James L., Fouladi, Maryam

Source: Journal of neuro-oncology. 149(3):511-522

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International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma

Authors: Tsoli, Maria, Shen, Han, Mayoh, Chelsea, Franshaw, Laura, Ehteda, Anahid, Upton, Danielle, Carvalho, Diana, Vinci, Maria, Meel, Michael H., van Vuurden, Dannis, Plessier, Alexander, Castel, David, Drissi, Rachid, Farrell, Michael, Cryan, Jane, Crimmins, Darach, Caird, John, Pears, Jane, Francis, Stephanie, Ludlow, Louise E. A., Carai, Andrea, Mastronuzzi, Angela, Liu, Bing, Hansford, Jordan, Gottardo, Nick, Hassall, Tim, Kirby, Maria, Fouladi, Maryam, Hawkins, Cynthia, Monje, Michelle, Grill, Jacques, Jones, Chris, Hulleman, Esther, Ziegler, David S.

Source: Journal of neuro-oncology. 141(2):253-263

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Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma

Authors: Lu, Fanghui, Chen, Ying, Zhao, Chuntao, Wang, Haibo, He, Danyang, Xu, Lingli, Wang, Jincheng, He, Xuelian, Deng, Yaqi, Lu, Ellen E., Liu, Xue, Verma, Ravinder, Bu, Hong, Drissi, Rachid, Fouladi, Maryam, Stemmer-Rachamimov, Anat O., Burns, Dennis, Xin, Mei, Rubin, Joshua B., Bahassi, El Mustapha, Canoll, Peter, Holland, Eric C., Lu, Q. Richard

Source: In Cancer Cell 9 May 2016 29(5):669-683

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

Authors: Sturm, Dominik, Orr, Brent A., Toprak, Umut H., Hovestadt, Volker, Jones, David T.W., Capper, David, Sill, Martin, Buchhalter, Ivo, Northcott, Paul A., Leis, Irina, Ryzhova, Marina, Koelsche, Christian, Pfaff, Elke, Allen, Sariah J., Balasubramanian, Gnanaprakash, Worst, Barbara C., Pajtler, Kristian W., Brabetz, Sebastian, Johann, Pascal D., Sahm, Felix, Reimand, Jüri, Mackay, Alan, Carvalho, Diana M., Remke, Marc, Phillips, Joanna J., Perry, Arie, Cowdrey, Cynthia, Drissi, Rachid, Fouladi, Maryam, Giangaspero, Felice, Łastowska, Maria, Grajkowska, Wiesława, Scheurlen, Wolfram, Pietsch, Torsten, Hagel, Christian, Gojo, Johannes, Lötsch, Daniela, Berger, Walter, Slavc, Irene, Haberler, Christine, Jouvet, Anne, Holm, Stefan, Hofer, Silvia, Prinz, Marco, Keohane, Catherine, Fried, Iris, Mawrin, Christian, Scheie, David, Mobley, Bret C., Schniederjan, Matthew J., Santi, Mariarita, Buccoliero, Anna M., Dahiya, Sonika, Kramm, Christof M., von Bueren, André O., von Hoff, Katja, Rutkowski, Stefan, Herold-Mende, Christel, Frühwald, Michael C., Milde, Till, Hasselblatt, Martin, Wesseling, Pieter, Rößler, Jochen, Schüller, Ulrich, Ebinger, Martin, Schittenhelm, Jens, Frank, Stephan, Grobholz, Rainer, Vajtai, Istvan, Hans, Volkmar, Schneppenheim, Reinhard, Zitterbart, Karel, Collins, V. Peter, Aronica, Eleonora, Varlet, Pascale, Puget, Stephanie, Dufour, Christelle, Grill, Jacques, Figarella-Branger, Dominique, Wolter, Marietta, Schuhmann, Martin U., Shalaby, Tarek, Grotzer, Michael, van Meter, Timothy, Monoranu, Camelia-Maria, Felsberg, Jörg, Reifenberger, Guido, Snuderl, Matija, Forrester, Lynn Ann, Koster, Jan, Versteeg, Rogier, Volckmann, Richard, van Sluis, Peter, Wolf, Stephan, Mikkelsen, Tom, Gajjar, Amar, Aldape, Kenneth, Moore, Andrew S., Taylor, Michael D., Jones, Chris, Jabado, Nada, Karajannis, Matthias A., Eils, Roland, Schlesner, Matthias, Lichter, Peter, von Deimling, Andreas, Pfister, Stefan M., Ellison, David W., Korshunov, Andrey, Kool, Marcel

Source: In Cell 25 February 2016 164(5):1060-1072

Preclinical pediatric brain tumor models for immunotherapy: Hurdles and a way forward.

Authors: Mishra, Deepak Kumar, Popovski, Dean, Morris, Shelli M, Bondoc, Andrew, Kumar, Shiva Senthil, Girard, Emily J, Rutka, James, Fouladi, Maryam, Huang, Annie, Olson, James M, Drissi, Rachid

Source: Neuro-Oncology; Feb2024, Vol. 26 Issue 2, p226-235, 10p

A pilot radiogenomic study of DIPG reveals distinct subgroups with unique clinical trajectories and therapeutic targets

Authors: Zhu, Xiaoting, Lazow, Margot A., Schafer, Austin, Bartlett, Allison, Senthil Kumar, Shiva, Mishra, Deepak Kumar, Dexheimer, Phillip, DeWire, Mariko, Fuller, Christine, Leach, James L., Fouladi, Maryam, Drissi, Rachid

Source: Acta neuropathologica communications. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191379509.0x000001&indx=1&recIds=ETOCvdc_100191379509.0x000001

Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas

Authors: Salloum, Ralph, McConechy, Melissa, Mikael, Leonie, Fuller, Christine, Drissi, Rachid, DeWire, Mariko, Nikbakht, Hamid, De Jay, Nicolas, Yang, Xiaodan, Boue, Daniel, Chow, Lionel, Finlay, Jonathan, Gayden, Tenzin, Karamchandani, Jason, Hummel, Trent, Olshefski, Randal, Osorio, Diana, Stevenson, Charles, Kleinman, Claudia, Majewski, Jacek, Fouladi, Maryam, Jabado, Nada

Source: Acta neuropathologica communications. 5(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100148021849.0x000001&indx=1&recIds=ETOCvdc_100148021849.0x000001

Vorinostat, temozolomide or bevacizumab with irradiation and maintenance BEV/TMZ in pediatric high-grade glioma: A Children's Oncology Group Study.

Authors: Lulla, Rishi R, Buxton, Allen, Krailo, Mark D, Lazow, Margot A, Boue, Daniel R, Leach, James L, Lin, Tong, Geller, James I, Kumar, Shiva Senthil, Nikiforova, Marina N, Chandran, Uma, Jogal, Sachin S, Nelson, Marvin D, Onar-Thomas, Arzu, Haas-Kogan, Daphne A, Cohen, Kenneth J, Kieran, Mark W, Gajjar, Amar, Drissi, Rachid, Pollack, Ian F

Source: Neuro-Oncology Advances; Jan-Dec2024, Vol. 6 Issue 1, p1-12, 12p

Nondestructive Measurement of Grapevine Leaf Area by Ground Normalized Difference Vegetation Index.

Authors: Drissi, Rachid, Goutouly, Jean-Pascal, Forget, Dominique

Source: Agronomy Journal; January/February 2009, Vol. 101 Issue 1, p226-231, 6p

Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas

Authors: Lazow, Margot A., Hoffman, Lindsey, Schafer, Austin, Osorio, Diana S., Boué, Daniel R., Rush, Sarah, Wright, Erin, Lane, Adam, DeWire-Schottmiller, Mariko D., Smolarek, Teresa, Sipple, Jared, Taggert, Heather, Reuss, Jaime, Salloum, Ralph, Hummel, Trent R., de Blank, Peter, Pillay-Smiley, Natasha, Sutton, Mary E., Asher, Anthony, Stevenson, Charles B., Drissi, Rachid, Finlay, Jonathan L., Fouladi, Maryam, Fuller, Christine

Source: Acta neuropathologica communications. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183572678.0x000001&indx=1&recIds=ETOCvdc_100183572678.0x000001

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

Authors: Sturm, Dominik, Witt, Hendrik, Hovestadt, Volker, Khuong-Quang, Dong-Anh, Jones, David T.W., Konermann, Carolin, Pfaff, Elke, Tönjes, Martje, Sill, Martin, Bender, Sebastian, Kool, Marcel, Zapatka, Marc, Becker, Natalia, Zucknick, Manuela, Hielscher, Thomas, Liu, Xiao-Yang, Fontebasso, Adam M., Ryzhova, Marina, Albrecht, Steffen, Jacob, Karine, Wolter, Marietta, Ebinger, Martin, Schuhmann, Martin U., van Meter, Timothy, Frühwald, Michael C., Hauch, Holger, Pekrun, Arnulf, Radlwimmer, Bernhard, Niehues, Tim, von Komorowski, Gregor, Dürken, Matthias, Kulozik, Andreas E., Madden, Jenny, Donson, Andrew, Foreman, Nicholas K., Drissi, Rachid, Fouladi, Maryam, Scheurlen, Wolfram, von Deimling, Andreas, Monoranu, Camelia, Roggendorf, Wolfgang, Herold-Mende, Christel, Unterberg, Andreas, Kramm, Christof M., Felsberg, Jörg, Hartmann, Christian, Wiestler, Benedikt, Wick, Wolfgang, Milde, Till, Witt, Olaf, Lindroth, Anders M., Schwartzentruber, Jeremy, Faury, Damien, Fleming, Adam, Zakrzewska, Magdalena, Liberski, Pawel P., Zakrzewski, Krzysztof, Hauser, Peter, Garami, Miklos, Klekner, Almos, Bognar, Laszlo, Morrissy, Sorana, Cavalli, Florence, Taylor, Michael D., van Sluis, Peter, Koster, Jan, Versteeg, Rogier, Volckmann, Richard, Mikkelsen, Tom, Aldape, Kenneth, Reifenberger, Guido, Collins, V. Peter, Majewski, Jacek, Korshunov, Andrey, Lichter, Peter, Plass, Christoph, Jabado, Nada, Pfister, Stefan M.

Source: In Cancer Cell 16 October 2012 22(4):425-437

Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse

Authors: Zhang, Liguo, He, Xuelian, Liu, Xuezhao, Zhang, Feng, Huang, L. Frank, Potter, Andrew S., Xu, Lingli, Zhou, Wenhao, Zheng, Tao, Luo, Zaili, Berry, Kalen P., Pribnow, Allison, Smith, Stephanie M., Fuller, Christine, Jones, Blaise V., Fouladi, Maryam, Drissi, Rachid, Yang, Zeng-Jie, Gustafson, W. Clay, Remke, Marc, Pomeroy, Scott L., Girard, Emily J., Olson, James M., Morrissy, A. Sorana, Vladoiu, Maria C., Zhang, Jiao, Tian, Weidong, Xin, Mei, Taylor, Michael D., Potter, S. Steven, Roussel, Martine F., Weiss, William A., Lu, Q. Richard

Source: Cancer cell. 36(3):302-318.e7

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100088630322.0x000001&indx=1&recIds=ETOCvdc_100088630322.0x000001

Alternative Lengthening of Telomeres in Pediatric High-Grade Glioma and Therapeutic Implications.

Authors: Umaru, Banlanjo, Sengupta, Satarupa, Senthil Kumar, Shiva, Drissi, Rachid

Source: Cancers; Jun2023, Vol. 15 Issue 12, p3070, 12p

Subject Terms: TELOMERES, THERAPEUTICS, PROTEIN kinases, GLIOMAS, PEDIATRICS, APOPTOSIS, BRAIN tumors, TELANGIECTASIA, RESEARCH funding, T-cell exhaustion, SENSITIVITY & specificity (Statistics)

EPCT-16. A PHASE IB STUDY OF PTC596 IN CHILDREN WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA AND HIGH GRADE GLIOMA

Authors: Smiley, Natasha Pillay, Baxter, Patricia, Kumar, Shiva, Hwang, Eugene, Breneman, John, Lane, Adam, Doughman, Renee, Deutsch, Michelle, Stevenson, Charles, Stewart, Clinton, Leach, Jim, Li, Xiao-Nan, Romero, Sonia, Maliakal, Pius, Gao, Lan, Fouladi, Maryam, Drissi, Rachid

Source: Neuro-oncology. 22(Supplement 3):iii306-iii307

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112157076.0x000001&indx=1&recIds=ETOCvdc_100112157076.0x000001

DIPG-74. RE-IRRADIATION OF DIPG: DATA FROM THE INTERNATIONAL DIPG REGISTRY

Authors: Lafay-Cousin, Lucie, Lane, Adam, Schafer, Austin, Saab, Raya, Cheng, Sylvia, Bandopadhayay, Pratiti, Zaghloul, Mohamed, El-Ayadi, Motasem, Dorris, Kathleen, Packer, Roger, Kilburn, Lindsey, Minturn, Jane, Dodgshun, Andrew, Parkin, Sara, Lombardi, Mercedes Garcia, Cohen, Kenneth, Gass, David, Goldman, Stewart, Sandler, Eric, Warren, Katherine, Greiner, Robert, Gottardo, Nicholas, Dholaria, Hetal, Hassall, Tim, Coven, Scott, Hansford, Jordan, Samson, Yvan, Leary, Sarah, Bartels, Ute, Bouffet, Eric, Ma, Jie, Tinkle, Christopher, Monje-Deisseroth, Michelle, Fisher, Paul, Tsui, Karen, Ziegler, David, Chintagumpala, Murali, Gururangan, Sridharan, Wagner, Lars, Koschmann, Carl, DeWire-Schottmiller, Mariko, Leach, James, Jones, Blaise, Fuller, Christine, Drissi, Rachid, Chaney, Brooklyn, Black, Katie, Fouladi, Maryam, Strother, Douglas

Source: Neuro-oncology. 22(Supplement 3):iii301-iii302

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112156732.0x000001&indx=1&recIds=ETOCvdc_100112156732.0x000001

DIPG-46. NON-DIPG PATIENTS ENROLLED IN THE INTERNATIONAL DIPG REGISTRY: HISTOPATHOLOGIC EVALUATION OF CENTRAL NEURO-IMAGING REVIEW

Authors: Lazow, Margot A, Fuller, Christine, Lane, Adam, DeWire-Schottmiller, Mariko D, Bandopadhayay, Pratiti, Bartels, Ute, Bouffet, Eric, Cheng, Sylvia, Cohen, Kenneth J, Cooney, Tabitha M, Coven, Scott L, Dholaria, Hetal, Diez, Blanca, Dorris, Kathleen, El-Ayadi, Motasem, El-Sheikh, Ayman, Fisher, Paul G, Lombardi, Mercedes Garcia, Greiner, Robert J, Goldman, Stewart, Gottardo, Nicholas, Gururangan, Sridharan, Hansford, Jordan R, Hassall, Tim, Hawkins, Cynthia, Kilburn, Lindsay, Koschmann, Carl J, Leary, Sarah E, Ma, Jie, Minturn, Jane E, Monje-Deisseroth, Michelle, Packer, Roger J, Samson, Yvan, Sandler, Eric S, Sevlever, Gustavo, Tinkle, Christopher, Tsui, Karen, Wagner, Lars M, Zaghloul, Mohamed, Ziegler, David S, Chaney, Brooklyn, Black, Katie, Asher, Anthony, Drissi, Rachid, Fouladi, Maryam, Jones, Blaise V, Leach, James L

Source: Neuro-oncology. 22(Supplement 3):iii295-iii296

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112156358.0x000001&indx=1&recIds=ETOCvdc_100112156358.0x000001