Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression

Authors: Aynekulu Mersha, Daniël G. ^a, Fromme, Sarah E. ^b, van Boven, Frank ^c, Arteaga-Henríquez, Gara ^{d, e, f}, Wijkhuijs, Annemarie ^a, van der Ent, Marianne ^a, Berghmans, Raf ^h, Baune, Bernard T. ^{b, g, h}, Drexhage, Hemmo A. ^{a, ⁎, 1}, Dalm, Virgil ^{a, 1}

Source: In Brain, Behavior, & Immunity - Health February 2025 43

Higher T central and lower effector memory cells in bipolar disorder: A differentiation abnormality?

Authors: Ioannou, Magdalini, Simon, Maria S., Borkent, Jenny, Wijkhuijs, Annemarie, Berghmans, Raf, Haarman, Bartholomeus C.M., Drexhage, Hemmo A.

Source: In Brain, Behavior, & Immunity - Health July 2024 38

Low-dose interleukin 2 antidepressant potentiation in unipolar and bipolar depression: Safety, efficacy, and immunological biomarkers

Authors: Poletti, Sara ^{a, b, ⁎}, Zanardi, Raffaella ^{b, c}, Mandelli, Alessandra ^d, Aggio, Veronica ^{a, b}, Finardi, Annamaria ^d, Lorenzi, Cristina ^a, Borsellino, Giovanna ^e, Carminati, Matteo ^{b, c}, Manfredi, Elena ^{b, c}, Tomasi, Enrico ^f, Spadini, Sara ^a, Colombo, Cristina ^{b, c}, Drexhage, Hemmo A. ^g, Furlan, Roberto ^{b, d}, Benedetti, Francesco ^{a, b}

Source: In Brain Behavior and Immunity May 2024 118:52-68

Exploring peripheral biomarkers of response to simvastatin supplementation in schizophrenia

Authors: Zaki, Jihan K., Lago, Santiago G., Spadaro, Benedetta, Rustogi, Nitin, Gangadin, Shiral S., Benacek, Jiri, Drexhage, Hemmo A., de Witte, Lot D., Kahn, René S., Sommer, Iris E.C., Bahn, Sabine, Tomasik, Jakub

Source: In Schizophrenia Research April 2024 266:66-74

Reduced numbers of naïve CD4 + T cells and an altered CD4/CD8 balance in depressed common variable immune deficiency (CVID) patients. Is thymosin-α1 a possible treatment?

Authors: Manusama, Olivia, Singh, Sajni, Brooimans, Rik A., Wijkhuijs, Annemarie, van der Ent, Marianne, Drexhage, Hemmo A., Dalm, Virgil A.

Source: In International Immunopharmacology June 2023 119

Premature T cell aging in major depression: A double hit by the state of disease and cytomegalovirus infection

Authors: Simon, Maria S., Ioannou, Magdalini, Arteaga-Henríquez, Gara, Wijkhuijs, Annemarie, Berghmans, Raf, Musil, Richard, Müller, Norbert, Drexhage, Hemmo A.

Source: In Brain, Behavior, & Immunity - Health May 2023 29

Inflammatory monocyte gene signature predicts beneficial within group effect of simvastatin in patients with schizophrenia spectrum disorders in a secondary analysis of a randomized controlled trial

Authors: Aichholzer, Mareike, Gangadin, Shiral S., Sommer, Iris E.C., Wijkhuis, Annemarie, de Witte, Lot D., Kahn, René S., Bahn, Sabine, Drexhage, Hemmo A., Schiweck, Carmen

Source: In Brain, Behavior, & Immunity - Health December 2022 26

A Sticky Situation: The Link Between Peripheral Inflammation, Neuroinflammation, and Severe Mental Illness

Authors: Tomasik, Jakub, Schiweck, Carmen, Drexhage, Hemmo A.

Source: Biological psychiatry. 93(2):107-109

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194111540.0x000001&indx=1&recIds=ETOCvdc_100194111540.0x000001

Conventional and new immunotherapies for immune system dysregulation in postpartum mood disorders: comparisons to immune system dysregulations in bipolar disorder, major depression, and postpartum autoimmune thyroid disease.

Authors: Drexhage, Hemmo A., Bergink, Veerle, Poletti, Sara, Benedetti, Francesco, Osborne, Lauren M.

Source: Expert Review of Clinical Immunology; Feb2025, Vol. 21 Issue 2, p113-135, 23p

Subject Terms: REGULATORY T cells, MOOD (Psychology), POSTPARTUM psychoses, POSTPARTUM depression, AFFECTIVE disorders

Monocyte mitochondrial dysfunction, inflammaging, and inflammatory pyroptosis in major depression

Authors: Simon, Maria S., Schiweck, Carmen, Arteaga-Henríquez, Gara, Poletti, Sara, Haarman, Bartholomeus C.M., Dik, Wim A., Schwarz, Markus, Vrieze, Elske, Mikova, Olya, Joergens, Silke, Musil, Richard, Claes, Stephan, Baune, Bernhard T., Leboyer, Marion, Benedetti, Francesco, Furlan, Roberto, Berghmans, Raf, de Wit, Harm, Wijkhuijs, Annemarie, Arolt, Volker, Müller, Norbert, Drexhage, Hemmo A.

Source: In Progress in Neuropsychopharmacology & Biological Psychiatry 20 December 2021 111

Bidirectional associations between treatment-resistant depression and general medical conditions

Authors: Madsen, Kathrine Bang, Momen, Natalie C., Petersen, Liselotte Vogdrup, Plana-Ripoll, Oleguer, Haarman, Bartholomeus C.M., Drexhage, Hemmo, Mortensen, Preben Bo, McGrath, John J., Munk-Olsen, Trine

Source: In European Neuropsychopharmacology October 2021 51:7-19

Activation and deactivation steps in the tryptophan breakdown pathway in major depressive disorder: A link to the monocyte inflammatory state of patients

Authors: Arteaga-Henriquez, Gara, Burger, Bianka, Weidinger, Elif, Grosse, Laura, Moll, Natalie, Schuetze, Gregor, Schwarz, Markus, Wijkhuijs, Annemarie, Op de Beeck, Gommaar, Berghmans, Raf, Versnel, Marjan A., Arolt, Volker, Müller, Norbert, Drexhage, Hemmo A.

Source: In Progress in Neuropsychopharmacology & Biological Psychiatry 20 April 2021 107

Brain-immune crosstalk in the treatment of major depressive disorder

Authors: Branchi, Igor, Poggini, Silvia, Capuron, Lucile, Benedetti, Francesco, Poletti, Sara, Tamouza, Ryad, Drexhage, Hemmo A., Penninx, Brenda W.J.H., Pariante, Carmine M.

Source: In European Neuropsychopharmacology April 2021 45:89-107

Simvastatin Augmentation for Patients With Early-Phase Schizophrenia-Spectrum Disorders: A Double-Blind, Randomized Placebo-Controlled Trial

Authors: Sommer, Iris E, Gangadin, Shiral S, de Witte, Lot D, Koops, Sanne, van Baal, C, Bahn, Sabine, Drexhage, Hemmo, van Haren, N E M, Veling, Wim, Bruggeman, R, Martens, Peter, Wiersma, Sybren, Veerman, Selene R T, Grootens, Koen P, van Beveren, Nico, Kahn, Rene S, Begemann, Marieke J H

Source: Schizophrenia bulletin. 47(4):1108-1115

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125528990.0x000001&indx=1&recIds=ETOCvdc_100125528990.0x000001

Depression and suicidality: A link to premature T helper cell aging and increased Th17 cells

Authors: Schiweck, Carmen, Valles-Colomer, Mireia, Arolt, Volker, Müller, Norbert, Raes, Jeroen, Wijkhuijs, Annemarie, Claes, Stephan, Drexhage, Hemmo, Vrieze, Elske

Source: In Brain Behavior and Immunity July 2020 87:603-609

T-cell defects and postpartum depression

Authors: Osborne, Lauren M., Gilden, Janneke, Kamperman, Astrid M., Hoogendijk, Witte J.G., Spicer, Julie, Drexhage, Hemmo A., Bergink, Veerle

Source: In Brain Behavior and Immunity July 2020 87:397-403

Childhood Adversity and Current Stress are related to Pro- and Anti-inflammatory Cytokines in Major Depression

Authors: Müller, Norbert, Krause, Daniela, Barth, Rike, Myint, Aye-Mu, Weidinger, Elif, Stettinger, Waltraud, Zill, Peter, Drexhage, Hemmo, Schwarz, Markus J.

Source: In Journal of Affective Disorders 15 June 2019 253:270-276

The circulating levels of CD4+ t helper cells are higher in bipolar disorder as compared to major depressive disorder

Authors: Becking, Karlijn, Haarman, Bartholomeus C.M., Grosse, Laura, Nolen, Willem A., Claes, Stephan, Arolt, Volker, Schoevers, Robert A., Drexhage, Hemmo A.

Source: In Journal of Neuroimmunology 15 June 2018 319:28-36

A pilot study on immuno-psychiatry in the 22q11.2 deletion syndrome: A role for Th17 cells in psychosis?

Authors: Vergaelen, Elfi, Schiweck, Carmen, Van Steeland, Kristof, Counotte, Jacqueline, Veling, Wim, Swillen, Ann, Drexhage, Hemmo, Claes, Stephan

Source: In Brain Behavior and Immunity May 2018 70:88-95

Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients

Authors: van Rees, Geertje Frederique, Lago, Santiago Guillermo, Cox, David Alan, Tomasik, Jakub, Rustogi, Nitin, Weigelt, Karin, Ozcan, Sureyya, Cooper, Jason, Drexhage, Hemmo, Leweke, F. Markus, Bahn, Sabine

Source: In Brain Behavior and Immunity January 2018 67:364-373