Enablers and Barriers to Deployment of Smartphone-Based Home Vision Monitoring in Clinical Practice Settings

Authors: Korot, Edward, Pontikos, Nikolas, Drawnel, Faye M.

Source: JAMA ophthalmology. 140(2):153-160

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633485608&indx=1&recIds=ETOCRN633485608

Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probeElectronic supplementary information (ESI) available: Supplementary figures and tables; general synthetic methods; compound synthesis and characterization; molecular docking; in vitro pharmacology; fluorescence spectroscopy; TR-FRET kinetic CB2R binding assay; FACS analysis; time-lapse confocal imaging; in vivo zebrafish imaging; NMR spectra; and N-terminal SNAP-hCB2R sequence. CCDC 1923120. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/d1sc06659e

Authors: Gazzi, Thais, Brennecke, Benjamin, Atz, Kenneth, Korn, Claudia, Sykes, David, Forn-Cuni, Gabriel, Pfaff, Patrick, Sarott, Roman C., Westphal, Matthias V., Mostinski, Yelena, Mach, Leonard, Wasinska-Kalwa, Malgorzata, Weise, Marie, Hoare, Bradley L., Miljuš, Tamara, Mexi, Maira, Roth, Nicolas, Koers, Eline J., Guba, Wolfgang, Alker, André, Rufer, Arne C., Kusznir, Eric A., Huber, Sylwia, Raposo, Catarina, Zirwes, Elisabeth A., Osterwald, Anja, Pavlovic, Anto, Moes, Svenja, Beck, Jennifer, Nettekoven, Matthias, Benito-Cuesta, Irene, Grande, Teresa, Drawnel, Faye, Widmer, Gabriella, Holzer, Daniela, van der Wel, Tom, Mandhair, Harpreet, Honer, Michael, Fingerle, Jürgen, Scheffel, Jörg, Broichhagen, Johannes, Gawrisch, Klaus, Romero, Julián, Hillard, Cecilia J., Varga, Zoltan V., van der Stelt, Mario, Pacher, Pal, Gertsch, Jürg, Ullmer, Christoph, McCormick, Peter J., Oddi, Sergio, Spaink, Herman P., Maccarrone, Mauro, Veprintsev, Dmitry B., Carreira, Erick M., Grether, Uwe, Nazaré, Marc

Source: Chemical science. 13(19):5539-5545

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150048376.0x000001&indx=1&recIds=ETOCvdc_100150048376.0x000001

DDR1 role in fibrosis and its pharmacological targeting

Authors: Moll, Solange, Desmoulière, Alexis, Moeller, Marcus J., Pache, Jean-Claude, Badi, Laura, Arcadu, Filippo, Richter, Hans, Satz, Alexander, Uhles, Sabine, Cavalli, Andrea, Drawnel, Faye, Scapozza, Leonardo, Prunotto, Marco

Source: In BBA - Molecular Cell Research November 2019 1866(11)

Indocyanine green molecular angiography of choroidal neovascularization

Authors: Feenstra, Derrick J., Seleci, Muharrem, Denk, Nora, Fauser, Sascha, Drawnel, Faye M., Jayagopal, Ashwath

Source: In Experimental Eye Research March 2019 180:122-128

The role of inflammation in diabetic eye disease

Authors: Mesquida, Marina, Drawnel, Faye, Fauser, Sascha

Source: Seminars in immunopathology. 41(4):427-445

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125505652.0x000001&indx=1&recIds=ETOCvdc_100125505652.0x000001

Regulated efflux of photoreceptor outer segment-derived cholesterol by human RPE cells

Authors: Storti, Federica, Raphael, Gabriele, Griesser, Vera, Klee, Katrin, Drawnel, Faye, Willburger, Carolin, Scholz, Rebecca, Langmann, Thomas, von Eckardstein, Arnold, Fingerle, Jürgen, Grimm, Christian, Maugeais, Cyrille

Source: In Experimental Eye Research December 2017 165:65-77

Endothelin-1 promotes hypertrophic remodelling of cardiac myocytes by activating sustained signalling and transcription downstream of endothelin type A receptors

Authors: Archer, Caroline R., Robinson, Emma L., Drawnel, Faye M., Roderick, H. Llewelyn

Source: In Cellular Signalling August 2017 36:240-254

Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime

Authors: Moll, Solange, Yasui, Yukari, Abed, Ahmed, Murata, Takeshi, Shimada, Hideaki, Maeda, Akira, Fukushima, Naoshi, Kanamori, Masakazu, Uhles, Sabine, Badi, Laura, Cagarelli, Thomas, Formentini, Ivan, Drawnel, Faye, Georges, Guy, Bergauer, Tobias, Gasser, Rodolfo, Bonfil, R., Fridman, Rafael, Richter, Hans, Funk, Juergen, Moeller, Marcus, Chatziantoniou, Christos, Prunotto, Marco

Source: Journal of translational medicine. 16(1):1-20

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164012642.0x000001&indx=1&recIds=ETOCvdc_100164012642.0x000001

Remote Monitoring of Visual Function in Patients with Maculopathy: The Aphelion Study.

Authors: Joseph, Anthony, Bullimore, Mark, Drawnel, Faye, Miranda, Marco, Morgan, Zoe, Wang, Yi-Zhong

Source: Ophthalmology & Therapy; Jan2024, Vol. 13 Issue 1, p409-422, 14p

Subject Terms: VISION, MACULAR degeneration, CONTRAST sensitivity (Vision), FORM perception, DIABETIC retinopathy

Home vision monitoring in patients with maculopathy: current and future options for digital technologies

Authors: Balaskas, Konstantinos, Drawnel, Faye, Khanani, Arshad M., Knox, Paul C., Mavromaras, George, Wang, Yi-Zhong

Source: Eye; October 2023, Vol. 37 Issue: 15 p3108-3120, 13p

Endothelin-1-Stimulated InsP3-Induced Ca2+ Release Is a Nexus for Hypertrophic Signaling in Cardiac Myocytes

Authors: Higazi, Daniel R., Fearnley, Claire J., Drawnel, Faye M., Talasila, Amarnath, Corps, Elaine M., Ritter, Oliver, McDonald, Fraser, Mikoshiba, Katsuhiko, Bootman, Martin D., Roderick, H. Llewelyn

Source: In Molecular Cell 27 February 2009 33(4):472-482

Characterization of Influenza-Like Illness Burden Using Commercial Wearable Sensor Data and Patient-Reported Outcomes: Mixed Methods Cohort Study.

Authors: Hunter, Victoria¹, Shapiro, Allison², Chawla, Devika¹, Drawnel, Faye³, Ramirez, Ernesto², Phillips, Elizabeth², Tadesse-Bell, Sara¹, Foschini, Luca², Ukachukwu, Vincent⁴, vincent.ukachukwu@roche.com

Source: Journal of Medical Internet Research; 2023, Vol. 25 Issue 1, p1-18, 18p

Predictors of Seeking Care for Influenza-Like Illness in a Novel Digital Study.

Authors: Chawla, Devika, Benitez, Alejandra, Xu, Hao, Whitehill, Victoria, Tadesse-Bell, Sara, Shapiro, Allison, Ramirez, Ernesto, Scherer, Kelly, Foschini, Luca, Drawnel, Faye, Clinch, Barry, Prunotto, Marco, Ukachukwu, Vincent

Source: Open Forum Infectious Diseases; Jan2023, Vol. 10 Issue 1, p1-10, 10p

Subject Terms: HEALTH insurance, MEDICAL care, DISEASE management, HEALTH behavior, RESPIRATORY infections

Geographic Terms: UNITED States

Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery

Authors: Drawnel, Faye Marie, Zhang, Jitao David, Küng, Erich, Aoyama, Natsuyo, Benmansour, Fethallah, Araujo Del Rosario, Andrea, Jensen Zoffmann, Sannah, Delobel, Frédéric, Prummer, Michael, Weibel, Franziska, Carlson, Coby, Anson, Blake, Iacone, Roberto, Certa, Ulrich, Singer, Thomas, Ebeling, Martin, Prunotto, Marco

Source: Cell chemical biology. 24(5):624-634.e3

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100051490528.0x000001&indx=1&recIds=ETOCvdc_100051490528.0x000001

Training and deploying a deep learning model for endoscopic severity grading in ulcerative colitis using multicenter clinical trial data.

Authors: Gutierrez Becker, Benjamin, Arcadu, Filippo, Thalhammer, Andreas, Gamez Serna, Citlalli, Feehan, Owen, Drawnel, Faye, Oh, Young S., Prunotto, Marco

Source: Therapeutic Advances in Gastrointestinal Endoscopy; 2/25/2021, p1-15, 15p

Subject Terms: ULCERATIVE colitis, DEEP learning, RESEARCH, COLONOSCOPY, RESEARCH evaluation, MEDICAL cooperation, SEVERITY of illness index, AUTOMATION, DESCRIPTIVE statistics, RECEIVER operating characteristic curves, ENDOSCOPY, MEDICAL education, VIDEO recording, ALGORITHMS

The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth.

Authors: Drawnel, Faye M¹, Archer, Caroline R¹, Roderick, H Llewelyn^1,2

Source: British Journal of Pharmacology. Jan2013, Vol. 168 Issue 2, p296-317. 22p. 3 Diagrams.

Subject Terms: *PARACRINE mechanisms, *AUTOCRINE mechanisms, *ENDOTHELINS, *CARDIAC contraction, *HEART development, *HEART physiology, *HYPERTROPHY

MSK-Mediated Phosphorylation of Histone H3 Ser28 Couples MAPK Signalling with Early Gene Induction and Cardiac Hypertrophy.

Authors: Robinson, Emma L.^1,2 (AUTHOR) emma.2.robinson@cuanschutz.edu, Drawnel, Faye M.^3,4 (AUTHOR) faye.drawnel@roche.com, Mehdi, Saher¹ (AUTHOR) chandan.kadurnagaraju@kuleuven.be, Archer, Caroline R.³ (AUTHOR) caroline.archer@astrazeneca.com, Liu, Wei⁵ (AUTHOR) Wei.Liu@manchester.ac.uk, Okkenhaug, Hanneke³ (AUTHOR) hanneke.okkenhaug@babraham.ac.uk, Alkass, Kanar⁶ (AUTHOR) kanar.alkass@ki.se, Aronsen, Jan Magnus^7,8 (AUTHOR) j.m.aronsen@medisin.uio.no, Nagaraju, Chandan K.¹ (AUTHOR) karin.sipido@kuleuven.be, Sjaastad, Ivar^7,9 (AUTHOR) ivar.sjaastad@medisin.uio.no, Sipido, Karin R.¹ (AUTHOR), Bergmann, Olaf¹⁰ (AUTHOR) olaf_bergmann@tu-dresden.de, Arthur, J. Simon C.¹¹ (AUTHOR) j.s.c.arthur@dundee.ac.uk, Wang, Xin⁵ (AUTHOR) xin.wang@manchester.ac.uk, Roderick, H. Llewelyn^1,9 (AUTHOR) emma.2.robinson@cuanschutz.edu

Source: Cells (2073-4409). Apr2022, Vol. 11 Issue 4, p604. 1p.

Subject Terms: *CARDIAC hypertrophy, *MITOGEN-activated protein kinases, *AP-1 transcription factor, *GENETIC regulation, *CHROMATIN-remodeling complexes, *PROTEIN kinases, *MITOGENS

Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells

Authors: Sarott, Roman C., Westphal, Matthias V., Pfaff, Patrick, Korn, Claudia, Sykes, David A., Gazzi, Thais, Brennecke, Benjamin, Atz, Kenneth, Weise, Marie, Mostinski, Yelena, Hompluem, Pattarin, Koers, Eline, Miljuš, Tamara, Roth, Nicolas J., Asmelash, Hermon, Vong, Man C., Piovesan, Jacopo, Guba, Wolfgang, Rufer, Arne C., Kusznir, Eric A., Huber, Sylwia, Raposo, Catarina, Zirwes, Elisabeth A., Osterwald, Anja, Pavlovic, Anto, Moes, Svenja, Beck, Jennifer, Benito-Cuesta, Irene, Grande, Teresa, Ruiz de Martı́n Esteban, Samuel, Yeliseev, Alexei, Drawnel, Faye, Widmer, Gabriella, Holzer, Daniela, van der Wel, Tom, Mandhair, Harpreet, Yuan, Cheng-Yin, Drobyski, William R., Saroz, Yurii, Grimsey, Natasha, Honer, Michael, Fingerle, Jürgen, Gawrisch, Klaus, Romero, Julian, Hillard, Cecilia J., Varga, Zoltan V., van der Stelt, Mario, Pacher, Pal, Gertsch, Jürg, McCormick, Peter J., Ullmer, Christoph, Oddi, Sergio, Maccarrone, Mauro, Veprintsev, Dmitry B., Nazaré, Marc, Grether, Uwe, Carreira, Erick M.

Source: Journal of the American Chemical Society; October 2020, Vol. 142 Issue: 40 p16953-16964, 12p

Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

Authors: Drawnel, Faye M., Boccardo, Stefano, Prummer, Michael, Delobel, Frédéric, Graff, Alexandra, Weber, Michael, Gérard, Régine, Badi, Laura, Kam-Thong, Tony, Bu, Lei, Jiang, Xin, Hoflack, Jean-Christophe, Kiialainen, Anna, Jeworutzki, Elena, Aoyama, Natsuyo, Carlson, Coby, Burcin, Mark, Gromo, Gianni, Boehringer, Markus, Stahlberg, Henning, Hall, Benjamin J., Magnone, Maria Chiara, Kolaja, Kyle, Chien, Kenneth R., Bailly, Jacques, Iacone, Roberto

Source: In Cell Reports 6 November 2014 9(3):810-820

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