Novel multitarget directed ligands inspired by riluzole: A serendipitous synthesis of substituted benzo[b][1,4]thiazepines potentially useful as neuroprotective agents

Authors: Maramai, Samuele, Saletti, Mario, Paolino, Marco, Giuliani, Germano, Cazzola, Jessica, Spaiardi, Paolo, Talpo, Francesca, Frosini, Maria, Pifferi, Alice, Ballarotto, Marco, Carotti, Andrea, Poggialini, Federica, Vagaggini, Chiara, Dreassi, Elena, Giorgi, Gianluca, Dondio, Giulio, Cappelli, Andrea, Rosario Biella, Gerardo, Anzini, Maurizio

Source: In Bioorganic & Medicinal Chemistry 1 October 2024 112

Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer

Authors: Albanese, Valentina, Missiroli, Sonia, Perrone, Mariasole, Fabbri, Martina, Boncompagni, Caterina, Pacifico, Salvatore, De Ventura, Tiziano, Ciancetta, Antonella, Dondio, Giulio, Kricek, Franz

Source: Journal of medicinal chemistry. 66(7):5223-5241

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632396982&indx=1&recIds=ETOCRN632396982

Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators

Authors: Bufano, Marianna, Puxeddu, Michela, Nalli, Marianna, La Regina, Giuseppe, Toto, Angelo, Liberati, Francesca Romana, Paone, Alessio, Cutruzzolà, Francesca, Masci, Domiziana, Bigogno, Chiara, Dondio, Giulio, Silvestri, Romano, Gianni, Stefano, Coluccia, Antonio

Source: In Bioorganic Chemistry September 2023 138

Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents

Authors: Linciano, Pasquale ^a, Sorbi, Claudia ^b, Rossino, Giacomo ^a, Rossi, Daniela ^a, Marsala, Andrea ^c, Denora, Nunzio ^d, Bedeschi, Martina ^e, Marino, Noemi ^e, Miserocchi, Giacomo ^e, Dondio, Giulio ^f, Peviani, Marco ^c, Tesei, Anna ^e, Collina, Simona ^a, Franchini, Silvia ^{b, ∗}

Source: In European Journal of Medicinal Chemistry 5 March 2023 249

Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties

Authors: Saletti, Mario, Maramai, Samuele, Reale, Annalisa, Paolino, Marco, Brogi, Simone, Di Capua, Angela, Cappelli, Andrea, Giorgi, Gianluca, D'Avino, Danilo, Rossi, Antonietta, Ghelardini, Carla, Di Cesare Mannelli, Lorenzo, Sardella, Roccaldo, Carotti, Andrea, Woelkart, Gerald, Klösch, Burkhard, Bigogno, Chiara, Dondio, Giulio, Anzini, Maurizio

Source: In European Journal of Medicinal Chemistry 5 November 2022 241

Development of N‑(4-(1H‑Imidazol-1-yl)phenyl)-4-chlorobenzenesulfonamide, a Novel Potent Inhibitor of β‑Catenin with Enhanced Antitumor Activity and Metabolic Stability.

Authors: Puxeddu, Michela, Ling, Lele, Ripa, Silvia, D'Ambrosio, Michele, Nalli, Marianna, Parisi, Anastasia, Sciò, Pietro, Coluccia, Antonio, Granese, Arianna, Santelli, Martina, Masci, Domiziana, Cuřínová, Petra, Naro, Chiara, Sette, Claudio, Pastore, Arianna, Stornaiuolo, Mariano, Bigogno, Chiara, Dondio, Giulio, Di Magno, Laura, Canettieri, Gianluca

Source: Journal of Medicinal Chemistry; 11/28/2024, Vol. 67 Issue 22, p20298-20314, 17p

RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo

Authors: Sebastiani, Jessica, Puxeddu, Michela, Nalli, Marianna, Bai, Ruoli, Altieri, Ludovica, Rovella, Paola, Gaudio, Eugenio, Trisciuoglio, Daniela, Spriano, Filippo, Lavia, Patrizia, Fionda, Cinzia, Masci, Domiziana, Urbani, Andrea, Bigogno, Chiara, Dondio, Giulio, Hamel, Ernest, Bertoni, Francesco, Silvestri, Romano, La Regina, Giuseppe

Source: European journal of medicinal chemistry. 246

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178231377.0x000001&indx=1&recIds=ETOCvdc_100178231377.0x000001

SAR Analysis of Novel Coxsackie virus A9 Capsid Binders.

Authors: Tammaro, Chiara, Plavec, Zlatka, Myllymäki, Laura, Mitchell, Cristopher, Consalvi, Sara, Biava, Mariangela, Ciogli, Alessia, Domanska, Aušra, Leppilampi, Valtteri, Buckner, Cienna, Manetto, Simone, Sciò, Pietro, Coluccia, Antonio, Laajala, Mira, Dondio, Giulio M., Bigogno, Chiara, Marjomäki, Varpu, Butcher, Sarah J., Poce, Giovanna

Source: Journal of Medicinal Chemistry; 10/10/2024, Vol. 67 Issue 19, p17144-17161, 18p

4‑(3-Phenylsulfonylindol-2-yl)-1-(pyridin-2-yl)piperazinyl-methanones as Potent Inhibitors of both SARS-CoV‑2 and HCoV-OC43 Viruses.

Authors: Puxeddu, Michela, Donalisio, Manuela, Bugert, Joachim Jakob, Corona, Angela, Cocomazzi, Paolo, Milani, Mario, Hucke, Friederike, Arduino, Irene, Esposito, Francesca, Moretti, Paolo, Ortore, Maria Grazia, Nalli, Marianna, Manetto, Simone, Mazzoccanti, Giulia, Bigogno, Chiara, Dondio, Giulio, Sciò, Pietro, Coluccia, Antonio, Fracella, Matteo, Antonelli, Guido

Source: ACS Infectious Diseases; 9/13/2024, Vol. 10 Issue 9, p3158-3175, 18p

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors

Authors: La Regina, Giuseppe, Bai, Ruoli, Coluccia, Antonio, Naccarato, Valentina, Famiglini, Valeria, Nalli, Marianna, Masci, Domiziana, Verrico, Annalisa, Rovella, Paola, Mazzoccoli, Carmela, Da Pozzo, Eleonora, Cavallini, Chiara, Martini, Claudia, Vultaggio, Stefania, Dondio, Giulio, Varasi, Mario, Mercurio, Ciro, Hamel, Ernest, Lavia, Patrizia, Silvestri, Romano

Source: In European Journal of Medicinal Chemistry 25 May 2018 152:283-297

In vivo and in vitro ADMET profiling and in vivo pharmacodynamic investigations of a selective α7 nicotinic acetylcholine receptor agonist with a spirocyclic Δ2-isoxazoline molecular skeleton

Authors: Matera, Carlo, Dondio, Giulio, Braida, Daniela, Ponzoni, Luisa, De Amici, Marco, Sala, Mariaelvina, Dallanoce, Clelia

Source: In European Journal of Pharmacology 5 February 2018 820:265-273

Novel analgesic/anti-inflammatory agents: 1, 5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties

Authors: Saletti, Mario, Maramai, Samuele, Reale, Annalisa, Paolino, Marco, Brogi, Simone, Di Capua, Angela, Cappelli, Andrea, Giorgi, Gianluca, D'Avino, Danilo, Rossi, Antonietta, Ghelardini, Carla, Di Cesare Mannelli, Lorenzo, Sardella, Roccaldo, Carotti, Andrea, Woelkart, Gerald, Klösch, Burkhard, Bigogno, Chiara, Dondio, Giulio, Anzini, Maurizio

Source: European journal of medicinal chemistry. 241

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170910458.0x000001&indx=1&recIds=ETOCvdc_100170910458.0x000001

Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors

Authors: Thaler, Florian, Moretti, Loris, Amici, Raffaella, Abate, Agnese, Colombo, Andrea, Carenzi, Giacomo, Fulco, Maria Carmela, Boggio, Roberto, Dondio, Giulio, Gagliardi, Stefania, Minucci, Saverio, Sartori, Luca, Varasi, Mario, Mercurio, Ciro

Source: In European Journal of Medicinal Chemistry 27 January 2016 108:53-67

Toward the identification of neuroprotective agents: g-scale synthesis, pharmacokinetic evaluation and CNS distribution of (R)-RC-33, a promising SIGMA1 receptor agonist

Authors: Marra, Annamaria, Rossi, Daniela, Pignataro, Luca, Bigogno, Chiara, Canta, Annalisa, Oggioni, Norberto, Malacrida, Alessio, Corbo, Massimo, Cavaletti, Guido, Peviani, Marco, Curti, Daniela, Dondio, Giulio, Collina, Simona

Source: Future medicinal chemistry. 8(3):287-295

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115568468.0x000001&indx=1&recIds=ETOCvdc_100115568468.0x000001

Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4′-piperidine] based histone deacetylase inhibitors

Authors: Thaler, Florian, Varasi, Mario, Abate, Agnese, Carenzi, Giacomo, Colombo, Andrea, Bigogno, Chiara, Boggio, Roberto, Zuffo, Roberto Dal, Rapetti, Daniela, Resconi, Anna, Regalia, Nickolas, Vultaggio, Stefania, Dondio, Giulio, Gagliardi, Stefania, Minucci, Saverio, Mercurio, Ciro

Source: In European Journal of Medicinal Chemistry June 2013 64:273-284

Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain.

Authors: Rossino, Giacomo, Marra, Annamaria, Listro, Roberta, Peviani, Marco, Poggio, Elena, Curti, Daniela, Pellavio, Giorgia, Laforenza, Umberto, Dondio, Giulio, Schepmann, Dirk, Wünsch, Bernhard, Bedeschi, Martina, Marino, Noemi, Tesei, Anna, Ha, Hee-Jin, Kim, Young-Ho, Ann, Jihyae, Lee, Jeewoo, Linciano, Pasquale, Di Giacomo, Marcello

Source: Pharmaceuticals (14248247); Jul2023, Vol. 16 Issue 7, p962, 29p

Subject Terms: NEURALGIA, AQUAPORINS, BIOSYNTHESIS, SPINAL nerves, OPIOID analgesics, SIGMA-1 receptor, ANALGESICS, DULOXETINE

Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities.

Authors: Basilico, Nicoletta, Parapini, Silvia, D'Alessandro, Sarah, Misiano, Paola, Romeo, Sergio, Dondio, Giulio, Yardley, Vanessa, Vivas, Livia, Nasser, Shereen, Rénia, Laurent, Russell, Bruce M., Suwanarusk, Rossarin, Nosten, François, Sparatore, Anna, Taramelli, Donatella

Source: Biomolecules (2218-273X); May2023, Vol. 13 Issue 5, p836, 23p

Subject Terms: ARTEMISININ derivatives, DRUG discovery, MALARIA, CHLOROQUINE, IN vitro studies

Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1 H-pyrrol-1-yl)-1 H-pyrazole-3-carboxamides as cannabinoid receptor ligands

Authors: Silvestri, Romano, Ligresti, Alessia, La Regina, Giuseppe, Piscitelli, Francesco, Gatti, Valerio, Lavecchia, Antonio, Brizzi, Antonella, Pasquini, Serena, Allarà, Marco, Fantini, Noemi, Carai, Mauro Antonio Maria, Bigogno, Chiara, Rozio, Marco Giulio, Sinisi, Roberta, Novellino, Ettore, Colombo, Giancarlo, Di Marzo, Vincenzo, Dondio, Giulio, Corelli, Federico

Source: In European Journal of Medicinal Chemistry 2010 45(12):5878-5886

Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor.

Authors: Puxeddu, Michela, Wu, Jianchao, Bai, Ruoli, D'Ambrosio, Michele, Nalli, Marianna, Coluccia, Antonio, Manetto, Simone, Ciogli, Alessia, Masci, Domiziana, Urbani, Andrea, Fionda, Cinzia, Coni, Sonia, Bordone, Rosa, Canettieri, Gianluca, Bigogno, Chiara, Dondio, Giulio, Hamel, Ernest, Liu, Te, Silvestri, Romano, La Regina, Giuseppe

Source: Journal of Medicinal Chemistry; 12/8/2022, Vol. 65 Issue 23, p15805-15818, 14p

Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics.

Authors: Taiarol, Lorenzo, Bigogno, Chiara, Sesana, Silvia, Kravicz, Marcelo, Viale, Francesca, Pozzi, Eleonora, Monza, Laura, Carozzi, Valentina Alda, Meregalli, Cristina, Valtorta, Silvia, Moresco, Rosa Maria, Koch, Marcus, Barbugian, Federica, Russo, Laura, Dondio, Giulio, Steinkühler, Christian, Re, Francesca

Source: Cancers; Jun2022, Vol. 14 Issue 12, p2978-N.PAG, 20p

Subject Terms: ARTIFICIAL membranes, ANIMAL experimentation, GLIOMAS, ANTINEOPLASTIC agents